7B2M
 
 | | Cryo-EM structure of complement C4b in complex with nanobody E3 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Anti-C4b nanobody E3, Complement C4 alpha chain, ... | | Authors: | Oosterheert, W, De la O Becerra, K.I, van den Bos, R.M, Gros, P. | | Deposit date: | 2020-11-27 | | Release date: | 2022-03-02 | | Last modified: | 2022-05-04 | | Method: | ELECTRON MICROSCOPY (3.39 Å) | | Cite: | Multifaceted Activities of Seven Nanobodies against Complement C4b.
J Immunol., 208, 2022
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7B2Q
 | | Cryo-EM structure of complement C4b in complex with nanobody B12 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Anti-C4b nanobody B12, ... | | Authors: | Oosterheert, W, De la O Becerra, K.I, Gros, P. | | Deposit date: | 2020-11-27 | | Release date: | 2022-03-02 | | Last modified: | 2022-05-04 | | Method: | ELECTRON MICROSCOPY (3.76 Å) | | Cite: | Multifaceted Activities of Seven Nanobodies against Complement C4b.
J Immunol., 208, 2022
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7B2P
 | | Cryo-EM structure of complement C4b in complex with nanobody B5 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C4 alpha chain, ... | | Authors: | Oosterheert, W, De la O Becerra, K.I, Gros, P. | | Deposit date: | 2020-11-27 | | Release date: | 2022-03-02 | | Last modified: | 2022-05-04 | | Method: | ELECTRON MICROSCOPY (3.43 Å) | | Cite: | Multifaceted Activities of Seven Nanobodies against Complement C4b.
J Immunol., 208, 2022
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1I78
 | | CRYSTAL STRUCTURE OF OUTER MEMBRANE PROTEASE OMPT FROM ESCHERICHIA COLI | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, PROTEASE VII, octyl beta-D-glucopyranoside | | Authors: | Vandeputte-Rutten, L, Kramer, R.A, Kroon, J, Dekker, N, Egmond, M.R, Gros, P. | | Deposit date: | 2001-03-08 | | Release date: | 2001-10-03 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Crystal structure of the outer membrane protease OmpT from Escherichia coli suggests a novel catalytic site.
EMBO J., 20, 2001
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6Y9B
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4A5W
 | | Crystal structure of C5b6 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, COMPLEMENT C5, ... | | Authors: | Hadders, M.A, Bubeck, D, Forneris, F, Pangburn, M, Llorca, O, Lea, S.M, Gros, P. | | Deposit date: | 2011-10-28 | | Release date: | 2012-03-14 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Assembly and Regulation of the Membrane Attack Complex Based on Structures of C5B6 and Sc5B9.
Cell Rep., 1, 2012
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6RLR
 | | Crystal structure of CD9 large extracellular loop | | Descriptor: | CD9 antigen | | Authors: | Neviani, V, Kroon-Batenburg, L, Lutz, M, Pearce, N.M, Pos, W, Schotte, R, Spits, H, Gros, P. | | Deposit date: | 2019-05-02 | | Release date: | 2020-09-23 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Implications for tetraspanin-enriched microdomain assembly based on structures of CD9 with EWI-F.
Life Sci Alliance, 3, 2020
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1UYO
 | | Translocator domain of autotransporter NalP from Neisseria meningitidis | | Descriptor: | NALP, PENTAETHYLENE GLYCOL MONODECYL ETHER | | Authors: | Oomen, C.J, Van Ulsen, P, Van Gelder, P, Feijen, M, Tommassen, J, Gros, P. | | Deposit date: | 2004-03-02 | | Release date: | 2004-03-19 | | Last modified: | 2019-07-24 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Structure of the Translocator Domain of a Bacterial Autotransporter
Embo J., 23, 2004
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1UYN
 | | Translocator domain of autotransporter NalP from Neisseria meningitidis | | Descriptor: | NALP, PENTAETHYLENE GLYCOL MONODECYL ETHER, SULFATE ION | | Authors: | Oomen, C.J, Van Ulsen, P, Van Gelder, P, Feijen, M, Tommassen, J, Gros, P. | | Deposit date: | 2004-03-02 | | Release date: | 2004-03-18 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structure of the Translocator Domain of a Bacterial Autotransporter
Embo J., 23, 2004
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7BAG
 | | C3b in complex with CP40 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACETAMIDE, AMINO GROUP, ... | | Authors: | Lamers, C, Xue, X, Smiesko, M, van Son, H, Wagner, B, Sfyroera, G, Gros, P, Lambris, J, Ricklin, D. | | Deposit date: | 2020-12-15 | | Release date: | 2022-01-12 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Insight into mode-of-action and structural determinants of the compstatin family of clinical complement inhibitors.
Nat Commun, 13, 2022
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5O35
 | | Structure of complement proteins complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3, Complement factor H,Complement factor H | | Authors: | Xue, X, Wu, J, Forneris, F, Gros, P. | | Deposit date: | 2017-05-23 | | Release date: | 2017-06-28 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (4.2 Å) | | Cite: | Regulator-dependent mechanisms of C3b processing by factor I allow differentiation of immune responses.
Nat. Struct. Mol. Biol., 24, 2017
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5O32
 | | The structure of complement complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Xue, X, Wu, J, Forneris, F, Gros, P. | | Deposit date: | 2017-05-23 | | Release date: | 2017-06-28 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (4.206209 Å) | | Cite: | Regulator-dependent mechanisms of C3b processing by factor I allow differentiation of immune responses.
Nat. Struct. Mol. Biol., 24, 2017
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1MPA
 | | BACTERICIDAL ANTIBODY AGAINST NEISSERIA MENINGITIDIS | | Descriptor: | CADMIUM ION, MN12H2 IGG2A-KAPPA, PORA P1.16 PEPTIDE FLUORESCEIN CONJUGATE | | Authors: | Van Den Elsen, J.M.H, Herron, J.N, Kroon, J, Gros, P. | | Deposit date: | 1997-02-26 | | Release date: | 1997-09-04 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Bactericidal antibody recognition of a PorA epitope of Neisseria meningitidis: crystal structure of a Fab fragment in complex with a fluorescein-conjugated peptide.
Proteins, 29, 1997
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6FCZ
 | | Model of gC1q-Fc complex based on 7A EM map | | Descriptor: | Complement C1q subcomponent subunit A, Complement C1q subcomponent subunit B, Complement C1q subcomponent subunit C, ... | | Authors: | Ugurlar, D, Howes, S.C, de Kreuk, B.J.K, de Jong, R.N, Beurskens, F.J, Koster, A.J, Parren, P.W.H.I, Sharp, T.H, Gros, P, Koning, R.I. | | Deposit date: | 2017-12-21 | | Release date: | 2018-02-28 | | Last modified: | 2018-10-24 | | Method: | ELECTRON MICROSCOPY (10 Å) | | Cite: | Structures of C1-IgG1 provide insights into how danger pattern recognition activates complement.
Science, 359, 2018
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6HCY
 | | human STEAP4 bound to NADP, FAD, heme and Fe(III)-NTA. | | Descriptor: | (2R)-3-(phosphonooxy)propane-1,2-diyl dihexanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, FLAVIN-ADENINE DINUCLEOTIDE, ... | | Authors: | Oosterheert, W, van Bezouwen, L.S, Rodenburg, R.N.P, Forster, F, Mattevi, A, Gros, P. | | Deposit date: | 2018-08-17 | | Release date: | 2018-10-24 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Cryo-EM structures of human STEAP4 reveal mechanism of iron(III) reduction.
Nat Commun, 9, 2018
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6HD1
 | | human STEAP4 bound to NADPH, FAD and heme. | | Descriptor: | (2R)-3-(phosphonooxy)propane-1,2-diyl dihexanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, FLAVIN-ADENINE DINUCLEOTIDE, ... | | Authors: | Oosterheert, W, van Bezouwen, L.S, Rodenburg, R.N.P, Forster, F, Mattevi, A, Gros, P. | | Deposit date: | 2018-08-17 | | Release date: | 2018-10-24 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Cryo-EM structures of human STEAP4 reveal mechanism of iron(III) reduction.
Nat Commun, 9, 2018
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1M0U
 | | Crystal Structure of the Drosophila Glutathione S-transferase-2 in Complex with Glutathione | | Descriptor: | GLUTATHIONE, GST2 gene product, SULFATE ION | | Authors: | Agianian, B, Tucker, P.A, Schouten, A, Leonard, K, Bullard, B, Gros, P. | | Deposit date: | 2002-06-14 | | Release date: | 2003-02-11 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Structure of a Drosophila Sigma Class Glutathione S-transferase Reveals a Novel
Active Site Topography Suited for Lipid Peroxidation Products
J.Mol.Biol., 326, 2003
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4AIW
 | | GAPR-1 with bound inositol hexakisphosphate | | Descriptor: | GOLGI-ASSOCIATED PLANT PATHOGENESIS-RELATED PROTEIN 1, INOSITOL HEXAKISPHOSPHATE | | Authors: | Schouten, A, Gros, P, Helms, J.B. | | Deposit date: | 2012-02-15 | | Release date: | 2012-08-08 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Interaction of Gapr-1 with Lipid Bilayers is Regulated by Alternative Homodimerization.
Biochim.Biophys.Acta, 1818, 2012
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6S08
 | | Crystal Structure of Properdin (TSR domains N1 & 456) | | Descriptor: | Properdin, SODIUM ION, TRIETHYLENE GLYCOL, ... | | Authors: | van den Bos, R.M, Pearce, N.M, Gros, P. | | Deposit date: | 2019-06-14 | | Release date: | 2019-09-04 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.03 Å) | | Cite: | Insights Into Enhanced Complement Activation by Structures of Properdin and Its Complex With the C-Terminal Domain of C3b.
Front Immunol, 10, 2019
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6S0A
 | | Crystal Structure of Properdin (TSR domains N12 & 456) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Properdin, alpha-D-mannopyranose, ... | | Authors: | van den Bos, R.M, Pearce, N.M, Gros, P. | | Deposit date: | 2019-06-14 | | Release date: | 2019-09-04 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.52 Å) | | Cite: | Insights Into Enhanced Complement Activation by Structures of Properdin and Its Complex With the C-Terminal Domain of C3b.
Front Immunol, 10, 2019
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6S0B
 | | Crystal Structure of Properdin in complex with the CTC domain of C3/C3b | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3, Properdin, ... | | Authors: | van den Bos, R.M, Pearce, N.M, Gros, P. | | Deposit date: | 2019-06-14 | | Release date: | 2019-09-04 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.312 Å) | | Cite: | Insights Into Enhanced Complement Activation by Structures of Properdin and Its Complex With the C-Terminal Domain of C3b.
Front Immunol, 10, 2019
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6RLO
 | | Crystal structure of AT1412dm Fab fragment in complex with CD9 large extracellular loop | | Descriptor: | AT1412dm Fab Fragment (Heavy Chain), AT1412dm Fab Fragment (Light Chain), CD9 antigen, ... | | Authors: | Neviani, V, Pearce, N.M, Pos, W, Schotte, R, Spits, H, Gros, P. | | Deposit date: | 2019-05-02 | | Release date: | 2021-05-12 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structural basis of a homo-dimerization site in tetraspanin CD9 targeted by a melanoma patient-derived antibody
To Be Published
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6RLM
 | | Crystal structure of AT1412dm Fab fragment | | Descriptor: | AT1412dm Fab (Heavy Chain), AT1412dm Fab (Light Chain), CHLORIDE ION | | Authors: | Neviani, V, Pearce, N.M, Pos, W, Schotte, R, Spits, H, Gros, P. | | Deposit date: | 2019-05-02 | | Release date: | 2021-05-12 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural basis of a homo-dimerization site in tetraspanin CD9 targeted by a melanoma patient-derived antibody
To Be Published
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2WII
 | | Complement C3b in complex with factor H domains 1-4 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, COMPLEMENT C3 BETA CHAIN, ... | | Authors: | Wu, J, Janssen, B.J.C, Gros, P. | | Deposit date: | 2009-05-12 | | Release date: | 2009-06-09 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structure of complement fragment C3b-factor H and implications for host protection by complement regulators.
Nat. Immunol., 10, 2009
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2WIN
 | | C3 convertase (C3bBb) stabilized by SCIN | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, COMPLEMENT C3 BETA CHAIN, ... | | Authors: | Wu, J, Janssen, B.J, Gros, P. | | Deposit date: | 2009-05-13 | | Release date: | 2009-06-09 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (3.9 Å) | | Cite: | Structural and functional implications of the alternative complement pathway C3 convertase stabilized by a staphylococcal inhibitor.
Nat. Immunol., 10, 2009
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