3W3G

Crystal structure of human TLR8 (unliganded form)

Summary for 3W3G

Entry DOI	10.2210/pdb3w3g/pdb
Descriptor	Toll-like receptor 8, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
Functional Keywords	leucine rich repeat, rna, glycosylation, innate immunity, seceted, rna recognition, ssrna, receptor, rna receptor, rna binding, secreted, immune system
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	191330.05
Authors	Tanji, H.,Ohto, U.,Shimizu, T. (deposition date: 2012-12-21, release date: 2013-04-03, Last modification date: 2020-07-29)
Primary citation	Tanji, H.,Ohto, U.,Shibata, T.,Miyake, K.,Shimizu, T. Structural reorganization of the Toll-like receptor 8 dimer induced by agonistic ligands Science, 339:1426-1429, 2013 Cited by PubMed: 23520111 DOI: 10.1126/science.1229159 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation