9AYA
 
 | | Crystal structure of CRAF/MEK complex with NST-628 and active RAF dimer | | Descriptor: | Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, N-[3-fluoro-4-({7-[(3-fluoropyridin-2-yl)oxy]-4-methyl-2-oxo-2H-1-benzopyran-3-yl}methyl)pyridin-2-yl]-N'-methylsulfuric diamide, ... | | Authors: | Quade, B, Huang, X. | | Deposit date: | 2024-03-07 | | Release date: | 2024-04-17 | | Last modified: | 2024-07-10 | | Method: | X-RAY DIFFRACTION (2.59 Å) | | Cite: | The Pan-RAF-MEK Nondegrading Molecular Glue NST-628 Is a Potent and Brain-Penetrant Inhibitor of the RAS-MAPK Pathway with Activity across Diverse RAS- and RAF-Driven Cancers.
Cancer Discov, 14, 2024
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9AXY
 | | Crystal structure of BRAF/MEK complex with NST-628 and inactive RAF | | Descriptor: | Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, N-[3-fluoro-4-({7-[(3-fluoropyridin-2-yl)oxy]-4-methyl-2-oxo-2H-1-benzopyran-3-yl}methyl)pyridin-2-yl]-N'-methylsulfuric diamide, ... | | Authors: | Quade, B, Huang, X. | | Deposit date: | 2024-03-06 | | Release date: | 2024-04-17 | | Last modified: | 2024-07-10 | | Method: | X-RAY DIFFRACTION (3.6 Å) | | Cite: | The Pan-RAF-MEK Nondegrading Molecular Glue NST-628 Is a Potent and Brain-Penetrant Inhibitor of the RAS-MAPK Pathway with Activity across Diverse RAS- and RAF-Driven Cancers.
Cancer Discov, 14, 2024
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9AXA
 | | CryoEM structure of activated CRAF/MEK/14-3-3 complex with NST-628 | | Descriptor: | 14-3-3 protein sigma, Dual specificity mitogen-activated protein kinase kinase 1, GST26/CRAF chimera, ... | | Authors: | Quade, B, Cohen, S.E, Huang, X. | | Deposit date: | 2024-03-06 | | Release date: | 2024-04-17 | | Last modified: | 2024-07-10 | | Method: | ELECTRON MICROSCOPY (4.36 Å) | | Cite: | The Pan-RAF-MEK Nondegrading Molecular Glue NST-628 Is a Potent and Brain-Penetrant Inhibitor of the RAS-MAPK Pathway with Activity across Diverse RAS- and RAF-Driven Cancers.
Cancer Discov, 14, 2024
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2RU2
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4ULW
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8FEG
 | | CryoEM structure of Kappa Opioid Receptor bound to a semi-peptide and Gi1 | | Descriptor: | ACE-TYR-ALA-DTY-THR-THR-CYS-THR-DPN-XT9, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Fay, J.F, Che, T. | | Deposit date: | 2022-12-06 | | Release date: | 2023-12-06 | | Last modified: | 2024-01-17 | | Method: | ELECTRON MICROSCOPY (2.54 Å) | | Cite: | Design and structural validation of peptide-drug conjugate ligands of the kappa-opioid receptor.
Nat Commun, 14, 2023
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6SWA
 | | Mus musculus brain neocortex ribosome 60S bound to Ebp1 | | Descriptor: | 28S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... | | Authors: | Kraushar, M.L, Sprink, T. | | Deposit date: | 2019-09-20 | | Release date: | 2020-09-30 | | Last modified: | 2021-02-17 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Protein Synthesis in the Developing Neocortex at Near-Atomic Resolution Reveals Ebp1-Mediated Neuronal Proteostasis at the 60S Tunnel Exit.
Mol.Cell, 81, 2021
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6SCT
 | | Cryo-EM structure of the consensus triskelion hub of the clathrin coat complex | | Descriptor: | Clathrin heavy chain, Clathrin light chain | | Authors: | Morris, K.L, Cameron, A.D, Sessions, R, Smith, C.J. | | Deposit date: | 2019-07-25 | | Release date: | 2019-10-02 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (4.69 Å) | | Cite: | Cryo-EM of multiple cage architectures reveals a universal mode of clathrin self-assembly.
Nat.Struct.Mol.Biol., 26, 2019
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2YP6
 | | Crystal structure of the pneumoccocal exposed lipoprotein thioredoxin sp_1000 (Etrx2) from Streptococcus pneumoniae strain TIGR4 in complex with Cyclofos 3 TM | | Descriptor: | 3-Cyclohexyl-1-Propylphosphocholine, MALONATE ION, THIOREDOXIN FAMILY PROTEIN | | Authors: | Bartual, S.G, Shalek, M, Abdullah, M.R, Jensch, I, Asmat, T.M, Petruschka, L, Pribyl, T, Hermoso, J.A, Hammerschmidt, S. | | Deposit date: | 2012-10-29 | | Release date: | 2013-10-30 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.767 Å) | | Cite: | Molecular Architecture of Streptococcus Pneumoniae Surface Thioredoxin-Fold Lipoproteins Crucial for Extracellular Oxidative Stress Resistance and Maintenance of Virulence.
Embo Mol.Med., 5, 2013
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8BTJ
 | | Murine cytomegalovirus protein M35 | | Descriptor: | (R,R)-2,3-BUTANEDIOL, MALONATE ION, Protein M35 | | Authors: | Schmelz, S, Van den Heuvel, J, Blankenfeldt, W. | | Deposit date: | 2022-11-29 | | Release date: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.94 Å) | | Cite: | The Cytomegalovirus M35 Protein Directly Binds to the Interferon-beta Enhancer and Modulates Transcription of Ifnb1 and Other IRF3-Driven Genes.
J.Virol., 97, 2023
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2MGO
 | | NMR solution structure of oxytocin | | Descriptor: | Oxytocin | | Authors: | Harvey, P.J, Craik, D.J. | | Deposit date: | 2013-11-01 | | Release date: | 2014-10-22 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | Oxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand design.
Proc.Natl.Acad.Sci.USA, 110, 2013
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2M9O
 | | Solution structure of kalata B7 | | Descriptor: | Kalata-B7 | | Authors: | Daly, N, Elliott, A, Craik, D. | | Deposit date: | 2013-06-18 | | Release date: | 2013-11-20 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | Cyclotides as templates for peptide GPCR ligand design - discovery of the target receptor of the oxytocic plant peptide kalata B7
Proc.Natl.Acad.Sci.USA, 2013
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1CLS
 | | CROSS-LINKED HUMAN HEMOGLOBIN DEOXY | | Descriptor: | HEMOGLOBIN, OXYGEN ATOM, PROTOPORPHYRIN IX CONTAINING FE, ... | | Authors: | Ji, X, Fronticelli, C, Bucci, E, Gilliland, G.L. | | Deposit date: | 1995-08-29 | | Release date: | 1996-10-14 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Positive and negative cooperativities at subsequent steps of oxygenation regulate the allosteric behavior of multistate sebacylhemoglobin.
Biochemistry, 35, 1996
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1Y0Q
 | | Crystal structure of an active group I ribozyme-product complex | | Descriptor: | 5'-R(*GP*CP*UP*U)-3', Group I ribozyme, MAGNESIUM ION, ... | | Authors: | Golden, B.L, Kim, H, Chase, E. | | Deposit date: | 2004-11-16 | | Release date: | 2004-12-21 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (3.6 Å) | | Cite: | Crystal structure of a phage Twort group I ribozyme-product complex
Nat.Struct.Mol.Biol., 12, 2005
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