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Crystal structure of phosphorylated SNF1 kinase domain
Descriptor:	Carbon catabolite-derepressing protein kinase
Authors:	Zheng, L.-S, Chen, L, Jiao, Z.-H, Wu, J.-W.
Deposit date:	2008-05-29
Release date:	2009-06-02
Last modified:	2023-11-01
Method:	X-RAY DIFFRACTION (2.899 Å)
Cite:	Structural insight into the autoinhibition mechanism of AMP-activated protein kinase Nature, 459, 2009

5TDL

Crystal structure of prefusion-stabilized bovine RSV fusion glycoprotein (single-chain DS2-v1 variant: strain 391-2 sc9 DS-Cav1 Q98C Q361C)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Bovine prefusion RSV F glycoprotein
Authors:	Chen, L, Zhang, B, Kwong, P.D.
Deposit date:	2016-09-19
Release date:	2017-08-16
Last modified:	2020-07-29
Method:	X-RAY DIFFRACTION (3.5 Å)
Cite:	Protection of calves by a prefusion-stabilized bovine RSV F vaccine. NPJ Vaccines, 2, 2017

2LOZ

The novel binding mode of DLC1 and Tensin2 PTB domain
Descriptor:	Rho GTPase-activating protein 7, Tensin-like C1 domain-containing phosphatase
Authors:	Liu, C, Chen, L, Zhu, G.
Deposit date:	2012-01-29
Release date:	2012-06-06
Last modified:	2024-05-15
Method:	SOLUTION NMR
Cite:	Solution structure of the phosphotyrosine binding (PTB) domain of human tensin2 protein in complex with deleted in liver cancer 1 (DLC1) peptide reveals a novel peptide binding mode. J.Biol.Chem., 287, 2012

3MQ0

Crystal Structure of Agobacterium tumefaciens repressor BlcR
Descriptor:	Transcriptional repressor of the blcABC operon
Authors:	Chen, L.
Deposit date:	2010-04-27
Release date:	2011-03-30
Last modified:	2024-02-21
Method:	X-RAY DIFFRACTION (1.793 Å)
Cite:	The Agrobacterium tumefaciens Transcription Factor BlcR Is Regulated via Oligomerization. J.Biol.Chem., 286, 2011

3RPT

Crystal structure of the anti-HIV b12 scaffold protein
Descriptor:	Endoglucanase E-2, SULFATE ION
Authors:	Chen, L, Kwong, P.D.
Deposit date:	2011-04-27
Release date:	2011-12-21
Last modified:	2017-07-26
Method:	X-RAY DIFFRACTION (1.303 Å)
Cite:	Computation-guided backbone grafting of a discontinuous motif onto a protein scaffold. Science, 334, 2011

7L7S

Human mitochondrial chaperonin mHsp60
Descriptor:	60 kDa heat shock protein, mitochondrial
Authors:	Chen, L, Wang, J.C.Y.
Deposit date:	2020-12-30
Release date:	2021-08-25
Last modified:	2024-05-29
Method:	ELECTRON MICROSCOPY (3.5 Å)
Cite:	Structural basis for the structural dynamics of human mitochondrial chaperonin mHsp60. Sci Rep, 11, 2021

3RJ2

Structural and functional characterization of a novel histone H3 binding protein ORF158L from the Singapore grouper iridovirus (SGIV)
Descriptor:	Putative uncharacterized protein
Authors:	Chen, L, Liu, Y, Sivaraman, J, Hew, C.L.
Deposit date:	2011-04-15
Release date:	2012-02-29
Last modified:	2024-03-20
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	Novel histone H3 binding protein ORF158L from the Singapore grouper iridovirus J.Virol., 85, 2011

8J1N

Structure of human UCP1 in the DNP-bound state
Descriptor:	1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2,4-DINITROPHENOL, CARDIOLIPIN, ...
Authors:	Chen, L, Kang, Y.
Deposit date:	2023-04-13
Release date:	2023-06-21
Last modified:	2023-08-30
Method:	ELECTRON MICROSCOPY (2.51 Å)
Cite:	Structural basis for the binding of DNP and purine nucleotides onto UCP1. Nature, 620, 2023

5YKF

Structure of pancreatic ATP-sensitive potassium channel bound with glibenclamide and ATPgammaS (3D class1 at 4.33A)
Descriptor:	5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, ...
Authors:	Chen, L, Wu, J.X.
Deposit date:	2017-10-14
Release date:	2018-04-18
Last modified:	2019-11-06
Method:	ELECTRON MICROSCOPY (4.33 Å)
Cite:	Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels. Protein Cell, 9, 2018

5YKG

Structure of pancreatic ATP-sensitive potassium channel bound with glibenclamide and ATPgammaS (Class2 at 4.57A)
Descriptor:	5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, ...
Authors:	Chen, L, Wu, J.X.
Deposit date:	2017-10-14
Release date:	2018-04-18
Last modified:	2018-06-13
Method:	ELECTRON MICROSCOPY (4.57 Å)
Cite:	Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels. Protein Cell, 9, 2018

5YKE

Structure of pancreatic ATP-sensitive potassium channel bound with glibenclamide and ATPgammaS (focused refinement on TM at 4.11A)
Descriptor:	5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11
Authors:	Chen, L, Wu, J.X.
Deposit date:	2017-10-14
Release date:	2018-04-18
Last modified:	2018-06-13
Method:	ELECTRON MICROSCOPY (4.11 Å)
Cite:	Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels. Protein Cell, 9, 2018

5YWC

Structure of pancreatic ATP-sensitive potassium channel bound with Mg-ADP (CTD class1 at 4.3A)
Descriptor:	ADENOSINE-5'-DIPHOSPHATE, ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, ...
Authors:	Chen, L, Wu, J.X.
Deposit date:	2017-11-29
Release date:	2018-05-02
Last modified:	2018-06-13
Method:	ELECTRON MICROSCOPY (4.3 Å)
Cite:	Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels. Protein Cell, 9, 2018

5YW9

Structure of pancreatic ATP-sensitive potassium channel bound with ATPgammaS (class1 5.0A)
Descriptor:	ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER
Authors:	Chen, L, Wu, J.X.
Deposit date:	2017-11-29
Release date:	2018-05-02
Last modified:	2018-06-13
Method:	ELECTRON MICROSCOPY (5 Å)
Cite:	Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels. Protein Cell, 9, 2018

5YWB

Structure of pancreatic ATP-sensitive potassium channel bound with Mg-ADP (CTD class2 at 5.2A)
Descriptor:	ADENOSINE-5'-DIPHOSPHATE, ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, ...
Authors:	Chen, L, Wu, J.X.
Deposit date:	2017-11-29
Release date:	2018-05-30
Last modified:	2019-11-06
Method:	ELECTRON MICROSCOPY (5.2 Å)
Cite:	Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels. Protein Cell, 9, 2018

5YW8

Structure of pancreatic ATP-sensitive potassium channel bound with ATPgammaS (all particles at 4.4A)
Descriptor:	ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER
Authors:	Chen, L, Wu, J.X.
Deposit date:	2017-11-29
Release date:	2018-05-02
Last modified:	2018-06-13
Method:	ELECTRON MICROSCOPY (4.4 Å)
Cite:	Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels. Protein Cell, 9, 2018

5Z1F

Structure of atOSCA3.1 channel
Descriptor:	CSC1-like protein ERD4
Authors:	Chen, L, Zhang, M, Kang, Y, Wu, J.X.
Deposit date:	2017-12-26
Release date:	2018-09-12
Last modified:	2024-03-27
Method:	ELECTRON MICROSCOPY (4.8 Å)
Cite:	Structure of the mechanosensitive OSCA channels. Nat. Struct. Mol. Biol., 25, 2018

5YWD

Structure of pancreatic ATP-sensitive potassium channel bound with Mg-ADP (focused refinement of SUR1 ABC transporter module at 4.22A)
Descriptor:	ADENOSINE-5'-DIPHOSPHATE, ATP-binding cassette sub-family C member 8 isoform X2, MAGNESIUM ION
Authors:	Chen, L, Wu, J.X.
Deposit date:	2017-11-29
Release date:	2018-05-02
Last modified:	2024-03-27
Method:	ELECTRON MICROSCOPY (4.2 Å)
Cite:	Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels. Protein Cell, 9, 2018

5YW7

Structure of pancreatic ATP-sensitive potassium channel bound with glibenclamide and ATPgammaS (focused refinement on SUR1 ABC transporter module at 4.4A)
Descriptor:	5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, ATP-binding cassette sub-family C member 8 isoform X2, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER
Authors:	Chen, L, Wu, J.X.
Deposit date:	2017-11-29
Release date:	2018-05-02
Last modified:	2024-03-27
Method:	ELECTRON MICROSCOPY (4.4 Å)
Cite:	Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels. Protein Cell, 9, 2018

5YWA

Structure of pancreatic ATP-sensitive potassium channel bound with ATPgammaS (CTD class 2 at 6.1A)
Descriptor:	ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER
Authors:	Chen, L, Wu, J.X.
Deposit date:	2017-11-29
Release date:	2018-05-02
Last modified:	2018-06-13
Method:	ELECTRON MICROSCOPY (6.1 Å)
Cite:	Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels. Protein Cell, 9, 2018

7E3X

Crystal structure of SDR family NAD(P)-dependent oxidoreductase from exiguobacterium
Descriptor:	NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Oxidoreductase
Authors:	Chen, L, Tang, J, Yuan, S, Zhang, F, Chen, S.
Deposit date:	2021-02-09
Release date:	2021-09-29
Last modified:	2023-11-29
Method:	X-RAY DIFFRACTION (2.58 Å)
Cite:	Structure-guided evolution of a ketoreductase forefficient and stereoselective bioreduction of bulkyalpha-aminobeta-keto esters Catalysis Science And Technology, 2021

8K5G

Structure of the SARS-CoV-2 BA.1 RBD with UT28-RD
Descriptor:	Spike protein S1, UT28K-RD Fab Heavy chain, UT28K-RD Fab Light chain
Authors:	Chen, L, Kita, S, Anraku, Y, Maenaka, K.
Deposit date:	2023-07-21
Release date:	2023-12-27
Method:	ELECTRON MICROSCOPY (3.41 Å)
Cite:	In silico-designed UT28K with two amino acid substitutions is capable of neutralization of resistant SARS-CoV2 Omicrons BA.1 valiant. To Be Published

8K5H

Structure of the SARS-CoV-2 BA.1 spike with UT28-RD
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ...
Authors:	Chen, L, Kita, S, Anraku, Y, Maenaka, K.
Deposit date:	2023-07-21
Release date:	2023-12-27
Method:	ELECTRON MICROSCOPY (3.22 Å)
Cite:	In silico-designed UT28K with two amino acid substitutions is capable of neutralization of resistant SARS-CoV2 Omicrons BA.1 valiant. To Be Published

6JB1

Structure of pancreatic ATP-sensitive potassium channel bound with repaglinide and ATPgammaS at 3.3A resolution
Descriptor:	(2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, ...
Authors:	Chen, L, Ding, D, Wang, M, Wu, J.-X, Kang, Y.
Deposit date:	2019-01-25
Release date:	2019-05-22
Last modified:	2021-09-29
Method:	ELECTRON MICROSCOPY (3.3 Å)
Cite:	The Structural Basis for the Binding of Repaglinide to the Pancreatic KATPChannel. Cell Rep, 27, 2019

6JPF

Structure of atOSCA1.1 channel at 3.52A
Descriptor:	Protein OSCA1
Authors:	Chen, L, Zhang, M, Kang, Y, Wu, J.X.
Deposit date:	2019-03-26
Release date:	2019-04-10
Last modified:	2024-03-27
Method:	ELECTRON MICROSCOPY (3.52 Å)
Cite:	Structure of the mechanosensitive OSCA channels. Nat. Struct. Mol. Biol., 25, 2018

6JB3

Structure of SUR1 subunit bound with repaglinide
Descriptor:	ATP-binding cassette sub-family C member 8 isoform X2, Digitonin, Repaglinide
Authors:	Chen, L, Ding, D, Wang, M, Wu, J.-X, Kang, Y.
Deposit date:	2019-01-25
Release date:	2019-05-22
Last modified:	2024-05-29
Method:	ELECTRON MICROSCOPY (3.53 Å)
Cite:	The Structural Basis for the Binding of Repaglinide to the Pancreatic KATPChannel. Cell Rep, 27, 2019

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