1RZF

Crystal structure of Human anti-HIV-1 GP120-reactive antibody E51

Summary for 1RZF

• Entry DOI: 10.2210/pdb1rzf/pdb
• Related: 1RZ7 1RZ8 1RZG 1RZI 1RZJ 1RZK
• Descriptor: Fab E51 light chain, Fab E51 heavy chain, GLYCEROL, ... (5 entities in total)
• Functional Keywords: hiv-1; gp120; cd4i; antibodies; tyrosine sulfation; vh-gene usage, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 48401.50

Authors

Huang, C.C.,Venturi, M.,Majeed, S.,Moore, M.J.,Phogat, S.,Zhang, M.-Y.,Dimitrov, D.S.,Hendrickson, W.A.,Robinson, J.,Sodroski, J.,Wyatt, R.,Choe, H.,Farzan, M.,Kwong, P.D. (deposition date: 2003-12-24, release date: 2004-02-03, Last modification date: 2023-08-23)

• Primary citation: Huang, C.C.,Venturi, M.,Majeed, S.,Moore, M.J.,Phogat, S.,Zhang, M.-Y.,Dimitrov, D.S.,Hendrickson, W.A.,Robinson, J.,Sodroski, J.,Wyatt, R.,Choe, H.,Farzan, M.,Kwong, P.D.; Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120; Proc.Natl.Acad.Sci.USA, 101:2706-2711, 2004; PubMed: 14981267; DOI: 10.1073/pnas.0308527100

Experimental method

X-RAY DIFFRACTION (1.7 Å)