8Q92
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8q92 by Molmil](/molmil-images/mine/8q92) | P301S Tau Filaments from the Brains of PS19 Transgenic Mouse Line | Descriptor: | Microtubule-associated protein tau | Authors: | Schweighauser, M, Murzin, A.G, Macdonald, J, Lavenir, I, Crowther, R.A, Scheres, S.H.W, Goedert, M. | Deposit date: | 2023-08-19 | Release date: | 2023-10-11 | Last modified: | 2023-10-18 | Method: | ELECTRON MICROSCOPY (3.05 Å) | Cite: | Cryo-EM structures of tau filaments from the brains of mice transgenic for human mutant P301S Tau. Acta Neuropathol Commun, 11, 2023
|
|
8Q96
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8q96 by Molmil](/molmil-images/mine/8q96) | P301S Tau Filaments from the Brains of Tg2541 Transgenic Mouse Line | Descriptor: | Isoform Tau-E of Microtubule-associated protein tau, Unknown protein | Authors: | Schweighauser, M, Murzin, A.G, Macdonald, J, Lavenir, I, Crowther, R.A, Scheres, S.H.W, Goedert, M. | Deposit date: | 2023-08-19 | Release date: | 2023-10-11 | Last modified: | 2023-10-18 | Method: | ELECTRON MICROSCOPY (3.09 Å) | Cite: | Cryo-EM structures of tau filaments from the brains of mice transgenic for human mutant P301S Tau. Acta Neuropathol Commun, 11, 2023
|
|
8BG9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8bg9 by Molmil](/molmil-images/mine/8bg9) | Murine amyloid-beta filaments with the Arctic mutation (E22G) from APP(NL-G-F) mouse brains | ABeta | Descriptor: | Amyloid-beta protein 40 | Authors: | Yang, Y, Zhang, W.J, Murzin, A.G, Schweighauser, M, Huang, M, Lovestam, S.K.A, Peak-Chew, S.Y, Macdonald, J, Lavenir, I, Ghetti, B, Graff, C, Kumar, A, Nordber, A, Goedert, M, Scheres, S.H.W. | Deposit date: | 2022-10-27 | Release date: | 2023-01-18 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Cryo-EM structures of amyloid-beta filaments with the Arctic mutation (E22G) from human and mouse brains. Acta Neuropathol, 145, 2023
|
|
8BG0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8bg0 by Molmil](/molmil-images/mine/8bg0) | Amyloid-beta tetrameric filaments with the Arctic mutation (E22G) from Alzheimer's disease brains | ABeta40 | Descriptor: | Amyloid-beta precursor protein | Authors: | Yang, Y, Zhang, W.J, Murzin, A.G, Schweighauser, M, Huang, M, Lovestam, S.K.A, Peak-Chew, S.Y, Macdonald, J, Lavenir, I, Ghetti, B, Graff, C, Kumar, A, Nordber, A, Goedert, M, Scheres, S.H.W. | Deposit date: | 2022-10-27 | Release date: | 2023-01-18 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (1.99 Å) | Cite: | Cryo-EM structures of amyloid-beta filaments with the Arctic mutation (E22G) from human and mouse brains. Acta Neuropathol, 145, 2023
|
|
8BFZ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8bfz by Molmil](/molmil-images/mine/8bfz) | Amyloid-beta 42 filaments extracted from the human brain with Arctic mutation (E22G) of Alzheimer's disease | ABeta42 | Descriptor: | Amyloid-beta precursor protein | Authors: | Yang, Y, Zhang, W.J, Murzin, A.G, Schweighauser, M, Huang, M, Lovestam, S.K.A, Peak-Chew, S.Y, Macdonald, J, Lavenir, I, Ghetti, B, Graff, C, Kumar, A, Nordberg, A, Goedert, M, Scheres, S.H.W. | Deposit date: | 2022-10-27 | Release date: | 2023-01-18 | Last modified: | 2024-01-31 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Cryo-EM structures of amyloid-beta filaments with the Arctic mutation (E22G) from human and mouse brains. Acta Neuropathol, 145, 2023
|
|
7Q4M
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7q4m by Molmil](/molmil-images/mine/7q4m) | Type II beta-amyloid 42 Filaments from Human Brain | Descriptor: | Amyloid-beta precursor protein, UNKNOWN ATOM OR ION | Authors: | Yang, Y, Arseni, D, Zhang, W, Huang, M, Lovestam, S.K.A, Schweighauser, M, Kotecha, A, Murzin, A.G, Peak-Chew, S.Y, Macdonald, J, Lavenir, I, Garringer, H.J, Gelpi, E, Newell, K.L, Kovacs, G.G, Vidal, R, Ghetti, B, Falcon, B, Scheres, S.H.W, Goedert, M. | Deposit date: | 2021-11-01 | Release date: | 2021-11-24 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Cryo-EM structures of amyloid-beta 42 filaments from human brains. Science, 375, 2022
|
|
7Q4B
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7q4b by Molmil](/molmil-images/mine/7q4b) | Type I beta-amyloid 42 Filaments from Human Brain | Descriptor: | Amyloid-beta precursor protein, UNKNOWN ATOM OR ION | Authors: | Yang, Y, Arseni, D, Zhang, W, Huang, M, Lovestam, S.K.A, Schweighauser, M, Kotecha, A, Murzin, A.G, Peak-Chew, S.Y, Macdonald, J, Lavenir, I, Garringer, H.J, Gelpi, E, Newell, K.L, Kovacs, G.G, Vidal, R, Ghetti, B, Falcon, B, Scheres, S.H.W, Goedert, M. | Deposit date: | 2021-10-30 | Release date: | 2021-11-24 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Cryo-EM structures of amyloid-beta 42 filaments from human brains. Science, 375, 2022
|
|
1OCN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1ocn by Molmil](/molmil-images/mine/1ocn) | Mutant D416A of the CELLOBIOHYDROLASE CEL6A FROM HUMICOLA INSOLENS in complex with a cellobio-derived isofagomine at 1.3 angstrom resolution | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-HYDROXYMETHYL-3,4-DIHYDROXYPIPERIDINE, CALCIUM ION, ... | Authors: | Varrot, A, Macdonald, J, Stick, R.V, Pell, G, Gilbert, H.J, Davies, G.J. | Deposit date: | 2003-02-09 | Release date: | 2003-05-22 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.31 Å) | Cite: | Distortion of a Cellobio-Derived Isofagomine Highlights the Potential Conformational Itinerary of Inverting Beta-Glucosidases Chem.Commun.(Camb.), 21, 2003
|
|
1UZ1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1uz1 by Molmil](/molmil-images/mine/1uz1) | Family 1 b-glucosidase from Thermotoga maritima in complex with isofagomine lactam | Descriptor: | (3S,4R,5R)-3,4-DIHYDROXY-5-(HYDROXYMETHYL)PIPERIDIN-2-ONE, BETA-GLUCOSIDASE A | Authors: | Gloster, T.M, Macdonald, J, Stick, R.V, Davies, G.J. | Deposit date: | 2004-03-03 | Release date: | 2004-11-23 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Common Inhibition of Both -Glucosidases and -Mannosidases by Isofagomine Lactam Reflects Different Conformational Itineraries for Pyranoside Hydrolysis Chembiochem, 5, 2004
|
|
1OCQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1ocq by Molmil](/molmil-images/mine/1ocq) | COMPLEX OF THE ENDOGLUCANASE CEL5A FROM BACILLUS AGARADHEARANS AT 1.08 ANGSTROM RESOLUTION with cellobio-derived isofagomine | Descriptor: | 5-HYDROXYMETHYL-3,4-DIHYDROXYPIPERIDINE, ENDOGLUCANASE 5A, GLYCEROL, ... | Authors: | Varrot, A, Macdonald, J, Stick, R.V, Withers, S.G, Davies, G.J. | Deposit date: | 2003-02-09 | Release date: | 2003-06-26 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.08 Å) | Cite: | Direct Observation of the Protonation State of an Imino Sugar Glycosidase Inhibitor Upon Binding J.Am.Chem.Soc., 125, 2003
|
|
5HCU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5hcu by Molmil](/molmil-images/mine/5hcu) | |
1UZ4
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1uz4 by Molmil](/molmil-images/mine/1uz4) | Common inhibition of beta-glucosidase and beta-mannosidase by isofagomine lactam reflects different conformational intineraries for glucoside and mannoside hydrolysis | Descriptor: | (3S,4R,5R)-3,4-DIHYDROXY-5-(HYDROXYMETHYL)PIPERIDIN-2-ONE, GLYCEROL, MAN5A, ... | Authors: | Vincent, F, Davies, G.J. | Deposit date: | 2004-03-04 | Release date: | 2004-11-03 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.71 Å) | Cite: | Common Inhibition of Both Beta-Glucosidases and Beta-Mannosidases by Isofagomine Lactam Reflects Different Conformational Itineraries for Pyranoside Hydrolysis Chembiochem, 5, 2004
|
|
3I2K
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3i2k by Molmil](/molmil-images/mine/3i2k) | Cocaine Esterase, wild type, bound to a DTT adduct | Descriptor: | (4S,5S)-4,5-BIS(MERCAPTOMETHYL)-1,3-DIOXOLAN-2-OL, CHLORIDE ION, Cocaine esterase, ... | Authors: | Tesmer, J.J.G, Nance, M.R. | Deposit date: | 2009-06-29 | Release date: | 2010-06-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.51 Å) | Cite: | Structural analysis of thermostabilizing mutations of cocaine esterase. Protein Eng.Des.Sel., 23, 2010
|
|
3I2F
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3i2f by Molmil](/molmil-images/mine/3i2f) | Cocaine Esterase with mutations T172R / G173Q, bound to DTT adduct | Descriptor: | (4S,5S)-4,5-BIS(MERCAPTOMETHYL)-1,3-DIOXOLAN-2-OL, CHLORIDE ION, Cocaine esterase, ... | Authors: | Tesmer, J.J.G, Nance, M.R. | Deposit date: | 2009-06-29 | Release date: | 2010-06-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural analysis of thermostabilizing mutations of cocaine esterase. Protein Eng.Des.Sel., 23, 2010
|
|
3I2J
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3i2j by Molmil](/molmil-images/mine/3i2j) | Cocaine Esterase, wild type, without a ligand | Descriptor: | CHLORIDE ION, Cocaine esterase, GLYCEROL, ... | Authors: | Tesmer, J.J.G, Nance, M.R. | Deposit date: | 2009-06-29 | Release date: | 2010-06-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Structural analysis of thermostabilizing mutations of cocaine esterase. Protein Eng.Des.Sel., 23, 2010
|
|
3I2I
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3i2i by Molmil](/molmil-images/mine/3i2i) | Cocaine Esterase with mutation T172R, bound to DTT adduct | Descriptor: | (4S,5S)-4,5-BIS(MERCAPTOMETHYL)-1,3-DIOXOLAN-2-OL, CHLORIDE ION, Cocaine esterase, ... | Authors: | Tesmer, J.J.G, Nance, M.R. | Deposit date: | 2009-06-29 | Release date: | 2010-06-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.14 Å) | Cite: | Structural analysis of thermostabilizing mutations of cocaine esterase. Protein Eng.Des.Sel., 23, 2010
|
|
3I2G
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3i2g by Molmil](/molmil-images/mine/3i2g) | Cocaine Esterase with mutation G173Q, bound to DTT adduct | Descriptor: | (4S,5S)-4,5-BIS(MERCAPTOMETHYL)-1,3-DIOXOLAN-2-OL, CHLORIDE ION, Cocaine esterase, ... | Authors: | Tesmer, J.J.G, Nance, M.R. | Deposit date: | 2009-06-29 | Release date: | 2010-06-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural analysis of thermostabilizing mutations of cocaine esterase. Protein Eng.Des.Sel., 23, 2010
|
|
3I2H
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3i2h by Molmil](/molmil-images/mine/3i2h) | Cocaine Esterase with mutation L169K, bound to DTT adduct | Descriptor: | (4S,5S)-4,5-BIS(MERCAPTOMETHYL)-1,3-DIOXOLAN-2-OL, CHLORIDE ION, Cocaine esterase, ... | Authors: | Tesmer, J.J.G, Nance, M.R. | Deposit date: | 2009-06-29 | Release date: | 2010-06-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Structural analysis of thermostabilizing mutations of cocaine esterase. Protein Eng.Des.Sel., 23, 2010
|
|
5DTJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5dtj by Molmil](/molmil-images/mine/5dtj) | |
5DTI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5dti by Molmil](/molmil-images/mine/5dti) | Crystal structure of mouse acetylcholinesterase | Descriptor: | Acetylcholinesterase | Authors: | Tran, T.H, Tong, L. | Deposit date: | 2015-09-18 | Release date: | 2015-10-21 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.003 Å) | Cite: | Discovery of New Classes of Compounds that Reactivate Acetylcholinesterase Inhibited by Organophosphates. Chembiochem, 16, 2015
|
|