4GWK
| Crystal structure of 6-phosphogluconate dehydrogenase complexed with 3-phosphoglyceric acid | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3-PHOSPHOGLYCERIC ACID, 6-phosphogluconate dehydrogenase, ... | Authors: | He, C, Zhou, L, Zhang, L. | Deposit date: | 2012-09-03 | Release date: | 2012-11-28 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.534 Å) | Cite: | Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth. Cancer Cell, 22, 2012
|
|
1HM9
| CRYSTAL STRUCTURE OF S.PNEUMONIAE N-ACETYLGLUCOSAMINE-1-PHOSPHATE URIDYLTRANSFERASE, GLMU, BOUND TO ACETYL COENZYME A AND UDP-N-ACETYLGLUCOSAMINE | Descriptor: | ACETYL COENZYME *A, CALCIUM ION, UDP-N-ACETYLGLUCOSAMINE-1-PHOSPHATE URIDYLTRANSFERASE, ... | Authors: | Sulzenbacher, G, Gal, L, Peneff, C, Fassy, F, Bourne, Y. | Deposit date: | 2000-12-05 | Release date: | 2001-11-30 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Crystal structure of Streptococcus pneumoniae N-acetylglucosamine-1-phosphate uridyltransferase bound to acetyl-coenzyme A reveals a novel active site architecture. J.Biol.Chem., 276, 2001
|
|
1HQ0
| CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF E.COLI CYTOTOXIC NECROTIZING FACTOR TYPE 1 | Descriptor: | CYTOTOXIC NECROTIZING FACTOR 1, PHOSPHATE ION | Authors: | Buetow, L, Flatau, G, Chiu, K, Boquet, P, Ghosh, P. | Deposit date: | 2000-12-13 | Release date: | 2001-07-04 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | Structure of the Rho-activating domain of Escherichia coli cytotoxic necrotizing factor 1. Nat.Struct.Biol., 8, 2001
|
|
1HQD
| PSEUDOMONAS CEPACIA LIPASE COMPLEXED WITH TRANSITION STATE ANALOGUE OF 1-PHENOXY-2-ACETOXY BUTANE | Descriptor: | (RP,SP)-O-(2R)-(1-PHENOXYBUT-2-YL)-METHYLPHOSPHONIC ACID CHLORIDE, CALCIUM ION, LIPASE | Authors: | Luic, M, Tomic, S, Lescic, I, Ljubovic, E, Sepac, D, Sunjic, V, Vitale, L, Saenger, W, Kojic-Prodic, B. | Deposit date: | 2000-12-15 | Release date: | 2001-08-22 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Complex of Burkholderia cepacia lipase with transition state analogue of 1-phenoxy-2-acetoxybutane: biocatalytic, structural and modelling study. Eur.J.Biochem., 268, 2001
|
|
1HZF
| C4ADG FRAGMENT OF HUMAN COMPLEMENT FACTOR C4A | Descriptor: | COMPLEMENT FACTOR C4A | Authors: | van den Elsen, J.M.H, Martin, A, Wong, V, Clemenza, L, Rose, D.R, Isenman, D.E. | Deposit date: | 2001-01-24 | Release date: | 2002-10-09 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | X-ray crystal structure of the C4d fragment of human complement component C4. J.Mol.Biol., 322, 2002
|
|
1HZG
| CRYSTAL STRUCTURE OF THE INACTIVE C866S MUTANT OF THE CATALYTIC DOMAIN OF E. COLI CYTOTOXIC NECROTIZING FACTOR 1 | Descriptor: | CYTOTOXIC NECROTIZING FACTOR 1, PHOSPHATE ION | Authors: | Buetow, L, Flatau, G, Chiu, K, Boquet, P, Ghosh, P. | Deposit date: | 2001-01-24 | Release date: | 2001-07-04 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Structure of the Rho-activating domain of Escherichia coli cytotoxic necrotizing factor 1. Nat.Struct.Biol., 8, 2001
|
|
1HZT
| CRYSTAL STRUCTURE OF METAL-FREE ISOPENTENYL DIPHOSPHATE:DIMETHYLALLYL DIPHOSPHATE ISOMERASE | Descriptor: | ISOPENTENYL DIPHOSPHATE DELTA-ISOMERASE | Authors: | Durbecq, V, Sainz, G, Oudjama, Y, Clantin, B, Bompard-Gilles, C, Tricot, C, Caillet, J, Stalon, V, Droogmans, L, Villeret, V. | Deposit date: | 2001-01-26 | Release date: | 2001-07-26 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Crystal structure of isopentenyl diphosphate:dimethylallyl diphosphate isomerase. Embo J., 20, 2001
|
|
2PL3
| Human DEAD-box RNA helicase DDX10, DEAD domain in complex with ADP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ETHANOL, MAGNESIUM ION, ... | Authors: | Karlberg, T, Lehtio, L, Arrowsmith, C.H, Berglund, H, Busam, R.D, Collins, R, Dahlgren, L.G, Edwards, A, Flodin, S, Flores, A, Graslund, S, Hallberg, B.M, Hammarstrom, M, Johansson, I, Kallas, A, Kotenyova, T, Moche, M, Nordlund, P, Nyman, T, Persson, C, Sagemark, J, Stenmark, P, Sundstrom, M, Thorsell, A.G, Van Den Berg, S, Weigelt, J, Holmberg-Schiavone, L, Structural Genomics Consortium (SGC) | Deposit date: | 2007-04-19 | Release date: | 2007-05-01 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Comparative Structural Analysis of Human DEAD-Box RNA Helicases. Plos One, 5, 2010
|
|
4GR0
| Crystal structure of the catalytic domain of Human MMP12 in complex with selective phosphinic inhibitor RXP470B | Descriptor: | CALCIUM ION, Macrophage metalloelastase, N-[(2S)-3-[(R)-(4-bromophenyl)(hydroxy)phosphoryl]-2-{[3-(3'-chlorobiphenyl-4-yl)-1,2-oxazol-5-yl]methyl}propanoyl]-L-a lanyl-L-alaninamide, ... | Authors: | Stura, E.A, Vera, L, Beau, F, Devel, L, Cassar-Lajeunesse, E, Dive, V. | Deposit date: | 2012-08-24 | Release date: | 2013-02-06 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.497 Å) | Cite: | Molecular determinants of a selective matrix metalloprotease-12 inhibitor: insights from crystallography and thermodynamic studies. J.Med.Chem., 56, 2013
|
|
4HFE
| The GLIC pentameric Ligand-Gated Ion Channel F14'A ethanol-sensitive mutant complexed to ethanol | Descriptor: | ACETATE ION, CHLORIDE ION, DIUNDECYL PHOSPHATIDYL CHOLINE, ... | Authors: | Sauguet, L, Howard, R.J, Malherbe, L, Lee, U.S, Corringer, P.J, Harris, R.A, Delarue, M. | Deposit date: | 2012-10-05 | Release date: | 2013-04-17 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural basis for potentiation by alcohols and anaesthetics in a ligand-gated ion channel. Nat Commun, 4, 2013
|
|
7DB7
| Crystal structure of Mycobacterium tuberculosis phenylalanyl-tRNA synthetase in complex with compound GDI05-001 | Descriptor: | 1-[3-[2-(1H-indol-3-yl)ethylsulfamoyl]phenyl]-3-(1,3-thiazol-2-yl)urea, Phenylalanine--tRNA ligase alpha subunit, Phenylalanine--tRNA ligase beta subunit, ... | Authors: | Xu, M, Zhang, X, Xu, L, Chen, S. | Deposit date: | 2020-10-19 | Release date: | 2021-01-13 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.71 Å) | Cite: | Re-discovery of PF-3845 as a new chemical scaffold inhibiting phenylalanyl-tRNA synthetase in Mycobacterium tuberculosis . J.Biol.Chem., 2021
|
|
3N70
| The Crystal Structure of the P-loop NTPase domain of the Sigma-54 transport activator from E. coli to 2.8A | Descriptor: | SULFATE ION, Transport activator | Authors: | Stein, A.J, Mulligan, R, Volkart, L, Freeman, L, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2010-05-26 | Release date: | 2010-07-21 | Last modified: | 2017-11-08 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | The Crystal Structure of the P-loop NTPase domain of the Sigma-54 transport activator from E. coli to 2.8A To be Published
|
|
4GXO
| Crystal structure of Staphylococcus aureus protein SarZ mutant C13E | Descriptor: | GLYCEROL, MarR family regulatory protein | Authors: | Sun, F, Ding, Y, Ji, Q, Liang, Z, Deng, X, Wong, C.C, Yi, C, Zhang, L, Xie, S, Alvarez, S, Hicks, L.M, Luo, C, Jiang, H, Lan, L, He, C. | Deposit date: | 2012-09-04 | Release date: | 2012-09-26 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Protein cysteine phosphorylation of SarA/MgrA family transcriptional regulators mediates bacterial virulence and antibiotic resistance. Proc.Natl.Acad.Sci.USA, 109, 2012
|
|
2PZY
| Structure of MK2 Complexed with Compound 76 | Descriptor: | (4R)-N-[4-({[2-(DIMETHYLAMINO)ETHYL]AMINO}CARBONYL)-1,3-THIAZOL-2-YL]-4-METHYL-1-OXO-2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLINE-6-CARBOXAMIDE, MAP kinase-activated protein kinase 2, STAUROSPORINE | Authors: | White, A, Wu, J.P, Wang, J, Abeywardane, A, Andersen, D, Emmanuel, M, Gautschi, E, Goldberg, D.R, Kashem, M.A, Lukas, S, Mao, W, Martin, L, Morwick, T, Moss, N, Pargellis, C, Patel, U.R, Patnaude, L, Peet, G.W, Skow, D, Snow, R.J, Ward, Y, Werneburg, B. | Deposit date: | 2007-05-18 | Release date: | 2007-07-31 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | The discovery of carboline analogs as potent MAPKAP-K2 inhibitors Bioorg.Med.Chem.Lett., 17, 2007
|
|
7DAW
| Crystal structure of Mycobacterium tuberculosis phenylalanyl-tRNA synthetase | Descriptor: | Phenylalanine--tRNA ligase alpha subunit, Phenylalanine--tRNA ligase beta subunit, SULFATE ION | Authors: | Xu, M, Zhang, X, Xu, L, Chen, S. | Deposit date: | 2020-10-18 | Release date: | 2021-01-13 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.83 Å) | Cite: | Re-discovery of PF-3845 as a new chemical scaffold inhibiting phenylalanyl-tRNA synthetase in Mycobacterium tuberculosis . J.Biol.Chem., 2021
|
|
3PP2
| Crystal structure of the pleckstrin homology domain of ArhGAP27 | Descriptor: | CITRIC ACID, GLYCEROL, Rho GTPase-activating protein 27, ... | Authors: | Shen, L, Tempel, W, Tong, Y, Nedyalkova, L, Li, Y, Wernimont, A.K, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Park, H, Structural Genomics Consortium (SGC) | Deposit date: | 2010-11-23 | Release date: | 2010-12-08 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.421 Å) | Cite: | Crystal structure of the pleckstrin homology domain of ArhGAP27 to be published
|
|
4GPZ
| |
4GR8
| Crystal structure of the catalytic domain of Human MMP12 in complex with selective phosphinic inhibitor RXP470C | Descriptor: | CALCIUM ION, IMIDAZOLE, Macrophage metalloelastase, ... | Authors: | Stura, E.A, Vera, L, Beau, F, Devel, L, Cassar-Lajeunesse, E, Dive, V. | Deposit date: | 2012-08-24 | Release date: | 2013-02-06 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.299 Å) | Cite: | Molecular determinants of a selective matrix metalloprotease-12 inhibitor: insights from crystallography and thermodynamic studies. J.Med.Chem., 56, 2013
|
|
3U5U
| Structures of Alkaloid Biosynthetic Glucosidases Decode Substrate Specificity | Descriptor: | CHLORIDE ION, Raucaffricine-O-beta-D-glucosidase | Authors: | Xia, L, Ruppert, M, Wang, M, Panjikar, S, Lin, H, Rajendran, C, Barleben, L, Stoeckigt, J. | Deposit date: | 2011-10-11 | Release date: | 2011-11-30 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structures of alkaloid biosynthetic glucosidases decode substrate specificity. Acs Chem.Biol., 7, 2012
|
|
2Y1V
| Full length structure of RrgB Pilus protein from Streptococcus pneumoniae | Descriptor: | CELL WALL SURFACE ANCHOR FAMILY PROTEIN, NICKEL (II) ION | Authors: | El-Mortaji, L, Contreras-Martel, C, Manzano, C, Vernet, T, Dessen, A, DiGuilmi, A.M. | Deposit date: | 2010-12-10 | Release date: | 2011-11-09 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (2.39 Å) | Cite: | The Full-Length Streptococcus Pneumoniae Major Pilin Rrgb Crystallizes in a Fibre-Like Structure, which Presents the D1 Isopeptide Bond and Provides Details on the Mechanism of Pilus Polymerization. Biochem.J., 441, 2012
|
|
2Q89
| Crystal structure of EhuB in complex with hydroxyectoine | Descriptor: | (4S,5S)-5-HYDROXY-2-METHYL-1,4,5,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, CADMIUM ION, Putative ABC transporter amino acid-binding protein | Authors: | Hanekop, N, Hoeing, M, Sohn-Bosser, L, Jebbar, M, Schmitt, L, Bremer, E. | Deposit date: | 2007-06-09 | Release date: | 2008-01-01 | Last modified: | 2017-10-18 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of the ligand-binding protein EhuB from Sinorhizobium meliloti reveals substrate recognition of the compatible solutes ectoine and hydroxyectoine. J.Mol.Biol., 374, 2007
|
|
3NF1
| Crystal structure of the TPR domain of kinesin light chain 1 | Descriptor: | Kinesin light chain 1 | Authors: | Tong, Y, Tempel, W, Shen, L, Shen, Y, Nedyalkova, L, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) | Deposit date: | 2010-06-09 | Release date: | 2011-05-25 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal structure of the TPR domain of kinesin light chain 1 to be published
|
|
4FHZ
| Crystal structure of a carboxyl esterase at 2.0 angstrom resolution | Descriptor: | DI(HYDROXYETHYL)ETHER, Phospholipase/Carboxylesterase, SODIUM ION | Authors: | Wu, L, Ma, J, Zhou, J, Yu, H. | Deposit date: | 2012-06-07 | Release date: | 2012-10-03 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Enhanced enantioselectivity of a carboxyl esterase from Rhodobacter sphaeroides by directed evolution. Appl.Microbiol.Biotechnol., 97, 2013
|
|
4HFC
| The GLIC pentameric Ligand-Gated Ion Channel F14'A ethanol-sensitive mutant complexed to 2-bromo-ethanol | Descriptor: | 2-BROMOETHANOL, ACETATE ION, CHLORIDE ION, ... | Authors: | Sauguet, L, Howard, R.J, Malherbe, L, Lee, U.S, Corringer, P.J, Harris, R.A, Delarue, M. | Deposit date: | 2012-10-05 | Release date: | 2013-04-17 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.05 Å) | Cite: | Structural basis for potentiation by alcohols and anaesthetics in a ligand-gated ion channel. Nat Commun, 4, 2013
|
|
2Q9N
| 4-Substituted Trinems as Broad Spectrum-Lactamase Inhibitors: Structure-based Design, Synthesis and Biological Activity | Descriptor: | (1S,4R,7AR)-4-BUTOXY-1-[(1R)-1-FORMYLPROPYL]-2,4,5,6,7,7A-HEXAHYDRO-1H-ISOINDOLE-3-CARBOXYLIC ACID, Beta-lactamase | Authors: | Plantan, I, Selic, L, Mesar, T, Stefanic Anderluh, P, Oblak, M, Prezelj, A, Hesse, L, Andrejasic, M, Vilar, M, Turk, D, Kocijan, A, Prevec, T, Vilfan, G, Kocjan, D, Copar, A, Urleb, U, Solmajer, T. | Deposit date: | 2007-06-13 | Release date: | 2007-08-21 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | 4-Substituted Trinems as Broad Spectrum beta-Lactamase Inhibitors: Structure-Based Design, Synthesis, and Biological Activity J.Med.Chem., 50, 2007
|
|