8TVR
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8tvr by Molmil](/molmil-images/mine/8tvr) | |
8U1O
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8u1o by Molmil](/molmil-images/mine/8u1o) | |
6LJA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6lja by Molmil](/molmil-images/mine/6lja) | Crystal Structure of exoHep from Bacteroides intestinalis DSM 17393 complexed with disaccharide product | Descriptor: | 4-deoxy-2-O-sulfo-alpha-L-threo-hex-4-enopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, CALCIUM ION, Heparinase II/III-like protein | Authors: | Zhang, Q.D, Cao, H.Y, Wei, L, Li, F.C, Zhang, Y.Z. | Deposit date: | 2019-12-13 | Release date: | 2020-12-23 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.978 Å) | Cite: | Discovery of exolytic heparinases and their catalytic mechanism and potential application. Nat Commun, 12, 2021
|
|
5VSC
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5vsc by Molmil](/molmil-images/mine/5vsc) | Structure of human G9a SET-domain (EHMT2) in complex with inhibitor 13 | Descriptor: | 6,7-dimethoxy-N~2~-methyl-N~4~-(1-methylpiperidin-4-yl)-N~2~-propylquinazoline-2,4-diamine, Histone-lysine N-methyltransferase EHMT2, S-ADENOSYLMETHIONINE, ... | Authors: | Babault, N, Xiong, Y, Liu, J, Jin, J. | Deposit date: | 2017-05-11 | Release date: | 2017-07-12 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Structure-activity relationship studies of G9a-like protein (GLP) inhibitors. Bioorg. Med. Chem., 25, 2017
|
|
8SQF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8sqf by Molmil](/molmil-images/mine/8sqf) | OXA-48 bound to inhibitor CDD-2725 | Descriptor: | (1M)-3'-(benzyloxy)-5-hydroxy[1,1'-biphenyl]-3,4'-dicarboxylic acid, BICARBONATE ION, Beta-lactamase | Authors: | Park, S, Judge, A, Fan, J, Sankaran, B, Prasad, B.V.V, Palzkill, T. | Deposit date: | 2023-05-04 | Release date: | 2024-01-03 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Exploiting the Carboxylate-Binding Pocket of beta-Lactamase Enzymes Using a Focused DNA-Encoded Chemical Library. J.Med.Chem., 67, 2024
|
|
8SQG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8sqg by Molmil](/molmil-images/mine/8sqg) | OXA-48 bound to inhibitor CDD-2801 | Descriptor: | (1M)-3'-(benzyloxy)-5-[2-(methylamino)-2-oxoethoxy][1,1'-biphenyl]-3,4'-dicarboxylic acid, BICARBONATE ION, Beta-lactamase | Authors: | Park, S, Judge, A, Fan, J, Sankaran, B, Palzkill, T. | Deposit date: | 2023-05-04 | Release date: | 2024-01-03 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | Exploiting the Carboxylate-Binding Pocket of beta-Lactamase Enzymes Using a Focused DNA-Encoded Chemical Library. J.Med.Chem., 67, 2024
|
|
2M0Y
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2m0y by Molmil](/molmil-images/mine/2m0y) | |
5GH9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5gh9 by Molmil](/molmil-images/mine/5gh9) | Crystal structure of CBP Bromodomain with H3K56ac peptide | Descriptor: | CREB-binding protein, Histone H3 | Authors: | Xu, L. | Deposit date: | 2016-06-19 | Release date: | 2017-06-21 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.451 Å) | Cite: | Structural insight into CBP bromodomain-mediated recognition of acetylated histone H3K56ac FEBS J., 2017
|
|
5XJ1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5xj1 by Molmil](/molmil-images/mine/5xj1) | Crystal structure of spRlmCD | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GLYCEROL, HEXAETHYLENE GLYCOL, ... | Authors: | Jiang, Y, Gong, Q. | Deposit date: | 2017-04-28 | Release date: | 2017-11-01 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.753 Å) | Cite: | Structural insights into substrate selectivity of ribosomal RNA methyltransferase RlmCD PLoS ONE, 12, 2017
|
|
5XJ2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5xj2 by Molmil](/molmil-images/mine/5xj2) | Structure of spRlmCD with U747 RNA | Descriptor: | RNA (5'-R(*GP*GP*CP*AP*CP*GP*UP*GP*CP*U)-3'), S-ADENOSYL-L-HOMOCYSTEINE, Uncharacterized RNA methyltransferase SP_1029, ... | Authors: | Jiang, Y, Gong, Q. | Deposit date: | 2017-04-28 | Release date: | 2017-11-01 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.84 Å) | Cite: | Structural insights into substrate selectivity of ribosomal RNA methyltransferase RlmCD PLoS ONE, 12, 2017
|
|
6LJL
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6ljl by Molmil](/molmil-images/mine/6ljl) | Crystal Structure of exoHep-Y390A/H555A complexed with a tetrasaccharide substrate | Descriptor: | 4-deoxy-alpha-L-threo-hex-4-enopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, CALCIUM ION, Heparinase II/III-like protein | Authors: | Zhang, Q.D, Cao, H.Y, Wei, L, Li, F.C, Zhang, Y.Z. | Deposit date: | 2019-12-17 | Release date: | 2020-12-23 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.73 Å) | Cite: | Discovery of exolytic heparinases and their catalytic mechanism and potential application. Nat Commun, 12, 2021
|
|
6KI6
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6ki6 by Molmil](/molmil-images/mine/6ki6) | Crystal structure of BCL11A in complex with gamma-globin -115 HPFH region | Descriptor: | B-cell lymphoma/leukemia 11A, DNA (5'-D(*AP*TP*AP*TP*TP*GP*GP*TP*CP*AP*AP*GP*G)-3'), DNA (5'-D(*TP*CP*CP*TP*TP*GP*AP*CP*CP*AP*AP*TP*A)-3'), ... | Authors: | Li, F.D, Yang, Y, Shi, Y.Y. | Deposit date: | 2019-07-17 | Release date: | 2019-09-11 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural insights into the recognition of gamma-globin gene promoter by BCL11A. Cell Res., 29, 2019
|
|
2MXP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2mxp by Molmil](/molmil-images/mine/2mxp) | |
5Y0U
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5y0u by Molmil](/molmil-images/mine/5y0u) | The solution structure of AEBP2 C2H2 zinc fingers | Descriptor: | ZINC ION, Zinc finger protein AEBP2 | Authors: | Sun, A, Shi, Y, Wu, J. | Deposit date: | 2017-07-18 | Release date: | 2018-08-01 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structural and biochemical insights into human zinc finger protein AEBP2 reveals interactions with RBBP4. Protein Cell, 9, 2018
|
|
5ZQ1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5zq1 by Molmil](/molmil-images/mine/5zq1) | Crystal structure of spRlmCD with U1939loop RNA at 3.10 angstrom | Descriptor: | RNA (5'-R(*AP*AP*AP*(MUM)P*UP*CP*CP*U)-3'), S-ADENOSYL-L-HOMOCYSTEINE, Uncharacterized RNA methyltransferase SP_1029 | Authors: | Yu, H.L, Jiang, Y.Y. | Deposit date: | 2018-04-17 | Release date: | 2018-10-24 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Unveiling the structural features that determine the dual methyltransferase activities of Streptococcus pneumoniae RlmCD PLoS Pathog., 14, 2018
|
|
5ZQ0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5zq0 by Molmil](/molmil-images/mine/5zq0) | Crystal structure of spRlmCD with U747loop RNA | Descriptor: | RNA (5'-R(*GP*UP*(MUM)P*GP*AP*AP*AP*A)-3'), S-ADENOSYL-L-HOMOCYSTEINE, Uncharacterized RNA methyltransferase SP_1029 | Authors: | Jiang, Y.Y, Yu, H.L. | Deposit date: | 2018-04-17 | Release date: | 2018-10-24 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Unveiling the structural features that determine the dual methyltransferase activities of Streptococcus pneumoniae RlmCD PLoS Pathog., 14, 2018
|
|
5ZTH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5zth by Molmil](/molmil-images/mine/5zth) | Crystal structure of spRlmCD with U1939loop RNA at 3.24 angstrom | Descriptor: | RNA (5'-R(P*AP*AP*AP*(MUM)P*UP*CP*CP*U)-3'), S-ADENOSYL-L-HOMOCYSTEINE, Uncharacterized RNA methyltransferase SP_1029 | Authors: | Jiang, Y.Y, Yu, H.L. | Deposit date: | 2018-05-03 | Release date: | 2018-10-24 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.24 Å) | Cite: | Unveiling the structural features that determine the dual methyltransferase activities of Streptococcus pneumoniae RlmCD PLoS Pathog., 14, 2018
|
|
5ZTM
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5ztm by Molmil](/molmil-images/mine/5ztm) | Crystal structure of MLE dsRBDs in complex with roX2 (R2H1) | Descriptor: | Dosage compensation regulator, non-coding mRNA sequence roX2 | Authors: | Lv, M.Q, Tang, Y.J. | Deposit date: | 2018-05-04 | Release date: | 2019-03-06 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.899 Å) | Cite: | Structural insights reveal the specific recognition of roX RNA by the dsRNA-binding domains of the RNA helicase MLE and its indispensable role in dosage compensation in Drosophila. Nucleic Acids Res., 47, 2019
|
|
7UMI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7umi by Molmil](/molmil-images/mine/7umi) | Importin a1 bound to Cp183-CTD | Descriptor: | HBV-NLS, Importin subunit alpha-1 | Authors: | Yang, R, Cingolani, G. | Deposit date: | 2022-04-07 | Release date: | 2023-10-25 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | Structural basis for nuclear import of hepatitis B virus (HBV) nucleocapsid core. Sci Adv, 10, 2024
|
|
6AAS
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6aas by Molmil](/molmil-images/mine/6aas) | Solution Structure for helix 45 in 3' end of 12S rRNA | Descriptor: | RNA (28-MER) | Authors: | Liu, X, Wu, P. | Deposit date: | 2018-07-19 | Release date: | 2019-06-05 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structural insights into dimethylation of 12S rRNA by TFB1M: indispensable role in translation of mitochondrial genes and mitochondrial function. Nucleic Acids Res., 47, 2019
|
|
7UBO
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7ubo by Molmil](/molmil-images/mine/7ubo) | Crystal Structure of the first bromodomain of human BRDT in complex with the inhibitor CCD-956 | Descriptor: | Bromodomain testis-specific protein, DIMETHYL SULFOXIDE, N-[(2R)-1-(methylamino)-3-{1-[(4-methyl-2-oxo-1,2-dihydroquinolin-6-yl)acetyl]piperidin-4-yl}-1-oxopropan-2-yl]-5-phenylpyridine-2-carboxamide | Authors: | Ta, H.M, Modukuri, R.K, Yu, Z, Tan, Z, Matzuk, M.M, Kim, C. | Deposit date: | 2022-03-15 | Release date: | 2022-06-08 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | Discovery of potent BET bromodomain 1 stereoselective inhibitors using DNA-encoded chemical library selections. Proc.Natl.Acad.Sci.USA, 119, 2022
|
|
7VYW
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7vyw by Molmil](/molmil-images/mine/7vyw) | |
7VZ2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7vz2 by Molmil](/molmil-images/mine/7vz2) | Crystal structure of chromodomain of Arabidopsis LHP1 | Descriptor: | Chromo domain-containing protein LHP1, UNKNOWN ATOM OR ION | Authors: | Liu, Y, Min, J. | Deposit date: | 2021-11-15 | Release date: | 2022-02-02 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural basis for the recognition of methylated histone H3 by the Arabidopsis LHP1 chromodomain. J.Biol.Chem., 298, 2022
|
|
7V6A
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7v6a by Molmil](/molmil-images/mine/7v6a) | Cry-EM structure of M4-c110-G protein complex | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | Authors: | Wang, J.J, Wu, M, Wu, L.J, Hua, T, Liu, Z.J, Wang, T. | Deposit date: | 2021-08-20 | Release date: | 2022-05-11 | Last modified: | 2022-11-23 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | The unconventional activation of the muscarinic acetylcholine receptor M4R by diverse ligands. Nat Commun, 13, 2022
|
|
7V69
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7v69 by Molmil](/molmil-images/mine/7v69) | Cryo-EM structure of a class A GPCR-G protein complex | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | Authors: | Wang, J.J, Wu, M, Wu, L.J, Hua, T, Liu, Z.J, Wang, T. | Deposit date: | 2021-08-20 | Release date: | 2022-05-11 | Last modified: | 2022-11-23 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | The unconventional activation of the muscarinic acetylcholine receptor M4R by diverse ligands. Nat Commun, 13, 2022
|
|