2I0J
Benzopyrans are Selective Estrogen Receptor beta Agonists (SERBAs) with Novel Activity in Models of Benign Prostatic Hyperplasia
Summary for 2I0J
| Entry DOI | 10.2210/pdb2i0j/pdb |
| Related | 2I0G |
| Descriptor | Estrogen receptor alpha, (3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL (2 entities in total) |
| Functional Keywords | nuclear receptor ligand binding domain, transcription |
| Biological source | Homo sapiens (human) |
| Cellular location | Isoform 1: Nucleus . Isoform 3: Nucleus. Nucleus: P03372 |
| Total number of polymer chains | 4 |
| Total formula weight | 112399.71 |
| Authors | Wang, Y. (deposition date: 2006-08-10, release date: 2006-10-24, Last modification date: 2023-08-30) |
| Primary citation | Norman, B.H.,Dodge, J.A.,Richardson, T.I.,Borromeo, P.S.,Lugar, C.W.,Jones, S.A.,Chen, K.,Wang, Y.,Durst, G.L.,Barr, R.J.,Montrose-Rafizadeh, C.,Osborne, H.E.,Amos, R.M.,Guo, S.,Boodhoo, A.,Krishnan, V. Benzopyrans are selective estrogen receptor Beta agonists with novel activity in models of benign prostatic hyperplasia. J.Med.Chem., 49:6155-6157, 2006 Cited by PubMed Abstract: Benzopyran selective estrogen receptor beta agonist-1 (SERBA-1) shows potent, selective binding and agonist function in estrogen receptor beta (ERbeta) in vitro assays. X-ray crystal structures of SERBA-1 in ERalpha and beta help explain observed beta-selectivity of this ligand. SERBA-1 in vivo demonstrates involution of the ventral prostate in CD-1 mice (ERbeta effect), while having no effect on gonadal hormone levels (ERalpha effect) at 10x the efficacious dose, consistent with in vitro properties of this molecule. PubMed: 17034120DOI: 10.1021/jm060491j PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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