5X8I
Crystal structure of human CLK1 in complex with compound 25
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | B, A | Dual specificity protein kinase CLK1 | polymer | 346 | 40565.6 | 2 | UniProt (P49759) Pfam (PF00069) In PDB | Homo sapiens (Human) | CDC-like kinase 1 |
2 | B, A | 5-[1-[(1S)-1-(4-fluorophenyl)ethyl]-[1,2,3]triazolo[4,5-c]quinolin-8-yl]-1,3-benzoxazole | non-polymer | 409.4 | 2 | Chemie (SQZ) | |||
3 | water | water | 18.0 | 630 | Chemie (HOH) |
Sequence modifications
B, A: 148 - 484 (UniProt: P49759)
PDB | External Database | Details |
---|---|---|
Met 147 | - | expression tag |
Ala 432 | Arg 432 | engineered mutation |
Leu 485 | - | expression tag |
Glu 486 | - | expression tag |
His 487 | - | expression tag |
His 488 | - | expression tag |
His 489 | - | expression tag |
His 490 | - | expression tag |
His 491 | - | expression tag |
His 492 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 81131.1 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 818.8 | |
All* | Total formula weight | 81950.0 |