5U8C
 
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5TQ2
 | | Crystal structure of amino terminal domains of the NMDA receptor subunit GluN1 and GluN2A in complex with zinc at GluN1 and GluN2A | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, FAB, HEAVY CHAIN, ... | | Authors: | Romero-Hernandez, A, Simorowski, N, Karakas, E, Furukawa, H. | | Deposit date: | 2016-10-21 | | Release date: | 2016-12-14 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (3.289 Å) | | Cite: | Molecular Basis for Subtype Specificity and High-Affinity Zinc Inhibition in the GluN1-GluN2A NMDA Receptor Amino-Terminal Domain.
Neuron, 92, 2016
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5TPW
 | | Crystal structure of amino terminal domains of the NMDA receptor subunit GluN1 and GluN2A in complex with zinc at the GluN2A | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, FAB, HEAVY CHAIN, ... | | Authors: | Romero-Hernandez, A, Simorowski, N, Karakas, E, Furukawa, H. | | Deposit date: | 2016-10-21 | | Release date: | 2016-12-14 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.909 Å) | | Cite: | Molecular Basis for Subtype Specificity and High-Affinity Zinc Inhibition in the GluN1-GluN2A NMDA Receptor Amino-Terminal Domain.
Neuron, 92, 2016
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5TPZ
 | | Crystal structure of amino terminal domains of the NMDA receptor subunit GluN1 and GluN2B in apo closed state | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, NMDA 2B, ... | | Authors: | Romero-Hernandez, A, Simorwski, N, Karakas, E, Furukawa, H. | | Deposit date: | 2016-10-21 | | Release date: | 2016-12-14 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (3.095 Å) | | Cite: | Molecular Basis for Subtype Specificity and High-Affinity Zinc Inhibition in the GluN1-GluN2A NMDA Receptor Amino-Terminal Domain.
Neuron, 92, 2016
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5TQ0
 | | Crystal structure of amino terminal domains of the NMDA receptor subunit GluN1 and GluN2A in the presence of EDTA | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, FAB, HEAVY CHAIN, ... | | Authors: | Romero-Hernandez, A, Simorowski, N, Karakas, E, Furukawa, H. | | Deposit date: | 2016-10-21 | | Release date: | 2016-12-14 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Molecular Basis for Subtype Specificity and High-Affinity Zinc Inhibition in the GluN1-GluN2A NMDA Receptor Amino-Terminal Domain.
Neuron, 92, 2016
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6E7R
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7SAB
 | | Phencyclidine-bound GluN1a-GluN2B NMDA receptors | | Descriptor: | 1-(PHENYL-1-CYCLOHEXYL)PIPERIDINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Chou, T.-H, Furukawa, H. | | Deposit date: | 2021-09-22 | | Release date: | 2022-07-20 | | Method: | ELECTRON MICROSCOPY (4.3 Å) | | Cite: | Structural insights into binding of therapeutic channel blockers in NMDA receptors.
Nat.Struct.Mol.Biol., 29, 2022
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7SAD
 | | Memantine-bound GluN1a-GluN2B NMDA receptors | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... | | Authors: | Chou, T.-H, Furukawa, H. | | Deposit date: | 2021-09-22 | | Release date: | 2022-07-20 | | Method: | ELECTRON MICROSCOPY (3.96 Å) | | Cite: | Structural insights into binding of therapeutic channel blockers in NMDA receptors.
Nat.Struct.Mol.Biol., 29, 2022
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7SAA
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7SAC
 | | S-(+)-ketamine bound GluN1a-GluN2B NMDA receptors at 3.69 Angstrom resolution | | Descriptor: | (2~{S})-2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Chou, T.-H, Furukawa, H. | | Deposit date: | 2021-09-22 | | Release date: | 2022-07-20 | | Last modified: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (3.69 Å) | | Cite: | Structural insights into binding of therapeutic channel blockers in NMDA receptors.
Nat.Struct.Mol.Biol., 29, 2022
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4PE5
 | | Crystal Structure of GluN1a/GluN2B NMDA Receptor Ion Channel | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[(1R,2S)-2-(4-benzylpiperidin-1-yl)-1-hydroxypropyl]phenol, ... | | Authors: | Karakas, E, Furukawa, H. | | Deposit date: | 2014-04-22 | | Release date: | 2014-06-04 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (3.96 Å) | | Cite: | Crystal structure of a heterotetrameric NMDA receptor ion channel.
Science, 344, 2014
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5B3J
 | | Activation of NMDA receptors and the mechanism of inhibition by ifenprodil | | Descriptor: | Fab, heavy chain, light chain, ... | | Authors: | Tajima, N, Karakas, E, Grant, T, Simorowski, N, Diaz-Avalos, R, Grigorieff, N, Furukawa, H. | | Deposit date: | 2016-03-01 | | Release date: | 2016-05-11 | | Last modified: | 2022-03-23 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Activation of NMDA receptors and the mechanism of inhibition by ifenprodil
Nature, 534, 2016
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6E7T
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6E7U
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6E7S
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6E7X
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6E7V
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6E7W
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8VUH
 | | Human GluN1-2A IgG 003-102 splayed conformation | | Descriptor: | 003-102 Heavy, 003-102 Light, Glutamate receptor ionotropic, ... | | Authors: | Michalski, K, Furukawa, H. | | Deposit date: | 2024-01-29 | | Release date: | 2024-09-11 | | Last modified: | 2024-09-18 | | Method: | ELECTRON MICROSCOPY (4.42 Å) | | Cite: | Structural and functional mechanisms of anti-NMDAR autoimmune encephalitis.
Nat.Struct.Mol.Biol., 2024
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8VUS
 | | Human GluN1-2A with IgG 007-168 | | Descriptor: | 007-168 Heavy, 007-168 Light, Glutamate receptor ionotropic, ... | | Authors: | Michalski, K, Furukawa, H. | | Deposit date: | 2024-01-29 | | Release date: | 2024-09-11 | | Last modified: | 2024-09-18 | | Method: | ELECTRON MICROSCOPY (3.99 Å) | | Cite: | Structural and functional mechanisms of anti-NMDAR autoimmune encephalitis.
Nat.Struct.Mol.Biol., 2024
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8VUT
 | | Human GluN1-2A with IgG 008-218 | | Descriptor: | 008-218 Heavy, 008-218 Light, Glutamate receptor ionotropic, ... | | Authors: | Michalski, K, Furukawa, H. | | Deposit date: | 2024-01-29 | | Release date: | 2024-09-11 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Structural and functional mechanisms of anti-NMDAR autoimmune encephalitis.
Nat.Struct.Mol.Biol., 2024
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8VUY
 | | Rat GluN1-2B with Fab 003-102 | | Descriptor: | 003-102 Heavy, 003-102 Light, Glutamate receptor ionotropic, ... | | Authors: | Michalski, K, Furukawa, H. | | Deposit date: | 2024-01-30 | | Release date: | 2024-09-11 | | Last modified: | 2024-09-18 | | Method: | ELECTRON MICROSCOPY (3.81 Å) | | Cite: | Structural and functional mechanisms of anti-NMDAR autoimmune encephalitis.
Nat.Struct.Mol.Biol., 2024
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8VUJ
 | | Human GluN1-2A with Fab 003-102 | | Descriptor: | 003-102 Heavy, 003-102 Light, Glutamate receptor ionotropic, ... | | Authors: | Michalski, K, Furukawa, H. | | Deposit date: | 2024-01-29 | | Release date: | 2024-09-11 | | Last modified: | 2024-09-18 | | Method: | ELECTRON MICROSCOPY (3.92 Å) | | Cite: | Structural and functional mechanisms of anti-NMDAR autoimmune encephalitis.
Nat.Struct.Mol.Biol., 2024
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8VUL
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8VUN
 | | Human GluN1-2A With Fab 008-218 | | Descriptor: | 008-218 Heavy, 008-218 Light, Glutamate receptor ionotropic, ... | | Authors: | Michalski, K, Furukawa, H. | | Deposit date: | 2024-01-29 | | Release date: | 2024-09-11 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (4.01 Å) | | Cite: | Structural and functional mechanisms of anti-NMDAR autoimmune encephalitis.
Nat.Struct.Mol.Biol., 2024
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