2GLZ
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3K26
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![BU of 3k26 by Molmil](/molmil-images/mine/3k26) | Complex structure of EED and trimethylated H3K4 | Descriptor: | HISTONE PEPTIDE, Polycomb protein EED | Authors: | Bian, C.B, Xu, C, Qiu, W, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2009-09-29 | Release date: | 2009-12-15 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2). Proc.Natl.Acad.Sci.USA, 107, 2010
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3JZH
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![BU of 3jzh by Molmil](/molmil-images/mine/3jzh) | EED-H3K79me3 | Descriptor: | HISTONE PEPTIDE, Polycomb protein EED | Authors: | Xu, C, Bian, C.B, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2009-09-23 | Release date: | 2009-12-15 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2). Proc.Natl.Acad.Sci.USA, 107, 2010
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2GVI
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3KK7
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8IYQ
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![BU of 8iyq by Molmil](/molmil-images/mine/8iyq) | Structure of CbCas9 bound to 20-nucleotide complementary DNA substrate | Descriptor: | NTS, TS, deadCbCas9, ... | Authors: | Zhang, S, Lin, S, Liu, J.J.G. | Deposit date: | 2023-04-05 | Release date: | 2024-06-05 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (2.46 Å) | Cite: | Pro-CRISPR PcrIIC1-associated Cas9 system for enhanced bacterial immunity. Nature, 630, 2024
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6W4Q
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![BU of 6w4q by Molmil](/molmil-images/mine/6w4q) | Crystal structure of full-length tailspike protein 2 (TSP2, ORF211) ) from Escherichia coli O157:H7 bacteriophage CAB120 | Descriptor: | 1,2-ETHANEDIOL, CARBONATE ION, CHLORIDE ION, ... | Authors: | Greenfield, J, Herzberg, O. | Deposit date: | 2020-03-11 | Release date: | 2021-01-20 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure and function of bacteriophage CBA120 ORF211 (TSP2), the determinant of phage specificity towards E. coli O157:H7. Sci Rep, 10, 2020
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5IGX
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5I8D
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3C7K
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![BU of 3c7k by Molmil](/molmil-images/mine/3c7k) | Molecular architecture of Galphao and the structural basis for RGS16-mediated deactivation | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(o) subunit alpha, MAGNESIUM ION, ... | Authors: | Slep, K.C, Kercher, M.A, Wieland, T, Chen, C, Simon, M.I, Sigler, P.B. | Deposit date: | 2008-02-07 | Release date: | 2008-05-06 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Molecular architecture of G{alpha}o and the structural basis for RGS16-mediated deactivation. Proc.Natl.Acad.Sci.Usa, 105, 2008
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5JNH
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3C7L
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![BU of 3c7l by Molmil](/molmil-images/mine/3c7l) | Molecular architecture of Galphao and the structural basis for RGS16-mediated deactivation | Descriptor: | Regulator of G-protein signaling 16 | Authors: | Slep, K.C, Kercher, M.A, Wieland, T, Chen, C, Simon, M.I, Sigler, P.B. | Deposit date: | 2008-02-07 | Release date: | 2008-05-06 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Molecular architecture of G{alpha}o and the structural basis for RGS16-mediated deactivation. Proc.Natl.Acad.Sci.Usa, 105, 2008
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5JP9
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4X09
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![BU of 4x09 by Molmil](/molmil-images/mine/4x09) | Structure of human RNase 6 in complex with sulphate anions | Descriptor: | GLYCEROL, Ribonuclease K6, SULFATE ION | Authors: | Prats-Ejarque, G, Arranz-Trullen, J, Blanco, J.A, Pulido, D, Moussaoui, M, Boix, E. | Deposit date: | 2014-11-21 | Release date: | 2016-04-06 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.722 Å) | Cite: | The first crystal structure of human RNase 6 reveals a novel substrate-binding and cleavage site arrangement. Biochem.J., 473, 2016
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6B57
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![BU of 6b57 by Molmil](/molmil-images/mine/6b57) | tudor in complex with ligand | Descriptor: | Tudor and KH domain-containing protein, UNKNOWN ATOM OR ION | Authors: | Zhang, H, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2017-09-28 | Release date: | 2017-11-01 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Structural basis for arginine methylation-independent recognition of PIWIL1 by TDRD2. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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8OGX
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![BU of 8ogx by Molmil](/molmil-images/mine/8ogx) | Beta-glucuronidase from Acidobacterium capsulatum in complex with inhibitor R3794 | Descriptor: | (3~{S},4~{S})-4,5,5-tris(oxidanyl)piperidine-3-carboxylic acid, PHOSPHATE ION, beta-glucuronidase from Acidobacterium capsulatum | Authors: | Moran, E.M, Davies, G.J, Chen, C, Nieuwendijk, E.V, Wu, L, Skoulikopoulou, F, Riet, V.V, Overkleeft, H.S, Armstrong, Z. | Deposit date: | 2023-03-20 | Release date: | 2024-01-10 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Molecular Basis for Inhibition of Heparanases and beta-Glucuronidases by Siastatin B. J.Am.Chem.Soc., 146, 2024
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5X8I
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![BU of 5x8i by Molmil](/molmil-images/mine/5x8i) | Crystal structure of human CLK1 in complex with compound 25 | Descriptor: | 5-[1-[(1S)-1-(4-fluorophenyl)ethyl]-[1,2,3]triazolo[4,5-c]quinolin-8-yl]-1,3-benzoxazole, Dual specificity protein kinase CLK1 | Authors: | Sun, Q.Z, Lin, G.F, Li, L.L, Jin, X.T, Huang, L.Y, Zhang, G, Wei, Y.Q, Lu, G.W, Yang, S.Y. | Deposit date: | 2017-03-02 | Release date: | 2017-08-16 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.902 Å) | Cite: | Discovery of Potent and Selective Inhibitors of Cdc2-Like Kinase 1 (CLK1) as a New Class of Autophagy Inducers J. Med. Chem., 60, 2017
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3HG8
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3IUR
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![BU of 3iur by Molmil](/molmil-images/mine/3iur) | apPEP_D266Nx+H2H3 opened state | Descriptor: | GLYCEROL, H2H3 helices from villin headpiece subdomain HP35, POLYETHYLENE GLYCOL (N=34), ... | Authors: | Chiu, T.K. | Deposit date: | 2009-08-31 | Release date: | 2010-05-05 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Induced-fit mechanism for prolyl endopeptidase J.Biol.Chem., 285, 2010
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3IVM
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![BU of 3ivm by Molmil](/molmil-images/mine/3ivm) | apPEP_WT+PP closed state | Descriptor: | N-BENZYLOXYCARBONYL-L-PROLYL-L-PROLINAL, prolyl endopeptidase | Authors: | Chiu, T.K. | Deposit date: | 2009-09-01 | Release date: | 2010-05-05 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Induced-fit mechanism for prolyl endopeptidase J.Biol.Chem., 285, 2010
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3IUQ
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![BU of 3iuq by Molmil](/molmil-images/mine/3iuq) | apPEP_D622N+PP closed state | Descriptor: | GLYCEROL, N-BENZYLOXYCARBONYL-L-PROLYL-L-PROLINAL, Prolyl Endopeptidase | Authors: | Chiu, T.K. | Deposit date: | 2009-08-31 | Release date: | 2010-05-05 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Induced-fit mechanism for prolyl endopeptidase J.Biol.Chem., 285, 2010
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3IJK
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![BU of 3ijk by Molmil](/molmil-images/mine/3ijk) | 5-OMe modified DNA 8mer | Descriptor: | 5'-D(*GP*(UMS)P*GP*(T5O)P*AP*CP*AP*C)-3' | Authors: | Sheng, J, Zhang, W, Hassan, A.E.A, Gan, J, Huang, Z. | Deposit date: | 2009-08-04 | Release date: | 2009-10-06 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Synthesis of Pyrimidine Modified Seleno-DNA as a Novel Approach to Antisense Candidate Chemistryselect, 8, 2023
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3IUL
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![BU of 3iul by Molmil](/molmil-images/mine/3iul) | apPEP_WT1 opened state | Descriptor: | GLYCEROL, Prolyl endopeptidase | Authors: | Chiu, T.K. | Deposit date: | 2009-08-31 | Release date: | 2010-05-05 | Last modified: | 2017-11-01 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Induced-fit mechanism for prolyl endopeptidase J.Biol.Chem., 285, 2010
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5GNK
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![BU of 5gnk by Molmil](/molmil-images/mine/5gnk) | Crystal structure of EGFR 696-988 T790M in complex with LXX-6-34 | Descriptor: | 1,2-ETHANEDIOL, 1-[(3R)-3-[4-azanyl-3-[3-chloranyl-4-[(1-methylimidazol-2-yl)methoxy]phenyl]pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one, CHLORIDE ION, ... | Authors: | Yan, X.E, Yun, C.H. | Deposit date: | 2016-07-21 | Release date: | 2017-04-05 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.796 Å) | Cite: | Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode. J. Med. Chem., 60, 2017
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3IUJ
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![BU of 3iuj by Molmil](/molmil-images/mine/3iuj) | apPEP_WT2 opened state | Descriptor: | Prolyl endopeptidase | Authors: | Chiu, T.K. | Deposit date: | 2009-08-31 | Release date: | 2010-05-05 | Last modified: | 2017-11-01 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Induced-fit mechanism for prolyl endopeptidase J.Biol.Chem., 285, 2010
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