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4LO7
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BU of 4lo7 by Molmil
HA70(D3)-HA17-HA33
Descriptor: HA-17, HA-33, HA-70
Authors:Lee, K, Gu, S, Jin, L, Le, T.T, Cheng, L.W, Strotmeier, J, Kruel, A.M, Yao, G, Perry, K, Rummel, A, Jin, R.
Deposit date:2013-07-12
Release date:2013-10-30
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.73 Å)
Cite:Structure of a Bimodular Botulinum Neurotoxin Complex Provides Insights into Its Oral Toxicity.
Plos Pathog., 9, 2013
4LO6
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BU of 4lo6 by Molmil
HA70-alpha2,6-SiaLC
Descriptor: CHLORIDE ION, HA-70, N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose
Authors:Lee, K, Gu, S, Jin, L, Le, T.T, Cheng, L.W, Strotmeier, J, Kruel, A.M, Yao, G, Perry, K, Rummel, A, Jin, R.
Deposit date:2013-07-12
Release date:2013-10-30
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of a Bimodular Botulinum Neurotoxin Complex Provides Insights into Its Oral Toxicity.
Plos Pathog., 9, 2013
4LO2
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BU of 4lo2 by Molmil
HA17-HA33-Lac
Descriptor: HA-17, HA-33, beta-D-galactopyranose-(1-4)-beta-D-glucopyranose
Authors:Lee, K, Gu, S, Jin, L, Le, T.T, Cheng, L.W, Strotmeier, J, Kruel, A.M, Yao, G, Perry, K, Rummel, A, Jin, R.
Deposit date:2013-07-12
Release date:2013-10-30
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.254 Å)
Cite:Structure of a Bimodular Botulinum Neurotoxin Complex Provides Insights into Its Oral Toxicity.
Plos Pathog., 9, 2013
4LO8
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BU of 4lo8 by Molmil
HA70(D3)-HA17
Descriptor: HA-17, HA-70
Authors:Lee, K, Gu, S, Jin, L, Le, T.T, Cheng, L.W, Strotmeier, J, Kruel, A.M, Yao, G, Perry, K, Rummel, A, Jin, R.
Deposit date:2013-07-12
Release date:2013-10-30
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of a Bimodular Botulinum Neurotoxin Complex Provides Insights into Its Oral Toxicity.
Plos Pathog., 9, 2013
4LO5
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BU of 4lo5 by Molmil
HA70-alpha2,3-SiaLC
Descriptor: CHLORIDE ION, HA-70, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-4)-alpha-D-glucopyranose
Authors:Lee, K, Gu, S, Jin, L, Le, T.T, Cheng, L.W, Strotmeier, J, Kruel, A.M, Yao, G, Perry, K, Rummel, A, Jin, R.
Deposit date:2013-07-12
Release date:2013-10-30
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure of a Bimodular Botulinum Neurotoxin Complex Provides Insights into Its Oral Toxicity.
Plos Pathog., 9, 2013
6MHJ
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BU of 6mhj by Molmil
Structure of BoNT mutant
Descriptor: Botulinum neurotoxin type A, PHOSPHATE ION
Authors:Lam, K, Jin, R.
Deposit date:2018-09-18
Release date:2018-12-26
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.019 Å)
Cite:A viral-fusion-peptide-like molecular switch drives membrane insertion of botulinum neurotoxin A1.
Nat Commun, 9, 2018
6OQ5
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BU of 6oq5 by Molmil
Structure of the full-length Clostridium difficile toxin B in complex with 3 VHHs
Descriptor: 5D, 7F, E3, ...
Authors:Chen, P, Lam, K, Jin, R.
Deposit date:2019-04-25
Release date:2019-07-10
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.87 Å)
Cite:Structure of the full-length Clostridium difficile toxin B.
Nat.Struct.Mol.Biol., 26, 2019
6OQ6
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BU of 6oq6 by Molmil
Structure of the pore forming fragment of Clostridium difficile toxin B in complex with VHH 5D
Descriptor: 5D, Toxin B
Authors:Chen, P, Lam, K, Jin, R.
Deposit date:2019-04-25
Release date:2019-07-10
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.97 Å)
Cite:Structure of the full-length Clostridium difficile toxin B.
Nat.Struct.Mol.Biol., 26, 2019
7NA9
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BU of 7na9 by Molmil
Crystal structure of BoNT/B-LC-JSG-C1
Descriptor: 1,2-ETHANEDIOL, Botulinum neurotoxin type B, JSG-C1, ...
Authors:Lam, K, Jin, R.
Deposit date:2021-06-20
Release date:2021-12-22
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Probing the structure and function of the protease domain of botulinum neurotoxins using single-domain antibodies.
Plos Pathog., 18, 2022
7ML7
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BU of 7ml7 by Molmil
Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection
Descriptor: Chondroitin sulfate proteoglycan 4, Toxin B, ZINC ION
Authors:Chen, P, Jin, R.
Deposit date:2021-04-27
Release date:2021-06-09
Last modified:2021-06-30
Method:ELECTRON MICROSCOPY (3.17 Å)
Cite:Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection.
Nat Commun, 12, 2021
5BP5
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BU of 5bp5 by Molmil
Crystal structure of HA17-HA33-IPT
Descriptor: 1-methylethyl 1-thio-beta-D-galactopyranoside, HA-17, HA-33
Authors:Lee, K, Lam, K, Jin, R.
Deposit date:2015-05-27
Release date:2015-09-02
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Inhibiting oral intoxication of botulinum neurotoxin A complex by carbohydrate receptor mimics.
Toxicon, 107, 2015
5BQU
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BU of 5bqu by Molmil
Crystal structure of HA17-HA33-Lactulose
Descriptor: HA-17, HA-33, beta-D-galactopyranose-(1-4)-beta-D-fructofuranose
Authors:Lee, K, Lam, K, Jin, R.
Deposit date:2015-05-29
Release date:2015-10-14
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Inhibiting oral intoxication of botulinum neurotoxin A complex by carbohydrate receptor mimics.
Toxicon, 107, 2015
5L21
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BU of 5l21 by Molmil
Crystal structure of BoNT/A receptor binding domain in complex with VHH C2
Descriptor: Botulinum neurotoxin type A, VHH-C2
Authors:Yao, G, Jin, R.
Deposit date:2016-07-29
Release date:2017-08-09
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:A camelid single-domain antibody neutralizes botulinum neurotoxin A by blocking host receptor binding.
Sci Rep, 7, 2017
6DKK
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BU of 6dkk by Molmil
Structure of BoNT
Descriptor: Botulinum neurotoxin type A, PHOSPHATE ION
Authors:Lam, K, Jin, R.
Deposit date:2018-05-29
Release date:2018-12-26
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A viral-fusion-peptide-like molecular switch drives membrane insertion of botulinum neurotoxin A1.
Nat Commun, 9, 2018
6C0B
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BU of 6c0b by Molmil
Structural basis for recognition of frizzled proteins by Clostridium difficile toxin B
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Frizzled-2, MALONATE ION, ...
Authors:Chen, P, Lam, K, Jin, R.
Deposit date:2017-12-28
Release date:2018-05-16
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for recognition of frizzled proteins byClostridium difficiletoxin B.
Science, 360, 2018
3OBR
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BU of 3obr by Molmil
Crystal structure of Botulinum neurotoxin serotype D binding domain
Descriptor: Botulinum neurotoxin type D, GLYCEROL
Authors:Zong, Y, Lee, K.K, Jin, R.
Deposit date:2010-08-09
Release date:2010-09-08
Last modified:2014-04-16
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Botulinum neurotoxin serotype D attacks neurons via two carbohydrate-binding sites in a ganglioside-dependent manner.
Biochem.J., 431, 2010
3V0C
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BU of 3v0c by Molmil
4.3 angstrom crystal structure of an inactive BoNT/A (E224Q/R363A/Y366F)
Descriptor: BoNT/A, ZINC ION
Authors:Gu, S, Rumpel, S, Zhou, J, Strotmeier, J, Bigalke, H, Perry, K, Shoemaker, C.B, Rummel, A, Jin, R.
Deposit date:2011-12-07
Release date:2012-03-14
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (4.3 Å)
Cite:Botulinum neurotoxin is shielded by NTNHA in an interlocked complex.
Science, 335, 2012
3V0B
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BU of 3v0b by Molmil
3.9 angstrom crystal structure of BoNT/Ai in complex with NTNHA
Descriptor: BoNT/A, CALCIUM ION, NTNH, ...
Authors:Gu, S, Rumpel, S, Zhou, J, Strotmeier, J, Bigalke, H, Perry, K, Shoemaker, C.B, Rummel, A, Jin, R.
Deposit date:2011-12-07
Release date:2012-03-14
Last modified:2013-09-25
Method:X-RAY DIFFRACTION (3.9 Å)
Cite:Botulinum neurotoxin is shielded by NTNHA in an interlocked complex.
Science, 335, 2012
3V0A
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BU of 3v0a by Molmil
2.7 angstrom crystal structure of BoNT/Ai in complex with NTNHA
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, BoNT/A, CALCIUM ION, ...
Authors:Gu, S, Rumpel, S, Zhou, J, Strotmeier, J, Bigalke, H, Perry, K, Shoemaker, C.B, Rummel, A, Jin, R.
Deposit date:2011-12-07
Release date:2012-03-14
Method:X-RAY DIFFRACTION (2.703 Å)
Cite:Botulinum neurotoxin is shielded by NTNHA in an interlocked complex.
Science, 335, 2012
3V64
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BU of 3v64 by Molmil
Crystal Structure of agrin and LRP4
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Low-density lipoprotein receptor-related protein 4, ...
Authors:Zong, Y, Zhang, B, Gu, S, Lee, K, Zhou, J, Yao, G, Figueiedo, D, Perry, K, Mei, L, Jin, R.
Deposit date:2011-12-18
Release date:2012-04-25
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structural basis of agrin-LRP4-MuSK signaling.
Genes Dev., 26, 2012
3V65
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BU of 3v65 by Molmil
Crystal structure of agrin and LRP4 complex
Descriptor: Agrin, CALCIUM ION, Low-density lipoprotein receptor-related protein 4
Authors:Zong, Y, Jin, R.
Deposit date:2011-12-18
Release date:2012-04-25
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structural basis of agrin-LRP4-MuSK signaling.
Genes Dev., 26, 2012
5V38
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BU of 5v38 by Molmil
Crystal Structure of The Receptor-binding Domain of Botulinum Neurotoxin Type HA
Descriptor: ACETIC ACID, HcHA
Authors:Yao, G, Lam, K.-H, Jin, R.
Deposit date:2017-03-06
Release date:2017-03-22
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structure of the Receptor-Binding Domain of Botulinum Neurotoxin Type HA, Also Known as Type FA or H.
Toxins (Basel), 9, 2017
7L6V
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BU of 7l6v by Molmil
Crystal structure of BoNT/A-LC-JPU-A5-JPU-C1-JPU-H7-JPU-D12-ciA-F12
Descriptor: 1,2-ETHANEDIOL, BoNT/A, JPU-A5, ...
Authors:Lam, K, Jin, R.
Deposit date:2020-12-24
Release date:2021-12-22
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Probing the structure and function of the protease domain of botulinum neurotoxins using single-domain antibodies.
Plos Pathog., 18, 2022
7K7Y
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BU of 7k7y by Molmil
Crystal structure of BoNT/E LC-HN domain in complex with VHH JLE-E9
Descriptor: Botulinum neurotoxin type E, JLE-E9
Authors:Lam, K, Jin, R.
Deposit date:2020-09-24
Release date:2020-10-14
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Two VHH Antibodies Neutralize Botulinum Neurotoxin E1 by Blocking Its Membrane Translocation in Host Cells.
Toxins, 12, 2020
7LZP
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BU of 7lzp by Molmil
LC/A-JPU-B9-JPU-A11-JPU-G11
Descriptor: Botulinum neurotoxin A light chain, JPU-A11, JPU-B9, ...
Authors:Lam, K, Jin, R.
Deposit date:2021-03-10
Release date:2021-12-22
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.86 Å)
Cite:Probing the structure and function of the protease domain of botulinum neurotoxins using single-domain antibodies.
Plos Pathog., 18, 2022

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