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6HUJ
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BU of 6huj by Molmil
CryoEM structure of human full-length heteromeric alpha1beta3gamma2L GABA(A)R in complex with picrotoxin, GABA and megabody Mb38.
Descriptor: (1aR,2aR,3S,6R,6aS,8aS,8bR,9R)-2a-hydroxy-8b-methyl-9-(prop-1-en-2-yl)hexahydro-3,6-methano-1,5,7-trioxacyclopenta[ij]c yclopropa[a]azulene-4,8(3H)-dione, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GAMMA-AMINO-BUTANOIC ACID, ...
Authors:Masiulis, S, Desai, R, Uchanski, T, Serna Martin, I, Laverty, D, Karia, D, Malinauskas, T, Jasenko, Z, Pardon, E, Kotecha, A, Steyaert, J, Miller, K.W, Aricescu, A.R.
Deposit date:2018-10-08
Release date:2019-01-02
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (3.04 Å)
Cite:GABAAreceptor signalling mechanisms revealed by structural pharmacology.
Nature, 565, 2019
6HUP
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BU of 6hup by Molmil
CryoEM structure of human full-length alpha1beta3gamma2L GABA(A)R in complex with diazepam (Valium), GABA and megabody Mb38.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 7-CHLORO-1-METHYL-5-PHENYL-1,3-DIHYDRO-2H-1,4-BENZODIAZEPIN-2-ONE, GAMMA-AMINO-BUTANOIC ACID, ...
Authors:Masiulis, S, Desai, R, Uchanski, T, Serna Martin, I, Laverty, D, Karia, D, Malinauskas, T, Jasenko, Z, Pardon, E, Kotecha, A, Steyaert, J, Miller, K.W, Aricescu, A.R.
Deposit date:2018-10-09
Release date:2019-01-02
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (3.58 Å)
Cite:GABAAreceptor signalling mechanisms revealed by structural pharmacology.
Nature, 565, 2019
6I53
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BU of 6i53 by Molmil
Cryo-EM structure of the human synaptic alpha1-beta3-gamma2 GABAA receptor in complex with Megabody38 in a lipid nanodisc
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Gamma-aminobutyric acid receptor subunit alpha-1, ...
Authors:Laverty, D, Desai, R, Uchanski, T, Masiulis, S, Wojciech, J.S, Malinauskas, T, Zivanov, J, Pardon, E, Steyaert, J, Miller, K.W, Aricescu, A.R.
Deposit date:2018-11-12
Release date:2019-01-02
Last modified:2022-03-30
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Cryo-EM structure of the human alpha 1 beta 3 gamma 2 GABAAreceptor in a lipid bilayer.
Nature, 565, 2019
6RTX
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BU of 6rtx by Molmil
Crystal structure of the Patched-1 (PTCH1) ectodomain 1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Protein patched homolog 1
Authors:Rudolf, A.F, Kowatsch, C, El Omari, K, Malinauskas, T, Kinnebrew, M, Ansell, T.B, Bishop, B, Pardon, E, Schwab, R.A, Qian, M, Duman, R, Covey, D.F, Steyaert, J, Wagner, A, Sansom, M.S.P, Rohatgi, R, Siebold, C.
Deposit date:2019-05-27
Release date:2019-10-02
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism.
Nat.Chem.Biol., 15, 2019
6RVD
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BU of 6rvd by Molmil
Revised cryo-EM structure of the human 2:1 Ptch1-Shh complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:El Omari, K, Rudolf, A.F, Kowatsch, C, Malinauskas, T, Kinnebrew, M, Ansell, T.B, Bishop, B, Pardon, E, Schwab, R.A, Qian, M, Duman, R, Covey, D.F, Steyaert, J, Wagner, A, Sansom, M.S.P, Rohatgi, R, Siebold, C.
Deposit date:2019-05-31
Release date:2019-10-02
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism.
Nat.Chem.Biol., 15, 2019
6RTY
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BU of 6rty by Molmil
Crystal structure of the Patched ectodomain in complex with nanobody NB64
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Llama-derived nanobody NB64, Protein patched homolog 1
Authors:Rudolf, A.F, Kowatsch, C, El Omari, K, Malinauskas, T, Kinnebrew, M, Ansell, T.B, Bishop, B, Pardon, E, Schwab, R.A, Qian, M, Duman, R, Covey, D.F, Steyaert, J, Wagner, A, Sansom, M.S.P, Rohatgi, R, Siebold, C.
Deposit date:2019-05-27
Release date:2019-10-02
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism.
Nat.Chem.Biol., 15, 2019
6RTW
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BU of 6rtw by Molmil
Crystal structure of the Patched-1 (PTCH1) ectodomain in complex with nanobody NB64 and cholesterol-hemisuccinate
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Llama-derived nanobody NB64, ...
Authors:Rudolf, A.F, Kowatsch, C, El Omari, K, Malinauskas, T, Kinnebrew, M, Ansell, T.B, Bishop, B, Pardon, E, Schwab, R.A, Qian, M, Duman, R, Covey, D.F, Steyaert, J, Wagner, A, Sansom, M.S.P, Rohatgi, R, Siebold, C.
Deposit date:2019-05-27
Release date:2019-10-02
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism.
Nat.Chem.Biol., 15, 2019
6RVC
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BU of 6rvc by Molmil
Crystal structure of Patched-1 ectodomain 2 (PTCH1-ECD2) in complex with nanobody 75
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Nanobody NB75, Protein patched homolog 1, ...
Authors:Rudolf, A.F, Kowatsch, C, El Omari, K, Malinauskas, T, Kinnebrew, M, Ansell, T.B, Bishop, B, Pardon, E, Schwab, R.A, Qian, M, Duman, R, Covey, D.F, Steyaert, J, Wagner, A, Sansom, M.S.P, Rohatgi, R, Siebold, C.
Deposit date:2019-05-31
Release date:2019-10-02
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism.
Nat.Chem.Biol., 15, 2019
7A5V
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BU of 7a5v by Molmil
CryoEM structure of a human gamma-aminobutyric acid receptor, the GABA(A)R-beta3 homopentamer, in complex with histamine and megabody Mb25 in lipid nanodisc
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ...
Authors:Nakane, T, Kotecha, A, Sente, A, Yamashita, K, McMullan, G, Masiulis, S, Brown, P.M.G.E, Grigoras, I.T, Malinauskaite, L, Malinauskas, T, Miehling, J, Yu, L, Karia, D, Pechnikova, E.V, de Jong, E, Keizer, J, Bischoff, M, McCormack, J, Tiemeijer, P, Hardwick, S.W, Chirgadze, D.Y, Murshudov, G, Aricescu, A.R, Scheres, S.H.W.
Deposit date:2020-08-22
Release date:2020-11-18
Last modified:2020-11-25
Method:ELECTRON MICROSCOPY (1.7 Å)
Cite:Single-particle cryo-EM at atomic resolution.
Nature, 587, 2020
7A4M
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BU of 7a4m by Molmil
Cryo-EM structure of mouse heavy-chain apoferritin at 1.22 A
Descriptor: FE (III) ION, Ferritin heavy chain, ZINC ION
Authors:Nakane, T, Kotecha, A, Sente, A, Yamashita, K, McMullan, G, Masiulis, S, Brown, P.M.G.E, Grigoras, I.T, Malinauskaite, L, Malinauskas, T, Miehling, J, Yu, L, Karia, D, Pechnikova, E.V, de Jong, E, Keizer, J, Bischoff, M, McCormack, J, Tiemeijer, P, Hardwick, S.W, Chirgadze, D.Y, Murshudov, G, Aricescu, A.R, Scheres, S.H.W.
Deposit date:2020-08-20
Release date:2020-10-28
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (1.22 Å)
Cite:Single-particle cryo-EM at atomic resolution.
Nature, 587, 2020
8BN2
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BU of 8bn2 by Molmil
Crystal structure of the ligand-binding domain (LBD) of human iGluR Delta-1 (GluD1) in complex with D-Serine
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Heroven, C, Malinauskas, T, Aricescu, A.R.
Deposit date:2022-11-11
Release date:2023-11-22
Last modified:2024-01-03
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:GluD1 binds GABA and controls inhibitory plasticity.
Science, 382, 2023
8BN5
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BU of 8bn5 by Molmil
Crystal structure of the ligand-binding domain (LBD) of human iGluR Delta-1 (GluD1) in complex with GABA
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Heroven, C, Malinauskas, T, Aricescu, A.R.
Deposit date:2022-11-12
Release date:2023-11-22
Last modified:2024-01-03
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:GluD1 binds GABA and controls inhibitory plasticity.
Science, 382, 2023
8BLJ
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BU of 8blj by Molmil
Crystal structure of the ligand-binding domain (LBD) of human iGluR Delta-1 (GluD1), apo state
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Heroven, C, Malinauskas, T, Aricescu, A.R.
Deposit date:2022-11-09
Release date:2023-11-22
Last modified:2024-01-03
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:GluD1 binds GABA and controls inhibitory plasticity.
Science, 382, 2023
8CSL
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BU of 8csl by Molmil
Sub-tomogram averaging of erythrocyte ankyrin-1 complex
Descriptor: Ammonium transporter Rh type A, Ankyrin-1, Band 3 anion transport protein, ...
Authors:Vallese, F, Kim, K, Yen, L.Y, Johnston, J.D, Noble, A.J, Cali, T, Clarke, O.B.
Deposit date:2022-05-12
Release date:2022-07-20
Last modified:2024-02-14
Method:ELECTRON MICROSCOPY (25 Å)
Cite:Architecture of the human erythrocyte ankyrin-1 complex.
Nat.Struct.Mol.Biol., 29, 2022
8CRQ
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BU of 8crq by Molmil
Local refinement of Band 3-I transmembrane domains, class 1 of erythrocyte ankyrin-1 complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Band 3 anion transport protein, CHOLESTEROL, ...
Authors:Vallese, F, Kim, K, Yen, L.Y, Johnston, J.D, Noble, A.J, Cali, T, Clarke, O.B.
Deposit date:2022-05-11
Release date:2022-07-20
Last modified:2022-07-27
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Architecture of the human erythrocyte ankyrin-1 complex.
Nat.Struct.Mol.Biol., 29, 2022
8CRR
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BU of 8crr by Molmil
Local refinement of Band 3-III transmembrane domains, class 1 of erythrocyte ankyrin-1 complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Band 3 anion transport protein, CHOLESTEROL, ...
Authors:Vallese, F, Kim, K, Yen, L.Y, Johnston, J.D, Noble, A.J, Cali, T, Clarke, O.B.
Deposit date:2022-05-11
Release date:2022-07-20
Last modified:2022-07-27
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Architecture of the human erythrocyte ankyrin-1 complex.
Nat.Struct.Mol.Biol., 29, 2022
8CS9
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BU of 8cs9 by Molmil
Composite reconstruction of Class 1 of the erythrocyte ankyrin-1 complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ammonium transporter Rh type A, ...
Authors:Vallese, F, Kim, K, Yen, L.Y, Johnston, J.D, Noble, A.J, Cali, T, Clarke, O.B.
Deposit date:2022-05-12
Release date:2022-07-20
Last modified:2022-07-27
Method:ELECTRON MICROSCOPY (2.74 Å)
Cite:Architecture of the human erythrocyte ankyrin-1 complex.
Nat.Struct.Mol.Biol., 29, 2022
8CRT
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BU of 8crt by Molmil
Local refinement of Rh trimer, glycophorin B and Band3-III transmembrane region, class 1a of erythrocyte ankyrin-1 complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ammonium transporter Rh type A, Band 3 anion transport protein, ...
Authors:Vallese, F, Kim, K, Yen, L.Y, Johnston, J.D, Noble, A.J, Cali, T, Clarke, O.B.
Deposit date:2022-05-11
Release date:2022-07-20
Last modified:2022-07-27
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Architecture of the human erythrocyte ankyrin-1 complex.
Nat.Struct.Mol.Biol., 29, 2022
4M7L
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BU of 4m7l by Molmil
Crystal structure of the complex between human tissue factor extracellular domain and antibody 10H10 FAB fragment
Descriptor: 10H10 heavy chain, 10H10 light chain, Tissue factor
Authors:Teplyakov, A, Obmolova, G, Malia, T, Gilliland, G.L.
Deposit date:2013-08-12
Release date:2014-08-13
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Crystal structure of the complex between human tissue factor extracellular domain and antibody 10H10 FAB fragment
To be Published
6Z43
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BU of 6z43 by Molmil
Cryo-EM Structure of SARS-CoV-2 Spike : H11-D4 Nanobody Complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Nanobody, ...
Authors:Ruza, R.R, Duyvesteyn, H.M.E, Shah, P, Carrique, L, Ren, J, Malinauskas, T, Zhou, D, Stuart, D.I, Naismith, J.H.
Deposit date:2020-05-22
Release date:2020-06-03
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural basis for a potent neutralising single-domain antibody that blocks SARS-CoV-2 binding to its receptor ACE2
To Be Published
6YOR
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BU of 6yor by Molmil
Structure of the SARS-CoV-2 spike S1 protein in complex with CR3022 Fab
Descriptor: IgG H chain, IgG L chain, Spike glycoprotein
Authors:Huo, J, Zhao, Y, Ren, J, Zhou, D, Duyvesteyn, H.M.E, Carrique, L, Malinauskas, T, Ruza, R.R, Shah, P.N.M, Fry, E.E, Owens, R, Stuart, D.I.
Deposit date:2020-04-15
Release date:2020-04-29
Last modified:2022-04-06
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike.
Cell Host Microbe, 28, 2020
6Z97
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BU of 6z97 by Molmil
Structure of the prefusion SARS-CoV-2 spike glycoprotein
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein,Fibritin
Authors:Duyvesteyn, H.M.E, Ren, J, Zhao, Y, Zhou, D, Huo, J, Carrique, L, Malinauskas, T, Ruza, R.R, Shah, P.N.M, Fry, E.E, Owens, R, Stuart, D.I.
Deposit date:2020-06-03
Release date:2020-07-01
Last modified:2020-09-23
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike.
Cell Host Microbe, 28, 2020
3NZH
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BU of 3nzh by Molmil
Crystal structure of anti-emmprin antibody 5F6 FAB
Descriptor: 5F6 HEAVY CHAIN, 5F6 LIGHT CHAIN, COBALT (II) ION, ...
Authors:Teplyakov, A, Obmolova, G, Malia, T, Gilliland, G.L.
Deposit date:2010-07-16
Release date:2011-07-27
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of anti-emmprin antibody 5F6 FAB
To be Published
3QPX
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BU of 3qpx by Molmil
Crystal structure of Fab C2507
Descriptor: CADMIUM ION, CHLORIDE ION, Fab C2507 heavy chain, ...
Authors:Luo, J, Teplyakov, A, Obmolova, O, Malia, T, Gilliland, G.L.
Deposit date:2011-02-14
Release date:2011-08-10
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of Fab C2507
To be Published
4GZA
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BU of 4gza by Molmil
Complex of mouse Plexin A2 - Semaphorin 3A - Neuropilin-1
Descriptor: CALCIUM ION, Neuropilin-1, Plexin-A2, ...
Authors:Janssen, B.J.C, Malinauskas, T, Siebold, C, Jones, E.Y.
Deposit date:2012-09-06
Release date:2012-10-17
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (7 Å)
Cite:Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex.
Nat.Struct.Mol.Biol., 19, 2012

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