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6UK6
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BU of 6uk6 by Molmil
Crystal structure of human GAC in complex with inhibitor UPGL00018
Descriptor: 5-{4-[(5-amino-1,3,4-thiadiazol-2-yl)oxy]piperidin-1-yl}-1,3,4-thiadiazol-2-amine, Glutaminase kidney isoform, mitochondrial
Authors:Huang, Q, Cerione, R.A.
Deposit date:2019-10-04
Release date:2020-10-07
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of human GAC in complex with inhibitor UPGL00018
To Be Published
6UKB
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BU of 6ukb by Molmil
Crystal structure of human GAC in complex with inhibitor UPGL00012
Descriptor: Glutaminase kidney isoform, mitochondrial, N-[5-(4-{[5-(acetylamino)-1,3,4-thiadiazol-2-yl]oxy}piperidin-1-yl)-1,3,4-thiadiazol-2-yl]acetamide
Authors:Huang, Q, Cerione, R.A.
Deposit date:2019-10-04
Release date:2020-10-07
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of human GAC in complex with inhibitor UPGL00020
To Be Published
6ULA
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BU of 6ula by Molmil
Crystal structure of human GAC in complex with inhibitor UPGL00012
Descriptor: 2-cyclopropyl-N-{5-[4-({5-[(cyclopropylacetyl)amino]-1,3,4-thiadiazol-2-yl}oxy)piperidin-1-yl]-1,3,4-thiadiazol-2-yl}acetamide, Glutaminase kidney isoform, mitochondrial
Authors:Huang, Q, Cerione, R.A.
Deposit date:2019-10-07
Release date:2020-10-14
Last modified:2024-12-25
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Crystal structure of human GAC in complex with inhibitor UPGL00030
To Be Published
6UJM
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BU of 6ujm by Molmil
Crystal structure of human GAC in complex with inhibitor UPGL00013
Descriptor: Glutaminase kidney isoform, mitochondrial, N-{5-[(3R)-3-{[5-(acetylamino)-1,3,4-thiadiazol-2-yl]amino}pyrrolidin-1-yl]-1,3,4-thiadiazol-2-yl}acetamide
Authors:Huang, Q, Cerione, R.A.
Deposit date:2019-10-03
Release date:2020-10-07
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of human GAC in complex with inhibitor UPGL00013
To Be Published
6UL9
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BU of 6ul9 by Molmil
Crystal structure of human GAC in complex with inhibitor UPGL00023
Descriptor: 2-phenyl-N-{5-[(1-{5-[(phenylacetyl)amino]-1,3,4-thiadiazol-2-yl}azetidin-3-yl)oxy]-1,3,4-thiadiazol-2-yl}acetamide, Glutaminase kidney isoform, mitochondrial
Authors:Huang, Q.Q, Cerione, R.A.
Deposit date:2019-10-07
Release date:2020-10-14
Last modified:2024-12-25
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of human GAC in complex with inhibitor UPGL00012
To Be Published
8XD7
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BU of 8xd7 by Molmil
Cryo-EM structure of inhibitor 25a bound human urea transporter A2.
Descriptor: N-(4-acetamidophenyl)-5-ethanoyl-furan-2-carboxamide, Urea transporter 2
Authors:Huang, S, Liu, L, Sun, J.
Deposit date:2023-12-10
Release date:2024-12-04
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Structural insights into the mechanisms of urea permeation and distinct inhibition modes of urea transporters.
Nat Commun, 15, 2024
8XDB
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BU of 8xdb by Molmil
Cryo-EM structure of human urea transporter A2.
Descriptor: (5E)-2-azanylidene-5-[(2,3-dimethoxyphenyl)methylidene]-1,3-thiazolidin-4-one, Urea transporter 2
Authors:Huang, S, Liu, L, Sun, J.
Deposit date:2023-12-10
Release date:2024-12-04
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural insights into the mechanisms of urea permeation and distinct inhibition modes of urea transporters.
Nat Commun, 15, 2024
8XDC
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BU of 8xdc by Molmil
Cryo-EM structure of human urea transporter A2.
Descriptor: N-[3-[1,1-bis(oxidanylidene)-1,2-thiazolidin-2-yl]-4-chloranyl-phenyl]-2-methoxy-5-methyl-benzenesulfonamide, Urea transporter 2
Authors:Huang, S, Liu, L, Sun, J.
Deposit date:2023-12-10
Release date:2024-12-04
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural insights into the mechanisms of urea permeation and distinct inhibition modes of urea transporters.
Nat Commun, 15, 2024
8XDI
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BU of 8xdi by Molmil
Cryo-EM structure of zebrafish urea transporter.
Descriptor: N-(4-acetamidophenyl)-5-ethanoyl-furan-2-carboxamide, Urea transporter
Authors:Huang, S, Liu, L, Sun, J.
Deposit date:2023-12-11
Release date:2024-12-04
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural insights into the mechanisms of urea permeation and distinct inhibition modes of urea transporters.
Nat Commun, 15, 2024
5ZTC
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BU of 5ztc by Molmil
Apo structure of TetR family transcription regulator Lmo2088 of Listeria monocytogenes EGDe
Descriptor: Lmo2088 protein, PENTAETHYLENE GLYCOL
Authors:Samad, A, Jin, T.
Deposit date:2018-05-02
Release date:2019-06-12
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:X-ray crystal structure of putative transcription regulator lmo2088 from Listeria monocytogenes.
Biochem.Biophys.Res.Commun., 520, 2019
6XEO
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BU of 6xeo by Molmil
Structure of Mfd bound to dsDNA
Descriptor: DNA (5'-D(P*AP*GP*GP*AP*TP*AP*CP*TP*TP*AP*CP*AP*GP*CP*CP*AP*TP*C)-3'), DNA (5'-D(P*GP*AP*TP*GP*GP*CP*TP*GP*TP*AP*AP*GP*TP*AP*TP*CP*CP*T)-3'), Transcription-repair-coupling factor
Authors:Brugger, C, Deaconescu, A.
Deposit date:2020-06-12
Release date:2020-08-19
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (5.5 Å)
Cite:Molecular determinants for dsDNA translocation by the transcription-repair coupling and evolvability factor Mfd.
Nat Commun, 11, 2020
8T8M
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BU of 8t8m by Molmil
Quis-bound intermediate mGlu5
Descriptor: (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, Metabotropic glutamate receptor 5, Nb43
Authors:Krishna Kumar, K, Wang, H, Kobilka, B.K.
Deposit date:2023-06-22
Release date:2023-10-11
Last modified:2025-05-21
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Stepwise activation of a metabotropic glutamate receptor.
Nature, 629, 2024
8T6J
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BU of 8t6j by Molmil
CDPPB-bound inactive mGlu5
Descriptor: 3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide, Metabotropic glutamate receptor 5
Authors:Krishna Kumar, K, Wang, H, Kobilka, B.K.
Deposit date:2023-06-16
Release date:2023-10-11
Last modified:2024-10-16
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Stepwise activation of a metabotropic glutamate receptor.
Nature, 629, 2024
8TAO
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BU of 8tao by Molmil
Quis and CDPPB bound active mGlu5
Descriptor: (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, 3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide, Metabotropic glutamate receptor 5, ...
Authors:Krishna Kumar, K, Wang, H, Kobilka, B.K.
Deposit date:2023-06-27
Release date:2023-10-11
Last modified:2025-05-28
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Stepwise activation of a metabotropic glutamate receptor.
Nature, 629, 2024
8T7H
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BU of 8t7h by Molmil
Quis-bound intermediate mGlu5
Descriptor: (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, Metabotropic glutamate receptor 5, Nanobody 43
Authors:Krishna Kumar, K, Wang, H, Kobilka, B.K.
Deposit date:2023-06-20
Release date:2023-10-11
Last modified:2025-05-14
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Stepwise activation of a metabotropic glutamate receptor.
Nature, 629, 2024
8HGI
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BU of 8hgi by Molmil
Crystal structure of VNAR aGFP14 in complex with GFP
Descriptor: GFP, VNAR aGFP14
Authors:Zheng, P, Zhu, C, Jin, T.
Deposit date:2022-11-14
Release date:2023-09-27
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Selection, identification and crystal structure of shark-derived single-domain antibodies against a green fluorescent protein.
Int.J.Biol.Macromol., 247, 2023
7U1Z
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BU of 7u1z by Molmil
Crystal structure of the DRBD and CROPs of TcdA
Descriptor: SULFATE ION, Toxin A
Authors:Baohua, C, Peng, C, Kay, P, Rongsheng, J.
Deposit date:2022-02-22
Release date:2022-03-09
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.18 Å)
Cite:Structure and conformational dynamics of Clostridioides difficile toxin A.
Life Sci Alliance, 5, 2022
8I88
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BU of 8i88 by Molmil
Cryo-EM structure of TIR-APAZ/Ago-gRNA complex
Descriptor: Piwi domain-containing protein, RNA (5'-R(P*GP*A)-3'), TIR domain-containing protein
Authors:Zhang, H, Li, Z, Yu, G.M, Li, X.Z, Wang, X.S.
Deposit date:2023-02-03
Release date:2023-07-05
Last modified:2023-09-13
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structural insights into mechanisms of Argonaute protein-associated NADase activation in bacterial immunity.
Cell Res., 33, 2023
8I87
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BU of 8i87 by Molmil
Cryo-EM structure of TIR-APAZ/Ago-gRNA-DNA complex
Descriptor: DNA (5'-D(P*TP*AP*TP*AP*CP*AP*AP*CP*CP*TP*AP*CP*TP*AP*CP*CP*TP*CP*A)-3'), MAGNESIUM ION, Piwi domain-containing protein, ...
Authors:Zhang, H, Deng, Z.Q, Yu, G.M, Li, X.Z, Wang, X.S.
Deposit date:2023-02-03
Release date:2023-07-19
Last modified:2023-09-13
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural insights into mechanisms of Argonaute protein-associated NADase activation in bacterial immunity.
Cell Res., 33, 2023
7YSX
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BU of 7ysx by Molmil
Crystal structure of PDE4D complexed with licoisoflavone A
Descriptor: 1,2-ETHANEDIOL, 3-[3-(3-methylbut-2-enyl)-2,4-bis(oxidanyl)phenyl]-5,7-bis(oxidanyl)chromen-4-one, MAGNESIUM ION, ...
Authors:Liu, J.Y, Li, M.J, Xu, Y.C.
Deposit date:2022-08-13
Release date:2023-07-12
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Bioactive compounds from Huashi Baidu decoction possess both antiviral and anti-inflammatory effects against COVID-19.
Proc.Natl.Acad.Sci.USA, 120, 2023
7YQF
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BU of 7yqf by Molmil
Crystal structure of PDE4D complexed with glycyrrhisoflavone
Descriptor: 1,2-ETHANEDIOL, 3-[3-(3-methylbut-2-enyl)-4,5-bis(oxidanyl)phenyl]-5,7-bis(oxidanyl)chromen-4-one, MAGNESIUM ION, ...
Authors:Liu, J.Y, Li, M.J, Xu, Y.C.
Deposit date:2022-08-06
Release date:2023-07-12
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Bioactive compounds from Huashi Baidu decoction possess both antiviral and anti-inflammatory effects against COVID-19.
Proc.Natl.Acad.Sci.USA, 120, 2023
8GDB
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BU of 8gdb by Molmil
Cryo-EM Structure of the Prostaglandin E2 Receptor 4 Coupled to G Protein
Descriptor: (Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxo-cyclopentyl]hept-5-enoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
Authors:Shenming, H, Mengyao, X, Lei, L, Jianqiang, M, Jinpeng, S.
Deposit date:2023-03-03
Release date:2024-01-10
Last modified:2024-11-13
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Single hormone or synthetic agonist induces G s /G i coupling selectivity of EP receptors via distinct binding modes and propagating paths.
Proc.Natl.Acad.Sci.USA, 120, 2023
8GDC
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BU of 8gdc by Molmil
Cryo-EM Structure of the Prostaglandin E2 Receptor 3 Coupled to G Protein
Descriptor: (Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxo-cyclopentyl]hept-5-enoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
Authors:Shenming, H, Mengyao, X, Lei, L, Yang, D, Shiyi, G, Jinpeng, S.
Deposit date:2023-03-03
Release date:2024-01-10
Last modified:2024-10-16
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Single hormone or synthetic agonist induces G s /G i coupling selectivity of EP receptors via distinct binding modes and propagating paths.
Proc.Natl.Acad.Sci.USA, 120, 2023
8W56
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BU of 8w56 by Molmil
Cryo-EM structure of DSR2-DSAD1 state 1
Descriptor: SIR2-like domain-containing protein, SPbeta prophage-derived uncharacterized protein YotI
Authors:Zhang, H, Li, Z, Li, X.Z.
Deposit date:2023-08-25
Release date:2024-05-01
Last modified:2025-06-25
Method:ELECTRON MICROSCOPY (3.59 Å)
Cite:Insights into the modulation of bacterial NADase activity by phage proteins.
Nat Commun, 15, 2024
5WWO
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BU of 5wwo by Molmil
Crystal structure of Enp1
Descriptor: Essential nuclear protein 1, Protein LTV1
Authors:Ye, K, Zhang, W.
Deposit date:2017-01-03
Release date:2017-06-28
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Molecular architecture of the 90S small subunit pre-ribosome
Elife, 6, 2017

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數據於2025-07-09公開中

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