3OBV

Autoinhibited Formin mDia1 Structure

Summary for 3OBV

• Entry DOI: 10.2210/pdb3obv/pdb
• Related: 1V9D 2BNX
• Related PRD ID: PRD_900003
• Descriptor: Protein diaphanous homolog 1, beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose (3 entities in total)
• Functional Keywords: autoinhibition, actin, nucleation, cytoskeleton, structural protein
• Biological source: Mus musculus (mouse); More
• Total number of polymer chains: 8
• Total formula weight: 365902.75

Authors

Tomchick, D.R.,Rosen, M.K.,Otomo, T. (deposition date: 2010-08-09, release date: 2010-11-24, Last modification date: 2024-02-21)

Primary citation

Otomo, T.,Tomchick, D.R.,Otomo, C.,Machius, M.,Rosen, M.K.
Crystal structure of the Formin mDia1 in autoinhibited conformation.
Plos One, 5:e12896-e12896, 2010

PubMed Abstract: Formin proteins utilize a conserved formin homology 2 (FH2) domain to nucleate new actin filaments. In mammalian diaphanous-related formins (DRFs) the FH2 domain is inhibited through an unknown mechanism by intramolecular binding of the diaphanous autoinhibitory domain (DAD) and the diaphanous inhibitory domain (DID).

PubMed: 20927343
DOI: 10.1371/journal.pone.0012896

Experimental method

X-RAY DIFFRACTION (2.75 Å)