3G7V
 
 | | Islet Amyloid Polypeptide (IAPP or Amylin) fused to Maltose Binding Protein | | Descriptor: | GLYCEROL, Maltose-binding periplasmic protein, Islet amyloid polypeptide fusion protein, ... | | Authors: | Wiltzius, J.J.W, Sawaya, M.R, Eisenberg, D. | | Deposit date: | 2009-02-10 | | Release date: | 2009-06-23 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.86 Å) | | Cite: | Atomic structures of IAPP (amylin) fusions suggest a mechanism for fibrillation and the role of insulin in the process
Protein Sci., 18, 2009
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3MLG
 | | 2ouf-2x, a designed knotted protein | | Descriptor: | 2X chimera of Helicobacter pylori protein HP0242 | | Authors: | King, N.P, Sawaya, M.R, Jacobitz, A.W, Yeates, T.O. | | Deposit date: | 2010-04-16 | | Release date: | 2010-05-12 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.29 Å) | | Cite: | Structure and folding of a designed knotted protein.
Proc.Natl.Acad.Sci.USA, 107, 2010
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3NFZ
 | | Crystal structure of murine aminoacylase 3 in complex with N-acetyl-L-tyrosine | | Descriptor: | Aspartoacylase-2, CHLORIDE ION, N-acetyl-L-tyrosine, ... | | Authors: | Hsieh, J.M, Tsirulnikov, K, Sawaya, M.R, Magilnick, N, Abuladze, N, Kurtz, I, Abramson, J, Pushkin, A. | | Deposit date: | 2010-06-10 | | Release date: | 2010-10-20 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.147 Å) | | Cite: | Structures of aminoacylase 3 in complex with acetylated substrates.
Proc.Natl.Acad.Sci.USA, 107, 2010
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3NH5
 | | Crystal structure of E177A-mutant murine aminoacylase 3 | | Descriptor: | ACETATE ION, Aspartoacylase-2, CHLORIDE ION, ... | | Authors: | Hsieh, J.M, Tsirulnikov, K, Sawaya, M.R, Magilnick, N, Abuladze, N, Kurtz, I, Abramson, J, Pushkin, A. | | Deposit date: | 2010-06-14 | | Release date: | 2010-10-20 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.094 Å) | | Cite: | Structures of aminoacylase 3 in complex with acetylated substrates.
Proc.Natl.Acad.Sci.USA, 107, 2010
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3H87
 | | Rv0301 Rv0300 Toxin Antitoxin Complex from Mycobacterium tuberculosis | | Descriptor: | BETA-MERCAPTOETHANOL, GLYCEROL, IMIDAZOLE, ... | | Authors: | Min, A, Sawaya, M.R, Cascio, D, Eisenberg, D, Integrated Center for Structure and Function Innovation (ISFI) | | Deposit date: | 2009-04-28 | | Release date: | 2009-05-05 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.49 Å) | | Cite: | The crystal structure of the Rv0301-Rv0300 VapBC-3 toxin-antitoxin complex from M. tuberculosis reveals a Mg(2+) ion in the active site and a putative RNA-binding site.
Protein Sci., 21, 2012
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3Q25
 | | Crystal structure of human alpha-synuclein (1-19) fused to maltose binding protein (MBP) | | Descriptor: | GLYCEROL, Maltose-binding periplasmic protein/alpha-synuclein chimeric protein, SULFATE ION, ... | | Authors: | Zhao, M, Sawaya, M.R, Cascio, D, Eisenberg, D. | | Deposit date: | 2010-12-19 | | Release date: | 2011-06-01 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structures of segments of alpha-synuclein fused to maltose-binding protein suggest intermediate states during amyloid formation
Protein Sci., 20, 2011
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3PZZ
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3FTK
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3NH4
 | | Crystal structure of murine aminoacylase 3 | | Descriptor: | ACETATE ION, Aspartoacylase-2, CESIUM ION, ... | | Authors: | Hsieh, J.M, Tsirulnikov, K, Sawaya, M.R, Magilnick, N, Abuladze, N, Kurtz, I, Abramson, J, Pushkin, A. | | Deposit date: | 2010-06-14 | | Release date: | 2010-10-20 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structures of aminoacylase 3 in complex with acetylated substrates.
Proc.Natl.Acad.Sci.USA, 107, 2010
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3NH8
 | | Crystal structure of murine aminoacylase 3 in complex with N-acetyl-S-1,2-dichlorovinyl-L-cysteine | | Descriptor: | Aspartoacylase-2, CHLORIDE ION, N-acetyl-S-[(1S)-1,2-dichloroethyl]-L-cysteine, ... | | Authors: | Hsieh, J.M, Tsirulnikov, K, Sawaya, M.R, Magilnick, N, Abuladze, N, Kurtz, I, Abramson, J, Pushkin, A. | | Deposit date: | 2010-06-14 | | Release date: | 2010-10-20 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.802 Å) | | Cite: | Structures of aminoacylase 3 in complex with acetylated substrates.
Proc.Natl.Acad.Sci.USA, 107, 2010
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3Q28
 | | Cyrstal structure of human alpha-synuclein (58-79) fused to maltose binding protein (MBP) | | Descriptor: | Maltose-binding periplasmic protein/alpha-synuclein chimeric protein, SULFATE ION, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | | Authors: | Zhao, M, Sawaya, M.R, Cascio, D, Eisenberg, D. | | Deposit date: | 2010-12-19 | | Release date: | 2011-06-01 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Structures of segments of alpha-synuclein fused to maltose-binding protein suggest intermediate states during amyloid formation
Protein Sci., 20, 2011
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3Q26
 | | Cyrstal structure of human alpha-synuclein (10-42) fused to maltose binding protein (MBP) | | Descriptor: | GLYCEROL, Maltose-binding periplasmic protein/alpha-synuclein chimeric protein, SULFATE ION, ... | | Authors: | Zhao, M, Sawaya, M.R, Cascio, D, Eisenberg, D. | | Deposit date: | 2010-12-19 | | Release date: | 2011-06-01 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.54 Å) | | Cite: | Structures of segments of alpha-synuclein fused to maltose-binding protein suggest intermediate states during amyloid formation
Protein Sci., 20, 2011
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3Q29
 | | Cyrstal structure of human alpha-synuclein (1-19) fused to maltose binding protein (MBP) | | Descriptor: | GLYCEROL, Maltose-binding periplasmic protein/alpha-synuclein chimeric protein, SULFATE ION, ... | | Authors: | Zhao, M, Sawaya, M.R, Cascio, D, Eisenberg, D. | | Deposit date: | 2010-12-19 | | Release date: | 2011-06-01 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structures of segments of alpha-synuclein fused to maltose-binding protein suggest intermediate states during amyloid formation
Protein Sci., 20, 2011
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3Q4H
 | | Crystal structure of the Mycobacterium smegmatis EsxGH complex (MSMEG_0620-MSMEG_0621) | | Descriptor: | Low molecular weight protein antigen 7, Pe family protein | | Authors: | Chan, S, Harris, L, Kuo, E, Ahn, C, Zhou, T.T, Nguyen, L, Shin, A, Sawaya, M.R, Cascio, D, Arbing, M.A, Eisenberg, D, Integrated Center for Structure and Function Innovation (ISFI), TB Structural Genomics Consortium (TBSGC) | | Deposit date: | 2010-12-23 | | Release date: | 2011-01-26 | | Last modified: | 2014-05-14 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Heterologous expression of mycobacterial Esx complexes in Escherichia coli for structural studies is facilitated by the use of maltose binding protein fusions.
Plos One, 8, 2013
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3H8Y
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3Q27
 | | Cyrstal structure of human alpha-synuclein (32-57) fused to maltose binding protein (MBP) | | Descriptor: | GLYCEROL, Maltose-binding periplasmic protein/alpha-synuclein chimeric protein, SULFATE ION, ... | | Authors: | Zhao, M, Sawaya, M.R, Cascio, D, Eisenberg, D. | | Deposit date: | 2010-12-19 | | Release date: | 2011-06-01 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.302 Å) | | Cite: | Structures of segments of alpha-synuclein fused to maltose-binding protein suggest intermediate states during amyloid formation
Protein Sci., 20, 2011
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3Q2X
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6AVB
 | | CryoEM structure of Mical Oxidized Actin (Class 1) | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle | | Authors: | Grintsevich, E.E, Ge, P, Sawaya, M.R, Yesilyurt, H.G, Terman, J.R, Zhou, Z.H, Reisler, E. | | Deposit date: | 2017-09-01 | | Release date: | 2018-01-17 | | Last modified: | 2019-11-06 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Catastrophic disassembly of actin filaments via Mical-mediated oxidation.
Nat Commun, 8, 2017
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6AV9
 | | CryoEM structure of Mical Oxidized Actin (Class 1) | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle | | Authors: | Grintsevich, E.E, Ge, P, Sawaya, M.R, Yesilyurt, H.G, Terman, J.R, Zhou, Z.H, Reisler, E. | | Deposit date: | 2017-09-01 | | Release date: | 2018-01-17 | | Last modified: | 2019-11-27 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Catastrophic disassembly of actin filaments via Mical-mediated oxidation.
Nat Commun, 8, 2017
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6B79
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6BCS
 | | LilrB2 D1D2 domains complexed with benzamidine | | Descriptor: | BENZAMIDINE, CHLORIDE ION, DIMETHYL SULFOXIDE, ... | | Authors: | Cao, Q, Sawaya, M.R, Eisenberg, D.S. | | Deposit date: | 2017-10-20 | | Release date: | 2018-09-05 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Inhibiting amyloid-beta cytotoxicity through its interaction with the cell surface receptor LilrB2 by structure-based design.
Nat Chem, 10, 2018
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6BWZ
 | | SYSGYS from low-complexity domain of FUS, residues 37-42 | | Descriptor: | SYSGYS peptide from low-complexity domain of FUS | | Authors: | Hughes, M.P, Rodriguez, J.A, Sawaya, M.R, Cascio, D, Tamir, G, Eisenberg, D.S. | | Deposit date: | 2017-12-15 | | Release date: | 2018-04-04 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.1 Å) | | Cite: | Atomic structures of low-complexity protein segments reveal kinked beta sheets that assemble networks.
Science, 359, 2018
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6C3T
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6BXX
 | | GYNGFG from low-complexity domain of hnRNPA1, residues 243-248 | | Descriptor: | hnRNPA1 | | Authors: | Hughes, M.P, Rodriguez, J.A, Sawaya, M.R, Cascio, D, Gonen, T, Eisenberg, D.S. | | Deposit date: | 2017-12-19 | | Release date: | 2018-04-04 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.1 Å) | | Cite: | Atomic structures of low-complexity protein segments reveal kinked beta sheets that assemble networks.
Science, 359, 2018
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6C3S
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