2I59
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![BU of 2i59 by Molmil](/molmil-images/mine/2i59) | Solution structure of RGS10 | Descriptor: | Regulator of G-protein signaling 10 | Authors: | Fedorov, O, Higman, V.A, Diehl, A, Leidert, M, Lemak, A, Schmieder, P, Oschkinat, H, Elkins, J, Soundarajan, M, Doyle, D.A, Arrowsmith, C, Sundstrom, M, Weigelt, J, Edwards, A, Ball, L.J, Structural Genomics Consortium (SGC) | Deposit date: | 2006-08-24 | Release date: | 2006-10-31 | Last modified: | 2024-05-08 | Method: | SOLUTION NMR | Cite: | Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits. Proc.Natl.Acad.Sci.Usa, 105, 2008
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3F3S
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![BU of 3f3s by Molmil](/molmil-images/mine/3f3s) | The Crystal Structure of Human Lambda-Crystallin, CRYL1 | Descriptor: | CHLORIDE ION, GLYCEROL, Lambda-crystallin homolog, ... | Authors: | Ugochukwu, E, Johansson, C, Yue, W.W, Kochan, G, Pilka, E, Kramm, A, Pike, A.C.W, Filippakopoulos, P, von Delft, F, Bountra, C, Arrowsmith, C.H, Weigelt, J, Edwards, A, Oppermann, U, Structural Genomics Consortium (SGC) | Deposit date: | 2008-10-31 | Release date: | 2008-11-25 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The Crystal Structure of Human Lambda-Crystallin, CRYL1 To be Published
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2J4E
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![BU of 2j4e by Molmil](/molmil-images/mine/2j4e) | THE ITP COMPLEX OF HUMAN INOSINE TRIPHOSPHATASE | Descriptor: | INOSINE 5'-TRIPHOSPHATE, INOSINE TRIPHOSPHATE PYROPHOSPHATASE, INOSINIC ACID, ... | Authors: | Stenmark, P, Kursula, P, Arrowsmith, C, Berglund, H, Busam, R, Collins, R, Edwards, A, Ehn, M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Hallberg, B.M, Holmbergschiavone, L, Hogbom, M, Kotenyova, T, Landry, R, Loppnau, P, Magnusdottir, A, Nilsson-Ehle, P, Nyman, T, Ogg, D, Persson, C, Sagemark, J, Sundstrom, M, Uppenberg, J, Thorsell, A.G, Schuler, H, Van Den Berg, S, Wallden, K, Weigelt, J, Nordlund, P. | Deposit date: | 2006-08-29 | Release date: | 2006-09-20 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal Structure of Human Inosine Triphosphatase: Substrate Binding and Implication of the Inosine Triphosphatase Deficiency Mutation P32T. J.Biol.Chem., 282, 2007
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3FLV
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![BU of 3flv by Molmil](/molmil-images/mine/3flv) | The crystal structure of human acyl-CoenzymeA binding domain containing 5 | Descriptor: | Acyl-CoA-binding domain-containing protein 5, COENZYME A, STEARIC ACID, ... | Authors: | Ugochukwu, E, Roos, A, Yue, W.W, Shafqat, N, Salah, E, Savitsky, P, Muniz, J.R.C, von Delft, F, Bountra, C, Arrowsmith, C.H, Weigelt, J, Edwards, A, Oppermann, U, Structural Genomics Consortium (SGC) | Deposit date: | 2008-12-19 | Release date: | 2009-02-03 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | The crystal structure of human acyl-Coenzyme A binding domain containing 5 To be Published
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3FUY
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![BU of 3fuy by Molmil](/molmil-images/mine/3fuy) | Structure from the mobile metagenome of Cole Harbour Salt Marsh: Integron Cassette Protein HFX_CASS1 | Descriptor: | Putative integron gene cassette protein, SULFATE ION | Authors: | Sureshan, V, Deshpande, C.N, Harrop, S.J, Kudrytska, M, Koenig, J.E, Evdokimova, E, Osipiuk, J, Edwards, A, Savchenko, A, Joachimiak, A, Doolittle, W.F, Stokes, H.W, Curmi, P.M.G, Mabbutt, B.C, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2009-01-15 | Release date: | 2009-02-24 | Last modified: | 2013-02-06 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Integron gene cassettes: a repository of novel protein folds with distinct interaction sites Plos One, 8, 2013
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2JRZ
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![BU of 2jrz by Molmil](/molmil-images/mine/2jrz) | Solution structure of the Bright/ARID domain from the human JARID1C protein. | Descriptor: | Histone demethylase JARID1C | Authors: | Koehler, C, Bishop, S, Dowler, E.F, Diehl, A, Schmieder, P, Leidert, M, Sundstrom, M, Arrowsmith, C.H, Wiegelt, J, Edwards, A, Oschkinat, H, Ball, L.J, Structural Genomics Consortium (SGC) | Deposit date: | 2007-06-29 | Release date: | 2007-07-10 | Last modified: | 2024-05-08 | Method: | SOLUTION NMR | Cite: | Backbone and sidechain 1H, 13C and 15N resonance assignments of the Bright/ARID domain from the human JARID1C (SMCX) protein. Biomol.Nmr Assign., 2, 2008
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2JC9
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![BU of 2jc9 by Molmil](/molmil-images/mine/2jc9) | Crystal structure of Human Cytosolic 5'-Nucleotidase II in complex with adenosine | Descriptor: | ADENOSINE, CYTOSOLIC PURINE 5'-NUCLEOTIDASE, GLYCEROL, ... | Authors: | Wallden, K, Stenmark, P, Arrowsmith, C, Berglund, H, Busam, R, Collins, R, Edwards, A, Ehn, M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Hallberg, B.M, Holmberg, S.L, Hogbom, M, Karlberg, T, Kotenyova, T, Magnusdottir, A, Nilsson-Ehle, P, Nyman, T, Ogg, D, Persson, C, Sagemark, J, Sundstrom, M, Uppenberg, J, Thorsell, A.G, Van Den Berg, S, Loppnau, P, Weigelt, J, Welin, M, Nordlund, P. | Deposit date: | 2006-12-21 | Release date: | 2007-01-02 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Crystal Structure of Human Cytosolic 5'-Nucleotidase II: Insights Into Allosteric Regulation and Substrate Recognition J.Biol.Chem., 282, 2007
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2KFV
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![BU of 2kfv by Molmil](/molmil-images/mine/2kfv) | Structure of the amino-terminal domain of human FK506-binding protein 3 / Northeast Structural Genomics Consortium Target HT99A | Descriptor: | FK506-binding protein 3 | Authors: | Sunnerhagen, M, Davis, T, Gutmanas, A, Fares, C, Ouyang, H, Lemak, A, Li, Y, Weigelt, J, Bountra, C, Edwards, A, Arrowsmith, C.H, Dhe-Paganon, S, Northeast Structural Genomics Consortium (NESG), Structural Genomics Consortium (SGC) | Deposit date: | 2009-02-27 | Release date: | 2009-06-23 | Last modified: | 2024-05-08 | Method: | SOLUTION NMR | Cite: | Structure of the N-terminal domain of FK506-binding protein 3 To be Published
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3FY6
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![BU of 3fy6 by Molmil](/molmil-images/mine/3fy6) | Structure from the mobile metagenome of V. Cholerae. Integron cassette protein VCH_CASS3 | Descriptor: | Integron cassette protein | Authors: | Deshpande, C.N, Sureshan, V, Harrop, S.J, Boucher, Y, Xu, X, Cui, H, Edwards, A, Savchenko, A, Joachimiak, A, Tan, K, Stokes, H.W, Curmi, P.M.G, Mabbutt, B.C, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2009-01-21 | Release date: | 2009-02-10 | Last modified: | 2013-03-27 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Integron gene cassettes: a repository of novel protein folds with distinct interaction sites. Plos One, 8, 2013
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2J2C
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![BU of 2j2c by Molmil](/molmil-images/mine/2j2c) | Crystal structure of Human Cytosolic 5'-Nucleotidase II (NT5C2, cN-II) | Descriptor: | CYTOSOLIC PURINE 5'-NUCLEOTIDASE, GLYCEROL, MAGNESIUM ION, ... | Authors: | Wallden, K, Stenmark, P, Arrowsmith, C, Berglund, H, Busam, R, Collins, R, Edwards, A, Ehn, M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Hallberg, B.M, Holmberg Schiavone, L, Hogbom, M, Karlberg, T, Kotenyova, T, Loppnau, P, Magnusdottir, A, Nilsson-Ehle, P, Nyman, T, Ogg, D, Persson, C, Sagemark, J, Sundstrom, M, Uppenberg, J, Thorsell, A.G, Van Den Berg, S, Weigelt, J, Welin, M, Nordlund, P. | Deposit date: | 2006-08-16 | Release date: | 2006-09-19 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal Structure of Human Cytosolic 5'- Nucleotidase II: Insights Into Allosteric Regulation and Substrate Recognition J.Biol.Chem., 282, 2007
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2HE7
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![BU of 2he7 by Molmil](/molmil-images/mine/2he7) | FERM domain of EPB41L3 (DAL-1) | Descriptor: | Band 4.1-like protein 3 | Authors: | Hallberg, B.M, Busam, R.D, Arrowsmith, C, Berglund, H, Collins, R, Edwards, A, Ehn, M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Schiavone, L.H, Johansson, I, Hogbom, M, Karlberg, T, Kotenyova, T, Nilvebrandt, J, Norberg, P, Stenmark, P, Nordlund, P, Nilsson-ehle, P, Nyman, T, Ogg, D, Sagemark, J, Sundstrom, M, Uppenberg, J, Van den berg, S, Weigelt, J, Persson, C, Thorsell, A.G, Structural Genomics Consortium (SGC) | Deposit date: | 2006-06-21 | Release date: | 2006-07-04 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis of tumor suppressor in lung cancer 1 (TSLC1) binding to differentially expressed in adenocarcinoma of the lung (DAL-1/4.1B). J.Biol.Chem., 286, 2011
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3RNJ
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![BU of 3rnj by Molmil](/molmil-images/mine/3rnj) | Crystal structure of the SH3 domain from IRSp53 (BAIAP2) | Descriptor: | 1,2-ETHANEDIOL, Brain-specific angiogenesis inhibitor 1-associated protein 2, ISOPROPYL ALCOHOL, ... | Authors: | Simister, P.C, Barilari, M, Muniz, J.R.C, Dente, L, Knapp, S, von Delft, F, Filippakopoulos, P, Vollmar, M, Chaikuad, A, Raynor, J, Tregubova, A, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Feller, S.M, Structural Genomics Consortium (SGC) | Deposit date: | 2011-04-22 | Release date: | 2011-05-04 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Crystal structure of the SH3 domain from IRSp53 (BAIAP2) To be Published
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5BOT
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![BU of 5bot by Molmil](/molmil-images/mine/5bot) | |
5BOY
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![BU of 5boy by Molmil](/molmil-images/mine/5boy) | |
2I75
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![BU of 2i75 by Molmil](/molmil-images/mine/2i75) | Crystal Structure of Human Protein Tyrosine Phosphatase N4 (PTPN4) | Descriptor: | SULFATE ION, Tyrosine-protein phosphatase non-receptor type 4 | Authors: | Ugochukwu, E, Barr, A, Savitsky, P, Burgess, N, Das, S, Turnbull, A, von Delft, F, Sundstrom, M, Edwards, A, Arrowsmith, C, Weigelt, J, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2006-08-30 | Release date: | 2006-10-17 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Large-scale structural analysis of the classical human protein tyrosine phosphatome. Cell(Cambridge,Mass.), 136, 2009
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1U60
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![BU of 1u60 by Molmil](/molmil-images/mine/1u60) | MCSG APC5046 Probable glutaminase ybaS | Descriptor: | 1,2-ETHANEDIOL, FORMIC ACID, Probable glutaminase ybaS | Authors: | Chang, C, Cuff, M.E, Joachimiak, A, Savchenko, A, Edwards, A, Skarina, T, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2004-07-28 | Release date: | 2004-09-07 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.61 Å) | Cite: | Functional and structural characterization of four glutaminases from Escherichia coli and Bacillus subtilis. Biochemistry, 47, 2008
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2HWG
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![BU of 2hwg by Molmil](/molmil-images/mine/2hwg) | Structure of phosphorylated Enzyme I of the phosphoenolpyruvate:sugar phosphotransferase system | Descriptor: | MAGNESIUM ION, OXALATE ION, Phosphoenolpyruvate-protein phosphotransferase | Authors: | Lim, K, Teplyakov, A, Herzberg, O. | Deposit date: | 2006-08-01 | Release date: | 2006-11-14 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structure of phosphorylated enzyme I, the phosphoenolpyruvate:sugar phosphotransferase system sugar translocation signal protein. Proc.Natl.Acad.Sci.Usa, 103, 2006
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2HW4
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![BU of 2hw4 by Molmil](/molmil-images/mine/2hw4) | Crystal structure of human phosphohistidine phosphatase | Descriptor: | 14 kDa phosphohistidine phosphatase, FORMIC ACID | Authors: | Busam, R.D, Thorsell, A.G, Arrowsmith, C, Berglund, H, Collins, R, Edwards, A, Ehn, M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Holmberg Schiavone, L, Hogbom, M, Kotenyova, T, Nilsson-Ehle, P, Nordlund, P, Nyman, T, Ogg, D, Stenmark, P, Sundstrom, M, Uppenberg, J, Van Den Berg, S, Weigelt, J, Persson, C, Hallberg, B.M, Structural Genomics Consortium (SGC) | Deposit date: | 2006-07-31 | Release date: | 2006-08-29 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | First structure of a eukaryotic phosphohistidine phosphatase J.Biol.Chem., 281, 2006
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3GZC
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![BU of 3gzc by Molmil](/molmil-images/mine/3gzc) | Structure of human selenocysteine lyase | Descriptor: | (5-HYDROXY-4,6-DIMETHYLPYRIDIN-3-YL)METHYL DIHYDROGEN PHOSPHATE, Selenocysteine lyase | Authors: | Collins, R, Hogbom, M, Arrowsmith, C, Berglund, H, Edwards, A, Ehn, M, Flodin, S, Flores, A, Graslund, S, Hallberg, B.M, Hammarstrom, M, Karlberg, T, Kotenyova, T, Nilsson-Ehle, P, Nordlund, P, Nyman, T, Ogg, D, Persson, C, Sagemark, J, Stenmark, P, Sundstrom, M, Thorsell, A.G, Uppenberg, J, Van Den Berg, S, Weigelt, J, Holmberg-Schiavone, L, Schuler, H, Structural Genomics Consortium (SGC) | Deposit date: | 2009-04-07 | Release date: | 2009-04-28 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Biochemical discrimination between selenium and sulfur 1: a single residue provides selenium specificity to human selenocysteine lyase. Plos One, 7, 2012
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2GSE
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![BU of 2gse by Molmil](/molmil-images/mine/2gse) | Crystal Structure of Human Dihydropyrimidinease-like 2 | Descriptor: | CALCIUM ION, Dihydropyrimidinase-related protein 2 | Authors: | Ogg, D, Stenmark, P, Arrowsmith, C, Berglund, H, Collins, R, Edwards, A, Ehn, M, Flodin, S, Flores, A, Graslund, S, Hallberg, B.M, Hammarstrom, M, Kotenyova, T, Kursula, P, Nilsson-Ehle, P, Nyman, T, Persson, C, Sagemark, J, Sundstrom, M, Holmberg-Schiavone, L, Thorsell, A.G, Uppenberg, J, Van Den Berg, S, Weigelt, J, Nordlund, P, Structural Genomics Consortium (SGC) | Deposit date: | 2006-04-26 | Release date: | 2006-05-09 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | The structure of human collapsin response mediator protein 2, a regulator of axonal growth. J.Neurochem., 101, 2007
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2JFD
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![BU of 2jfd by Molmil](/molmil-images/mine/2jfd) | Structure of the MAT domain of human FAS | Descriptor: | FATTY ACID SYNTHASE | Authors: | Bunkoczi, G, Kavanagh, K, Hozjan, V, Rojkova, A, Wu, X, Arrowsmith, C.H, Edwards, A, Sundstrom, M, Weigelt, J, Smith, S, Oppermann, U. | Deposit date: | 2007-01-31 | Release date: | 2007-02-13 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.81 Å) | Cite: | Structural basis for different specificities of acyltransferases associated with the human cytosolic and mitochondrial fatty acid synthases. Chem. Biol., 16, 2009
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2J6L
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![BU of 2j6l by Molmil](/molmil-images/mine/2j6l) | Structure of aminoadipate-semialdehyde dehydrogenase | Descriptor: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, ALDEHYDE DEHYDROGENASE FAMILY 7 MEMBER A1, BROMIDE ION, ... | Authors: | Bunkoczi, G, Guo, K, Debreczeni, J.E, Smee, C, Arrowsmith, C, Edwards, A, Sundstrom, M, Weigelt, J, von Delft, F, Oppermann, U. | Deposit date: | 2006-09-29 | Release date: | 2006-10-12 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Aldehyde Dehydrogenase 7A1 (Aldh7A1) is a Novel Enzyme Involved in Cellular Defense Against Hyperosmotic Stress. J.Biol.Chem., 285, 2010
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2J51
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![BU of 2j51 by Molmil](/molmil-images/mine/2j51) | Crystal structure of Human STE20-like kinase bound to 5-Amino-3-((4-(aminosulfonyl)phenyl)amino) -N-(2,6-difluorophenyl)-1H-1,2,4-triazole- 1-carbothioamide | Descriptor: | 1,2-ETHANEDIOL, 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE, STE20-LIKE SERINE/THREONINE-PROTEIN KINASE, ... | Authors: | Pike, A.C.W, Rellos, P, Fedorov, O, Keates, T, Salah, E, Savitsky, P, Papagrigoriou, E, Turnbull, A.P, Debreczeni, J.E, von Delft, F, Arrowsmith, C, Edwards, A, Weigelt, J, Sundstrom, M, Knapp, S. | Deposit date: | 2006-09-08 | Release date: | 2006-10-03 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Activation Segment Dimerization: A Mechanism for Kinase Autophosphorylation of Non-Consensus Sites. Embo J., 27, 2008
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2BIJ
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![BU of 2bij by Molmil](/molmil-images/mine/2bij) | Crystal structure of the human protein tyrosine phosphatase PTPN5 (STEP, striatum enriched enriched Phosphatase) | Descriptor: | SULFATE ION, TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 5 | Authors: | Barr, A.J, Debreczeni, J.E, Eswaran, J, Smee, C, Burgess, N, Gileadi, O, Sundstrom, M, Arrowsmith, C, Edwards, A, Knapp, S, von Delft, F. | Deposit date: | 2005-01-21 | Release date: | 2005-03-17 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases. Biochem. J., 395, 2006
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2J90
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![BU of 2j90 by Molmil](/molmil-images/mine/2j90) | Crystal structure of human ZIP kinase in complex with a tetracyclic pyridone inhibitor (Pyridone 6) | Descriptor: | 1,2-ETHANEDIOL, 2-TERT-BUTYL-9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLINE-7-ONE, CHLORIDE ION, ... | Authors: | Turnbull, A.P, Berridge, G, Fedorov, O, Pike, A.C.W, Savitsky, P, Eswaran, J, Papagrigoriou, E, Ugochukwa, E, von Delft, F, Gileadi, O, Arrowsmith, C.H, Edwards, A, Weigelt, J, Sundstrom, M, Knapp, S. | Deposit date: | 2006-10-31 | Release date: | 2006-11-07 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Activation Segment Dimerization: A Mechanism for Kinase Autophosphorylation of Non-Consensus Sites. Embo J., 27, 2008
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