7BV4
 
 | | Crystal structure of STX17 LIR region in complex with GABARAP | | Descriptor: | DI(HYDROXYETHYL)ETHER, GLYCEROL, Gamma-aminobutyric acid receptor-associated protein, ... | | Authors: | Li, Y, Pan, L.F. | | Deposit date: | 2020-04-09 | | Release date: | 2020-09-02 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Decoding three distinct states of the Syntaxin17 SNARE motif in mediating autophagosome-lysosome fusion.
Proc.Natl.Acad.Sci.USA, 117, 2020
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7ROQ
 | | Alternative Structure of Human ABCA1 | | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Aller, S.G. | | Deposit date: | 2021-08-01 | | Release date: | 2022-01-19 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | Refined ABCA1 with Domain-swapped Regulatory Domains
Plos One, 2022
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5C9C
 | | CRYSTAL STRUCTURE OF BRAF(V600E) IN COMPLEX WITH LY3009120 COMPND | | Descriptor: | 1-(3,3-dimethylbutyl)-3-{2-fluoro-4-methyl-5-[7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl]phenyl}urea, CHLORIDE ION, Serine/threonine-protein kinase B-raf | | Authors: | Edwards, T, Abendroth, J, Chun, L. | | Deposit date: | 2015-06-26 | | Release date: | 2015-07-15 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Inhibition of RAF Isoforms and Active Dimers by LY3009120 Leads to Anti-tumor Activities in RAS or BRAF Mutant Cancers.
Cancer Cell, 28, 2015
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4GBY
 | | The structure of the MFS (major facilitator superfamily) proton:xylose symporter XylE bound to D-xylose | | Descriptor: | D-xylose-proton symporter, beta-D-xylopyranose, nonyl beta-D-glucopyranoside | | Authors: | Sun, L.F, Zeng, X, Yan, C.Y, Yan, N. | | Deposit date: | 2012-07-28 | | Release date: | 2012-10-17 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.808 Å) | | Cite: | Crystal structure of a bacterial homologue of glucose transporters GLUT1-4.
Nature, 490, 2012
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4GBZ
 | | The structure of the MFS (major facilitator superfamily) proton:xylose symporter XylE bound to D-glucose | | Descriptor: | D-xylose-proton symporter, beta-D-glucopyranose, nonyl beta-D-glucopyranoside | | Authors: | Sun, L.F, Zeng, X, Yan, C.Y, Yan, N. | | Deposit date: | 2012-07-28 | | Release date: | 2012-10-17 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.894 Å) | | Cite: | Crystal structure of a bacterial homologue of glucose transporters GLUT1-4.
Nature, 490, 2012
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4GC0
 | | The structure of the MFS (major facilitator superfamily) proton:xylose symporter XylE bound to 6-bromo-6-deoxy-D-glucose | | Descriptor: | 6-bromo-6-deoxy-beta-D-glucopyranose, D-xylose-proton symporter, nonyl beta-D-glucopyranoside | | Authors: | Yan, N, Sun, L.F, Zeng, X, Yan, C.Y. | | Deposit date: | 2012-07-28 | | Release date: | 2012-10-17 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Crystal structure of a bacterial homologue of glucose transporters GLUT1-4.
Nature, 490, 2012
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6M79
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5GUF
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4HYD
 | | Structure of a presenilin family intramembrane aspartate protease in C2221 space group | | Descriptor: | Putative uncharacterized protein | | Authors: | Li, X, Dang, S, Yan, C, Wang, J, Shi, Y. | | Deposit date: | 2012-11-13 | | Release date: | 2012-12-19 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (3.8 Å) | | Cite: | Structure of a presenilin family intramembrane aspartate protease
Nature, 493, 2013
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4HYG
 | | Structure of a presenilin family intramembrane aspartate protease in C222 space group | | Descriptor: | Putative uncharacterized protein | | Authors: | Li, X, Dang, S, Yan, C, Wang, J, Shi, Y. | | Deposit date: | 2012-11-13 | | Release date: | 2012-12-19 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (3.32 Å) | | Cite: | Structure of a presenilin family intramembrane aspartate protease
Nature, 493, 2013
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4HYC
 | | Structure of a presenilin family intramembrane aspartate protease in P2 space group | | Descriptor: | Putative uncharacterized protein | | Authors: | Li, X, Dang, S, Yan, C, Wang, J, Shi, Y. | | Deposit date: | 2012-11-13 | | Release date: | 2012-12-19 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (3.95 Å) | | Cite: | Structure of a presenilin family intramembrane aspartate protease
Nature, 493, 2013
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4HZU
 | | Structure of a bacterial energy-coupling factor transporter | | Descriptor: | Energy-coupling factor transporter ATP-binding protein EcfA 1, Energy-coupling factor transporter ATP-binding protein EcfA 2, Energy-coupling factor transporter transmembrane protein EcfT, ... | | Authors: | Wang, T.L, Fu, G.B, Pan, X.J, Shi, Y.G. | | Deposit date: | 2012-11-15 | | Release date: | 2013-04-17 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (3.53 Å) | | Cite: | Structure of a bacterial energy-coupling factor transporter.
Nature, 497, 2013
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6IWI
 | | Crystal structure of PDE5A in complex with a novel inhibitor | | Descriptor: | MAGNESIUM ION, N-[3-(4,5-diethyl-6-oxo-1,6-dihydropyrimidin-2-yl)-4-propoxyphenyl]-2-(4-methylpiperazin-1-yl)acetamide, ZINC ION, ... | | Authors: | Zhang, X.L, Xu, Y.C. | | Deposit date: | 2018-12-05 | | Release date: | 2019-12-11 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2.155 Å) | | Cite: | Pharmacokinetics-Driven Optimization of 4(3 H)-Pyrimidinones as Phosphodiesterase Type 5 Inhibitors Leading to TPN171, a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension.
J.Med.Chem., 62, 2019
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2MKV
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6IWW
 | | Cryo-EM structure of the S. typhimurium oxaloacetate decarboxylase beta-gamma sub-complex | | Descriptor: | DODECYL-BETA-D-MALTOSIDE, Oxaloacetate decarboxylase beta chain, Probable oxaloacetate decarboxylase gamma chain | | Authors: | Xu, X, Shi, H, Zhang, X, Xiang, S. | | Deposit date: | 2018-12-08 | | Release date: | 2020-06-17 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Structural insights into sodium transport by the oxaloacetate decarboxylase sodium pump.
Elife, 9, 2020
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6IVA
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3PP1
 | | Crystal Structure of the Human Mitogen-activated protein kinase kinase 1 (MEK 1) in complex with ligand and MgATP | | Descriptor: | 3-[(2R)-2,3-dihydroxypropyl]-6-fluoro-5-[(2-fluoro-4-iodophenyl)amino]-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione, ACETATE ION, ADENOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Dougan, D.R. | | Deposit date: | 2010-11-23 | | Release date: | 2011-02-23 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Discovery of TAK-733, a potent and selective MEK allosteric site inhibitor for the treatment of cancer.
Bioorg.Med.Chem.Lett., 21, 2011
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5GNE
 | | Crystal structure of LapB from Legionella pneumophila | | Descriptor: | Leucine aminopeptidase, SULFATE ION, ZINC ION | | Authors: | Zhang, N, Ge, H. | | Deposit date: | 2016-07-20 | | Release date: | 2017-08-30 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal Structure and Biochemical Characterization of an Aminopeptidase LapB from Legionella pneumophila.
J. Agric. Food Chem., 65, 2017
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5JCE
 | | Crystal structure of OsCEBiP complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Chitin elicitor-binding protein | | Authors: | Chai, J.J, Liu, S.M, Wang, J.Z. | | Deposit date: | 2016-04-15 | | Release date: | 2016-06-08 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.51 Å) | | Cite: | Molecular Mechanism for Fungal Cell Wall Recognition by Rice Chitin Receptor OsCEBiP
Structure, 24, 2016
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8JC5
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8JCA
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4M68
 | | Crystal structure of the mouse MLKL kinase-like domain | | Descriptor: | GLYCEROL, Mixed lineage kinase domain-like protein | | Authors: | Xie, T, Peng, W, Yan, C, Wu, J, Shi, Y. | | Deposit date: | 2013-08-09 | | Release date: | 2013-10-16 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.696 Å) | | Cite: | Structural Insights into RIP3-Mediated Necroptotic Signaling
Cell Rep, 5, 2013
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4M66
 | | Crystal structure of the mouse RIP3 kinase domain | | Descriptor: | Receptor-interacting serine/threonine-protein kinase 3 | | Authors: | Xie, T, Peng, W, Yan, C, Wu, J, Shi, Y. | | Deposit date: | 2013-08-09 | | Release date: | 2013-10-16 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.401 Å) | | Cite: | Structural Insights into RIP3-Mediated Necroptotic Signaling
Cell Rep, 5, 2013
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4M9Z
 | | Crystal structure of CED-4 bound CED-3 fragment | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CED-3 fragment, Cell death protein 4, ... | | Authors: | Huang, W.J, Jinag, T.Y, Choi, W.Y, Wang, J.W, Shi, Y.G. | | Deposit date: | 2013-08-15 | | Release date: | 2013-10-23 | | Last modified: | 2023-12-06 | | Method: | X-RAY DIFFRACTION (3.405 Å) | | Cite: | Mechanistic insights into CED-4-mediated activation of CED-3.
Genes Dev., 27, 2013
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4M67
 | | Crystal structure of the human MLKL kinase-like domain | | Descriptor: | Mixed lineage kinase domain-like protein | | Authors: | Xie, T, Peng, W, Yan, C, Wu, J, Shi, Y. | | Deposit date: | 2013-08-09 | | Release date: | 2013-10-16 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural Insights into RIP3-Mediated Necroptotic Signaling
Cell Rep, 5, 2013
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