4GWK

Crystal structure of 6-phosphogluconate dehydrogenase complexed with 3-phosphoglyceric acid

Summary for 4GWK

• Entry DOI: 10.2210/pdb4gwk/pdb
• Related: 2JKV 4GWG
• Descriptor: 6-phosphogluconate dehydrogenase, decarboxylating, 3-PHOSPHOGLYCERIC ACID, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (4 entities in total)
• Functional Keywords: 6-phosphogluconate dehydrogenase, 3-phosphoglycerate, dehydrogenase, nadp, oxidoreductase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm (By similarity): P52209
• Total number of polymer chains: 1
• Total formula weight: 54037.43

Authors

He, C.,Zhou, L.,Zhang, L. (deposition date: 2012-09-03, release date: 2012-11-28, Last modification date: 2023-09-13)

• Primary citation: Hitosugi, T.,Zhou, L.,Elf, S.,Fan, J.,Kang, H.B.,Seo, J.H.,Shan, C.,Dai, Q.,Zhang, L.,Xie, J.,Gu, T.L.,Jin, P.,Aleckovic, M.,Leroy, G.,Kang, Y.,Sudderth, J.A.,Deberardinis, R.J.,Luan, C.H.,Chen, G.Z.,Muller, S.,Shin, D.M.,Owonikoko, T.K.,Lonial, S.,Arellano, M.L.,Khoury, H.J.,Khuri, F.R.,Lee, B.H.,Ye, K.,Boggon, T.J.,Kang, S.,He, C.,Chen, J.; Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth.; Cancer Cell, 22:585-600, 2012; PubMed: 23153533; DOI: 10.1016/j.ccr.2012.09.020

Experimental method

X-RAY DIFFRACTION (1.534 Å)