7E9Y
| Crystal structure of eLACCO1 | Descriptor: | (2S)-2-HYDROXYPROPANOIC ACID, CALCIUM ION, Lactate-binding periplasmic protein TTHA0766,Lactate-binding periplasmic protein TTHA0766 | Authors: | Wen, Y, Campbell, R.E, Lemieux, M.J, Nasu, Y. | Deposit date: | 2021-03-05 | Release date: | 2021-12-22 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | A genetically encoded fluorescent biosensor for extracellular L-lactate. Nat Commun, 12, 2021
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3NKD
| Structure of CRISP-associated protein Cas1 from Escherichia coli str. K-12 | Descriptor: | CRISPR-associated protein Cas1 | Authors: | Nocek, B, Skarina, T, Beloglazova, N, Savchenko, A, Joachimiak, A, Yakunin, A. | Deposit date: | 2010-06-18 | Release date: | 2010-08-25 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | A dual function of the CRISPR-Cas system in bacterial antivirus immunity and DNA repair. Mol.Microbiol., 79, 2011
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2H2Q
| Crystal structure of Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate synthase | Descriptor: | 2'-DEOXYURIDINE-5'-MONOPHOSPHATE, Bifunctional dihydrofolate reductase-thymidylate synthase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Senkovich, O, Schormann, N, Chattopadhyay, D. | Deposit date: | 2006-05-19 | Release date: | 2008-04-08 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure-based approach to pharmacophore identification, in silico screening, and three-dimensional quantitative structure-activity relationship studies for inhibitors of Trypanosoma cruzi dihydrofolate reductase function. Proteins, 73, 2008
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3KJV
| HIV-1 reverse transcriptase in complex with DNA | Descriptor: | 5'-D(*AP*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*GP*CP*GP*CP*CP*(DOC))-3', 5'-D(*AP*TP*GP*GP*TP*GP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*GP*TP*G)-3', MAGNESIUM ION, ... | Authors: | Lansdon, E.B. | Deposit date: | 2009-11-03 | Release date: | 2010-03-23 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Visualizing the molecular interactions of a nucleotide analog, GS-9148, with HIV-1 reverse transcriptase-DNA complex. J.Mol.Biol., 397, 2010
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5C8F
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3KK2
| HIV-1 reverse transcriptase-DNA complex with dATP bound in the nucleotide binding site | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 5'-D(*A*TP*GP*GP*TP*GP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*GP*TP*G)-3', 5'-D(*AP*CP*A*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*GP*CP*GP*CP*CP*(DOC))-3', ... | Authors: | Lansdon, E.B. | Deposit date: | 2009-11-04 | Release date: | 2010-03-23 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Visualizing the molecular interactions of a nucleotide analog, GS-9148, with HIV-1 reverse transcriptase-DNA complex. J.Mol.Biol., 397, 2010
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1ML4
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1G0Z
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3KLN
| Vibrio cholerae VpsT | Descriptor: | Transcriptional regulator, LuxR family | Authors: | Krasteva, P.V, Navarro, V.A.S, Sondermann, H. | Deposit date: | 2009-11-08 | Release date: | 2010-02-09 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3.078 Å) | Cite: | Vibrio cholerae VpsT Regulates Matrix Production and Motility by Directly Sensing Cyclic di-GMP. Science, 327, 2010
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5C9I
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3KLO
| Vibrio cholerae VpsT bound to c-di-GMP | Descriptor: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), D(-)-TARTARIC ACID, Transcriptional regulator VpsT | Authors: | Krasteva, P.V, Navarro, V.A.S, Sondermann, H. | Deposit date: | 2009-11-08 | Release date: | 2010-02-09 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.802 Å) | Cite: | Vibrio cholerae VpsT Regulates Matrix Production and Motility by Directly Sensing Cyclic di-GMP. Science, 327, 2010
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5DER
| RNA oligonucleotide containing (R)-C5'-ME-2'F U | Descriptor: | RNA oligonucleotide containing (R)-C5'-Me-2'-FU | Authors: | Harp, J.M, Egli, M. | Deposit date: | 2015-08-25 | Release date: | 2016-06-29 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural Basis of Duplex Thermodynamic Stability and Enhanced Nuclease Resistance of 5'-C-Methyl Pyrimidine-Modified Oligonucleotides. J.Org.Chem., 81, 2016
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5D8T
| RNA octamer containing (S)-5' methyl, 2'-F U. | Descriptor: | COBALT HEXAMMINE(III), RNA oligonucleotide containing (S)-C5'-Me-2'-FU | Authors: | Harp, J.M, Egli, M. | Deposit date: | 2015-08-17 | Release date: | 2016-06-29 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Structural Basis of Duplex Thermodynamic Stability and Enhanced Nuclease Resistance of 5'-C-Methyl Pyrimidine-Modified Oligonucleotides. J.Org.Chem., 81, 2016
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4L72
| Crystal structure of MERS-CoV complexed with human DPP4 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Dipeptidyl peptidase 4, ... | Authors: | Wang, X.Q, Wang, N.S. | Deposit date: | 2013-06-13 | Release date: | 2013-08-21 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.005 Å) | Cite: | Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4 Cell Res., 23, 2013
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6JK3
| Crystal structure of a mini fungal lectin, PhoSL in complex with core-fucosylated chitobiose | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Lectin | Authors: | Lou, Y.C, Chou, C.C, Yeh, H.H, Chien, C.Y, Sushant, S, Chen, C, Hsu, C.H. | Deposit date: | 2019-02-27 | Release date: | 2020-03-04 | Last modified: | 2024-10-23 | Method: | X-RAY DIFFRACTION (1.12 Å) | Cite: | Structural insights into the role of N-terminal integrity in PhoSL for core-fucosylated N-glycan recognition. Int.J.Biol.Macromol., 255, 2023
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4M7C
| Crystal structure of the TRF2-binding motif of SLX4 in complex with the TRFH domain of TRF2 | Descriptor: | Peptide from Structure-specific endonuclease subunit SLX4, Telomeric repeat-binding factor 2 | Authors: | Wan, B, Chen, Y, Wu, J, Liu, Y, Lei, M. | Deposit date: | 2013-08-12 | Release date: | 2013-09-25 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | SLX4 Assembles a Telomere Maintenance Toolkit by Bridging Multiple Endonucleases with Telomeres Cell Rep, 4, 2013
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4HQQ
| Crystal structure of RV144-elicited antibody CH58 | Descriptor: | CH58 Fab heavy chain, CH58 Fab light chain | Authors: | McLellan, J.S, Haynes, B.F, Kwong, P.D. | Deposit date: | 2012-10-25 | Release date: | 2013-02-06 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Vaccine Induction of Antibodies against a Structurally Heterogeneous Site of Immune Pressure within HIV-1 Envelope Protein Variable Regions 1 and 2. Immunity, 38, 2013
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3NS7
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4HPY
| Crystal structure of RV144-elicited antibody CH59 in complex with V2 peptide | Descriptor: | CH59 Fab heavy chain, CH59 Fab light chain, Envelope glycoprotein gp160, ... | Authors: | McLellan, J.S, Gorman, J, Haynes, B.F, Kwong, P.D. | Deposit date: | 2012-10-24 | Release date: | 2013-02-06 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Vaccine Induction of Antibodies against a Structurally Heterogeneous Site of Immune Pressure within HIV-1 Envelope Protein Variable Regions 1 and 2. Immunity, 38, 2013
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4HPO
| Crystal structure of RV144-elicited antibody CH58 in complex with V2 peptide | Descriptor: | CH58 Fab heavy chain, CH58 Fab light chain, Envelope glycoprotein gp160, ... | Authors: | McLellan, J.S, Gorman, J, Haynes, B.F, Kwong, P.D. | Deposit date: | 2012-10-24 | Release date: | 2013-02-06 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.694 Å) | Cite: | Vaccine Induction of Antibodies against a Structurally Heterogeneous Site of Immune Pressure within HIV-1 Envelope Protein Variable Regions 1 and 2. Immunity, 38, 2013
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2L3N
| Solution structure of Rap1-Taz1 fusion protein | Descriptor: | DNA-binding protein rap1,Telomere length regulator taz1 | Authors: | Zhou, Z.R, Wang, F, Chen, Y, Lei, M, Hu, H. | Deposit date: | 2010-09-19 | Release date: | 2011-01-12 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | A conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organisms. Nat.Struct.Mol.Biol., 18, 2011
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5K98
| Structure of HipA-HipB-O2-O3 complex | Descriptor: | Antitoxin HipB, DNA (5'-D(*CP*TP*AP*TP*CP*CP*CP*CP*TP*TP*AP*AP*GP*GP*GP*GP*AP*TP*AP*GP*GP*GP*A)-3'), DNA (5'-D(*TP*CP*CP*CP*TP*AP*TP*CP*CP*CP*CP*TP*TP*AP*AP*GP*GP*GP*GP*AP*TP*AP*G)-3'), ... | Authors: | Schumacher, M. | Deposit date: | 2016-05-31 | Release date: | 2016-06-22 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.99 Å) | Cite: | HipBA-promoter structures reveal the basis of heritable multidrug tolerance. Nature, 524, 2015
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5OHI
| Crystal structure of autotaxin in complex with BI-2545 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3,6,9,12,15-PENTAOXAHEPTADECANE, CALCIUM ION, ... | Authors: | Hoerer, S. | Deposit date: | 2017-07-17 | Release date: | 2018-01-03 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.66 Å) | Cite: | Discovery of BI-2545: A Novel Autotaxin Inhibitor That Significantly Reduces LPA Levels in Vivo. ACS Med Chem Lett, 8, 2017
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5OLB
| crystal structure of autotaxin in complex with PF-8380 | Descriptor: | (3,5-dichlorophenyl)methyl 4-[3-oxo-3-(2-oxo-2,3-dihydro-1,3-benzoxazol-6-yl)propyl]piperazine-1-carboxylate, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Hoerer, S, Lammens, A. | Deposit date: | 2017-07-27 | Release date: | 2018-01-03 | Last modified: | 2024-10-23 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | Discovery of BI-2545: A Novel Autotaxin Inhibitor That Significantly Reduces LPA Levels in Vivo. ACS Med Chem Lett, 8, 2017
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7FJP
| Cryo EM structure of lysosomal ATPase | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHATE ION, ... | Authors: | Zhang, S.S. | Deposit date: | 2021-08-04 | Release date: | 2023-03-08 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Cryo-EM structures and transport mechanism of human P5B type ATPase ATP13A2. Cell Discov, 7, 2021
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