8U39

Structure of Human Mitochondrial Chaperonin V72I mutant

Summary for 8U39

• Entry DOI: 10.2210/pdb8u39/pdb
• EMDB information: 41854
• Descriptor: 60 kDa heat shock protein, mitochondrial (1 entity in total)
• Functional Keywords: chaperonin, human mitochondrial mhsp60, hereditary spastic paraplegia spg13, cryo-em, molecular dynamic simulation, chaperone
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 7
• Total formula weight: 391126.15

Authors

Chen, L.,Wang, J. (deposition date: 2023-09-07, release date: 2024-08-14)

• Primary citation: Syed, A.,Zhai, J.,Guo, B.,Zhao, Y.,Wang, J.C.,Chen, L.; Cryo-EM structure and molecular dynamic simulations explain the enhanced stability and ATP activity of the pathological chaperonin mutant.; Structure, 32:575-584.e3, 2024; PubMed: 38412855; DOI: 10.1016/j.str.2024.02.001

Experimental method