1RZF

Crystal structure of Human anti-HIV-1 GP120-reactive antibody E51

Summary for 1RZF

Related1RZ7 1RZ8 1RZG 1RZI 1RZJ 1RZK
DescriptorFab E51 light chain, Fab E51 heavy chain, GLYCEROL, ... (5 entities in total)
Functional Keywordshiv-1; gp120; cd4i; antibodies; tyrosine sulfation; vh-gene usage, immune system
Biological sourceHomo sapiens (human)
Total number of polymer chains2
Total molecular weight48401.5
Authors
Primary citation
Huang, C.C.,Venturi, M.,Majeed, S.,Moore, M.J.,Phogat, S.,Zhang, M.-Y.,Dimitrov, D.S.,Hendrickson, W.A.,Robinson, J.,Sodroski, J.,Wyatt, R.,Choe, H.,Farzan, M.,Kwong, P.D.
Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120
Proc.Natl.Acad.Sci.USA, 101:2706-2711, 2004
PubMed: 14981267 (PDB entries with the same primary citation)
DOI: 10.1073/pnas.0308527100
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.7 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.236600.6%4.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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