5X8I

Crystal structure of human CLK1 in complex with compound 25

Summary for 5X8I

Entry DOI	10.2210/pdb5x8i/pdb
Descriptor	Dual specificity protein kinase CLK1, 5-[1-[(1S)-1-(4-fluorophenyl)ethyl]-[1,2,3]triazolo[4,5-c]quinolin-8-yl]-1,3-benzoxazole (3 entities in total)
Functional Keywords	inhibitor, complex, kinase, clk1, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Nucleus: P49759
Total number of polymer chains	2
Total formula weight	81949.97
Authors	Sun, Q.Z.,Lin, G.F.,Li, L.L.,Jin, X.T.,Huang, L.Y.,Zhang, G.,Wei, Y.Q.,Lu, G.W.,Yang, S.Y. (deposition date: 2017-03-02, release date: 2017-08-16, Last modification date: 2023-11-22)
Primary citation	Sun, Q.Z.,Lin, G.F.,Li, L.L.,Jin, X.T.,Huang, L.Y.,Zhang, G.,Yang, W.,Chen, K.,Xiang, R.,Chen, C.,Wei, Y.Q.,Lu, G.W.,Yang, S.Y. Discovery of Potent and Selective Inhibitors of Cdc2-Like Kinase 1 (CLK1) as a New Class of Autophagy Inducers J. Med. Chem., 60:6337-6352, 2017 Cited by PubMed: 28692292 DOI: 10.1021/acs.jmedchem.7b00665 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.902 Å)

Structure validation