5NSG
 
 | | Fc DEDE homodimer variant | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, Putative uncharacterized protein DKFZp686C11235, ... | | Authors: | De Nardis, C, Hendriks, L.J.A, Poirier, E, Arvinte, T, Gros, P, Bakker, A.B.H, de Kruif, J. | | Deposit date: | 2017-04-26 | | Release date: | 2017-07-05 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.22 Å) | | Cite: | A new approach for generating bispecific antibodies based on a common light chain format and the stable architecture of human immunoglobulin G1.
J. Biol. Chem., 292, 2017
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5O4G
 | | HER2 in complex with Fab MF3958 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, MF3958 FAB heavy chain, ... | | Authors: | De Nardis, C, Gros, P. | | Deposit date: | 2017-05-29 | | Release date: | 2018-05-16 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Unbiased Combinatorial Screening Identifies a Bispecific IgG1 that Potently Inhibits HER3 Signaling via HER2-Guided Ligand Blockade.
Cancer Cell, 33, 2018
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5O4O
 | | HER3 in complex with Fab MF3178 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, MF3178 FAB heavy chain, ... | | Authors: | De Nardis, C, Gros, P. | | Deposit date: | 2017-05-30 | | Release date: | 2018-05-16 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (3.4 Å) | | Cite: | Unbiased Combinatorial Screening Identifies a Bispecific IgG1 that Potently Inhibits HER3 Signaling via HER2-Guided Ligand Blockade.
Cancer Cell, 33, 2018
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5O7P
 | | HER3 in complex with Fab MF3178 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, MF3178 FAB heavy chain, MF3178 FAB light chain, ... | | Authors: | De Nardis, C, Gros, P. | | Deposit date: | 2017-06-09 | | Release date: | 2018-05-16 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (4.5 Å) | | Cite: | Unbiased Combinatorial Screening Identifies a Bispecific IgG1 that Potently Inhibits HER3 Signaling via HER2-Guided Ligand Blockade.
Cancer Cell, 33, 2018
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1UYO
 | | Translocator domain of autotransporter NalP from Neisseria meningitidis | | Descriptor: | NALP, PENTAETHYLENE GLYCOL MONODECYL ETHER | | Authors: | Oomen, C.J, Van Ulsen, P, Van Gelder, P, Feijen, M, Tommassen, J, Gros, P. | | Deposit date: | 2004-03-02 | | Release date: | 2004-03-19 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Structure of the Translocator Domain of a Bacterial Autotransporter
Embo J., 23, 2004
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1UYN
 | | Translocator domain of autotransporter NalP from Neisseria meningitidis | | Descriptor: | NALP, PENTAETHYLENE GLYCOL MONODECYL ETHER, SULFATE ION | | Authors: | Oomen, C.J, Van Ulsen, P, Van Gelder, P, Feijen, M, Tommassen, J, Gros, P. | | Deposit date: | 2004-03-02 | | Release date: | 2004-03-18 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structure of the Translocator Domain of a Bacterial Autotransporter
Embo J., 23, 2004
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2A73
 | | Human Complement Component C3 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3, alpha-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | | Authors: | Janssen, B.J.C, Huizinga, E.G, Raaijmakers, H.C.A, Roos, A, Daha, M.R, Nilsson-Ekdahl, K, Nilsson, B, Gros, P. | | Deposit date: | 2005-07-04 | | Release date: | 2005-09-27 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Structures of complement component C3 provide insights into the function and evolution of immunity.
Nature, 437, 2005
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2A74
 | | Human Complement Component C3c | | Descriptor: | 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose, Complement Component C3c, GLYCEROL, ... | | Authors: | Janssen, B.J.C, Huizinga, E.G, Raaijmakers, H.C.A, Roos, A, Daha, M.R, Nilsson-Ekdahl, K, Nilsson, B, Gros, P. | | Deposit date: | 2005-07-04 | | Release date: | 2005-09-27 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structures of complement component C3 provide insights into the function and evolution of immunity.
Nature, 437, 2005
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4AIW
 | | GAPR-1 with bound inositol hexakisphosphate | | Descriptor: | GOLGI-ASSOCIATED PLANT PATHOGENESIS-RELATED PROTEIN 1, INOSITOL HEXAKISPHOSPHATE | | Authors: | Schouten, A, Gros, P, Helms, J.B. | | Deposit date: | 2012-02-15 | | Release date: | 2012-08-08 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Interaction of Gapr-1 with Lipid Bilayers is Regulated by Alternative Homodimerization.
Biochim.Biophys.Acta, 1818, 2012
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2MPA
 | | BACTERICIDAL ANTIBODY AGAINST NEISSERIA MENINGITIDIS | | Descriptor: | CADMIUM ION, CONJUGATE OF PORA P1.16 PEPTIDE WITH FLUORESCEIN, MN12H2 IGG2A-KAPPA, ... | | Authors: | Van Den Elsen, J.M.H, Herron, J.N, Kroon, J, Gros, P. | | Deposit date: | 1999-06-09 | | Release date: | 1999-06-23 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Bactericidal antibody recognition of a PorA epitope of Neisseria meningitidis: crystal structure of a Fab fragment in complex with a fluorescein-conjugated peptide.
Proteins, 29, 1997
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1PCF
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2WII
 | | Complement C3b in complex with factor H domains 1-4 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, COMPLEMENT C3 BETA CHAIN, ... | | Authors: | Wu, J, Janssen, B.J.C, Gros, P. | | Deposit date: | 2009-05-12 | | Release date: | 2009-06-09 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structure of complement fragment C3b-factor H and implications for host protection by complement regulators.
Nat. Immunol., 10, 2009
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2WIN
 | | C3 convertase (C3bBb) stabilized by SCIN | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, COMPLEMENT C3 BETA CHAIN, ... | | Authors: | Wu, J, Janssen, B.J, Gros, P. | | Deposit date: | 2009-05-13 | | Release date: | 2009-06-09 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (3.9 Å) | | Cite: | Structural and functional implications of the alternative complement pathway C3 convertase stabilized by a staphylococcal inhibitor.
Nat. Immunol., 10, 2009
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1QYN
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2XW9
 | | Crystal Structure of Complement Factor D mutant S183A | | Descriptor: | COMPLEMENT FACTOR D, GLYCEROL | | Authors: | Forneris, F, Ricklin, D, Wu, J, Tzekou, A, Wallace, R.S, Lambris, J.D, Gros, P. | | Deposit date: | 2010-11-01 | | Release date: | 2011-01-12 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.2 Å) | | Cite: | Structures of C3B in Complex with Factors B and D Give Insight Into Complement Convertase Formation.
Science, 330, 2010
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1QUB
 | | CRYSTAL STRUCTURE OF THE GLYCOSYLATED FIVE-DOMAIN HUMAN BETA2-GLYCOPROTEIN I PURIFIED FROM BLOOD PLASMA | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, PROTEIN (human beta2-Glycoprotein I), ... | | Authors: | Bouma, B, de Groot, P.G, van den Elsen, J.M.H, Ravelli, R.B.G, Schouten, A, Simmelink, M.J.A, Derksen, R.H.W.M, Kroon, J, Gros, P. | | Deposit date: | 1999-07-01 | | Release date: | 1999-10-08 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Adhesion mechanism of human beta(2)-glycoprotein I to phospholipids based on its crystal structure.
EMBO J., 18, 1999
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2XWA
 | | Crystal Structure of Complement Factor D Mutant R202A | | Descriptor: | COMPLEMENT FACTOR D, GLYCEROL | | Authors: | Forneris, F, Ricklin, D, Wu, J, Tzekou, A, Wallace, R.S, Lambris, J.D, Gros, P. | | Deposit date: | 2010-11-01 | | Release date: | 2011-01-12 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structures of C3B in Complex with Factors B and D Give Insight Into Complement Convertase Formation.
Science, 330, 2010
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1P4T
 | | Crystal structure of Neisserial surface protein A (NspA) | | Descriptor: | ETHANOLAMINE, PENTAETHYLENE GLYCOL MONODECYL ETHER, SULFATE ION, ... | | Authors: | Vandeputte-Rutten, L, Bos, M.P, Tommassen, J, Gros, P. | | Deposit date: | 2003-04-24 | | Release date: | 2003-07-22 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | Crystal structure of Neisserial Surface Protein A (NspA),
a conserved outer membrane protein with vaccine potential
J.Biol.Chem., 278, 2003
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2XWJ
 | | Crystal Structure of Complement C3b in Complex with Factor B | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, COMPLEMENT C3 ALPHA CHAIN, COMPLEMENT C3 BETA CHAIN, ... | | Authors: | Forneris, F, Ricklin, D, Wu, J, Tzekou, A, Wallace, R.S, Lambris, J.D, Gros, P. | | Deposit date: | 2010-11-04 | | Release date: | 2011-01-12 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (4 Å) | | Cite: | Structures of C3B in Complex with Factors B and D Give Insight Into Complement Convertase Formation.
Science, 330, 2010
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2XWB
 | | Crystal Structure of Complement C3b in complex with Factors B and D | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, COMPLEMENT C3B ALPHA' CHAIN, ... | | Authors: | Forneris, F, Ricklin, D, Wu, J, Tzekou, A, Wallace, R.S, Lambris, J.D, Gros, P. | | Deposit date: | 2010-11-01 | | Release date: | 2011-01-12 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (3.49 Å) | | Cite: | Structures of C3B in Complex with Factors B and D Give Insight Into Complement Convertase Formation.
Science, 330, 2010
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2OK5
 | | Human Complement factor B | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Complement factor B, ... | | Authors: | Milder, F.J, Gomes, L, Schouten, A, Janssen, B.J.C, Huizinga, E.G, Romijn, R.A, Hemrika, W, Roos, A, Daha, M.R, Gros, P. | | Deposit date: | 2007-01-16 | | Release date: | 2007-02-27 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Factor B structure provides insights into activation of the central protease of the complement system.
Nat.Struct.Mol.Biol., 14, 2007
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2QQH
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2QKI
 | | Human C3c in complex with the inhibitor compstatin | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BROMIDE ION, Complement C3, ... | | Authors: | Janssen, B.J.C, Halff, E.F, Lambris, J.D, Gros, P. | | Deposit date: | 2007-07-11 | | Release date: | 2007-08-14 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structure of compstatin in complex with complement component C3c reveals a new mechanism of complement inhibition.
J.Biol.Chem., 282, 2007
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2QFF
 | | Crystal structure of Staphylococcal Complement Inhibitor | | Descriptor: | Hypothetical protein | | Authors: | Milder, F.J, Rooijakkers, S.H.M, Bardoel, B.W, Ruyken, M, Van Strijp, J.A.G, Gros, P. | | Deposit date: | 2007-06-27 | | Release date: | 2007-09-04 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Staphylococcal complement inhibitor: structure and active sites.
J.Immunol., 179, 2007
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8CML
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