8JUF

Crystal structure of human MMP-7 in complex with inhibitor

Summary for 8JUF

• Entry DOI: 10.2210/pdb8juf/pdb
• Descriptor: Matrilysin, Peptide Inhibitor, CALCIUM ION, ... (5 entities in total)
• Functional Keywords: matrilysin, matrin, matrix metalloproteinase-7, pump-1 protease, uterine metalloproteinase, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 20372.95

Authors

Kamitani, M.,Abe-Sato, K.,Oka, Y. (deposition date: 2023-06-26, release date: 2023-11-01, Last modification date: 2023-11-22)

• Primary citation: Abe-Sato, K.,Tabuse, H.,Kanazawa, H.,Kamitani, M.,Endo, M.,Tokura, S.,Wakabayashi, S.,Yahara, T.,Takeda, T.,Hitaka, K.,Gunji, E.,Kojima, N.,Oka, Y.; Structure-Based Optimization and Biological Evaluation of Potent and Selective MMP-7 Inhibitors for Kidney Fibrosis.; J.Med.Chem., 66:14653-14668, 2023; PubMed: 37861435; DOI: 10.1021/acs.jmedchem.3c01166

Experimental method

X-RAY DIFFRACTION (1.39 Å)