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5WRM
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BU of 5wrm by Molmil
Mu2 subunit of the clathrin adaptor complex AP2 in complex with IRS-1 Y658 peptide
Descriptor: AP-2 complex subunit mu, Insulin receptor substrate 1
Authors:Yoneyama, Y, Niwa, H, Umehara, T, Yokoyama, S, Hakuno, F, Takahashi, S.
Deposit date:2016-12-02
Release date:2017-12-06
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.597 Å)
Cite:IRS-1 acts as an endocytic regulator of IGF-I receptor to facilitate sustained IGF signaling
Elife, 7, 2018
2D9Q
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BU of 2d9q by Molmil
Crystal Structure of the Human GCSF-Receptor Signaling Complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CSF3, Granulocyte colony-stimulating factor receptor
Authors:Tamada, T, Kuroki, R.
Deposit date:2005-12-12
Release date:2006-02-07
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Homodimeric cross-over structure of the human granulocyte colony-stimulating factor (GCSF) receptor signaling complex
Proc.Natl.Acad.Sci.Usa, 103, 2006
5BS3
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BU of 5bs3 by Molmil
Crystal Structure of S.A. gyrase in complex with Compound 7
Descriptor: (4R)-3-fluoro-4-hydroxy-4-{[(1r,4R)-4-{[(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-6-yl)methyl]amino}-2-oxabicyclo[2.2.2]oct-1-yl]methyl}-4,5-dihydro-7H-pyrrolo[3,2,1-de][1,5]naphthyridin-7-one, DNA gyrase subunit A and B, DNA/RNA (5'-R(P*AP*GP*CP*CP*G)-D(P*T)-R(P*AP*GP*GP*GP*CP*CP*C)-D(P*T)-R(P*AP*CP*GP*GP*C)-D(P*T)-3'), ...
Authors:Lu, J, Patel, S, Soisson, S.
Deposit date:2015-06-01
Release date:2015-06-17
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Tricyclic 1,5-naphthyridinone oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents-SAR of left-hand-side moiety (Part-2).
Bioorg.Med.Chem.Lett., 25, 2015
3N4O
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BU of 3n4o by Molmil
Insights into the stabilizing contributions of a bicyclic cytosine analogue: crystal structures of DNA duplexes containing 7,8-dihydropyrido[2,3-d]pyrimidin-2-one
Descriptor: 2'-(4-HYDROXYPHENYL)-5-(4-METHYL-1-PIPERAZINYL)-2,5'-BI-BENZIMIDAZOLE, 5'-D(*CP*GP*CP*GP*AP*AP*TP*(B7C)P*CP*GP*CP*G)-3'
Authors:Takenaka, A, Juan, E.C.M, Shimizu, S.
Deposit date:2010-05-22
Release date:2010-08-11
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Insights into the DNA stabilizing contributions of a bicyclic cytosine analogue: crystal structures of DNA duplexes containing 7,8-dihydropyrido [2,3-d]pyrimidin-2-one.
Nucleic Acids Res., 2010
3N4N
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BU of 3n4n by Molmil
Insights into the stabilizing contributions of a bicyclic cytosine analogue: crystal structures of DNA duplexes containing 7,8-dihydropyrido[2,3-d]pyrimidin-2-one
Descriptor: 5'-D(*CP*GP*CP*GP*AP*A)-3', 5'-D(P*TP*TP*(B7C)P*GP*CP*G)-3'
Authors:Takenaka, A, Juan, E.C.M, Shimizu, S.
Deposit date:2010-05-22
Release date:2010-08-11
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Insights into the DNA stabilizing contributions of a bicyclic cytosine analogue: crystal structures of DNA duplexes containing 7,8-dihydropyrido [2,3-d]pyrimidin-2-one.
Nucleic Acids Res., 2010
4R0A
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BU of 4r0a by Molmil
Crystal structure of human TLR8 in complex with uridine mononucleoside
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Toll-like receptor 8, ...
Authors:Tanji, H, Ohto, U, Shimizu, T.
Deposit date:2014-07-30
Release date:2015-01-14
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Toll-like receptor 8 senses degradation products of single-stranded RNA.
Nat.Struct.Mol.Biol., 22, 2015
4R09
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BU of 4r09 by Molmil
Crystal structure of human TLR8 in complex with ORN06S
Descriptor: 1-[(2R,3aR,4R,6R,6aR)-2-hydroxy-6-(hydroxymethyl)-2-sulfidotetrahydrofuro[3,4-d][1,3,2]dioxaphosphol-4-yl]pyrimidine-2,4(1H,3H)-dione, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Tanji, H, Ohto, U, Shimizu, T.
Deposit date:2014-07-30
Release date:2015-01-14
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Toll-like receptor 8 senses degradation products of single-stranded RNA.
Nat.Struct.Mol.Biol., 22, 2015
3L85
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BU of 3l85 by Molmil
Crystal structure of human NUDT5 complexed with 8-oxo-dGMP
Descriptor: 8-OXO-2'-DEOXY-GUANOSINE-5'-MONOPHOSPHATE, ADP-sugar pyrophosphatase
Authors:Arimori, T, Yamagata, Y.
Deposit date:2009-12-29
Release date:2011-01-12
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.301 Å)
Cite:Diverse substrate recognition and hydrolysis mechanisms of human NUDT5
Nucleic Acids Res., 39, 2011
4R08
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BU of 4r08 by Molmil
Crystal structure of human TLR8 in complex with ssRNA40
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3'-O-[(R)-{[(2R,3aR,4R,6R,6aR)-6-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-hydroxy-2-oxidotetrahydrofuro[3,4-d][1,3,2]dioxaphosphol-4-yl]methoxy}(hydroxy)phosphoryl]uridine 5'-(dihydrogen phosphate), ...
Authors:Tanji, H, Ohto, U, Shimizu, T.
Deposit date:2014-07-30
Release date:2015-01-14
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Toll-like receptor 8 senses degradation products of single-stranded RNA.
Nat.Struct.Mol.Biol., 22, 2015
5IRM
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BU of 5irm by Molmil
Crystal structure of rabbit NOD2 in an ADP-bound state (Crystal form2)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Uncharacterized protein
Authors:Maekawa, S, Ohto, U, Shimizu, T.
Deposit date:2016-03-14
Release date:2016-06-29
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (3.31 Å)
Cite:Crystal structure of NOD2 and its implications in human disease.
Nat Commun, 7, 2016
5IRN
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BU of 5irn by Molmil
Crystal structure of rabbit NOD2 in an ADP-bound state (Crystal form1)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Uncharacterized protein
Authors:Maekawa, S, Ohto, U, Shimizu, T.
Deposit date:2016-03-14
Release date:2016-06-29
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Crystal structure of NOD2 and its implications in human disease.
Nat Commun, 7, 2016
7BPZ
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BU of 7bpz by Molmil
X-ray structure of human PPARalpha ligand binding domain-bezafibrate-SRC1 coactivator peptide co-crystals obtained by soaking
Descriptor: 15-meric peptide from Nuclear receptor coactivator 1, 2-[P-[2-P-CHLOROBENZAMIDO)ETHYL]PHENOXY]-2-METHYLPROPIONIC ACID, Peroxisome proliferator-activated receptor alpha
Authors:Kamata, S, Ishikawa, R, Akahane, M, Oyama, T, Ishii, I.
Deposit date:2020-03-23
Release date:2020-11-11
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:PPAR alpha Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates.
Iscience, 23, 2020
7BQ0
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BU of 7bq0 by Molmil
X-ray structure of human PPARalpha ligand binding domain-fenofibric acid-SRC1 coactivator peptide co-crystals obtained by delipidation and co-crystallization
Descriptor: 15-meric peptide from Nuclear receptor coactivator 1, 2-[4-(4-chlorobenzene-1-carbonyl)phenoxy]-2-methylpropanoic acid, Peroxisome proliferator-activated receptor alpha
Authors:Kamata, S, Ishikawa, R, Akahane, M, Oyama, T, Ishii, I.
Deposit date:2020-03-23
Release date:2020-11-11
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.771 Å)
Cite:PPAR alpha Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates.
Iscience, 23, 2020
7BQ1
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BU of 7bq1 by Molmil
X-ray structure of human PPARalpha ligand binding domain-intrinsic fatty acid (E. coli origin)-SRC1 coactivator peptide co-crystals obtained by co-crystallization
Descriptor: 15-meric peptide from Nuclear receptor coactivator 1, GLYCEROL, PALMITIC ACID, ...
Authors:Kamata, S, Ishikawa, R, Akahane, M, Oyama, T, Ishii, I.
Deposit date:2020-03-23
Release date:2020-11-11
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.521 Å)
Cite:PPAR alpha Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates.
Iscience, 23, 2020
7BPY
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BU of 7bpy by Molmil
X-ray structure of human PPARalpha ligand binding domain-clofibric acid-SRC1 coactivator peptide co-crystals obtained by delipidation and co-crystallization
Descriptor: 15-meric peptide from Nuclear receptor coactivator 1, 2-(4-chloranylphenoxy)-2-methyl-propanoic acid, Peroxisome proliferator-activated receptor alpha
Authors:Kamata, S, Ishikawa, R, Akahane, M, Oyama, T, Ishii, I.
Deposit date:2020-03-23
Release date:2020-11-11
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:PPAR alpha Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates.
Iscience, 23, 2020
7BQ2
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BU of 7bq2 by Molmil
X-ray structure of human PPARalpha ligand binding domain-pemafibrate-SRC1 coactivator peptide co-crystals obtained by soaking
Descriptor: (2~{R})-2-[3-[[1,3-benzoxazol-2-yl-[3-(4-methoxyphenoxy)propyl]amino]methyl]phenoxy]butanoic acid, 15-meric peptide from Nuclear receptor coactivator 1, GLYCEROL, ...
Authors:Kamata, S, Ishikawa, R, Akahane, M, Oyama, T, Ishii, I.
Deposit date:2020-03-23
Release date:2020-11-11
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:PPAR alpha Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates.
Iscience, 23, 2020
5IRL
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BU of 5irl by Molmil
Crystal structure of rabbit NOD2 SER mutant in an ADP-bound state
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Uncharacterized protein
Authors:Maekawa, S, Ohto, U, Shimizu, T.
Deposit date:2016-03-14
Release date:2016-06-29
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (3.09 Å)
Cite:Crystal structure of NOD2 and its implications in human disease.
Nat Commun, 7, 2016
7BQ3
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BU of 7bq3 by Molmil
X-ray structure of human PPARalpha ligand binding domain-GW7647-SRC1 coactivator peptide co-crystals obtained by delipidation and co-crystallization
Descriptor: 15-meric peptide from Nuclear receptor coactivator 1, 2-[(4-{2-[(4-cyclohexylbutyl)(cyclohexylcarbamoyl)amino]ethyl}phenyl)sulfanyl]-2-methylpropanoic acid, Peroxisome proliferator-activated receptor alpha
Authors:Kamata, S, Ishikawa, R, Akahane, M, Oyama, T, Ishii, I.
Deposit date:2020-03-23
Release date:2020-11-11
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:PPAR alpha Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates.
Iscience, 23, 2020
7BQ4
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BU of 7bq4 by Molmil
X-ray structure of human PPARalpha ligand binding domain-eicosapentaenoic acid (EPA)-SRC1 coactivator peptide co-crystals obtained by delipidation and co-crystallization
Descriptor: 15-meric peptide from Nuclear receptor coactivator 1, 5,8,11,14,17-EICOSAPENTAENOIC ACID, GLYCEROL, ...
Authors:Kamata, S, Ishikawa, R, Akahane, M, Oyama, T, Ishii, I.
Deposit date:2020-03-23
Release date:2020-11-11
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:PPAR alpha Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates.
Iscience, 23, 2020
1BTC
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BU of 1btc by Molmil
THREE-DIMENSIONAL STRUCTURE OF SOYBEAN BETA-AMYLASE DETERMINED AT 3.0 ANGSTROMS RESOLUTION: PRELIMINARY CHAIN TRACING OF THE COMPLEX WITH ALPHA-CYCLODEXTRIN
Descriptor: BETA-AMYLASE, BETA-MERCAPTOETHANOL, Cyclohexakis-(1-4)-(alpha-D-glucopyranose), ...
Authors:Mikami, B, Hehre, E.J, Sato, M, Katsube, Y, Hirose, M, Morita, Y, Sacchettini, J.C.
Deposit date:1993-02-18
Release date:1993-10-31
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:The 2.0-A resolution structure of soybean beta-amylase complexed with alpha-cyclodextrin.
Biochemistry, 32, 1993
3GJH
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BU of 3gjh by Molmil
Crystal structure of a DNA duplex containing 7,8-dihydropyridol[2,3-d]pyrimidin-2-one
Descriptor: 5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*(B7C)P*GP*CP*G)-3', 6-AMIDINE-2-(4-AMIDINO-PHENYL)INDOLE
Authors:Takenaka, A, Juan, E.C.M, Shimizu, S, Haraguchi, T, Xiao, M, Kurose, T.
Deposit date:2009-03-09
Release date:2010-03-31
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Insights into the stabilizing contributions of bicyclic cytosine analogues: crystal structures of DNA duplexes containing 7,8-dihydropyridol[2,3-d]pyrimidin-2-one
To be Published
8YKI
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BU of 8yki by Molmil
FGFR-1 in complex with ligand tasurgratinib
Descriptor: CHLORIDE ION, Fibroblast growth factor receptor 1, Tasurgratinib
Authors:Ikemori-Kawada, M, Watanabe Miyano, S.
Deposit date:2024-03-05
Release date:2024-06-12
Method:X-RAY DIFFRACTION (2.79 Å)
Cite:Antitumor Activity of Tasurgratinib as an Orally Available FGFR1-3 Inhibitor in Cholangiocarcinoma Models With FGFR2-fusion.
Anticancer Res., 44, 2024
5GMF
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BU of 5gmf by Molmil
Crystal structure of monkey TLR7 in complex with guanosine and polyU
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Zhang, Z, Ohto, U, Shimizu, T.
Deposit date:2016-07-14
Release date:2016-11-02
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Analysis Reveals that Toll-like Receptor 7 Is a Dual Receptor for Guanosine and Single-Stranded RNA
Immunity, 45, 2016
5GMG
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BU of 5gmg by Molmil
Crystal structure of monkey TLR7 in complex with loxoribine and polyU
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-azanyl-9-[(2~{R},3~{R},4~{S},5~{R})-5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolan-2-yl]-7-prop-2-enyl-1~{H}-purine-6,8-dione, ...
Authors:Zhang, Z, Ohto, U, Shimizu, T.
Deposit date:2016-07-14
Release date:2016-11-02
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural Analysis Reveals that Toll-like Receptor 7 Is a Dual Receptor for Guanosine and Single-Stranded RNA
Immunity, 45, 2016
5GMH
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BU of 5gmh by Molmil
Crystal structure of monkey TLR7 in complex with R848
Descriptor: 1-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Zhang, Z, Ohto, U, Shimizu, T.
Deposit date:2016-07-14
Release date:2016-11-02
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Analysis Reveals that Toll-like Receptor 7 Is a Dual Receptor for Guanosine and Single-Stranded RNA
Immunity, 45, 2016

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