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RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES
Descriptor:	BIS(5-AMIDINO-2-BENZIMIDAZOLYL)METHANE KETONE, CALCIUM ION, MAGNESIUM ION, ...
Authors:	Katz, B.A, Luong, C.
Deposit date:	1999-07-21
Release date:	2000-07-26
Last modified:	2023-12-27
Method:	X-RAY DIFFRACTION (1.4 Å)
Cite:	Design of potent selective zinc-mediated serine protease inhibitors. Nature, 391, 1998

1EER

CRYSTAL STRUCTURE OF HUMAN ERYTHROPOIETIN COMPLEXED TO ITS RECEPTOR AT 1.9 ANGSTROMS
Descriptor:	ERYTHROPOIETIN, ERYTHROPOIETIN RECEPTOR
Authors:	Syed, R.S, Li, C.
Deposit date:	1998-07-24
Release date:	1999-10-01
Last modified:	2021-11-03
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Efficiency of signalling through cytokine receptors depends critically on receptor orientation. Nature, 395, 1998

1C2G

RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES
Descriptor:	BIS(5-AMIDINO-2-BENZIMIDAZOLYL)METHANE KETONE HYDRATE, CALCIUM ION, DIMETHYL SULFOXIDE, ...
Authors:	Katz, B.A, Luong, C.
Deposit date:	1999-07-21
Release date:	2000-07-26
Last modified:	2023-12-27
Method:	X-RAY DIFFRACTION (1.65 Å)
Cite:	Design of potent selective zinc-mediated serine protease inhibitors. Nature, 391, 1998

1C1U

RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES
Descriptor:	(5-AMIDINO-2-BENZIMIDAZOLYL)(2-BENZIMIDAZOLYL)METHANE, ACETYL HIRUDIN, ALPHA THROMBIN, ...
Authors:	Katz, B.A, Luong, C.
Deposit date:	1999-07-21
Release date:	2000-07-26
Last modified:	2023-11-15
Method:	X-RAY DIFFRACTION (1.75 Å)
Cite:	Design of potent selective zinc-mediated serine protease inhibitors. Nature, 391, 1998

1C2F

RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES
Descriptor:	BIS(5-AMIDINO-2-BENZIMIDAZOLYL)METHANE KETONE HYDRATE, CALCIUM ION, DIMETHYL SULFOXIDE, ...
Authors:	Katz, B.A, Luong, C.
Deposit date:	1999-07-21
Release date:	2000-07-26
Last modified:	2023-12-27
Method:	X-RAY DIFFRACTION (1.7 Å)
Cite:	Design of potent selective zinc-mediated serine protease inhibitors. Nature, 391, 1998

1C1R

RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES
Descriptor:	(5-AMIDINO-2-BENZIMIDAZOLYL)(2-BENZIMIDAZOLYL)METHANE, CALCIUM ION, DIMETHYL SULFOXIDE, ...
Authors:	Katz, B.A, Luong, C.
Deposit date:	1999-07-21
Release date:	2000-07-26
Last modified:	2023-12-27
Method:	X-RAY DIFFRACTION (1.37 Å)
Cite:	Design of potent selective zinc-mediated serine protease inhibitors. Nature, 391, 1998

1C2E

RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES
Descriptor:	BIS(5-AMIDINO-2-BENZIMIDAZOLYL)METHANE KETONE, CALCIUM ION, MAGNESIUM ION, ...
Authors:	Katz, B.A, Luong, C.
Deposit date:	1999-07-22
Release date:	2000-07-26
Last modified:	2023-12-27
Method:	X-RAY DIFFRACTION (1.65 Å)
Cite:	Design of potent selective zinc-mediated serine protease inhibitors. Nature, 391, 1998

1C2K

RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES
Descriptor:	5-AMIDINO-BENZIMIDAZOLE, CALCIUM ION, CHLORIDE ION, ...
Authors:	Katz, B.A, Luong, C.
Deposit date:	1999-07-21
Release date:	2000-07-26
Last modified:	2023-12-27
Method:	X-RAY DIFFRACTION (1.65 Å)
Cite:	Design of potent selective zinc-mediated serine protease inhibitors. Nature, 391, 1998

2PY9

Protein-RNA Interaction involving KH1 domain from Human Poly(C)-Binding Protein-2
Descriptor:	12-mer C-rich strand of human telomeric RNA, Poly(rC)-binding protein 2
Authors:	James, T.L, Du, Z, Lee, J.K.
Deposit date:	2007-05-15
Release date:	2007-06-12
Last modified:	2011-07-13
Method:	X-RAY DIFFRACTION (2.56 Å)
Cite:	X-ray crystallographic and NMR studies of protein-protein and protein-nucleic acid interactions involving the KH domains from human poly(C)-binding protein-2. Rna, 13, 2007

2PQU

Crystal structure of KH1 domain of human PCBP2 complexed to single-stranded 12-mer telomeric dna
Descriptor:	12-mer C-rich strand of human telomeric DNA, Poly(rC)-binding protein 2
Authors:	James, T.L, Lee, J.
Deposit date:	2007-05-02
Release date:	2007-06-12
Last modified:	2019-07-24
Method:	X-RAY DIFFRACTION (2.12 Å)
Cite:	X-ray crystallographic and NMR studies of protein-protein and protein-nucleic acid interactions involving the KH domains from human poly(C)-binding protein-2. Rna, 13, 2007

1C2I

RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES
Descriptor:	BIS(5-AMIDINO-2-BENZIMIDAZOLYL)METHANE KETONE, CALCIUM ION, CHLORIDE ION, ...
Authors:	Katz, B.A, Luong, C.
Deposit date:	1999-07-21
Release date:	2000-07-26
Last modified:	2023-12-27
Method:	X-RAY DIFFRACTION (1.47 Å)
Cite:	Design of potent selective zinc-mediated serine protease inhibitors. Nature, 391, 1998

1C1Q

RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES
Descriptor:	(5-AMIDINO-2-BENZIMIDAZOLYL)(2-BENZIMIDAZOLYL)METHANE, CALCIUM ION, MAGNESIUM ION, ...
Authors:	Katz, B.A, Luong, C.
Deposit date:	1999-07-21
Release date:	2000-07-26
Last modified:	2023-12-27
Method:	X-RAY DIFFRACTION (1.37 Å)
Cite:	Design of potent selective zinc-mediated serine protease inhibitors. Nature, 391, 1998

1C2D

RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES
Descriptor:	BIS(5-AMIDINO-2-BENZIMIDAZOLYL)METHANE KETONE, CALCIUM ION, MAGNESIUM ION, ...
Authors:	Katz, B.A, Luong, C.
Deposit date:	1999-07-21
Release date:	2000-07-26
Last modified:	2023-12-27
Method:	X-RAY DIFFRACTION (1.65 Å)
Cite:	Design of potent selective zinc-mediated serine protease inhibitors. Nature, 391, 1998

1C1O

RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES
Descriptor:	CALCIUM ION, MAGNESIUM ION, SULFATE ION, ...
Authors:	Katz, B.A, Luong, C.
Deposit date:	1999-07-21
Release date:	2000-07-26
Last modified:	2023-12-27
Method:	X-RAY DIFFRACTION (1.4 Å)
Cite:	Design of potent selective zinc-mediated serine protease inhibitors. Nature, 391, 1998

1C1V

RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES
Descriptor:	BIS(5-AMIDINO-BENZIMIDAZOLYL)METHANE, Hirudin-2, SODIUM ION, ...
Authors:	Katz, B.A, Luong, C.
Deposit date:	1999-07-21
Release date:	2000-07-26
Last modified:	2023-11-15
Method:	X-RAY DIFFRACTION (1.98 Å)
Cite:	Design of potent selective zinc-mediated serine protease inhibitors. Nature, 391, 1998

2B6P

X-ray structure of lens Aquaporin-0 (AQP0) (lens MIP) in an open pore state
Descriptor:	Lens fiber major intrinsic protein
Authors:	Gonen, T, Cheng, Y, Sliz, P, Hiroaki, Y, Fujiyoshi, Y, Harrison, S.C, Walz, T.
Deposit date:	2005-10-03
Release date:	2005-12-06
Last modified:	2024-02-14
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	Lipid-protein interactions in double-layered two-dimensional AQP0 crystals. Nature, 438, 2005

7KDT

Human Tom70 in complex with SARS CoV2 Orf9b
Descriptor:	Mitochondrial import receptor subunit TOM70, ORF9b protein
Authors:	QCRG Structural Biology Consortium
Deposit date:	2020-10-09
Release date:	2020-10-21
Last modified:	2024-03-06
Method:	ELECTRON MICROSCOPY (3.05 Å)
Cite:	Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms. Science, 370, 2020

4ZE1

Saccharomyces cerevisiae CYP51 Y140F mutant complexed with posaconazole in the active site
Descriptor:	Lanosterol 14-alpha demethylase, POSACONAZOLE, PROTOPORPHYRIN IX CONTAINING FE
Authors:	Sagatova, A, Keniya, M.V, Wilson, R, Tyndall, J.D.A, Monk, B.C.
Deposit date:	2015-04-20
Release date:	2016-03-30
Last modified:	2024-03-13
Method:	X-RAY DIFFRACTION (2.05 Å)
Cite:	Triazole resistance mediated by mutations of a conserved active site tyrosine in fungal lanosterol 14 alpha-demethylase. Sci Rep, 6, 2016

4ZE2

Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) Y140H mutant complexed with itraconazole
Descriptor:	2-[(2R)-butan-2-yl]-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-2,4-dihydro-3H-1,2,4-triazol-3-one, Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE
Authors:	Sagatova, A, Keniya, M.V, Wilson, R, Monk, B.C, Tyndall, J.D.A.
Deposit date:	2015-04-20
Release date:	2016-03-30
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Triazole resistance mediated by mutations of a conserved active site tyrosine in fungal lanosterol 14 alpha-demethylase. Sci Rep, 6, 2016

4ZE0

Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) Y140F mutant complexed with Voriconazole
Descriptor:	Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE, Voriconazole
Authors:	Sagatova, A, Keniya, M.V, Wilson, R, Tyndall, J.D.A, Monk, B.C.
Deposit date:	2015-04-20
Release date:	2016-03-30
Last modified:	2024-03-13
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	Triazole resistance mediated by mutations of a conserved active site tyrosine in fungal lanosterol 14 alpha-demethylase. Sci Rep, 6, 2016

4ZDZ

Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) Y140F mutant complexed with fluconazole
Descriptor:	2-(2,4-DIFLUOROPHENYL)-1,3-DI(1H-1,2,4-TRIAZOL-1-YL)PROPAN-2-OL, Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE
Authors:	Sagatova, A, Keniya, M.V, Wilson, R.K, Tyndall, J.D.A, Monk, B.C.
Deposit date:	2015-04-20
Release date:	2016-03-30
Last modified:	2024-03-13
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Triazole resistance mediated by mutations of a conserved active site tyrosine in fungal lanosterol 14 alpha-demethylase. Sci Rep, 6, 2016

4ZDY

Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) Y140F mutant complexed with itraconazole
Descriptor:	2-[(2R)-butan-2-yl]-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-2,4-dihydro-3H-1,2,4-triazol-3-one, Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE
Authors:	Sagatova, A, Keniya, M.V, Wilson, R.K, Tyndall, J.D.A, Monk, B.C.
Deposit date:	2015-04-20
Release date:	2016-03-30
Last modified:	2024-03-13
Method:	X-RAY DIFFRACTION (2.02 Å)
Cite:	Triazole resistance mediated by mutations of a conserved active site tyrosine in fungal lanosterol 14 alpha-demethylase. Sci Rep, 6, 2016

4ZE3

Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) Y140H mutant complexed with fluconazole
Descriptor:	2-(2,4-DIFLUOROPHENYL)-1,3-DI(1H-1,2,4-TRIAZOL-1-YL)PROPAN-2-OL, Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE
Authors:	Sagatova, A, Keniya, M.V, Wilson, R, Monk, B.C, Tyndall, J.D.A.
Deposit date:	2015-04-20
Release date:	2016-03-30
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	Triazole resistance mediated by mutations of a conserved active site tyrosine in fungal lanosterol 14 alpha-demethylase. Sci Rep, 6, 2016

1TRM

THE THREE-DIMENSIONAL STRUCTURE OF ASN102 MUTANT OF TRYPSIN. ROLE OF ASP102 IN SERINE PROTEASE CATALYSIS
Descriptor:	BENZAMIDINE, CALCIUM ION, TRYPSIN
Authors:	Sprang, S, Standing, T, Fletterick, R.J.
Deposit date:	1987-10-21
Release date:	1988-07-16
Last modified:	2017-11-29
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	The three-dimensional structure of Asn102 mutant of trypsin: role of Asp102 in serine protease catalysis. Science, 237, 1987

2RTJ

STREPTAVIDIN-GLYCOLURIL COMPLEX, PH 2.50, SPACE GROUP I4122
Descriptor:	FORMIC ACID, GLYCOLURIL, STREPTAVIDIN
Authors:	Katz, B.A.
Deposit date:	1997-09-11
Release date:	1998-10-14
Last modified:	2024-02-21
Method:	X-RAY DIFFRACTION (1.4 Å)
Cite:	Binding of biotin to streptavidin stabilizes intersubunit salt bridges between Asp61 and His87 at low pH. J.Mol.Biol., 274, 1997

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Displayed results:	25
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