2I0J
Benzopyrans are Selective Estrogen Receptor beta Agonists (SERBAs) with Novel Activity in Models of Benign Prostatic Hyperplasia
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Estrogen receptor alpha | polymer | 244 | 27817.6 | 4 | UniProt (P03372) Pfam (PF00104) | Homo sapiens (human) | ER, Estradiol receptor, ER-alpha |
| 2 | E, F, G, H (A, B, C, D) | (3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL | non-polymer | 282.3 | 4 | Chemie (I0G) |
Sequence modifications
A, B, C, D: 304 - 547 (UniProt: P03372)
| PDB | External Database | Details |
|---|---|---|
| Ser 381 | Cys 381 | engineered mutation |
| Ser 417 | Cys 417 | engineered mutation |
| Ser 530 | Cys 530 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 111270.4 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1129.3 | |
| All* | Total formula weight | 112399.7 |
