3NU1
 
 | | Structure of holo form of a periplasmic heme binding protein | | Descriptor: | Hemin-binding periplasmic protein, PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Mattle, D, Goetz, B.A, Woo, J.S, Locher, K.P. | | Deposit date: | 2010-07-06 | | Release date: | 2010-10-13 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Two stacked heme molecules in the binding pocket of the periplasmic heme-binding protein HmuT from Yersinia pestis.
J.Mol.Biol., 404, 2010
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5C73
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7O9W
 | | Encequidar-bound human P-glycoprotein in complex with UIC2-Fab | | Descriptor: | Multidrug resistance protein 1, UIC2 Fab-fragment heavy chain, UIC2 Fab-fragment light chain, ... | | Authors: | Nosol, K, Locher, K.P. | | Deposit date: | 2021-04-17 | | Release date: | 2022-01-12 | | Last modified: | 2022-01-26 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Discovery and Characterization of Potent Dual P-Glycoprotein and CYP3A4 Inhibitors: Design, Synthesis, Cryo-EM Analysis, and Biological Evaluations.
J.Med.Chem., 65, 2022
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5C78
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7OCI
 | | Cryo-EM structure of yeast Ost6p containing oligosaccharyltransferase complex | | Descriptor: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Wild, R, Neuhaus, J.D, Eyring, J, Irobalieva, R.N, Kowal, J, Lin, C.W, Locher, K.P, Aebi, M. | | Deposit date: | 2021-04-27 | | Release date: | 2022-02-16 | | Method: | ELECTRON MICROSCOPY (3.46 Å) | | Cite: | Functional analysis of Ost3p and Ost6p containing yeast oligosaccharyltransferases.
Glycobiology, 31, 2021
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7OJ8
 | | ABCG2 E1S turnover-2 state | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Broad substrate specificity ATP-binding cassette transporter ABCG2, CHOLESTEROL, ... | | Authors: | Ni, D, Yu, Q, Kowal, J, Manolaridis, I, Jackson, S.M, Stahlberg, H, Locher, K.P. | | Deposit date: | 2021-05-14 | | Release date: | 2021-07-21 | | Last modified: | 2021-07-28 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism.
Nat Commun, 12, 2021
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7OJH
 | | ABCG2 topotecan turnover-1 state | | Descriptor: | (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE, ADENOSINE-5'-TRIPHOSPHATE, Broad substrate specificity ATP-binding cassette transporter ABCG2, ... | | Authors: | Yu, Q, Ni, D, Kowal, J, Manolaridis, I, Jackson, S.M, Stahlberg, H, Locher, K.P. | | Deposit date: | 2021-05-15 | | Release date: | 2021-07-21 | | Last modified: | 2021-07-28 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism.
Nat Commun, 12, 2021
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7OJI
 | | ABCG2 topotecan turnover-2 state | | Descriptor: | (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE, ADENOSINE-5'-TRIPHOSPHATE, Broad substrate specificity ATP-binding cassette transporter ABCG2, ... | | Authors: | Yu, Q, Ni, D, Kowal, J, Manolaridis, I, Jackson, S.M, Stahlberg, H, Locher, K.P. | | Deposit date: | 2021-05-16 | | Release date: | 2021-07-21 | | Last modified: | 2021-07-28 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism.
Nat Commun, 12, 2021
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7OZ1
 | | Cryo-EM structure of ABCG1 E242Q mutant with ATP and cholesteryl hemisuccinate bound | | Descriptor: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, ADENOSINE-5'-TRIPHOSPHATE, CHOLESTEROL HEMISUCCINATE, ... | | Authors: | Skarda, L, Kowal, J, Locher, K.P. | | Deposit date: | 2021-06-25 | | Release date: | 2021-09-22 | | Last modified: | 2021-09-29 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Structure of the Human Cholesterol Transporter ABCG1.
J.Mol.Biol., 433, 2021
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5C76
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4DBL
 | | Crystal structure of E159Q mutant of BtuCDF | | Descriptor: | PHOSPHATE ION, SULFATE ION, Vitamin B12 import ATP-binding protein BtuD, ... | | Authors: | Korkhov, V.M, Mireku, S.M, Hvorup, R.N, Locher, K.P. | | Deposit date: | 2012-01-16 | | Release date: | 2012-03-07 | | Last modified: | 2012-05-23 | | Method: | X-RAY DIFFRACTION (3.493 Å) | | Cite: | Asymmetric states of vitamin B12 transporter BtuCD are not discriminated by its cognate substrate binding protein BtuF.
Febs Lett., 586, 2012
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4FI3
 | | Structure of vitamin B12 transporter BtuCD-F in a nucleotide-bound state | | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Vitamin B12 import ATP-binding protein BtuD, ... | | Authors: | Korkhov, V.M, Mireku, S.A, Locher, K.P. | | Deposit date: | 2012-06-07 | | Release date: | 2012-09-19 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (3.466 Å) | | Cite: | Structure of AMP-PNP-bound vitamin B12 transporter BtuCD-F.
Nature, 490, 2012
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4G1U
 | | X-ray structure of the bacterial heme transporter HmuUV from Yersinia pestis | | Descriptor: | Hemin import ATP-binding protein HmuV, Hemin transport system permease protein hmuU, PHOSPHATE ION | | Authors: | Woo, J.-S, Goetz, B.A, Zeltina, A, Locher, K.P. | | Deposit date: | 2012-07-11 | | Release date: | 2012-12-19 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (3.008 Å) | | Cite: | X-ray structure of the Yersinia pestis heme transporter HmuUV.
Nat.Struct.Mol.Biol., 19, 2012
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3CFZ
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3D31
 | | ModBC from Methanosarcina acetivorans | | Descriptor: | Sulfate/molybdate ABC transporter, ATP-binding protein, permease protein, ... | | Authors: | Gerber, S, Comellas-Bigler, M, Locher, K.P. | | Deposit date: | 2008-05-09 | | Release date: | 2008-06-10 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Structural basis of trans-inhibition in a molybdate/tungstate ABC transporter.
Science, 321, 2008
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3CIJ
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3CG3
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3CFX
 | | Crystal structure of M. acetivorans periplasmic binding protein ModA/WtpA with bound tungstate | | Descriptor: | GLYCEROL, MAGNESIUM ION, TUNGSTATE(VI)ION, ... | | Authors: | Comellas-Bigler, M, Hollenstein, K, Locher, K.P. | | Deposit date: | 2008-03-04 | | Release date: | 2009-03-10 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Distorted octahedral coordination of tungstate in a subfamily of specific binding proteins.
J.Biol.Inorg.Chem., 14, 2009
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3CG1
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6FFC
 | | Structure of an inhibitor-bound ABC transporter | | Descriptor: | ATP-binding cassette sub-family G member 2, ~{tert}-butyl 3-[(2~{S},5~{S},8~{S})-14-cyclopentyloxy-2-(2-methylpropyl)-4,7-bis(oxidanylidene)-3,6,17-triazatetracyclo[8.7.0.0^{3,8}.0^{11,16}]heptadeca-1(10),11,13,15-tetraen-5-yl]propanoate | | Authors: | Jackson, S.M, Manolaridis, I, Kowal, J, Zechner, M, Taylor, N.M.I, Bause, M, Bauer, S, Bartholomaeus, R, Stahlberg, H, Bernhardt, G, Koenig, B, Buschauer, A, Altmann, K.H, Locher, K.P. | | Deposit date: | 2018-01-06 | | Release date: | 2018-04-11 | | Last modified: | 2019-12-11 | | Method: | ELECTRON MICROSCOPY (3.56 Å) | | Cite: | Structural basis of small-molecule inhibition of human multidrug transporter ABCG2.
Nat. Struct. Mol. Biol., 25, 2018
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6FEQ
 | | Structure of inhibitor-bound ABCG2 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 5D3(Fab) heavy chain variable domain, 5D3(Fab) light chain variable domain, ... | | Authors: | Jackson, S.M, Manolaridis, I, Kowal, J, Zechner, M, Altmann, K.H, Locher, K.P. | | Deposit date: | 2018-01-03 | | Release date: | 2018-04-11 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Structural basis of small-molecule inhibition of human multidrug transporter ABCG2.
Nat. Struct. Mol. Biol., 25, 2018
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6FN4
 | | Apo form of UIC2 Fab complex of human-mouse chimeric ABCB1 (ABCB1HM) | | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, Apo form of Human-mouse chimeric ABCB1 (ABCB1HM) in complex with Antigen binding fragment of UIC2., ... | | Authors: | Alam, A, Locher, K.P. | | Deposit date: | 2018-02-02 | | Release date: | 2018-02-21 | | Last modified: | 2021-06-02 | | Method: | ELECTRON MICROSCOPY (4.14 Å) | | Cite: | Structure of a zosuquidar and UIC2-bound human-mouse chimeric ABCB1.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6FN1
 | | Zosuquidar and UIC2 Fab complex of human-mouse chimeric ABCB1 (ABCB1HM) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Human-mouse chimeric ABCB1 (ABCBHM), UIC2 Antigen Binding Fragment Heavy Chain, ... | | Authors: | Alam, A, Locher, K.P. | | Deposit date: | 2018-02-02 | | Release date: | 2018-02-21 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (3.58 Å) | | Cite: | Structure of a zosuquidar and UIC2-bound human-mouse chimeric ABCB1.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6GXC
 | | Bacterial oligosaccharyltransferase PglB in complex with an inhibitory peptide and a reactive lipid-linked oligosaccharide analog | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, GLY-ASP-GLN-DAB-ALA-THR-PPN-GLY, ... | | Authors: | Napiorkowska, M, Locher, K.P, Boilevin, J, Darbre, T, Reymond, J.-L. | | Deposit date: | 2018-06-27 | | Release date: | 2018-11-14 | | Method: | X-RAY DIFFRACTION (3.401 Å) | | Cite: | Structure of bacterial oligosaccharyltransferase PglB bound to a reactive LLO and an inhibitory peptide.
Sci Rep, 8, 2018
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6QEX
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