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2ZSJ
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BU of 2zsj by Molmil
Crystal structure of threonine synthase from Aquifex aeolicus VF5
Descriptor: PYRIDOXAL-5'-PHOSPHATE, Threonine synthase
Authors:Mizutani, H, Kunishima, N.
Deposit date:2008-09-11
Release date:2008-10-21
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of threonine synthase from Aquifex aeolicus VF5
To be Published
2ZSG
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BU of 2zsg by Molmil
Crystal structure of X-Pro aminopeptidase from Thermotoga maritima MSB8
Descriptor: Aminopeptidase P, putative, CHLORIDE ION, ...
Authors:Mizutani, H, Kunishima, N.
Deposit date:2008-09-10
Release date:2008-10-14
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Crystal structure of X-Pro aminopeptidase from Thermotoga maritima MSB8
To be Published
2ZSM
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BU of 2zsm by Molmil
Crystal structure of glutamate-1-semialdehyde 2,1-aminomutase from Aeropyrum pernix, hexagonal form
Descriptor: 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, CHLORIDE ION, Glutamate-1-semialdehyde 2,1-aminomutase
Authors:Mizutani, H, Kunishima, N.
Deposit date:2008-09-17
Release date:2008-10-21
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of glutamate-1-semialdehyde 2,1-aminomutase from Aeropyrum pernix
To be Published
2ZSU
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BU of 2zsu by Molmil
Crystal structure of spermidine synthase from Pyrococcus horikoshii OT3, P1 form
Descriptor: 1-{4-[(3-aminopropyl)amino]butyl}guanidine, spermidine synthase
Authors:Mizutani, H, Kunishima, N.
Deposit date:2008-09-17
Release date:2008-10-21
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of spermidine synthase from Pyrococcus horikoshii OT3
To be Published
2ZSL
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BU of 2zsl by Molmil
Crystal structure of glutamate-1-semialdehyde 2,1-aminomutase from Aeropyrum pernix
Descriptor: 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, Glutamate-1-semialdehyde 2,1-aminomutase
Authors:Mizutani, H, Kunishima, N.
Deposit date:2008-09-17
Release date:2008-10-21
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of glutamate-1-semialdehyde 2,1-aminomutase from Aeropyrum pernix
To be Published
3W3J
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BU of 3w3j by Molmil
Crystal structure of human TLR8 in complex with CL097
Descriptor: 2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-4-amine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Tanji, H, Ohto, U, Shimizu, T.
Deposit date:2012-12-22
Release date:2013-04-03
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural reorganization of the Toll-like receptor 8 dimer induced by agonistic ligands
Science, 339, 2013
3W3G
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BU of 3w3g by Molmil
Crystal structure of human TLR8 (unliganded form)
Descriptor: (R,R)-2,3-BUTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Tanji, H, Ohto, U, Shimizu, T.
Deposit date:2012-12-21
Release date:2013-04-03
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural reorganization of the Toll-like receptor 8 dimer induced by agonistic ligands
Science, 339, 2013
3W3M
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BU of 3w3m by Molmil
Crystal structure of human TLR8 in complex with Resiquimod (R848) crystal form 2
Descriptor: 1-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol, 2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, ...
Authors:Tanji, H, Ohto, U, Shimizu, T.
Deposit date:2012-12-22
Release date:2013-04-03
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural reorganization of the Toll-like receptor 8 dimer induced by agonistic ligands
Science, 339, 2013
3W3K
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BU of 3w3k by Molmil
Crystal structure of human TLR8 in complex with CL075
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-propyl[1,3]thiazolo[4,5-c]quinolin-4-amine, ...
Authors:Tanji, H, Ohto, U, Shimizu, T.
Deposit date:2012-12-22
Release date:2013-04-03
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural reorganization of the Toll-like receptor 8 dimer induced by agonistic ligands
Science, 339, 2013
3W3N
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BU of 3w3n by Molmil
Crystal structure of human TLR8 in complex with Resiquimod (R848) crystal form 3
Descriptor: 1-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol, 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ...
Authors:Tanji, H, Ohto, U, Shimizu, T.
Deposit date:2012-12-22
Release date:2013-04-03
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural reorganization of the Toll-like receptor 8 dimer induced by agonistic ligands
Science, 339, 2013
3W3L
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BU of 3w3l by Molmil
Crystal structure of human TLR8 in complex with Resiquimod (R848) crystal form 1
Descriptor: 1-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol, 2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, ...
Authors:Tanji, H, Ohto, U, Shimizu, T.
Deposit date:2012-12-22
Release date:2013-04-03
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:Structural reorganization of the Toll-like receptor 8 dimer induced by agonistic ligands
Science, 339, 2013
4V60
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BU of 4v60 by Molmil
The structure of rat liver vault at 3.5 angstrom resolution
Descriptor: Major vault protein
Authors:Kato, K, Zhou, Y, Tanaka, H, Yao, M, Yamashita, E, Yoshimura, M, Tsukihara, T.
Deposit date:2008-10-24
Release date:2014-07-09
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:The structure of rat liver vault at 3.5 angstrom resolution
Science, 323, 2009
5Z14
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BU of 5z14 by Molmil
Crystal structure of human TLR8 in complex with CU-CPT9a
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(7-methoxyquinolin-4-yl)-2-methyl-phenol, ...
Authors:Tanji, H, Ohto, U, Shimizu, T.
Deposit date:2017-12-25
Release date:2018-07-04
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Inhibition of Toll-like Receptor 8 by Specifically Targeting a Unique Allosteric Site and Locking Its Resting State
To Be Published
7WKC
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BU of 7wkc by Molmil
A prototype protein nanocage minimized from carboxysomes with gated oxygen permeability
Descriptor: Carboxysome shell vertex protein CcmL
Authors:Tan, H, Yang, J.
Deposit date:2022-01-08
Release date:2022-02-16
Last modified:2024-05-15
Method:SOLID-STATE NMR
Cite:A prototype protein nanocage minimized from carboxysomes with gated oxygen permeability.
Proc.Natl.Acad.Sci.USA, 119, 2022
8H2U
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BU of 8h2u by Molmil
X-ray Structure of photosystem I-LHCI super complex from Chlamydomonas reinhardtii.
Descriptor: (3R,3'R,6S)-4,5-DIDEHYDRO-5,6-DIHYDRO-BETA,BETA-CAROTENE-3,3'-DIOL, (3S,5R,6S,3'S,5'R,6'S)-5,6,5',6'-DIEPOXY-5,6,5',6'- TETRAHYDRO-BETA,BETA-CAROTENE-3,3'-DIOL, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, ...
Authors:Tanaka, H, Kubota-Kawai, H, Misumi, Y, Kurisu, G.
Deposit date:2022-10-07
Release date:2023-06-14
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Three structures of PSI-LHCI from Chlamydomonas reinhardtii suggest a resting state re-activated by ferredoxin.
Biochim Biophys Acta Bioenerg, 1864, 2023
6KYA
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BU of 6kya by Molmil
Crystal structure of human TLR8 in complex TH1027
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[5-methylsulfanyl-4-(3,4,5-trimethylphenyl)-1,2,4-triazol-3-yl]propan-1-ol, ...
Authors:Tanji, H, Sakaniwa, K, Ohto, U, Shimizu, T.
Deposit date:2019-09-17
Release date:2020-05-27
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.89 Å)
Cite:Rationally Designed Small-Molecule Inhibitors Targeting an Unconventional Pocket on the TLR8 Protein-Protein Interface.
J.Med.Chem., 63, 2020
8JAH
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BU of 8jah by Molmil
Crystal structure of human CLEC12A C-type lectin domain
Descriptor: C-type lectin domain family 12 member A, POTASSIUM ION, SULFATE ION
Authors:Lei, Q, Tang, H, Dong, X.
Deposit date:2023-05-06
Release date:2024-03-13
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.58 Å)
Cite:Mechanistic insights into the C-type lectin receptor CLEC12A-mediated immune recognition of monosodium urate crystal.
J.Biol.Chem., 300, 2024
5AWB
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BU of 5awb by Molmil
Crystal structure of human TLR8 in complex with N1-3-aminomethylbenzyl (meta-amine)
Descriptor: 1-[[3-(aminomethyl)phenyl]methyl]-2-butyl-imidazo[4,5-c]quinolin-4-amine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Tanji, H, Ohto, U, Shimizu, T.
Deposit date:2015-07-03
Release date:2015-09-23
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure-Based Design of Human TLR8-Specific Agonists with Augmented Potency and Adjuvanticity.
J.Med.Chem., 58, 2015
5AWC
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BU of 5awc by Molmil
Crystal structure of human TLR8 in complex with MB-564
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-(4-azanylbutyl)-3-pentyl-quinolin-2-amine, ...
Authors:Tanji, H, Ohto, U, Shimizu, T.
Deposit date:2015-07-03
Release date:2016-07-20
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure-based Design of Human TLR8-specific Agonists with Augmented Potency and Adjuvanticity
To Be Published
5XX0
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BU of 5xx0 by Molmil
Crystal structure of the four N-terminal immunoglogulin domains of Sidekick-2 protein
Descriptor: Protein sidekick-2
Authors:Dong, Y, Tang, H, He, Y.
Deposit date:2017-06-30
Release date:2018-08-29
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Architecture of cell-cell adhesion mediated by sidekicks.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5AWD
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BU of 5awd by Molmil
Crystal structure of human TLR8 in complex with N1-4-aminomethylbenzyl (IMDQ)
Descriptor: 1-[[4-(aminomethyl)phenyl]methyl]-2-butyl-imidazo[4,5-c]quinolin-4-amine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Tanji, H, Ohto, U, Shimizu, T.
Deposit date:2015-07-03
Release date:2015-09-23
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structure-Based Design of Human TLR8-Specific Agonists with Augmented Potency and Adjuvanticity.
J.Med.Chem., 58, 2015
5AWA
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BU of 5awa by Molmil
Crystal structure of human TLR8 in complex with MB-568
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-[[3-(aminomethyl)phenyl]methyl]-3-pentyl-quinolin-2-amine, ...
Authors:Tanji, H, Ohto, U, Shimizu, T.
Deposit date:2015-07-03
Release date:2016-07-20
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure-based Design of Human TLR8-specific Agonists with Augmented Potency and Adjuvanticity
To Be Published
4R6A
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BU of 4r6a by Molmil
Crystal structure of human TLR8 in complex with Hybrid-2
Descriptor: 1-(4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)-2-methylpropan-2-ol, 2-acetamido-2-deoxy-beta-D-glucopyranose, Toll-like receptor 8, ...
Authors:Tanji, H, Ohto, U, Shimizu, T.
Deposit date:2014-08-22
Release date:2015-08-26
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Hybrid-2: AnImidazoquinoline Dual Toll-like receptor 7/8 Agonist that Potently Activates Cytokine Production by Human Newborn and Adult Leukocytes
To be Published
4QC0
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BU of 4qc0 by Molmil
Crystal structure of human TLR8 in complex with XG-1-236
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-butyl-2H-pyrazolo[3,4-c]quinolin-4-amine, Toll-like receptor 8, ...
Authors:Tanji, H, Ohto, U, Shimizu, T.
Deposit date:2014-05-09
Release date:2014-10-22
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Determinants of Activity at Human Toll-like Receptors 7 and 8: Quantitative Structure-Activity Relationship (QSAR) of Diverse Heterocyclic Scaffolds
J.Med.Chem., 57, 2014
4QBZ
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BU of 4qbz by Molmil
Crystal structure of human TLR8 in complex with DS-802
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-butyl[1,3]oxazolo[4,5-c]quinolin-4-amine, ...
Authors:Tanji, H, Ohto, U, Shimizu, T.
Deposit date:2014-05-09
Release date:2014-10-22
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (2 Å)
Cite:Determinants of Activity at Human Toll-like Receptors 7 and 8: Quantitative Structure-Activity Relationship (QSAR) of Diverse Heterocyclic Scaffolds
J.Med.Chem., 57, 2014

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數據於2024-10-16公開中

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