1AJW
 
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1GDF
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3KY9
 | | Autoinhibited Vav1 | | Descriptor: | Proto-oncogene vav, ZINC ION | | Authors: | Tomchick, D.R, Rosen, M.K, Machius, M, Yu, B. | | Deposit date: | 2009-12-04 | | Release date: | 2010-02-23 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.731 Å) | | Cite: | Structural and Energetic Mechanisms of Cooperative Autoinhibition and Activation of Vav1
Cell(Cambridge,Mass.), 140, 2010
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1FKT
 | | SOLUTION STRUCTURE OF FKBP, A ROTAMASE ENZYME AND RECEPTOR FOR FK506 AND RAPAMYCIN | | Descriptor: | FK506 AND RAPAMYCIN-BINDING PROTEIN | | Authors: | Michnick, S.W, Rosen, M.K, Wandless, T.J, Karplus, M, Schreiber, S.L. | | Deposit date: | 1992-03-05 | | Release date: | 1994-01-31 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | Solution structure of FKBP, a rotamase enzyme and receptor for FK506 and rapamycin.
Science, 252, 1991
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1FKS
 | | SOLUTION STRUCTURE OF FKBP, A ROTAMASE ENZYME AND RECEPTOR FOR FK506 AND RAPAMYCIN | | Descriptor: | FK506 AND RAPAMYCIN-BINDING PROTEIN | | Authors: | Michnick, S.W, Rosen, M.K, Wandless, T.J, Karplus, M, Schreiber, S.L. | | Deposit date: | 1992-03-05 | | Release date: | 1994-01-31 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | Solution structure of FKBP, a rotamase enzyme and receptor for FK506 and rapamycin.
Science, 252, 1991
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1FKR
 | | SOLUTION STRUCTURE OF FKBP, A ROTAMASE ENZYME AND RECEPTOR FOR FK506 AND RAPAMYCIN | | Descriptor: | FK506 AND RAPAMYCIN-BINDING PROTEIN | | Authors: | Michnick, S.W, Rosen, M.K, Wandless, T.J, Karplus, M, Schreiber, S.L. | | Deposit date: | 1992-03-05 | | Release date: | 1994-01-31 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | Solution structure of FKBP, a rotamase enzyme and receptor for FK506 and rapamycin.
Science, 252, 1991
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3OBV
 | | Autoinhibited Formin mDia1 Structure | | Descriptor: | Protein diaphanous homolog 1, beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose | | Authors: | Tomchick, D.R, Rosen, M.K, Otomo, T. | | Deposit date: | 2010-08-09 | | Release date: | 2010-11-24 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.75 Å) | | Cite: | Crystal structure of the Formin mDia1 in autoinhibited conformation.
Plos One, 5, 2010
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3P8C
 | | Structure and Control of the Actin Regulatory WAVE Complex | | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Abl interactor 2, CHLORIDE ION, ... | | Authors: | Chen, Z, Borek, D, Padrick, S.B, Gomez, T.S, Metlagel, Z, Ismail, A.M, Umetani, J, Billadeau, D.D, Otwinowski, Z, Rosen, M.K. | | Deposit date: | 2010-10-13 | | Release date: | 2010-12-01 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.29 Å) | | Cite: | Structure and control of the actin regulatory WAVE complex.
Nature, 468, 2010
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2BNX
 | | Crystal structure of the dimeric regulatory domain of mouse diaphaneous-related formin (DRF), mDia1 | | Descriptor: | CHLORIDE ION, DIAPHANOUS PROTEIN HOMOLOG 1 | | Authors: | Otomo, T, Otomo, C, Tomchick, D.R, Machius, M, Rosen, M.K. | | Deposit date: | 2005-04-05 | | Release date: | 2005-06-13 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural Basis of Rho Gtpase-Mediated Activation of the Formin Mdia1
Mol.Cell, 18, 2005
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3SEO
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1BY1
 | | DBL homology domain from beta-PIX | | Descriptor: | PROTEIN (PIX) | | Authors: | Aghazadeh, B, Zhu, K, Kubiseski, T.J, Liu, G.A, Pawson, T, Zheng, Y, Rosen, M.K. | | Deposit date: | 1998-10-22 | | Release date: | 1999-10-24 | | Last modified: | 2023-12-27 | | Method: | SOLUTION NMR | | Cite: | Structure and Mutagenesis of the Dbl Homology Domain
Nat.Struct.Biol., 5, 1998
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1Y64
 | | Bni1p Formin Homology 2 Domain complexed with ATP-actin | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Actin, alpha skeletal muscle, ... | | Authors: | Otomo, T, Tomchick, D.R, Otomo, C, Panchal, S.C, Machius, M, Rosen, M.K. | | Deposit date: | 2004-12-03 | | Release date: | 2005-01-18 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (3.05 Å) | | Cite: | Structural basis of actin filament nucleation and processive capping by a formin homology 2 domain
Nature, 433, 2005
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1ZZV
 | | Solution NMR Structure of the Periplasmic Signaling Domain of the Outer Membrane Iron Transporter FecA from Escherichia coli. | | Descriptor: | Iron(III) dicitrate transport protein fecA | | Authors: | Ferguson, A.D, Amezcua, C.A, Chelliah, Y, Rosen, M.K, Deisenhofer, J. | | Deposit date: | 2005-06-14 | | Release date: | 2006-09-26 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Signal transduction pathway of TonB-dependent transporters.
Proc.Natl.Acad.Sci.Usa, 2, 2006
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2A02
 | | Solution NMR Structure of the Periplasmic Signaling Domain of the Outer Membrane Iron Transporter PupA from Pseudomonas putida. | | Descriptor: | Ferric-pseudobactin 358 receptor | | Authors: | Ferguson, A.D, Amezcua, C.A, Chelliah, Y, Rosen, M.K, Deisenhofer, J. | | Deposit date: | 2005-06-15 | | Release date: | 2006-09-26 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Signal transduction pathway of TonB-dependent transporters.
Proc.Natl.Acad.Sci.Usa, 2, 2006
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2K42
 | | Solution Structure of the GTPase Binding Domain of WASP in Complex with EspFU, an EHEC Effector | | Descriptor: | ESPFU, Wiskott-Aldrich syndrome protein | | Authors: | Cheng, H.-C, Skehan, B.M, Campellone, K.G, Leong, J.M, Rosen, M.K. | | Deposit date: | 2008-05-27 | | Release date: | 2008-07-22 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Structural mechanism of WASP activation by the enterohaemorrhagic E. coli effector EspF(U).
Nature, 454, 2008
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1CEE
 | | SOLUTION STRUCTURE OF CDC42 IN COMPLEX WITH THE GTPASE BINDING DOMAIN OF WASP | | Descriptor: | GTP-BINDING RHO-LIKE PROTEIN, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, ... | | Authors: | Abdul-Manan, N, Aghazadeh, B, Liu, G.A, Majumdar, A, Ouerfelli, O, Rosen, M.K. | | Deposit date: | 1999-03-08 | | Release date: | 1999-06-30 | | Last modified: | 2023-12-27 | | Method: | SOLUTION NMR | | Cite: | Structure of Cdc42 in complex with the GTPase-binding domain of the 'Wiskott-Aldrich syndrome' protein.
Nature, 399, 1999
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1EJ5
 | | SOLUTION STRUCTURE OF THE AUTOINHIBITED CONFORMATION OF WASP | | Descriptor: | WISKOTT-ALDRICH SYNDROME PROTEIN | | Authors: | Kim, A.S, Kakalis, L.T, Abdul-Manan, N, Liu, G.A, Rosen, M.K. | | Deposit date: | 2000-02-29 | | Release date: | 2000-04-05 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein.
Nature, 404, 2000
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1F5X
 | | NMR STRUCTURE OF THE Y174 AUTOINHIBITED DBL HOMOLOGY DOMAIN | | Descriptor: | RHO-GEF VAV | | Authors: | Aghazadeh, B, Rosen, M.K, Lowry, W.E, Huang, X.Y. | | Deposit date: | 2000-06-18 | | Release date: | 2000-09-15 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation.
Cell(Cambridge,Mass.), 102, 2000
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1OMA
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1OMB
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1NF3
 | | Structure of Cdc42 in a complex with the GTPase-binding domain of the cell polarity protein, Par6 | | Descriptor: | G25K GTP-binding protein, placental isoform, MAGNESIUM ION, ... | | Authors: | Garrard, S.M, Capaldo, C.T, Gao, L, Rosen, M.K, Macara, I.G, Tomchick, D.R. | | Deposit date: | 2002-12-12 | | Release date: | 2003-03-04 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structure of Cdc42 in a complex with the GTPase-binding domain of the cell polarity protein, Par6
Embo J., 22, 2003
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1SRM
 | | 1H AND 15N ASSIGNMENTS AND SECONDARY STRUCTURE OF THE SRC SH3 DOMAIN | | Descriptor: | SRC TYROSINE KINASE SH3 DOMAIN | | Authors: | Yu, H, Rosen, M.K, Shin, T.B, Seidel-Dugan, C, Brugge, J.S, Schreiber, S.L. | | Deposit date: | 1994-03-07 | | Release date: | 1994-05-31 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | 1H and 15N assignments and secondary structure of the Src SH3 domain.
FEBS Lett., 324, 1993
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1SRL
 | | 1H AND 15N ASSIGNMENTS AND SECONDARY STRUCTURE OF THE SRC SH3 DOMAIN | | Descriptor: | SRC TYROSINE KINASE SH3 DOMAIN | | Authors: | Yu, H, Rosen, M.K, Shin, T.B, Seidel-Dugan, C, Brugge, J.S, Schreiber, S.L. | | Deposit date: | 1994-03-07 | | Release date: | 1994-05-31 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | 1H and 15N assignments and secondary structure of the Src SH3 domain.
FEBS Lett., 324, 1993
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4M63
 | | Crystal Structure of a Filament-Like Actin Trimer Bound to the Bacterial Effector VopL | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Actin-5C, CALCIUM ION, ... | | Authors: | Tomchick, D.R, Zahm, J.A, Rosen, M.K. | | Deposit date: | 2013-08-08 | | Release date: | 2013-10-23 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.748 Å) | | Cite: | The Bacterial Effector VopL Organizes Actin into Filament-like Structures.
Cell(Cambridge,Mass.), 155, 2013
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1T84
 | | Solution structure of the Wiskott-Aldrich Syndrome Protein (WASP) autoinhibited core domain complexed with (S)-wiskostatin, a small molecule inhibitor | | Descriptor: | (2S)-1-(3,6-DIBROMO-9H-CARBAZOL-9-YL)-3-(DIMETHYLAMINO)PROPAN-2-OL, Wiskott-Aldrich syndrome protein | | Authors: | Peterson, J.R, Bickford, L.C, Morgan, D, Kim, A.S, Ouerfelli, O, Kirschner, M.W, Rosen, M.K. | | Deposit date: | 2004-05-11 | | Release date: | 2004-07-13 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation.
Nat.Struct.Mol.Biol., 11, 2004
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