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6XR2
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BU of 6xr2 by Molmil
Computationally designed right-handed alpha/alpha homotrimeric toroid with 3 repeats per subunit
Descriptor: dTor_3x57R
Authors:Hallinan, J.P, Doyle, L, Bradley, P, Stoddard, B.L.
Deposit date:2020-07-10
Release date:2021-07-14
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Design of functionalised circular tandem repeat proteins with longer repeat topologies and enhanced subunit contact surfaces.
Commun Biol, 4, 2021
6XR1
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BU of 6xr1 by Molmil
Computationally designed right-handed alpha/alpha single-chain toroid with 9 repeats
Descriptor: dTor_9x57R
Authors:Hallinan, J.P, Doyle, L, Bradley, P, Stoddard, B.L.
Deposit date:2020-07-10
Release date:2021-07-14
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Design of functionalised circular tandem repeat proteins with longer repeat topologies and enhanced subunit contact surfaces.
Commun Biol, 4, 2021
5ESP
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BU of 5esp by Molmil
Crystal Structure of LAGLIDADG Meganuclease I-PanMI with coordinated Calcium ions
Descriptor: CALCIUM ION, DNA (27-MER), GLYCEROL, ...
Authors:Hallinan, J.P, Stoddard, B.L.
Deposit date:2015-11-16
Release date:2016-03-30
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.995 Å)
Cite:Indirect DNA Sequence Recognition and Its Impact on Nuclease Cleavage Activity.
Structure, 24, 2016
5THG
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BU of 5thg by Molmil
Engineered variant of I-OnuI meganuclease targeting the HIV CCR5 gene; harbors 43 point mutations relative to wild-type I-OnuI
Descriptor: CALCIUM ION, DNA (29-MER), GLYCEROL, ...
Authors:Hallinan, J.P, Stoddard, B.L.
Deposit date:2016-09-29
Release date:2017-05-03
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (3.106 Å)
Cite:The structural basis of altered gene specificity resulting from meganuclease and MegaTAL engineering
to be published
4Z20
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BU of 4z20 by Molmil
Crystal Structure of Meganuclease I-SmaMI Bound to Uncleaveable DNA with a TTGT Central Four
Descriptor: CALCIUM ION, DNA (26-MER), GLYCEROL, ...
Authors:Hallinan, J.P, Stoddard, B.L.
Deposit date:2015-03-27
Release date:2016-03-30
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Indirect DNA Sequence Recognition and Its Impact on Nuclease Cleavage Activity.
Structure, 24, 2016
4Z1Z
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BU of 4z1z by Molmil
Crystal Structure of Meganuclease I-SmaMI Bound to Uncleaveable DNA with a TTCT Central Four
Descriptor: CALCIUM ION, DNA (28-MER), GLYCEROL, ...
Authors:Hallinan, J.P, Stoddard, B.L.
Deposit date:2015-03-27
Release date:2016-03-30
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Indirect DNA Sequence Recognition and Its Impact on Nuclease Cleavage Activity.
Structure, 24, 2016
4YHX
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BU of 4yhx by Molmil
Crystal Structure of LAGLIDADG Meganuclease I-GpeMI Bound to Uncleaved DNA
Descriptor: CALCIUM ION, DNA (27-MER), Ribosomal protein 3/homing endonuclease-like fusion protein
Authors:Hallinan, J.P, Kaiser, B.K, Stoddard, B.L.
Deposit date:2015-02-27
Release date:2016-03-09
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Indirect DNA Sequence Recognition and Its Impact on Nuclease Cleavage Activity.
Structure, 24, 2016
4YIT
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BU of 4yit by Molmil
Crystal Structure of LAGLIDADG Meganuclease I-AabMI Bound to Uncleaved DNA
Descriptor: CALCIUM ION, DNA (25-MER), DNA (25MER), ...
Authors:Hallinan, J.P, Stoddard, B.L.
Deposit date:2015-03-02
Release date:2016-03-23
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.24 Å)
Cite:Indirect DNA Sequence Recognition and Its Impact on Nuclease Cleavage Activity.
Structure, 24, 2016
4YIS
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BU of 4yis by Molmil
Crystal Structure of LAGLIDADG Meganuclease I-CpaMI Bound to Uncleaved DNA
Descriptor: 1,2-ETHANEDIOL, CALCIUM ION, DNA (28-MER), ...
Authors:Hallinan, J.P, Kaiser, B.K, Stoddard, B.L.
Deposit date:2015-03-02
Release date:2016-03-23
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.89 Å)
Cite:Indirect DNA Sequence Recognition and Its Impact on Nuclease Cleavage Activity.
Structure, 24, 2016
4YY2
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BU of 4yy2 by Molmil
Computationally designed left-handed alpha/alpha toroid with 3 repeats in space group P212121
Descriptor: SODIUM ION, dTor_3x33L
Authors:Hallinan, J.P, Bradley, P, Stoddard, B.L.
Deposit date:2015-03-23
Release date:2015-12-16
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.854 Å)
Cite:Rational design of alpha-helical tandem repeat proteins with closed architectures.
Nature, 528, 2015
4YY5
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BU of 4yy5 by Molmil
Computationally designed left-handed alpha/alpha toroid with 3 repeats in space group P43212
Descriptor: dTor_3x33L
Authors:Hallinan, J.P, Bradley, P, Stoddard, B.L.
Deposit date:2015-03-23
Release date:2015-12-16
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:Rational design of alpha-helical tandem repeat proteins with closed architectures.
Nature, 528, 2015
7RDR
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BU of 7rdr by Molmil
Circular tandem repeat protein with novel repeat topology and enhanced subunit contact surfaces
Descriptor: Circular tendon repeat protein
Authors:Shen, B.W, Stoddard, B.L.
Deposit date:2021-07-10
Release date:2021-09-01
Last modified:2021-11-17
Method:ELECTRON MICROSCOPY (6.5 Å)
Cite:Design of functionalised circular tandem repeat proteins with longer repeat topologies and enhanced subunit contact surfaces.
Commun Biol, 4, 2021
5T2O
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BU of 5t2o by Molmil
Engineered variant of I-OnuI meganuclease targeting the Anopheles AGAP011377 gene; harbors 53 point mutations relative to wild-type I-OnuI
Descriptor: CALCIUM ION, DNA (26-MER), I-OnuI_e-ag011377
Authors:Stoddard, B.L, Werther, R.
Deposit date:2016-08-23
Release date:2017-05-03
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.801 Å)
Cite:Crystallographic analyses illustrate significant plasticity and efficient recoding of meganuclease target specificity.
Nucleic Acids Res., 45, 2017
5T2H
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BU of 5t2h by Molmil
Engineered variant of I-OnuI meganuclease targeting the Human TCRa gene; harbors 43 point mutations relative to wild-type I-OnuI
Descriptor: CALCIUM ION, DNA (26-MER), I-OnuI_e-hTCRa
Authors:Stoddard, B.L, Werther, R.
Deposit date:2016-08-23
Release date:2017-05-03
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.517 Å)
Cite:Crystallographic analyses illustrate significant plasticity and efficient recoding of meganuclease target specificity.
Nucleic Acids Res., 45, 2017
5T2N
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BU of 5t2n by Molmil
Engineered variant of I-OnuI meganuclease targeting the Anopheles AGAP007280 gene; harbors 38 point mutations relative to wild-type I-OnuI
Descriptor: CALCIUM ION, DNA (26-MER), I-OnuI_e-ag007820
Authors:Stoddard, B.L, Werther, R.
Deposit date:2016-08-23
Release date:2017-05-03
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.079 Å)
Cite:Crystallographic analyses illustrate significant plasticity and efficient recoding of meganuclease target specificity.
Nucleic Acids Res., 45, 2017
6UVW
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BU of 6uvw by Molmil
Engineered variant of I-OnuI meganuclease with improved thermostability
Descriptor: CALCIUM ION, DNA (27-MER), I-OnuI-e-Therm
Authors:Werther, R, Stoddard, B.L.
Deposit date:2019-11-04
Release date:2019-12-18
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.551 Å)
Cite:Optimization of Protein Thermostability and Exploitation of Recognition Behavior to Engineer Altered Protein-DNA Recognition.
Structure, 28, 2020
6UWK
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BU of 6uwk by Molmil
Engineered variant of I-OnuI meganuclease with improved stability and fully altered specificity targeting human chromosome 11 trans integration site
Descriptor: 1,2-ETHANEDIOL, CALCIUM ION, DNA (27-MER), ...
Authors:Werther, R, Stoddard, B.L.
Deposit date:2019-11-05
Release date:2019-12-18
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.533 Å)
Cite:Optimization of Protein Thermostability and Exploitation of Recognition Behavior to Engineer Altered Protein-DNA Recognition.
Structure, 28, 2020
6UWJ
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BU of 6uwj by Molmil
Intermediate engineered variant of I-OnuI meganuclease with improved thermostability and partially altered specificity
Descriptor: CALCIUM ION, DNA (27-MER), I-OnuI-e-Therm-hChr11v2
Authors:Werther, R, Stoddard, B.L.
Deposit date:2019-11-05
Release date:2019-12-18
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.852 Å)
Cite:Optimization of Protein Thermostability and Exploitation of Recognition Behavior to Engineer Altered Protein-DNA Recognition.
Structure, 28, 2020
6UWH
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BU of 6uwh by Molmil
Intermediate engineered variant of I-OnuI meganuclease with improved thermostability and partially altered specificity
Descriptor: 1,2-ETHANEDIOL, CALCIUM ION, DNA (26-MER), ...
Authors:Werther, R, Stoddard, B.L.
Deposit date:2019-11-05
Release date:2019-12-18
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.299 Å)
Cite:Optimization of Protein Thermostability and Exploitation of Recognition Behavior to Engineer Altered Protein-DNA Recognition.
Structure, 28, 2020
6UW0
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BU of 6uw0 by Molmil
Engineered variant of I-OnuI meganuclease with improved thermostability and fully altered specificity targeting cholera toxin A subunit
Descriptor: 1,2-ETHANEDIOL, CALCIUM ION, DNA (27-MER), ...
Authors:Werther, R, Stoddard, B.L.
Deposit date:2019-11-04
Release date:2019-12-18
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.72 Å)
Cite:Optimization of Protein Thermostability and Exploitation of Recognition Behavior to Engineer Altered Protein-DNA Recognition.
Structure, 28, 2020
6UWG
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BU of 6uwg by Molmil
Engineered variant of I-OnuI meganuclease with improved thermostability and E178D mutation at catalytic site
Descriptor: 1,2-ETHANEDIOL, CALCIUM ION, DNA (26-MER), ...
Authors:Werther, R, Stoddard, B.L.
Deposit date:2019-11-05
Release date:2019-12-18
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Optimization of Protein Thermostability and Exploitation of Recognition Behavior to Engineer Altered Protein-DNA Recognition.
Structure, 28, 2020

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數據於2024-11-06公開中

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