5NYX
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8JJS
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![BU of 8jjs by Molmil](/molmil-images/mine/8jjs) | Human K-Ras G12D (GDP-bound) in complex with cyclic peptide inhibitor AP10343 | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Isoform 2B of GTPase KRas, MAA-ILE-SAR-SAR-7T2-SAR-IAE-LEU-MEA-MLE-7TK, ... | Authors: | Irie, M, Fukami, T.A, Tanada, M, Ohta, A, Torizawa, T. | Deposit date: | 2023-05-31 | Release date: | 2023-07-26 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.534 Å) | Cite: | Development of Orally Bioavailable Peptides Targeting an Intracellular Protein: From a Hit to a Clinical KRAS Inhibitor. J.Am.Chem.Soc., 145, 2023
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8JUD
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![BU of 8jud by Molmil](/molmil-images/mine/8jud) | Crystal structure of human MMP-7 in complex with inhibitor | Descriptor: | CALCIUM ION, Matrilysin, Peptide Inhibitor, ... | Authors: | Kamitani, M, Abe-Sato, K, Oka, Y. | Deposit date: | 2023-06-26 | Release date: | 2023-11-01 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structure-Based Optimization and Biological Evaluation of Potent and Selective MMP-7 Inhibitors for Kidney Fibrosis. J.Med.Chem., 66, 2023
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8JUF
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![BU of 8juf by Molmil](/molmil-images/mine/8juf) | Crystal structure of human MMP-7 in complex with inhibitor | Descriptor: | CALCIUM ION, Matrilysin, Peptide Inhibitor, ... | Authors: | Kamitani, M, Abe-Sato, K, Oka, Y. | Deposit date: | 2023-06-26 | Release date: | 2023-11-01 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.39 Å) | Cite: | Structure-Based Optimization and Biological Evaluation of Potent and Selective MMP-7 Inhibitors for Kidney Fibrosis. J.Med.Chem., 66, 2023
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8JUG
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![BU of 8jug by Molmil](/molmil-images/mine/8jug) | Crystal structure of human MMP-7 in complex with inhibitor | Descriptor: | CALCIUM ION, Matrilysin, Peptide Inhibitor, ... | Authors: | Kamitani, M, Abe-Sato, K, Oka, Y. | Deposit date: | 2023-06-26 | Release date: | 2023-11-01 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Structure-Based Optimization and Biological Evaluation of Potent and Selective MMP-7 Inhibitors for Kidney Fibrosis. J.Med.Chem., 66, 2023
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8K4Z
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3VU3
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7XJO
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![BU of 7xjo by Molmil](/molmil-images/mine/7xjo) | Crystal structure of human MMP-2 catalytic domain in complex with inhibitor | Descriptor: | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, CHLORIDE ION, ... | Authors: | Kamitani, M, Mima, M, Takeuchi, T. | Deposit date: | 2022-04-18 | Release date: | 2022-06-29 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Discovery of Aryloxyphenyl-Heptapeptide Hybrids as Potent and Selective Matrix Metalloproteinase-2 Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis. J.Med.Chem., 65, 2022
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7XGJ
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![BU of 7xgj by Molmil](/molmil-images/mine/7xgj) | Crystal structure of human MMP-2 catalytic domain in complex with inhibitor | Descriptor: | CALCIUM ION, GZS-ASN-ASP-ALA-LEU-IML-EOE-NH2, Matrix metalloproteinase-2, ... | Authors: | Kamitani, M, Mima, M, Takeuchi, T. | Deposit date: | 2022-04-05 | Release date: | 2022-06-29 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Discovery of Aryloxyphenyl-Heptapeptide Hybrids as Potent and Selective Matrix Metalloproteinase-2 Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis. J.Med.Chem., 65, 2022
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2ZA0
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![BU of 2za0 by Molmil](/molmil-images/mine/2za0) | Crystal structure of mouse glyoxalase I complexed with methyl-gerfelin | Descriptor: | Glyoxalase I, ZINC ION, methyl 4-(2,3-dihydroxy-5-methylphenoxy)-2-hydroxy-6-methylbenzoate | Authors: | Okumura, H, Kawatani, M, Osada, H. | Deposit date: | 2007-09-26 | Release date: | 2008-08-12 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | The identification of an osteoclastogenesis inhibitor through the inhibition of glyoxalase I Proc.Natl.Acad.Sci.Usa, 105, 2008
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3A4T
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3AJD
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![BU of 3ajd by Molmil](/molmil-images/mine/3ajd) | Crystal structure of ATRM4 | Descriptor: | GLYCEROL, ISOPROPYL ALCOHOL, Putative methyltransferase MJ0026 | Authors: | Hirano, M, Kuratani, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2010-06-01 | Release date: | 2010-06-30 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.27 Å) | Cite: | Crystal structure of Methanocaldococcus jannaschii Trm4 complexed with sinefungin. J.Mol.Biol., 401, 2010
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7WXX
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![BU of 7wxx by Molmil](/molmil-images/mine/7wxx) | Crystal structure of human MMP-7 in complex with inhibitor | Descriptor: | CALCIUM ION, Matrilysin, Peptide Inhibitor, ... | Authors: | Kamitani, M, Oka, Y, Tabuse, H. | Deposit date: | 2022-02-15 | Release date: | 2022-10-05 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Discovery of Highly Potent and Selective Matrix Metalloproteinase-7 Inhibitors by Hybridizing the S1' Subsite Binder with Short Peptides. J.Med.Chem., 65, 2022
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2E3U
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2ROR
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![BU of 2ror by Molmil](/molmil-images/mine/2ror) | Solution structure of the VAV1 SH2 domain complexed with a tyrosine-phosphorylated peptide from SLP76 | Descriptor: | 15-meric peptide from Lymphocyte cytosolic protein 2, Proto-oncogene vav | Authors: | Tanaka, M, Kasai, T, Koshiba, S, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2008-04-08 | Release date: | 2009-04-21 | Last modified: | 2022-03-16 | Method: | SOLUTION NMR | Cite: | Solution structure of the VAV1 SH2 domain complexed with a tyrosine-phosphorylated peptide from SLP76 To be Published
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3AEV
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![BU of 3aev by Molmil](/molmil-images/mine/3aev) | Crystal structure of a/eIF2alpha-aDim2p-rRNA complex from Pyrococcus horikoshii OT3 | Descriptor: | Putative uncharacterized protein PH1566, RNA (5'-R(*GP*GP*AP*UP*CP*AP*CP*CP*UP*CP*C)-3'), Translation initiation factor 2 subunit alpha | Authors: | Tanokura, M, Jia, M.Z, Nagata, K. | Deposit date: | 2010-02-10 | Release date: | 2010-04-21 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | An archaeal Dim2-like protein, aDim2p, forms a ternary complex with a/eIF2 alpha and the 3' end fragment of 16S rRNA J.Mol.Biol., 398, 2010
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7WDN
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![BU of 7wdn by Molmil](/molmil-images/mine/7wdn) | Crystal structures of MeBglD2 in complex with various saccharides | Descriptor: | alpha-D-glucopyranose, beta-glucosidase | Authors: | Watanabe, M, Matsuzawa, T, Nakamichi, Y, Akita, H, Yaoi, K. | Deposit date: | 2021-12-22 | Release date: | 2023-01-04 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of metagenomic beta-glycosidase MeBglD2 in complex with various saccharides. Appl.Microbiol.Biotechnol., 106, 2022
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7WDO
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![BU of 7wdo by Molmil](/molmil-images/mine/7wdo) | Crystal structures of MeBglD2 in complex with various saccharides | Descriptor: | Beta-glucosidase, SULFATE ION, beta-D-glucopyranose, ... | Authors: | Watanabe, M, Matsuzawa, T, Nakamichi, Y, Akita, H, Yaoi, K. | Deposit date: | 2021-12-22 | Release date: | 2022-11-02 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.21 Å) | Cite: | Crystal structure of metagenomic beta-glycosidase MeBglD2 in complex with various saccharides Appl.Microbiol.Biotechnol., 106, 2022
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7WDR
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![BU of 7wdr by Molmil](/molmil-images/mine/7wdr) | Crystal structures of MeBglD2 in complex with various saccharides | Descriptor: | 4-nitrophenyl beta-D-glucopyranoside, Beta-glucosidase, SULFATE ION | Authors: | Watanabe, M, Matsuzawa, T, Nakamichi, Y, Akita, H, Yaoi, K. | Deposit date: | 2021-12-22 | Release date: | 2022-11-02 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of metagenomic beta-glycosidase MeBglD2 in complex with various saccharides Appl.Microbiol.Biotechnol., 106, 2022
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7WDP
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![BU of 7wdp by Molmil](/molmil-images/mine/7wdp) | Crystal structures of MeBglD2 in complex with various saccharides | Descriptor: | Beta-glucosidase, SULFATE ION, alpha-D-glucopyranose, ... | Authors: | Watanabe, M, Matsuzawa, T, Nakamichi, Y, Akita, H, Yaoi, K. | Deposit date: | 2021-12-22 | Release date: | 2022-11-02 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.39 Å) | Cite: | Crystal structure of metagenomic beta-glycosidase MeBglD2 in complex with various saccharides Appl.Microbiol.Biotechnol., 106, 2022
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7WDS
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![BU of 7wds by Molmil](/molmil-images/mine/7wds) | Crystal structures of MeBglD2 in complex with various saccharides | Descriptor: | Beta-glucosidase, SULFATE ION, beta-D-xylopyranose | Authors: | Watanabe, M, Matsuzawa, T, Nakamichi, Y, Akita, H, Yaoi, K. | Deposit date: | 2021-12-22 | Release date: | 2022-11-02 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.68 Å) | Cite: | Crystal structure of metagenomic beta-glycosidase MeBglD2 in complex with various saccharides Appl.Microbiol.Biotechnol., 106, 2022
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7WDV
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![BU of 7wdv by Molmil](/molmil-images/mine/7wdv) | Crystal structures of MeBglD2 in complex with various saccharides | Descriptor: | Beta-glucosidase, SULFATE ION, beta-D-glucopyranose, ... | Authors: | Watanabe, M, Matsuzawa, T, Nakamichi, Y, Akita, H, Yaoi, K. | Deposit date: | 2021-12-22 | Release date: | 2022-11-02 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.812 Å) | Cite: | Crystal structure of metagenomic beta-glycosidase MeBglD2 in complex with various saccharides Appl.Microbiol.Biotechnol., 106, 2022
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5XGZ
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![BU of 5xgz by Molmil](/molmil-images/mine/5xgz) | Metagenomic glucose-tolerant glycosidase | Descriptor: | Beta-glycosidase, GLYCEROL, NICKEL (II) ION, ... | Authors: | Watanabe, M, Matsuzawa, T, Yaoi, K. | Deposit date: | 2017-04-19 | Release date: | 2018-05-02 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Improved thermostability of a metagenomic glucose-tolerant beta-glycosidase based on its X-ray crystal structure. Appl.Microbiol.Biotechnol., 101, 2017
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5XHF
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![BU of 5xhf by Molmil](/molmil-images/mine/5xhf) | Crystal structure of Trastuzumab Fab fragment bearing p-azido-L-phenylalanine | Descriptor: | polypeptide (H chain), polypeptide (L chain) | Authors: | Kuratani, M, Yanagisawa, T, Sakamoto, K, Yokoyama, S. | Deposit date: | 2017-04-20 | Release date: | 2017-12-20 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.205 Å) | Cite: | Extensive Survey of Antibody Invariant Positions for Efficient Chemical Conjugation Using Expanded Genetic Codes. Bioconjug. Chem., 28, 2017
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5YHS
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![BU of 5yhs by Molmil](/molmil-images/mine/5yhs) | Pyruvylated beta-D-galactosidase from Bacillus sp. HMA207, apo form | Descriptor: | Pyruvylated beta-D-galactosidase | Authors: | Tanuma, M, Yamada, C, Arakawa, T, Higuchi, Y, Takegawa, K, Fushinobu, S. | Deposit date: | 2017-09-29 | Release date: | 2018-08-29 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Identification and characterization of a novel beta-D-galactosidase that releases pyruvylated galactose. Sci Rep, 8, 2018
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