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6MQE
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BU of 6mqe by Molmil
Vaccine-elicited NHP FP-targeting HIV neutralizing antibody DFPH-a.15 in complex with HIV fusion peptide (residue 512-519)
Descriptor: DFPHa.15 antibody Fab heavy chain, DFPHa.15 antibody Fab light chain, HIV fusion peptide
Authors:Xu, K, Wang, Y, Kwong, P.D.
Deposit date:2018-10-09
Release date:2019-07-31
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.459 Å)
Cite:Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV Neutralization.
Cell, 178, 2019
6MQS
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BU of 6mqs by Molmil
Vaccine-elicited NHP FP-targeting HIV neutralizing antibody A12V163-a.01 in complex with HIV fusion peptide (residue 512-519)
Descriptor: HIV fusion peptide residue 512-519, antibody A12V163-a.01 heavy chain, antibody A12V163-a.01 light chain
Authors:Xu, K, Wang, Y, Kwong, P.D.
Deposit date:2018-10-10
Release date:2019-07-31
Last modified:2019-11-13
Method:X-RAY DIFFRACTION (2.997 Å)
Cite:Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV Neutralization.
Cell, 178, 2019
6NM6
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BU of 6nm6 by Molmil
Crystal Structure of HIV-1 BG505 SOSIP.664 Prefusion Env Trimer Bound to N6 FR3-03 scFv in Complex with Crystallization Chaperones 3H109L Fab and 35O22 scFv at 3.2 Angstrom
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 35O22 scFv heavy chain, ...
Authors:Lai, Y.-T, Kwong, P.D.
Deposit date:2019-01-10
Release date:2019-02-27
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.739 Å)
Cite:Improvement of antibody functionality by structure-guided paratope engraftment.
Nat Commun, 10, 2019
6NNF
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BU of 6nnf by Molmil
Crystal Structure of HIV-1 BG505 SOSIP.664 Prefusion Env Trimer Bound to VRC01 FR3-03 scFv in Complex with Crystallization Chaperones 3H109L Fab and 35O22 scFv at 3.5 Angstrom
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 35O22 scFv heavy chain, ...
Authors:Lai, Y.-T, Kwong, P.D.
Deposit date:2019-01-14
Release date:2019-02-27
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.762 Å)
Cite:Improvement of antibody functionality by structure-guided paratope engraftment.
Nat Commun, 10, 2019
6NF2
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BU of 6nf2 by Molmil
Cryo-EM structure of vaccine-elicited antibody 0PV-c.01 in complex with HIV-1 Env BG505 DS-SOSIP and antibodies VRC03 and PGT122
Descriptor: 0PV-c.01 Heavy Chain, 0PV-c.01 Light Chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Gorman, J, Kwong, P.D.
Deposit date:2018-12-18
Release date:2019-07-24
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV Neutralization.
Cell, 178, 2019
7R73
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BU of 7r73 by Molmil
Crystal structure of llama VHH antibody D7 in complex with HIV-1 gp120 core
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Glycoprotein 120, Llama antibody D7
Authors:Zhou, T, Kwong, P.D.
Deposit date:2021-06-24
Release date:2022-03-30
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Structural basis for llama nanobody recognition and neutralization of HIV-1 at the CD4-binding site.
Structure, 30, 2022
7RI1
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BU of 7ri1 by Molmil
Crystal structure of anti-HIV llama VHH antibody J3 in complex with HIV-1 C1086 gp120
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Glycoprotein 120, Lamma VHH antibody J3, ...
Authors:Zhou, T, Kwong, P.D.
Deposit date:2021-07-19
Release date:2022-03-30
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structural basis for llama nanobody recognition and neutralization of HIV-1 at the CD4-binding site.
Structure, 30, 2022
7RI2
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BU of 7ri2 by Molmil
Crystal structure of anti-HIV llama VHH antibody A12 in complex with HIV-1 C1086 gp120
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Glycoprotein 120, anti-HIV llama VHH antibody A12
Authors:Zhou, T, Kwong, P.D.
Deposit date:2021-07-19
Release date:2022-03-30
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis for llama nanobody recognition and neutralization of HIV-1 at the CD4-binding site.
Structure, 30, 2022
7R74
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BU of 7r74 by Molmil
Crystal structure of llama VHH antibody in complex with HIV-1 HXBC2 gp120 core
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody C8 VHH domain, Glycoprotein 120
Authors:Zhou, T, Kwong, P.D.
Deposit date:2021-06-24
Release date:2022-03-30
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.76 Å)
Cite:Structural basis for llama nanobody recognition and neutralization of HIV-1 at the CD4-binding site.
Structure, 30, 2022
1RZK
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BU of 1rzk by Molmil
HIV-1 YU2 GP120 ENVELOPE GLYCOPROTEIN COMPLEXED WITH CD4 AND INDUCED NEUTRALIZING ANTIBODY 17B
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, ANTIBODY 17B, HEAVY CHAIN, ...
Authors:Huang, C.C, Venturi, M, Majeed, S, Moore, M.J, Phogat, S, Zhang, M.-Y, Dimitrov, D.S, Hendrickson, W.A, Robinson, J, Sodroski, J, Wyatt, R, Choe, H, Farzan, M, Kwong, P.D.
Deposit date:2003-12-24
Release date:2004-02-03
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120
Proc.Natl.Acad.Sci.USA, 101, 2004
1RZJ
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BU of 1rzj by Molmil
HIV-1 HXBC2 GP120 ENVELOPE GLYCOPROTEIN COMPLEXED WITH CD4 AND INDUCED NEUTRALIZING ANTIBODY 17B
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, ANTIBODY 17B, HEAVY CHAIN, ...
Authors:Huang, C.C, Venturi, M, Majeed, S, Moore, M.J, Phogat, S, Zhang, M.-Y, Dimitrov, D.S, Hendrickson, W.A, Robinson, J, Sodroski, J, Wyatt, R, Choe, H, Farzan, M, Kwong, P.D.
Deposit date:2003-12-24
Release date:2004-02-03
Last modified:2021-10-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120
Proc.Natl.Acad.Sci.USA, 101, 2004
1RZF
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BU of 1rzf by Molmil
Crystal structure of Human anti-HIV-1 GP120-reactive antibody E51
Descriptor: Fab E51 heavy chain, Fab E51 light chain, GLYCEROL, ...
Authors:Huang, C.C, Venturi, M, Majeed, S, Moore, M.J, Phogat, S, Zhang, M.-Y, Dimitrov, D.S, Hendrickson, W.A, Robinson, J, Sodroski, J, Wyatt, R, Choe, H, Farzan, M, Kwong, P.D.
Deposit date:2003-12-24
Release date:2004-02-03
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120
Proc.Natl.Acad.Sci.USA, 101, 2004
1RZ8
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BU of 1rz8 by Molmil
CRYSTAL STRUCTURE OF HUMAN ANTI-HIV-1 GP120-REACTIVE ANTIBODY 17B
Descriptor: Fab 17b heavy chain, Fab 17b light chain
Authors:Huang, C.C, Venturi, M, Majeed, S, Moore, M.J, Phogat, S, Zhang, M.-Y, Dimitrov, D.S, Hendrickson, W.A, Robinson, J, Sodroski, J, Wyatt, R, Choe, H, Farzan, M, Kwong, P.D.
Deposit date:2003-12-24
Release date:2004-02-03
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120
Proc.Natl.Acad.Sci.USA, 101, 2004
1RZG
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BU of 1rzg by Molmil
Crystal structure of Human anti-HIV-1 GP120 reactive antibody 412d
Descriptor: ASPARTIC ACID, CYSTEINE, Fab 412d heavy chain, ...
Authors:Huang, C.C, Venturi, M, Majeed, S, Moore, M.J, Phogat, S, Zhang, M.-Y, Dimitrov, D.S, Hendrickson, W.A, Robinson, J, Sodroski, J, Wyatt, R, Choe, H, Farzan, M, Kwong, P.D.
Deposit date:2003-12-24
Release date:2004-02-03
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120
Proc.Natl.Acad.Sci.USA, 101, 2004
1RZ7
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BU of 1rz7 by Molmil
CRYSTAL STRUCTURE OF HUMAN ANTI-HIV-1 GP120-REACTIVE ANTIBODY 48D
Descriptor: Fab 48d heavy chain, Fab 48d light chain, GLYCEROL
Authors:Huang, C.C, Venturi, M, Majeed, S, Moore, M.J, Phogat, S, Zhang, M.-Y, Dimitrov, D.S, Hendrickson, W.A, Robinson, J, Sodroski, J, Wyatt, R, Choe, H, Farzan, M, Kwong, P.D.
Deposit date:2003-12-24
Release date:2004-02-03
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120
Proc.Natl.Acad.Sci.USA, 101, 2004
1RZI
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BU of 1rzi by Molmil
Crystal structure of human anti-HIV-1 gp120-reactive antibody 47e fab
Descriptor: Fab 47e heavy chain, Fab 47e light chain
Authors:Huang, C.C, Venturi, M, Majeed, S, Moore, M.J, Phogat, S, Zhang, M.-Y, Dimitrov, D.S, Hendrickson, W.A, Robinson, J, Sodroski, J, Wyatt, R, Choe, H, Farzan, M, Kwong, P.D.
Deposit date:2003-12-24
Release date:2004-02-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120
Proc.Natl.Acad.Sci.USA, 101, 2004
1TJI
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BU of 1tji by Molmil
Crystal Structure of the broadly neutralizing anti-HIV-1 antibody 2F5 in complex with a gp41 17mer epitope
Descriptor: 1,2-ETHANEDIOL, Envelope Glycoprotein GP41, ISOPROPYL ALCOHOL, ...
Authors:Ofek, G, Tang, M, Sambor, A, Katinger, H, Mascola, J.R, Wyatt, R, Kwong, P.D.
Deposit date:2004-06-04
Release date:2004-10-05
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure and mechanistic analysis of the Anti-Human Immunodeficiency Virus type 1 antibody 2F5 in complex with its gp41 epitope
J.Virol., 78, 2004
1TJG
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BU of 1tjg by Molmil
Crystal Structure of the broadly neutralizing anti-HIV-1 antibody 2F5 in complex with a gp41 7mer epitope
Descriptor: 1,2-ETHANEDIOL, Envelope glycoprotein GP41, FAB 2F5 Heavy Chain, ...
Authors:Ofek, G, Tang, M, Sambor, A, Katinger, H, Mascola, J.R, Wyatt, R, Kwong, P.D.
Deposit date:2004-06-04
Release date:2004-10-05
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure and mechanistic analysis of the Anti-Human Immunodeficiency Virus Type 1 antibody 2F5 in complex with its gp41 epitope
J.Virol., 78, 2004
1TJH
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BU of 1tjh by Molmil
Crystal Structure of the broadly neutralizing anti-HIV-1 antibody 2F5 in complex with a gp41 11mer epitope
Descriptor: 1,2-ETHANEDIOL, Envelope glycoprotein GP41, ISOPROPYL ALCOHOL, ...
Authors:Ofek, G, Tang, M, Sambor, A, Katinger, H, Mascola, J.R, Wyatt, R, Kwong, P.D.
Deposit date:2004-06-04
Release date:2004-10-05
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure and mechanistic analysis of the anti-human immunodeficiency virus type 1 antibody 2F5 in complex with its gp41 epitope
J.Virol., 78, 2004
7JWY
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BU of 7jwy by Molmil
Structure of SARS-CoV-2 spike at pH 4.5
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:Zhou, T, Tsybovsky, Y, Kwong, P.D.
Deposit date:2020-08-26
Release date:2020-11-25
Last modified:2021-12-15
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains.
Cell Host Microbe, 28, 2020
5TDG
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BU of 5tdg by Molmil
Crystal structure of prefusion-stabilized bovine RSV F (DS-Cav1 variant: strain ATue51908)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fusion glycoprotein F0,Fibritin
Authors:Chen, L, Zhang, B, Kwong, P.D.
Deposit date:2016-09-19
Release date:2017-08-16
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Protection of calves by a prefusion-stabilized bovine RSV F vaccine.
NPJ Vaccines, 2, 2017
5U7O
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BU of 5u7o by Molmil
Crystal Structure of HIV-1 BG505 SOSIP.664 Prefusion Env Trimer Bound to Small Molecule HIV-1 Entry Inhibitor BMS-626529 in Complex with Human Antibodies PGT122 and 35O22 at 3.8 Angstrom
Descriptor: 1-[4-(benzenecarbonyl)piperazin-1-yl]-2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]ethane-1,2-dione, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Pancera, M, Lai, Y.-T, Kwong, P.D.
Deposit date:2016-12-12
Release date:2017-08-30
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.031 Å)
Cite:Crystal structures of trimeric HIV envelope with entry inhibitors BMS-378806 and BMS-626529.
Nat. Chem. Biol., 13, 2017
5U7M
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BU of 5u7m by Molmil
Crystal Structure of HIV-1 BG505 SOSIP.664 Prefusion Env Trimer Bound to Small Molecule HIV-1 Entry Inhibitor BMS-378806 in Complex with Human Antibodies PGT122 and 35O22 at 3.8 Angstrom
Descriptor: 1-[(2R)-4-(benzenecarbonyl)-2-methylpiperazin-1-yl]-2-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)ethane-1,2-dione, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Pancera, M, Lai, Y.-T, Kwong, P.D.
Deposit date:2016-12-12
Release date:2017-08-30
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.025 Å)
Cite:Crystal structures of trimeric HIV envelope with entry inhibitors BMS-378806 and BMS-626529.
Nat. Chem. Biol., 13, 2017
5T33
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BU of 5t33 by Molmil
Crystal structure of strain-specific glycan-dependent CD4 binding site-directed neutralizing antibody CAP257-RH1, in complex with HIV-1 strain RHPA gp120 core with an oligomannose N276 glycan.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CAP257-RH1 heavy chain, ...
Authors:Wibmer, C.K, Gorman, J, Kwong, P.D.
Deposit date:2016-08-24
Release date:2016-09-07
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.2092 Å)
Cite:Structure of an N276-Dependent HIV-1 Neutralizing Antibody Targeting a Rare V5 Glycan Hole Adjacent to the CD4 Binding Site.
J.Virol., 90, 2016
5TR8
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BU of 5tr8 by Molmil
Crystal structure of vaccine-elicited pan- influenza H1N1 neutralizing murine antibody 441D6.
Descriptor: 441D6 Fab Heavy chain, 441D6 Fab Light chain, NICKEL (II) ION
Authors:Joyce, M.G, Kanekiyo, M, Mascola, J.R, Graham, B.S, Kwong, P.D.
Deposit date:2016-10-25
Release date:2018-05-09
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Mosaic nanoparticle display of diverse influenza virus hemagglutinins elicits broad B cell responses.
Nat.Immunol., 20, 2019

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