6CBY
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![BU of 6cby by Molmil](/molmil-images/mine/6cby) | Crystal structure of human SET and MYND Domain Containing protein 2 with MTF9975 | Descriptor: | N-lysine methyltransferase SMYD2, ZINC ION, [3-(4-amino-6-methyl-1H-imidazo[4,5-c]pyridin-1-yl)-3-methylazetidin-1-yl][1-({1-[(1R)-cyclohept-2-en-1-yl]piperidin-4-yl}methyl)-1H-pyrrol-3-yl]methanone | Authors: | ZENG, H, DONG, A, Hutchinson, A, Seitova, A, TATLOCK, J, KUMPF, R, OWEN, A, TAYLOR, A, Casimiro-Garcia, A, Bountra, C, Arrowsmith, C.H, Edwards, A.M, BROWN, P.J, WU, H, Structural Genomics Consortium (SGC) | Deposit date: | 2018-02-05 | Release date: | 2018-03-14 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Selective, Small-Molecule Co-Factor Binding Site Inhibition of a Su(var)3-9, Enhancer of Zeste, Trithorax Domain Containing Lysine Methyltransferase. J.Med.Chem., 62, 2019
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6DLP
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![BU of 6dlp by Molmil](/molmil-images/mine/6dlp) | Crystal structure of LRRK2 WD40 domain dimer | Descriptor: | Leucine-rich repeat serine/threonine-protein kinase 2, PLATINUM (II) ION | Authors: | Zhang, P, Ru, H, Wang, L, Wu, H. | Deposit date: | 2018-06-02 | Release date: | 2019-01-09 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (4 Å) | Cite: | Crystal structure of the WD40 domain dimer of LRRK2. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
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8UIP
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5E8R
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![BU of 5e8r by Molmil](/molmil-images/mine/5e8r) | Human HMT1 hnRNP methyltransferase-like protein 6 (S. cerevisiae) | Descriptor: | CHLORIDE ION, N-methyl-N-({4-[4-(propan-2-yloxy)phenyl]-1H-pyrrol-3-yl}methyl)ethane-1,2-diamine, Protein arginine N-methyltransferase 6, ... | Authors: | DONG, A, ZENG, H, LIU, J, TEMPEL, W, Seitova, A, Hutchinson, A, Bountra, C, Arrowsmith, C.H, Edwards, A.M, JIN, J, BROWN, P.J, WU, H, Structural Genomics Consortium (SGC) | Deposit date: | 2015-10-14 | Release date: | 2015-12-09 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases. Acs Chem.Biol., 11, 2016
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5FAI
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![BU of 5fai by Molmil](/molmil-images/mine/5fai) | EMG1 N1-Specific Pseudouridine Methyltransferase | Descriptor: | CITRIC ACID, Ribosomal RNA small subunit methyltransferase NEP1, S-ADENOSYL-L-HOMOCYSTEINE, ... | Authors: | DONG, A, ZENG, H, LI, Y, TEMPEL, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, BROWN, P.J, WU, H, Structural Genomics Consortium (SGC) | Deposit date: | 2015-12-11 | Release date: | 2016-01-20 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | EMG1 N1-Specific Pseudouridine Methyltransferase to be published
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5EGS
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![BU of 5egs by Molmil](/molmil-images/mine/5egs) | Human PRMT6 with bound fragment-type inhibitor | Descriptor: | 2-[4-(phenylmethyl)piperidin-1-yl]ethanamine, Protein arginine N-methyltransferase 6, S-ADENOSYL-L-HOMOCYSTEINE | Authors: | Steuber, H, Egner, U, Kania, J, Wu, H, Brown, P.J. | Deposit date: | 2015-10-27 | Release date: | 2016-02-03 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Discovery of a Potent Class I Protein Arginine Methyltransferase Fragment Inhibitor. J.Med.Chem., 59, 2016
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6CBX
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![BU of 6cbx by Molmil](/molmil-images/mine/6cbx) | Crystal structure of human SET and MYND Domain Containing protein 2 with MTF1497 | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, N-lysine methyltransferase SMYD2, ... | Authors: | ZENG, H, DONG, A, Hutchinson, A, Seitova, A, TATLOCK, J, KUMPF, R, OWEN, A, TAYLOR, A, Casimiro-Garcia, A, Bountra, C, Arrowsmith, C.H, Edwards, A.M, BROWN, P.J, WU, H, Structural Genomics Consortium (SGC) | Deposit date: | 2018-02-05 | Release date: | 2018-03-14 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.94 Å) | Cite: | Crystal structure of human SET and MYND Domain Containing protein 2 with MTF1497 to be published
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1F3V
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![BU of 1f3v by Molmil](/molmil-images/mine/1f3v) | Crystal structure of the complex between the N-terminal domain of TRADD and the TRAF domain of TRAF2 | Descriptor: | TUMOR NECROSIS FACTOR RECEPTOR TYPE 1 ASSOCIATED DEATH DOMAIN PROTEIN, TUMOR NECROSIS FACTOR RECEPTOR-ASSOCIATED PROTEIN | Authors: | Park, Y.C, Ye, H, Hsia, C, Segal, D, Rich, R, Liou, H.-C, Myszka, D, Wu, H. | Deposit date: | 2000-06-06 | Release date: | 2000-09-06 | Last modified: | 2017-10-04 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction. Cell(Cambridge,Mass.), 101, 2000
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6WWZ
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![BU of 6wwz by Molmil](/molmil-images/mine/6wwz) | Cryo-EM structure of the human chemokine receptor CCR6 in complex with CCL20 and a Go protein | Descriptor: | C-C chemokine receptor type 6,C-C chemokine receptor type 6, C-C motif chemokine 20, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Wasilko, D.J, Johnson, Z.L, Ammirati, M, Han, S, Wu, H. | Deposit date: | 2020-05-09 | Release date: | 2020-06-24 | Last modified: | 2020-07-01 | Method: | ELECTRON MICROSCOPY (3.34 Å) | Cite: | Structural basis for chemokine receptor CCR6 activation by the endogenous protein ligand CCL20. Nat Commun, 11, 2020
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7LJ1
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![BU of 7lj1 by Molmil](/molmil-images/mine/7lj1) | Human Prx1-Srx Decameric Complex | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, DI(HYDROXYETHYL)ETHER, ... | Authors: | Forshaw, T.E, Reisz, J.A, Nelson, K.J, Gumpena, R, Lawson, J.R, Jonsson, T, Wu, H, Clodfelter, J.E, Johnson, L, Furdui, C.M, Lowther, W.T. | Deposit date: | 2021-01-28 | Release date: | 2021-07-14 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.97 Å) | Cite: | Specificity of Human Sulfiredoxin for Reductant and Peroxiredoxin Oligomeric State. Antioxidants (Basel), 10, 2021
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1M6I
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![BU of 1m6i by Molmil](/molmil-images/mine/1m6i) | Crystal Structure of Apoptosis Inducing Factor (AIF) | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, Programmed cell death protein 8 | Authors: | Ye, H, Cande, C, Stephanou, N.C, Jiang, S, Gurbuxani, S, Larochette, N, Daugas, E, Garrido, C, Kroemer, G, Wu, H. | Deposit date: | 2002-07-16 | Release date: | 2002-08-28 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | DNA binding is required for the apoptogenic action of apoptosis inducing factor. Nat.Struct.Biol., 9, 2002
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3JBW
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![BU of 3jbw by Molmil](/molmil-images/mine/3jbw) | Cryo-electron microscopy structure of RAG Paired Complex (with NBD, no symmetry) | Descriptor: | 12-RSS signal end forward strand, 5'-D(P*GP*AP*TP*CP*TP*GP*GP*CP*CP*TP*GP*TP*CP*TP*TP*A)-3', Nicked 12-RSS intermediate reverse strand, ... | Authors: | Ru, H, Chambers, M.G, Fu, T.-M, Tong, A.B, Liao, M, Wu, H. | Deposit date: | 2015-10-21 | Release date: | 2015-12-09 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (4.6 Å) | Cite: | Molecular Mechanism of V(D)J Recombination from Synaptic RAG1-RAG2 Complex Structures. Cell(Cambridge,Mass.), 163, 2015
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3JBY
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![BU of 3jby by Molmil](/molmil-images/mine/3jby) | Cryo-electron microscopy structure of RAG Paired Complex (C2 symmetry) | Descriptor: | '-D(P*GP*AP*TP*CP*TP*GP*GP*CP*CP*TP*GP*TP*CP*TP*TP*A)-3', 5'-D(P*CP*AP*CP*AP*GP*TP*GP*CP*TP*AP*CP*AP*GP*AP*C)-3', CALCIUM ION, ... | Authors: | Ru, H, Chambers, M.G, Fu, T.-M, Tong, A.B, Liao, M, Wu, H. | Deposit date: | 2015-10-22 | Release date: | 2015-12-09 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Molecular Mechanism of V(D)J Recombination from Synaptic RAG1-RAG2 Complex Structures. Cell(Cambridge,Mass.), 163, 2015
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1LB6
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![BU of 1lb6 by Molmil](/molmil-images/mine/1lb6) | TRAF6-CD40 Complex | Descriptor: | CD40 antigen, TNF receptor-associated factor 6 | Authors: | Ye, H, Arron, J.R, Lamothe, B, Cirilli, M, Kobayashi, T, Shevde, N.K, Segal, D, Dzivenu, O, Vologodskaia, M, Yim, M, Du, K, Singh, S, Pike, J.W, Darnay, B.G, Choi, Y, Wu, H. | Deposit date: | 2002-04-02 | Release date: | 2002-07-31 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Distinct molecular mechanism for initiating TRAF6 signalling. Nature, 418, 2002
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1LB4
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![BU of 1lb4 by Molmil](/molmil-images/mine/1lb4) | TRAF6 apo structure | Descriptor: | TNF receptor-associated factor 6 | Authors: | Ye, H, Arron, J.R, Lamothe, B, Cirilli, M, Kobayashi, T, Shevde, N.K, Segal, D, Dzivenu, O, Vologodskaia, M, Yim, M, Du, K, Singh, S, Pike, J.W, Darnay, B.G, Choi, Y, Wu, H. | Deposit date: | 2002-04-02 | Release date: | 2002-07-31 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Distinct molecular mechanism for initiating TRAF6 signalling. Nature, 418, 2002
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1LB5
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![BU of 1lb5 by Molmil](/molmil-images/mine/1lb5) | TRAF6-RANK Complex | Descriptor: | TNF receptor-associated factor 6, receptor activator of nuclear factor-kappa B | Authors: | Ye, H, Arron, J.R, Lamothe, B, Cirilli, M, Kobayashi, T, Shevde, N.K, Segal, D, Dzivenu, O, Vologodskaia, M, Yim, M, Du, K, Singh, S, Pike, J.W, Darnay, B.G, Choi, Y, Wu, H. | Deposit date: | 2002-04-02 | Release date: | 2002-07-31 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Distinct molecular mechanism for initiating TRAF6 signalling. Nature, 418, 2002
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3JBX
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![BU of 3jbx by Molmil](/molmil-images/mine/3jbx) | Cryo-electron microscopy structure of RAG Signal End Complex (C2 symmetry) | Descriptor: | 5'-D(*CP*AP*CP*AP*GP*TP*GP*CP*TP*AP*CP*AP*GP*AP*C)-3', 5'-D(*GP*CP*GP*AP*TP*GP*GP*TP*TP*AP*AP*CP*CP*A)-3', 5'-D(P*GP*TP*CP*TP*GP*TP*AP*GP*CP*AP*CP*TP*GP*TP*G)-3', ... | Authors: | Ru, H, Chambers, M.G, Fu, T.-M, Tong, A.B, Liao, M, Wu, H. | Deposit date: | 2015-10-22 | Release date: | 2015-12-09 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Molecular Mechanism of V(D)J Recombination from Synaptic RAG1-RAG2 Complex Structures. Cell(Cambridge,Mass.), 163, 2015
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1WM7
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![BU of 1wm7 by Molmil](/molmil-images/mine/1wm7) | Solution Structure of BmP01 from the Venom of Scorpion Buthus martensii Karsch, 9 structures | Descriptor: | Neurotoxin BmP01 | Authors: | Wu, G, Li, Y, Wei, D, He, F, Jiang, S, Hu, G, Wu, H, Chen, X. | Deposit date: | 2004-07-05 | Release date: | 2004-07-27 | Last modified: | 2022-03-02 | Method: | SOLUTION NMR | Cite: | Solution Structure of BmP01 from the Venom of Scorpion Buthus martensii Karsch Biochem.Biophys.Res.Commun., 276, 2000
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3QA8
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![BU of 3qa8 by Molmil](/molmil-images/mine/3qa8) | Crystal Structure of inhibitor of kappa B kinase beta | Descriptor: | MGC80376 protein | Authors: | Xu, G, Lo, Y.C, Li, Q, Napolitano, G, Wu, X, Jiang, X, Dreano, M, Karin, M, Wu, H. | Deposit date: | 2011-01-10 | Release date: | 2011-04-06 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | Crystal structure of inhibitor of kappa B kinase beta. Nature, 472, 2011
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1S8K
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![BU of 1s8k by Molmil](/molmil-images/mine/1s8k) | Solution Structure of BmKK4, A Novel Potassium Channel Blocker from Scorpion Buthus martensii Karsch, 25 structures | Descriptor: | Toxin BmKK4 | Authors: | Zhang, N, Chen, X, Li, M, Cao, C, Wang, Y, Hu, G, Wu, H. | Deposit date: | 2004-02-02 | Release date: | 2005-02-08 | Last modified: | 2022-03-02 | Method: | SOLUTION NMR | Cite: | Solution structure of BmKK4, the first member of subfamily alpha-KTx 17 of scorpion toxins Biochemistry, 43, 2004
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1PM3
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![BU of 1pm3 by Molmil](/molmil-images/mine/1pm3) | |
5JQE
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![BU of 5jqe by Molmil](/molmil-images/mine/5jqe) | Crystal structure of caspase8 tDED | Descriptor: | Sugar ABC transporter substrate-binding protein,Caspase-8 chimera | Authors: | Fu, T, Li, Y, Lu, A, Wu, H. | Deposit date: | 2016-05-04 | Release date: | 2016-10-26 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (3.157 Å) | Cite: | Cryo-EM Structure of Caspase-8 Tandem DED Filament Reveals Assembly and Regulation Mechanisms of the Death-Inducing Signaling Complex. Mol. Cell, 64, 2016
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8FK2
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![BU of 8fk2 by Molmil](/molmil-images/mine/8fk2) | The N-terminal VicR from Streptococcus mutans | Descriptor: | Putative response regulator CovR VicR-like protein | Authors: | Zhang, H, Wu, H. | Deposit date: | 2022-12-20 | Release date: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.29 Å) | Cite: | Small Molecule Attenuates Bacterial Virulence by Targeting Conserved Response Regulator. Mbio, 14, 2023
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5L08
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![BU of 5l08 by Molmil](/molmil-images/mine/5l08) | Cryo-EM structure of Casp-8 tDED filament | Descriptor: | Caspase-8 | Authors: | Fu, T.M, Li, Y, Lu, A, Wu, H. | Deposit date: | 2016-07-26 | Release date: | 2016-11-02 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (4.6 Å) | Cite: | Cryo-EM Structure of Caspase-8 Tandem DED Filament Reveals Assembly and Regulation Mechanisms of the Death-Inducing Signaling Complex. Mol.Cell, 64, 2016
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3FX0
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![BU of 3fx0 by Molmil](/molmil-images/mine/3fx0) | |