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6UWH

Intermediate engineered variant of I-OnuI meganuclease with improved thermostability and partially altered specificity

Summary for 6UWH
Entry DOI10.2210/pdb6uwh/pdb
DescriptorI-OnuI-e-Therm-hChr11v1, DNA (26-MER), CALCIUM ION, ... (6 entities in total)
Functional Keywordsmeganuclease, homing endonuclease, dna binding protein, dna binding protein-dna complex, dna binding protein/dna
Biological sourcesynthetic construct
More
Total number of polymer chains3
Total formula weight50309.38
Authors
Werther, R.,Stoddard, B.L. (deposition date: 2019-11-05, release date: 2019-12-18, Last modification date: 2023-10-11)
Primary citationLambert, A.R.,Hallinan, J.P.,Werther, R.,Glow, D.,Stoddard, B.L.
Optimization of Protein Thermostability and Exploitation of Recognition Behavior to Engineer Altered Protein-DNA Recognition.
Structure, 28:760-775.e8, 2020
Cited by
PubMed: 32359399
DOI: 10.1016/j.str.2020.04.009
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.299 Å)
Structure validation

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