3W3K

Crystal structure of human TLR8 in complex with CL075

Summary for 3W3K

• Entry DOI: 10.2210/pdb3w3k/pdb
• Related: 3W3G 3W3J 3W3L 3W3M 3W3N
• Descriptor: Toll-like receptor 8, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• Functional Keywords: leucine rich repeat, rna, glycosylation, rna recognition, ssrna, receptor, rna receptor, innate immunity, rna binding, secreted, cl075, immune system
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 192138.87

Authors

Tanji, H.,Ohto, U.,Shimizu, T. (deposition date: 2012-12-22, release date: 2013-04-03, Last modification date: 2020-07-29)

• Primary citation: Tanji, H.,Ohto, U.,Shibata, T.,Miyake, K.,Shimizu, T.; Structural reorganization of the Toll-like receptor 8 dimer induced by agonistic ligands; Science, 339:1426-1429, 2013; PubMed: 23520111; DOI: 10.1126/science.1229159

Experimental method

X-RAY DIFFRACTION (2.3 Å)