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8JLJ
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BU of 8jlj by Molmil
T1AM-bound mTAAR1-Gs protein complex
Descriptor: 4-[4-(2-azanylethyl)-2-iodanyl-phenoxy]phenol, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Xu, Z, Guo, L.L, Zhao, C, Shen, S.Y, Sun, J.P, Shao, Z.H.
Deposit date:2023-06-02
Release date:2023-11-15
Last modified:2024-01-03
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Ligand recognition and G-protein coupling of trace amine receptor TAAR1.
Nature, 624, 2023
8JSO
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BU of 8jso by Molmil
AMPH-bound hTAAR1-Gs protein complex
Descriptor: (2S)-1-phenylpropan-2-amine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Xu, Z, Guo, L.L, Zhao, C, Shen, S.Y, Sun, J.P, Shao, Z.H.
Deposit date:2023-06-20
Release date:2023-11-15
Last modified:2024-01-03
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Ligand recognition and G-protein coupling of trace amine receptor TAAR1.
Nature, 624, 2023
8JLR
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BU of 8jlr by Molmil
A77636-bound hTAAR1-Gs protein complex
Descriptor: (1~{S},3~{R})-3-(1-adamantyl)-1-(aminomethyl)-3,4-dihydro-1~{H}-isochromene-5,6-diol, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Xu, Z, Guo, L.L, Zhao, C, Shen, S.Y, Sun, J.P, Shao, Z.H.
Deposit date:2023-06-02
Release date:2023-11-15
Last modified:2024-01-03
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Ligand recognition and G-protein coupling of trace amine receptor TAAR1.
Nature, 624, 2023
8JSP
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BU of 8jsp by Molmil
Ulotaront(SEP-363856)-bound Serotonin 1A (5-HT1A) receptor-Gi complex
Descriptor: 1-[(7~{S})-5,7-dihydro-4~{H}-thieno[2,3-c]pyran-7-yl]-~{N}-methyl-methanamine, 5-hydroxytryptamine receptor 1A, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Xu, Z, Guo, L.L, Zhao, C, Shen, S.Y, Sun, J.P, Shao, Z.H.
Deposit date:2023-06-20
Release date:2023-11-15
Last modified:2024-01-03
Method:ELECTRON MICROSCOPY (3.65 Å)
Cite:Ligand recognition and G-protein coupling of trace amine receptor TAAR1.
Nature, 624, 2023
2I0G
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BU of 2i0g by Molmil
Benzopyrans are Selective Estrogen Receptor beta Agonists (SERBAs) with Novel Activity in Models of Benign Prostatic Hyperplasia
Descriptor: (3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL, Estrogen receptor beta
Authors:Wang, Y.
Deposit date:2006-08-10
Release date:2006-10-24
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Benzopyrans are selective estrogen receptor Beta agonists with novel activity in models of benign prostatic hyperplasia.
J.Med.Chem., 49, 2006
4PFC
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BU of 4pfc by Molmil
Crystal structure of insulin degrading enzyme complexed with inhibitor
Descriptor: Insulin-degrading enzyme, ZINC ION, methyl [(2S)-2-(5-{5-[4-({(2S)-2-[(3S)-3-amino-2-oxopiperidin-1-yl]-2-cyclohexylacetyl}amino)phenyl]pentyl}-2-fluorophenyl)-3-(quinolin-3-yl)propyl]carbamate
Authors:Wang, Y, Guo, S.
Deposit date:2014-04-28
Release date:2015-06-17
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo.
J.Biol.Chem., 290, 2015
2I0J
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BU of 2i0j by Molmil
Benzopyrans are Selective Estrogen Receptor beta Agonists (SERBAs) with Novel Activity in Models of Benign Prostatic Hyperplasia
Descriptor: (3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL, Estrogen receptor alpha
Authors:Wang, Y.
Deposit date:2006-08-10
Release date:2006-10-24
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Benzopyrans are selective estrogen receptor Beta agonists with novel activity in models of benign prostatic hyperplasia.
J.Med.Chem., 49, 2006
4PF9
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BU of 4pf9 by Molmil
Crystal structure of insulin degrading enzyme complexed with inhibitor
Descriptor: Insulin-degrading enzyme, ZINC ION, methyl [(2S)-2-[4-({5-[4-({(2S)-2-[(3S)-3-amino-2-oxopiperidin-1-yl]-2-cyclohexylacetyl}amino)phenyl]pentyl}oxy)phenyl]-3-(quinolin-3-yl)propyl]carbamate
Authors:Wang, Y, Guo, S.
Deposit date:2014-04-28
Release date:2015-06-17
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo.
J.Biol.Chem., 290, 2015
4PF7
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BU of 4pf7 by Molmil
Crystal structure of insulin degrading enzyme complexed with inhibitor
Descriptor: (2S)-2-amino-N-{(1S)-1-cyclohexyl-2-[(4-methylphenyl)amino]-2-oxoethyl}-4-(methylselanyl)butanamide, Insulin-degrading enzyme, ZINC ION
Authors:Wang, Y, Guo, S.
Deposit date:2014-04-28
Release date:2015-06-17
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo.
J.Biol.Chem., 290, 2015
2N6N
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BU of 2n6n by Molmil
Structure Determination for spider toxin, U4-agatoxin-Ao1a
Descriptor: U4-agatoxin-Ao1a
Authors:Pineda, S.S, Chin, Y.K.-Y, Mobli, M.S, King, G.F.
Deposit date:2015-08-27
Release date:2016-08-31
Last modified:2023-03-08
Method:SOLUTION NMR
Cite:Structural venomics reveals evolution of a complex venom by duplication and diversification of an ancient peptide-encoding gene.
Proc.Natl.Acad.Sci.USA, 117, 2020
2N6R
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BU of 2n6r by Molmil
NMR structure of spider toxin U4-hexatoxin-Hi1a
Descriptor: U4-hexatoxin-Hi1a
Authors:Pineda, S.S, Chin, Y.K.-Y, King, G.F.
Deposit date:2015-08-28
Release date:2016-08-31
Last modified:2023-03-08
Method:SOLUTION NMR
Cite:Structural venomics reveals evolution of a complex venom by duplication and diversification of an ancient peptide-encoding gene.
Proc.Natl.Acad.Sci.USA, 117, 2020
2N8K
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BU of 2n8k by Molmil
Chemical Shift Assignments and Structure Determination for spider toxin, U33-theraphotoxin-Cg1c
Descriptor: U33-theraphotoxin-Cg1b
Authors:Chin, Y.K.-Y, Pineda, S.S, Mobli, M, King, G.F.
Deposit date:2015-10-20
Release date:2016-08-31
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structural venomics reveals evolution of a complex venom by duplication and diversification of an ancient peptide-encoding gene.
Proc.Natl.Acad.Sci.USA, 117, 2020
6FM2
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BU of 6fm2 by Molmil
CARP domain of mouse cyclase-associated protein 1 (CAP1) bound to ADP-actin
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ...
Authors:Kotila, T.M, Kogan, K, Lappalainen, P.
Deposit date:2018-01-30
Release date:2018-05-16
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis of actin monomer re-charging by cyclase-associated protein.
Nat Commun, 9, 2018
8SEM
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BU of 8sem by Molmil
Structural and functional characterisation of Tst2, a novel TRPV1 inhibitory peptide from the Australian sea anemone Telmatactis stephensoni
Descriptor: TRPV1 inhibitory peptide Tst2
Authors:Elnahriry, K.A, Wai, D.C.C, Norton, R.S.
Deposit date:2023-04-10
Release date:2023-09-27
Method:SOLUTION NMR
Cite:Structural and functional characterisation of Tst2, a novel TRPV1 inhibitory peptide from the Australian sea anemone Telmatactis stephensoni.
Biochim Biophys Acta Proteins Proteom, 1872, 2023
8X17
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BU of 8x17 by Molmil
Cryo-EM structure of adenosine receptor A3AR bound to CF102
Descriptor: Adenosine receptor A3, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Cai, H, Xu, Y, Xu, H.E.
Deposit date:2023-11-06
Release date:2024-04-24
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (3.19 Å)
Cite:Cryo-EM structures of adenosine receptor A 3 AR bound to selective agonists.
Nat Commun, 15, 2024
8X16
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BU of 8x16 by Molmil
Cryo-EM structure of adenosine receptor A3AR bound to CF101
Descriptor: Adenosine receptor A3, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Cai, H, Xu, Y, Xu, H.E.
Deposit date:2023-11-06
Release date:2024-04-24
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (3.29 Å)
Cite:Cryo-EM structures of adenosine receptor A 3 AR bound to selective agonists.
Nat Commun, 15, 2024
8UNG
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BU of 8ung by Molmil
Solution structure of toxin, U-RDTX-Pp19, from assassin bug Pristhesancus plagipennis
Descriptor: Venom peptide Pp19a
Authors:Chin, Y.K.Y, Walker, A.A, King, G.F.
Deposit date:2023-10-18
Release date:2024-05-29
Method:SOLUTION NMR
Cite:Structure and bioactivity of an insecticidal trans-defensin from assassin bug venom
Structure, 2024
3QAH
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BU of 3qah by Molmil
Crystal structure of apo-form human MOF catalytic domain
Descriptor: Probable histone acetyltransferase MYST1, ZINC ION
Authors:Sun, B, Tang, Q, Zhong, C, Ding, J.
Deposit date:2011-01-11
Release date:2011-07-06
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Regulation of the histone acetyltransferase activity of hMOF via autoacetylation of Lys274
Cell Res., 21, 2011
1NF3
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BU of 1nf3 by Molmil
Structure of Cdc42 in a complex with the GTPase-binding domain of the cell polarity protein, Par6
Descriptor: G25K GTP-binding protein, placental isoform, MAGNESIUM ION, ...
Authors:Garrard, S.M, Capaldo, C.T, Gao, L, Rosen, M.K, Macara, I.G, Tomchick, D.R.
Deposit date:2002-12-12
Release date:2003-03-04
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of Cdc42 in a complex with the GTPase-binding domain of the cell polarity protein, Par6
Embo J., 22, 2003
6F08
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BU of 6f08 by Molmil
14-3-3 zeta in complex with the human Son of sevenless homolog 1 (SOS1)
Descriptor: 14-3-3 protein zeta/delta, PENTAETHYLENE GLYCOL, Son of sevenless homolog 1
Authors:Ballone, A, Centorrino, F, Ottmann, C, Guo, S, Leysen, S.
Deposit date:2017-11-17
Release date:2018-02-14
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural characterization of 14-3-3 zeta in complex with the human Son of sevenless homolog 1 (SOS1).
J. Struct. Biol., 202, 2018
6F09
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BU of 6f09 by Molmil
Binary complex of 14-3-3 zeta with ubiquitin specific protease 8 (USP8) pSer718 peptide
Descriptor: 14-3-3 protein zeta/delta, Ubiquitin carboxyl-terminal hydrolase 8
Authors:Centorrino, F, Ballone, A, Ottmann, C, Guo, S, Leysen, S.
Deposit date:2017-11-17
Release date:2018-03-07
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.594 Å)
Cite:Biophysical and structural insight into the USP8/14-3-3 interaction.
FEBS Lett., 592, 2018
4NFE
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BU of 4nfe by Molmil
Human kallikrein-related peptidase 2 in complex with benzamidine
Descriptor: BENZAMIDINE, Kallikrein-2, SULFATE ION
Authors:Skala, W, Brandstetter, H, Magdolen, V, Goettig, P.
Deposit date:2013-10-31
Release date:2014-10-29
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure-function analyses of human kallikrein-related peptidase 2 establish the 99-loop as master regulator of activity
J.Biol.Chem., 289, 2014
4NFF
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BU of 4nff by Molmil
Human kallikrein-related peptidase 2 in complex with PPACK
Descriptor: D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, Kallikrein-2
Authors:Skala, W, Brandstetter, H, Magdolen, V, Goettig, P.
Deposit date:2013-10-31
Release date:2014-10-29
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure-function analyses of human kallikrein-related peptidase 2 establish the 99-loop as master regulator of activity
J.Biol.Chem., 289, 2014
6LAN
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BU of 6lan by Molmil
Structure of CCDC50 and LC3B complex
Descriptor: Coiled-coil domain-containing protein 50,Microtubule-associated proteins 1A/1B light chain 3B
Authors:Liu, L, Li, J, Hou, P.
Deposit date:2019-11-12
Release date:2020-09-30
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.41 Å)
Cite:A novel selective autophagy receptor, CCDC50, delivers K63 polyubiquitination-activated RIG-I/MDA5 for degradation during viral infection.
Cell Res., 31, 2021
8HRD
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BU of 8hrd by Molmil
Crystal structure of the receptor binding domain of SARS-CoV-2 Delta variant in complex with IMCAS74 Fab and W14 Fab
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, IMCAS74 Fab heavy chain, IMCAS74 Fab light chain, ...
Authors:Zhao, R.C, Wu, L.L, Han, P.
Deposit date:2022-12-15
Release date:2023-12-20
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.86 Å)
Cite:Defining a de novo non-RBM antibody as RBD-8 and its synergistic rescue of immune-evaded antibodies to neutralize Omicron SARS-CoV-2.
Proc.Natl.Acad.Sci.USA, 120, 2023

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PDB entries from 2024-06-19

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