5T33

Crystal structure of strain-specific glycan-dependent CD4 binding site-directed neutralizing antibody CAP257-RH1, in complex with HIV-1 strain RHPA gp120 core with an oligomannose N276 glycan.

Summary for 5T33

• Entry DOI: 10.2210/pdb5t33/pdb
• Descriptor: CAP257-RH1 heavy chain, CAP257-RH1 light chain, RHPA gp120 core, ... (7 entities in total)
• Functional Keywords: hiv, strain-specific, neutralizing antibody, cd4 binding site, n276 glycan, glycan-free v5, immune system
• Biological source: Homo sapiens; More
• Total number of polymer chains: 3
• Total formula weight: 91003.32

Authors

Wibmer, C.K.,Gorman, J.,Kwong, P.D. (deposition date: 2016-08-24, release date: 2016-09-07, Last modification date: 2023-10-04)

• Primary citation: Wibmer, C.K.,Gorman, J.,Anthony, C.S.,Mkhize, N.N.,Druz, A.,York, T.,Schmidt, S.D.,Labuschagne, P.,Louder, M.K.,Bailer, R.T.,Abdool Karim, S.S.,Mascola, J.R.,Williamson, C.,Moore, P.L.,Kwong, P.D.,Morris, L.; Structure of an N276-Dependent HIV-1 Neutralizing Antibody Targeting a Rare V5 Glycan Hole Adjacent to the CD4 Binding Site.; J.Virol., 90:10220-10235, 2016; PubMed: 27581986; DOI: 10.1128/JVI.01357-16

Experimental method

X-RAY DIFFRACTION (3.2092 Å)