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8J0N
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BU of 8j0n by Molmil
cryo-EM structure of human EMC
Descriptor: ER membrane protein complex subunit 1, ER membrane protein complex subunit 10, ER membrane protein complex subunit 2, ...
Authors:Li, M, Zhang, C, Wu, J, Lei, M.
Deposit date:2023-04-11
Release date:2024-04-03
Last modified:2024-10-23
Method:ELECTRON MICROSCOPY (3.47 Å)
Cite:Structural insights into human EMC and its interaction with VDAC.
Aging (Albany NY), 16, 2024
8J0O
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BU of 8j0o by Molmil
cryo-EM structure of human EMC and VDAC
Descriptor: ER membrane protein complex subunit 1, ER membrane protein complex subunit 10, ER membrane protein complex subunit 2, ...
Authors:Li, M, Zhang, C, Wu, J, Lei, M.
Deposit date:2023-04-11
Release date:2024-04-03
Last modified:2024-04-17
Method:ELECTRON MICROSCOPY (3.32 Å)
Cite:Structural insights into human EMC and its interaction with VDAC.
Aging (Albany NY), 16, 2024
7WTD
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BU of 7wtd by Molmil
Cryo-EM structure of human pyruvate carboxylase with acetyl-CoA in the intermediate state 1
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, COENZYME A, Pyruvate carboxylase, ...
Authors:Chai, P, Lan, P, Wu, J, Lei, M.
Deposit date:2022-02-04
Release date:2022-11-09
Last modified:2022-11-16
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Mechanistic insight into allosteric activation of human pyruvate carboxylase by acetyl-CoA.
Mol.Cell, 82, 2022
7WTE
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BU of 7wte by Molmil
Cryo-EM structure of human pyruvate carboxylase with acetyl-CoA in the intermediate state 2
Descriptor: ACETYL COENZYME *A, ADENOSINE-5'-TRIPHOSPHATE, Pyruvate carboxylase, ...
Authors:Chai, P, Lan, P, Wu, J, Lei, M.
Deposit date:2022-02-04
Release date:2022-11-09
Last modified:2024-10-23
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Mechanistic insight into allosteric activation of human pyruvate carboxylase by acetyl-CoA.
Mol.Cell, 82, 2022
7WTA
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BU of 7wta by Molmil
Cryo-EM structure of human pyruvate carboxylase in apo state
Descriptor: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, Pyruvate carboxylase, mitochondrial
Authors:Chai, P, Lan, P, Wu, J, Lei, M.
Deposit date:2022-02-04
Release date:2022-11-09
Last modified:2022-11-16
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Mechanistic insight into allosteric activation of human pyruvate carboxylase by acetyl-CoA.
Mol.Cell, 82, 2022
7WTC
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BU of 7wtc by Molmil
Cryo-EM structure of human pyruvate carboxylase with acetyl-CoA in the ground state
Descriptor: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, ACETYL COENZYME *A, Pyruvate carboxylase, ...
Authors:Chai, P, Lan, P, Wu, J, Lei, M.
Deposit date:2022-02-04
Release date:2022-11-09
Last modified:2022-11-16
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Mechanistic insight into allosteric activation of human pyruvate carboxylase by acetyl-CoA.
Mol.Cell, 82, 2022
7WTB
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BU of 7wtb by Molmil
Cryo-EM structure of human pyruvate carboxylase with acetyl-CoA
Descriptor: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, ACETYL COENZYME *A, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Chai, P, Lan, P, Wu, J, Lei, M.
Deposit date:2022-02-04
Release date:2022-11-09
Last modified:2022-11-16
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Mechanistic insight into allosteric activation of human pyruvate carboxylase by acetyl-CoA.
Mol.Cell, 82, 2022
7X9G
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BU of 7x9g by Molmil
Crystal structure of human EDA and EDAR
Descriptor: Ectodysplasin-A, secreted form, Tumor necrosis factor receptor superfamily member EDAR
Authors:Yu, K, Wan, F, Huang, C, Wu, J, Lei, M.
Deposit date:2022-03-15
Release date:2023-02-22
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural insights into pathogenic mechanism of hypohidrotic ectodermal dysplasia caused by ectodysplasin A variants.
Nat Commun, 14, 2023
6LBU
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BU of 6lbu by Molmil
Crystal structure of yeast Stn1 and Ten1
Descriptor: KLLA0C11825p, KLLA0E09417p
Authors:Ge, Y, Wu, Z, Wu, J, Lei, M.
Deposit date:2019-11-14
Release date:2020-07-15
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural insights into telomere protection and homeostasis regulation by yeast CST complex.
Nat.Struct.Mol.Biol., 27, 2020
6L7P
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BU of 6l7p by Molmil
cryo-EM structure of cyanobacteria NDH-1LdelV complex
Descriptor: 1,2-DI-O-ACYL-3-O-[6-DEOXY-6-SULFO-ALPHA-D-GLUCOPYRANOSYL]-SN-GLYCEROL, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, BETA-CAROTENE, ...
Authors:Zhang, C, Shuai, J, Wu, J, Lei, M.
Deposit date:2019-11-02
Release date:2020-02-19
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structural insights into NDH-1 mediated cyclic electron transfer.
Nat Commun, 11, 2020
5H65
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BU of 5h65 by Molmil
Crystal structure of human POT1 and TPP1
Descriptor: Adrenocortical dysplasia protein homolog, Protection of telomeres protein 1, ZINC ION
Authors:Chen, C, Wu, J, Lei, M.
Deposit date:2016-11-10
Release date:2017-05-31
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural insights into POT1-TPP1 interaction and POT1 C-terminal mutations in human cancer.
Nat Commun, 8, 2017
4GM8
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BU of 4gm8 by Molmil
Crystal structure of human WD repeat domain 5 with compound MM-102
Descriptor: MM-102, WD repeat-containing protein 5
Authors:Karatas, H, Townsend, E.C, Chen, Y, Bernard, D, Cao, F, Liu, L, Lei, M, Dou, Y, Wang, S.
Deposit date:2012-08-15
Release date:2013-07-31
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (2.601 Å)
Cite:High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction.
J.Am.Chem.Soc., 135, 2013
4GM3
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BU of 4gm3 by Molmil
Crystal structure of human WD repeat domain 5 with compound MM-101
Descriptor: MM-101, WD repeat-containing protein 5
Authors:Karatas, H, Townsend, E.C, Chen, Y, Bernard, D, Cao, F, Liu, L, Lei, M, Dou, Y, Wang, S.
Deposit date:2012-08-15
Release date:2013-07-31
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (3.393 Å)
Cite:High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction.
J.Am.Chem.Soc., 135, 2013
4GMB
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BU of 4gmb by Molmil
Crystal structure of human WD repeat domain 5 with compound MM-402
Descriptor: MM-402, WD repeat-containing protein 5
Authors:Karatas, H, Townsend, E.C, Chen, Y, Bernard, D, Cao, F, Liu, L, Lei, M, Dou, Y, Wang, S.
Deposit date:2012-08-15
Release date:2014-02-19
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.781 Å)
Cite:Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)-Mixed Lineage Leukemia (MLL) Protein-Protein Interaction.
J.Med.Chem., 60, 2017
4GM9
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BU of 4gm9 by Molmil
Crystal structure of human WD repeat domain 5 with compound MM-401
Descriptor: MM-401, WD repeat-containing protein 5
Authors:Karatas, H, Townsend, E.C, Chen, Y, Bernard, D, Liu, L, Dou, Y, Lei, M, Wang, S.
Deposit date:2012-08-15
Release date:2014-02-19
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of human WD repeat domain 5 with compound MM-401
To be Published
4I80
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BU of 4i80 by Molmil
Crystal structure of human menin in complex with a high-affinity macrocyclic peptidomimetics
Descriptor: Menin, macrocyclic peptidomimetic
Authors:Huang, J, Lei, M.
Deposit date:2012-12-01
Release date:2013-03-06
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure-Based Design of High-Affinity Macrocyclic Peptidomimetics to Block the Menin-Mixed Lineage Leukemia 1 (MLL1) Protein-Protein Interaction.
J.Med.Chem., 56, 2013
3KEY
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BU of 3key by Molmil
Crystal structure of S. cerevisiae Stn1 C-terminal
Descriptor: Protein STN1
Authors:Sun, J, Yu, E.Y, Yang, Y.T, Confer, L.A, Sun, S.H, Wan, K, Lue, N.F, Lei, M.
Deposit date:2009-10-26
Release date:2009-12-22
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Stn1-Ten1 is an Rpa2-Rpa3-like complex at telomeres.
Genes Dev., 23, 2009
3KF8
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BU of 3kf8 by Molmil
Crystal structure of C. tropicalis Stn1-ten1 complex
Descriptor: Protein stn1, Protein ten1
Authors:Sun, J, Yu, E.Y, Yang, Y.T, Confer, L.A, Sun, S.H, Wan, K, Lue, N.F, Lei, M.
Deposit date:2009-10-27
Release date:2009-12-22
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Stn1-Ten1 is an Rpa2-Rpa3-like complex at telomeres.
Genes Dev., 23, 2009
3L82
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BU of 3l82 by Molmil
X-ray Crystal structure of TRF1 and Fbx4 complex
Descriptor: F-box only protein 4, Telomeric repeat-binding factor 1
Authors:Zeng, Z.X, Wang, W, Yang, Y.T, Chen, Y, Yang, X.M, Diehl, J.A, Liu, X.D, Lei, M.
Deposit date:2009-12-29
Release date:2010-03-09
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural Basis of Selective Ubiquitination of TRF1 by SCF(Fbx4)
Dev.Cell, 18, 2010
3NBI
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BU of 3nbi by Molmil
Crystal structure of human RMI1 N-terminus
Descriptor: RecQ-mediated genome instability protein 1
Authors:Wang, F, Yang, Y, Singh, T.R, Busygina, V, Guo, R, Wan, K, Wang, W, Sung, P, Meetei, A.R, Lei, M.
Deposit date:2010-06-03
Release date:2010-09-22
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structures of RMI1 and RMI2, Two OB-Fold Regulatory Subunits of the BLM Complex.
Structure, 18, 2010
3NBH
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BU of 3nbh by Molmil
Crystal structure of human RMI1C-RMI2 complex
Descriptor: RecQ-mediated genome instability protein 1, RecQ-mediated genome instability protein 2
Authors:Wang, F, Yang, Y, Singh, T.R, Busygina, V, Guo, R, Wan, K, Wang, W, Sung, P, Meetei, A.R, Lei, M.
Deposit date:2010-06-03
Release date:2010-09-22
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structures of RMI1 and RMI2, Two OB-Fold Regulatory Subunits of the BLM Complex.
Structure, 18, 2010
2L3N
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BU of 2l3n by Molmil
Solution structure of Rap1-Taz1 fusion protein
Descriptor: DNA-binding protein rap1,Telomere length regulator taz1
Authors:Zhou, Z.R, Wang, F, Chen, Y, Lei, M, Hu, H.
Deposit date:2010-09-19
Release date:2011-01-12
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:A conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organisms.
Nat.Struct.Mol.Biol., 18, 2011
6MLC
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BU of 6mlc by Molmil
PHD6 domain of MLL3 in complex with histone H4
Descriptor: GLYCEROL, Histone H4, Histone-lysine N-methyltransferase 2C, ...
Authors:Dong, A, Liu, Y, Qin, S, Lei, M, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2018-09-27
Release date:2018-10-24
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural insights into trans-histone regulation of H3K4 methylation by unique histone H4 binding of MLL3/4.
Nat Commun, 10, 2019
2HKO
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BU of 2hko by Molmil
Crystal structure of LSD1
Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, Lysine-specific histone demethylase 1
Authors:Chen, Y, Yang, Y.T, Wang, F, Yanane, K, Zhang, Y, Lei, M.
Deposit date:2006-07-05
Release date:2006-08-29
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of human histone lysine-specific demethylase 1 (LSD1).
Proc.Natl.Acad.Sci.Usa, 103, 2006
2I46
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BU of 2i46 by Molmil
Crystal structure of human TPP1
Descriptor: Adrenocortical dysplasia protein homolog
Authors:Wang, F, Podell, E.R, Zaug, A.J, Yang, Y.T, Baciu, P, Else, T, Hammer, G.D, Cech, T.R, Lei, M.
Deposit date:2006-08-21
Release date:2006-11-28
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The POT1-TPP1 telomere complex is a telomerase processivity factor.
Nature, 445, 2007

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數據於2024-10-30公開中

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