2M00
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2MUV
| NOE-based model of the influenza A virus M2 (19-49) bound to drug 11 | Descriptor: | (3s,5s,7s)-N-[(5-bromothiophen-2-yl)methyl]tricyclo[3.3.1.1~3,7~]decan-1-aminium, Matrix protein 2 | Authors: | Wu, Y, Wang, J, DeGrado, W. | Deposit date: | 2014-09-18 | Release date: | 2014-12-24 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Flipping in the Pore: Discovery of Dual Inhibitors That Bind in Different Orientations to the Wild-Type versus the Amantadine-Resistant S31N Mutant of the Influenza A Virus M2 Proton Channel. J.Am.Chem.Soc., 136, 2014
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7E04
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7F6W
| Crystal structure of Saccharomyces cerevisiae lysyl-tRNA Synthetase | Descriptor: | 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, 5'-O-[(L-LYSYLAMINO)SULFONYL]ADENOSINE, Lysine--tRNA ligase | Authors: | Wu, S, Li, P, Hei, Z, Zheng, L, Wang, J, Fang, P. | Deposit date: | 2021-06-26 | Release date: | 2022-02-16 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.607 Å) | Cite: | Human lysyl-tRNA synthetase evolves a dynamic structure that can be stabilized by forming complex. Cell.Mol.Life Sci., 79, 2022
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2MUW
| NOE-based model of the influenza A virus N31S mutant (19-49) bound to drug 11 | Descriptor: | (3s,5s,7s)-N-[(5-bromothiophen-2-yl)methyl]tricyclo[3.3.1.1~3,7~]decan-1-aminium, Matrix protein 2 | Authors: | Wu, Y, Wang, J, DeGrado, W. | Deposit date: | 2014-09-18 | Release date: | 2014-12-24 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Flipping in the Pore: Discovery of Dual Inhibitors That Bind in Different Orientations to the Wild-Type versus the Amantadine-Resistant S31N Mutant of the Influenza A Virus M2 Proton Channel. J.Am.Chem.Soc., 136, 2014
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2LEO
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7EOZ
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2PZY
| Structure of MK2 Complexed with Compound 76 | Descriptor: | (4R)-N-[4-({[2-(DIMETHYLAMINO)ETHYL]AMINO}CARBONYL)-1,3-THIAZOL-2-YL]-4-METHYL-1-OXO-2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLINE-6-CARBOXAMIDE, MAP kinase-activated protein kinase 2, STAUROSPORINE | Authors: | White, A, Wu, J.P, Wang, J, Abeywardane, A, Andersen, D, Emmanuel, M, Gautschi, E, Goldberg, D.R, Kashem, M.A, Lukas, S, Mao, W, Martin, L, Morwick, T, Moss, N, Pargellis, C, Patel, U.R, Patnaude, L, Peet, G.W, Skow, D, Snow, R.J, Ward, Y, Werneburg, B. | Deposit date: | 2007-05-18 | Release date: | 2007-07-31 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | The discovery of carboline analogs as potent MAPKAP-K2 inhibitors Bioorg.Med.Chem.Lett., 17, 2007
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2LA9
| NMR structure of Pseudouridine_ASL_Tyr | Descriptor: | RNA (5'-R(*GP*GP*GP*GP*AP*CP*UP*GP*UP*AP*AP*AP*(PSU)P*CP*CP*CP*C)-3') | Authors: | Denmon, A.P, Wang, J, Nikonowicz, E.P. | Deposit date: | 2011-03-09 | Release date: | 2011-08-03 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Conformation Effects of Base Modification on the Anticodon Stem-Loop of Bacillus subtilis tRNA(Tyr). J.Mol.Biol., 412, 2011
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7DFV
| Cryo-EM structure of plant NLR RPP1 tetramer core part | Descriptor: | NAD+ hydrolase (NADase) | Authors: | Ma, S.C, Lapin, D, Liu, L, Sun, Y, Song, W, Zhang, X.X, Logemann, E, Yu, D.L, Wang, J, Jirschitzka, J, Han, Z.F, SchulzeLefert, P, Parker, J.E, Chai, J.J. | Deposit date: | 2020-11-10 | Release date: | 2020-12-16 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (2.99 Å) | Cite: | Direct pathogen-induced assembly of an NLR immune receptor complex to form a holoenzyme. Science, 370, 2020
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7CR0
| human KCNQ2 in apo state | Descriptor: | Potassium voltage-gated channel subfamily KQT member 2 | Authors: | Li, X, Lv, D, Wang, J, Ye, S, Guo, J. | Deposit date: | 2020-08-12 | Release date: | 2020-09-16 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Molecular basis for ligand activation of the human KCNQ2 channel. Cell Res., 31, 2021
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7CR3
| human KCNQ2-CaM in apo state | Descriptor: | Calmodulin-3, Potassium voltage-gated channel subfamily KQT member 2 | Authors: | Li, X, Lv, D, Wang, J, Ye, S, Guo, J. | Deposit date: | 2020-08-12 | Release date: | 2020-09-16 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Molecular basis for ligand activation of the human KCNQ2 channel. Cell Res., 31, 2021
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7CR2
| human KCNQ2 in complex with retigabine | Descriptor: | Potassium voltage-gated channel subfamily KQT member 2, ethyl N-[2-azanyl-4-[(4-fluorophenyl)methylamino]phenyl]carbamate | Authors: | Li, X, Lv, D, Wang, J, Ye, S, Guo, J. | Deposit date: | 2020-08-12 | Release date: | 2020-09-16 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Molecular basis for ligand activation of the human KCNQ2 channel. Cell Res., 31, 2021
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7CRC
| Cryo-EM structure of plant NLR RPP1 tetramer in complex with ATR1 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Avirulence protein ATR1, ... | Authors: | Ma, S.C, Lapin, D, Liu, L, Sun, Y, Song, W, Zhang, X.X, Logemann, E, Yu, D.L, Wang, J, Jirschitzka, J, Han, Z.F, SchulzeLefert, P, Parker, J.E, Chai, J.J. | Deposit date: | 2020-08-13 | Release date: | 2020-12-16 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.02 Å) | Cite: | Direct pathogen-induced assembly of an NLR immune receptor complex to form a holoenzyme. Science, 370, 2020
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7CR7
| human KCNQ2-CaM in complex with retigabine | Descriptor: | Calmodulin-3, Potassium voltage-gated channel subfamily KQT member 2, ethyl N-[2-azanyl-4-[(4-fluorophenyl)methylamino]phenyl]carbamate | Authors: | Li, X, Lv, D, Wang, J, Ye, S, Guo, J. | Deposit date: | 2020-08-12 | Release date: | 2020-09-16 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Molecular basis for ligand activation of the human KCNQ2 channel. Cell Res., 31, 2021
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7CR4
| human KCNQ2-CaM in complex with ztz240 | Descriptor: | Calmodulin-3, N-(6-chloranylpyridin-3-yl)-4-fluoranyl-benzamide, Potassium voltage-gated channel subfamily KQT member 2 | Authors: | Li, X, Lv, D, Wang, J, Ye, S, Guo, J. | Deposit date: | 2020-08-12 | Release date: | 2020-09-16 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Molecular basis for ligand activation of the human KCNQ2 channel. Cell Res., 31, 2021
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7CRB
| Cryo-EM structure of plant NLR RPP1 LRR-ID domain in complex with ATR1 | Descriptor: | Avirulence protein ATR1, NAD+ hydrolase (NADase) | Authors: | Ma, S.C, Lapin, D, Liu, L, Sun, Y, Song, W, Zhang, X.X, Logemann, E, Yu, D.L, Wang, J, Jirschitzka, J, Han, Z.F, SchulzeLefert, P, Parker, J.E, Chai, J.J. | Deposit date: | 2020-08-13 | Release date: | 2020-12-16 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.16 Å) | Cite: | Direct pathogen-induced assembly of an NLR immune receptor complex to form a holoenzyme. Science, 370, 2020
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7CR1
| human KCNQ2 in complex with ztz240 | Descriptor: | N-(6-chloranylpyridin-3-yl)-4-fluoranyl-benzamide, Potassium voltage-gated channel subfamily KQT member 2 | Authors: | Li, X, Lv, D, Wang, J, Ye, S, Guo, J. | Deposit date: | 2020-08-12 | Release date: | 2020-09-16 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Molecular basis for ligand activation of the human KCNQ2 channel. Cell Res., 31, 2021
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7C4U
| MicroED structure of orthorhombic Vancomycin at 1.2 A resolution | Descriptor: | CHLORIDE ION, Vancomycin, vancosamine-(1-2)-beta-D-glucopyranose | Authors: | Fan, Q, Zhou, H, Li, X, Wang, J. | Deposit date: | 2020-05-18 | Release date: | 2020-08-12 | Last modified: | 2021-03-17 | Method: | ELECTRON CRYSTALLOGRAPHY (1.2 Å) | Cite: | Precise Control Over Kinetics of Molecular Assembly: Production of Particles with Tunable Sizes and Crystalline Forms. Angew.Chem.Int.Ed.Engl., 59, 2020
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7C4V
| MicroED structure of anorthic Vancomycin at 1.05 A resolution | Descriptor: | CHLORIDE ION, Vancomycin, vancosamine-(1-2)-beta-D-glucopyranose | Authors: | Fan, Q, Zhou, H, Li, X, Wang, J. | Deposit date: | 2020-05-18 | Release date: | 2020-08-12 | Last modified: | 2023-11-29 | Method: | ELECTRON CRYSTALLOGRAPHY (1.05 Å) | Cite: | Precise Control Over Kinetics of Molecular Assembly: Production of Particles with Tunable Sizes and Crystalline Forms. Angew.Chem.Int.Ed.Engl., 59, 2020
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7E2M
| Crystal structure of the RWD domain of human GCN2 - 2 | Descriptor: | eIF-2-alpha kinase GCN2 | Authors: | Hei, Z, Zhou, J, Liu, Z, Wang, J, Fang, P. | Deposit date: | 2021-02-05 | Release date: | 2021-03-17 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Crystal structures reveal a novel dimer of the RWD domain of human general control nonderepressible 2. Biochem.Biophys.Res.Commun., 549, 2021
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7E2K
| Crystal structure of the RWD domain of human GCN2 - 1 | Descriptor: | eIF-2-alpha kinase GCN2 | Authors: | Hei, Z, Zhou, J, Liu, Z, Wang, J, Fang, P. | Deposit date: | 2021-02-05 | Release date: | 2021-03-17 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.041 Å) | Cite: | Crystal structures reveal a novel dimer of the RWD domain of human general control nonderepressible 2. Biochem.Biophys.Res.Commun., 549, 2021
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7EA9
| Crystal Structure of human lysyl-tRNA synthetase Y145H mutant | Descriptor: | 5'-O-[(L-LYSYLAMINO)SULFONYL]ADENOSINE, GLYCEROL, Lysine--tRNA ligase | Authors: | Wu, S, Hei, Z, Zheng, L, Zhou, J, Liu, Z, Wang, J, Fang, P. | Deposit date: | 2021-03-06 | Release date: | 2021-03-31 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural analyses of a human lysyl-tRNA synthetase mutant associated with autosomal recessive nonsyndromic hearing impairment. Biochem.Biophys.Res.Commun., 554, 2021
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7F4Y
| Crystal structure of replisomal dimer of DNA polymerase from bacteriophage RB69 with DNA duplexes | Descriptor: | 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*GP*AP*GP*CP*GP*GP*AP*CP*TP*GP*CP*TP*TP*AP*C)-3'), ... | Authors: | Youn, H.-S, Park, J, An, J.Y, Lee, Y, Eom, S.H, Wang, J. | Deposit date: | 2021-06-21 | Release date: | 2021-07-14 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure of New Binary and Ternary DNA Polymerase Complexes From Bacteriophage RB69. Front Mol Biosci, 8, 2021
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7CUN
| The structure of human Integrator-PP2A complex | Descriptor: | Integrator complex subunit 1, Integrator complex subunit 11, Integrator complex subunit 2, ... | Authors: | Zheng, H, Qi, Y, Liu, W, Li, J, Wang, J, Xu, Y. | Deposit date: | 2020-08-23 | Release date: | 2020-11-25 | Last modified: | 2020-12-09 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Identification of Integrator-PP2A complex (INTAC), an RNA polymerase II phosphatase. Science, 370, 2020
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