7Y27
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![BU of 7y27 by Molmil](/molmil-images/mine/7y27) | Cryo-EM structure of the SST-14-bound SSTR2-miniGq-scFv16 complex | Descriptor: | CHOLESTEROL, Engineered Guanine nucleotide-binding protein G(q) subunit alpha, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Chen, S, Zheng, S. | Deposit date: | 2022-06-09 | Release date: | 2022-10-19 | Last modified: | 2023-02-15 | Method: | ELECTRON MICROSCOPY (3.48 Å) | Cite: | Molecular basis for the selective G protein signaling of somatostatin receptors. Nat.Chem.Biol., 19, 2023
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7Y26
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![BU of 7y26 by Molmil](/molmil-images/mine/7y26) | Cryo-EM structure of the octreotide-bound SSTR2-miniGq-scFv16 complex | Descriptor: | Engineered Guanine nucleotide-binding protein G(q) subunit alpha, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Chen, S, Zheng, S. | Deposit date: | 2022-06-09 | Release date: | 2022-10-19 | Last modified: | 2023-02-15 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Molecular basis for the selective G protein signaling of somatostatin receptors. Nat.Chem.Biol., 19, 2023
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8BDC
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![BU of 8bdc by Molmil](/molmil-images/mine/8bdc) | Human apo TRPM8 in a closed state (composite map) | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CHOLESTEROL HEMISUCCINATE, SODIUM ION, ... | Authors: | Palchevskyi, S, Czarnocki-Cieciura, M, Vistoli, G, Gervasoni, S, Nowak, E, Beccari, A.R, Nowotny, M, Talarico, C. | Deposit date: | 2022-10-19 | Release date: | 2023-11-01 | Method: | ELECTRON MICROSCOPY (2.65 Å) | Cite: | Structure of human TRPM8 channel. Commun Biol, 6, 2023
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1Z4A
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![BU of 1z4a by Molmil](/molmil-images/mine/1z4a) | |
7NXD
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![BU of 7nxd by Molmil](/molmil-images/mine/7nxd) | Cryo-EM structure of human integrin alpha5beta1 in the half-bent conformation | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Schumacher, S, Dedden, D, Vazquez Nunez, R, Matoba, K, Takagi, J, Biertumpfel, C, Mizuno, N. | Deposit date: | 2021-03-18 | Release date: | 2021-08-25 | Method: | ELECTRON MICROSCOPY (4.6 Å) | Cite: | Structural insights into integrin alpha 5 beta 1 opening by fibronectin ligand. Sci Adv, 7, 2021
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7NWL
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![BU of 7nwl by Molmil](/molmil-images/mine/7nwl) | Cryo-EM structure of human integrin alpha5beta1 (open form) in complex with fibronectin and TS2/16 Fv-clasp | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Integrin alpha-5, ... | Authors: | Schumacher, S, Dedden, D, Vazquez Nunez, R, Matoba, K, Takagi, J, Biertumpfel, C, Mizuno, N. | Deposit date: | 2021-03-17 | Release date: | 2021-06-02 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural insights into integrin alpha 5 beta 1 opening by fibronectin ligand. Sci Adv, 7, 2021
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7BEV
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7ONY
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![BU of 7ony by Molmil](/molmil-images/mine/7ony) | Crystal structure of PBP3 from P. aeruginosa | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DIMETHYL SULFOXIDE, GLYCEROL, ... | Authors: | Freischem, S, Grimm, I, Weiergraeber, O.H. | Deposit date: | 2021-05-26 | Release date: | 2021-08-04 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.77 Å) | Cite: | Interaction Mode of the Novel Monobactam AIC499 Targeting Penicillin Binding Protein 3 of Gram-Negative Bacteria. Biomolecules, 11, 2021
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7ONO
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7ONZ
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7ONW
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![BU of 7onw by Molmil](/molmil-images/mine/7onw) | Crystal structure of PBP3 from E. coli in complex with AIC499 | Descriptor: | (2S)-2-[(Z)-[1-(2-azanyl-1,3-thiazol-4-yl)-2-[[(2S)-3-methyl-1-oxidanylidene-3-(sulfooxyamino)butan-2-yl]amino]-2-oxidanylidene-ethylidene]amino]oxy-3-[4-[N-[(3R)-piperidin-3-yl]carbamimidoyl]phenoxy]propanoic acid, (4S)-2-METHYL-2,4-PENTANEDIOL, PHOSPHATE ION, ... | Authors: | Freischem, S, Grimm, I, Weiergraeber, O.H. | Deposit date: | 2021-05-26 | Release date: | 2021-08-04 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Interaction Mode of the Novel Monobactam AIC499 Targeting Penicillin Binding Protein 3 of Gram-Negative Bacteria. Biomolecules, 11, 2021
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7ONK
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![BU of 7onk by Molmil](/molmil-images/mine/7onk) | Crystal structure of PBP3 from P. aeruginosa in complex with AIC499 | Descriptor: | (2S)-2-[(Z)-[1-(2-azanyl-1,3-thiazol-4-yl)-2-[[(2S)-3-methyl-1-oxidanylidene-3-(sulfooxyamino)butan-2-yl]amino]-2-oxidanylidene-ethylidene]amino]oxy-3-[4-[N-[(3R)-piperidin-3-yl]carbamimidoyl]phenoxy]propanoic acid, CHLORIDE ION, GLYCEROL, ... | Authors: | Freischem, S, Grimm, I, Weiergraeber, O.H. | Deposit date: | 2021-05-25 | Release date: | 2021-08-04 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.73 Å) | Cite: | Interaction Mode of the Novel Monobactam AIC499 Targeting Penicillin Binding Protein 3 of Gram-Negative Bacteria. Biomolecules, 11, 2021
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7ONN
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![BU of 7onn by Molmil](/molmil-images/mine/7onn) | Crystal structure of PBP3 transpeptidase domain from E. coli in complex with AIC499 | Descriptor: | (2S)-2-[(Z)-[1-(2-azanyl-1,3-thiazol-4-yl)-2-[[(2S)-3-methyl-1-oxidanylidene-3-(sulfooxyamino)butan-2-yl]amino]-2-oxidanylidene-ethylidene]amino]oxy-3-[4-[N-[(3R)-piperidin-3-yl]carbamimidoyl]phenoxy]propanoic acid, DODECAETHYLENE GLYCOL, Peptidoglycan D,D-transpeptidase FtsI | Authors: | Freischem, S, Grimm, I, Weiergraeber, O.H. | Deposit date: | 2021-05-25 | Release date: | 2021-08-04 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | Interaction Mode of the Novel Monobactam AIC499 Targeting Penicillin Binding Protein 3 of Gram-Negative Bacteria. Biomolecules, 11, 2021
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7ONX
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![BU of 7onx by Molmil](/molmil-images/mine/7onx) | Crystal structure of PBP3 from P. aeruginosa | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, Peptidoglycan D,D-transpeptidase FtsI | Authors: | Freischem, S, Grimm, I, Weiergraeber, O.H. | Deposit date: | 2021-05-26 | Release date: | 2021-08-04 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.16 Å) | Cite: | Interaction Mode of the Novel Monobactam AIC499 Targeting Penicillin Binding Protein 3 of Gram-Negative Bacteria. Biomolecules, 11, 2021
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8EZB
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![BU of 8ezb by Molmil](/molmil-images/mine/8ezb) | NHEJ Long-range complex with ATP | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, DNA (30-MER), DNA (31-MER), ... | Authors: | Chen, S, He, Y. | Deposit date: | 2022-10-31 | Release date: | 2023-06-14 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (8.9 Å) | Cite: | Cryo-EM visualization of DNA-PKcs structural intermediates in NHEJ. Sci Adv, 9, 2023
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8EZA
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![BU of 8eza by Molmil](/molmil-images/mine/8eza) | NHEJ Long-range complex with PAXX | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, DNA (30-MER), DNA (31-MER), ... | Authors: | Chen, S, He, Y. | Deposit date: | 2022-10-31 | Release date: | 2023-06-14 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (4.39 Å) | Cite: | Cryo-EM visualization of DNA-PKcs structural intermediates in NHEJ. Sci Adv, 9, 2023
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8EZ9
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![BU of 8ez9 by Molmil](/molmil-images/mine/8ez9) | Dimeric complex of DNA-PKcs | Descriptor: | DNA-dependent protein kinase catalytic subunit, unknown region of DNA-PKcs | Authors: | Chen, S, He, Y. | Deposit date: | 2022-10-31 | Release date: | 2023-06-14 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (5.67 Å) | Cite: | Cryo-EM visualization of DNA-PKcs structural intermediates in NHEJ. Sci Adv, 9, 2023
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5T0I
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![BU of 5t0i by Molmil](/molmil-images/mine/5t0i) | Structural basis for dynamic regulation of the human 26S proteasome | Descriptor: | 26S protease regulatory subunit 10B, 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, ... | Authors: | Chen, S, Wu, J, Lu, Y, Ma, Y.B, Lee, B.H, Yu, Z, Ouyang, Q, Finley, D, Kirschner, M.W, Mao, Y. | Deposit date: | 2016-08-16 | Release date: | 2016-10-19 | Last modified: | 2016-11-30 | Method: | ELECTRON MICROSCOPY (8 Å) | Cite: | Structural basis for dynamic regulation of the human 26S proteasome. Proc.Natl.Acad.Sci.USA, 113, 2016
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5T0C
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![BU of 5t0c by Molmil](/molmil-images/mine/5t0c) | Structural basis for dynamic regulation of the human 26S proteasome | Descriptor: | 26S protease regulatory subunit 10B, 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, ... | Authors: | Chen, S, Wu, J, Lu, Y, Ma, Y.B, Lee, B.H, Yu, Z, Ouyang, Q, Finley, D, Kirschner, M.W, Mao, Y. | Deposit date: | 2016-08-15 | Release date: | 2016-10-19 | Last modified: | 2018-07-18 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structural basis for dynamic regulation of the human 26S proteasome. Proc.Natl.Acad.Sci.USA, 113, 2016
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1YBG
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![BU of 1ybg by Molmil](/molmil-images/mine/1ybg) | MurA inhibited by a derivative of 5-sulfonoxy-anthranilic acid | Descriptor: | N-METHYL-N-{2-[(2-NAPHTHYLSULFONYL)AMINO]-5-[(2-NAPHTHYLSULFONYL)OXY]BENZOYL}-L-ASPARTIC ACID, UDP-N-acetylglucosamine 1-carboxyvinyltransferase | Authors: | Eschenburg, S, Priestman, M.A, Abdul-Latif, F.A, Delachaume, C, Fassy, F, Schonbrunn, E. | Deposit date: | 2004-12-20 | Release date: | 2005-02-15 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | A Novel Inhibitor That Suspends the Induced Fit Mechanism of UDP-N-acetylglucosamine Enolpyruvyl Transferase (MurA). J.Biol.Chem., 280, 2005
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5T0J
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![BU of 5t0j by Molmil](/molmil-images/mine/5t0j) | Structural basis for dynamic regulation of the human 26S proteasome | Descriptor: | 26S protease regulatory subunit 10B, 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, ... | Authors: | Chen, S, Wu, J, Lu, Y, Ma, Y.B, Lee, B.H, Yu, Z, Ouyang, Q, Finley, D, Kirschner, M.W, Mao, Y. | Deposit date: | 2016-08-16 | Release date: | 2016-10-19 | Last modified: | 2016-11-30 | Method: | ELECTRON MICROSCOPY (8 Å) | Cite: | Structural basis for dynamic regulation of the human 26S proteasome. Proc.Natl.Acad.Sci.USA, 113, 2016
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5VOU
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![BU of 5vou by Molmil](/molmil-images/mine/5vou) | Structure of AMPA receptor-TARP complex | Descriptor: | Glutamate receptor 2, Voltage-dependent calcium channel gamma-2 subunit | Authors: | Chen, S, Zhao, Y, Wang, Y.S, Shekhar, M, Tajkhorshid, E, Gouaux, E. | Deposit date: | 2017-05-03 | Release date: | 2017-07-12 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (6.4 Å) | Cite: | Activation and Desensitization Mechanism of AMPA Receptor-TARP Complex by Cryo-EM. Cell, 170, 2017
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1JY8
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![BU of 1jy8 by Molmil](/molmil-images/mine/1jy8) | 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (IspF) | Descriptor: | 2C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE, 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, CYTIDINE-5'-MONOPHOSPHATE, ... | Authors: | Steinbacher, S, Kaiser, J, Wungsintaweekul, J, Hecht, S, Eisenreich, W, Gerhardt, S, Bacher, A, Rohdich, F. | Deposit date: | 2001-09-11 | Release date: | 2002-01-30 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure of 2C-methyl-d-erythritol-2,4-cyclodiphosphate synthase involved in mevalonate-independent biosynthesis of isoprenoids. J.Mol.Biol., 316, 2002
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5VOT
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![BU of 5vot by Molmil](/molmil-images/mine/5vot) | Structure of AMPA receptor-TARP complex | Descriptor: | Glutamate receptor 2, Voltage-dependent calcium channel gamma-2 subunit | Authors: | Chen, S, Zhao, Y, Wang, Y.S, Shekhar, M, Tajkhorshid, E, Gouaux, E. | Deposit date: | 2017-05-03 | Release date: | 2017-07-12 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (4.9 Å) | Cite: | Activation and Desensitization Mechanism of AMPA Receptor-TARP Complex by Cryo-EM. Cell, 170, 2017
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5T0G
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![BU of 5t0g by Molmil](/molmil-images/mine/5t0g) | Structural basis for dynamic regulation of the human 26S proteasome | Descriptor: | 26S protease regulatory subunit 10B, 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, ... | Authors: | Chen, S, Wu, J, Lu, Y, Ma, Y.B, Lee, B.H, Yu, Z, Ouyang, Q, Finley, D, Kirschner, M.W, Mao, Y. | Deposit date: | 2016-08-16 | Release date: | 2016-10-19 | Last modified: | 2016-11-30 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | Structural basis for dynamic regulation of the human 26S proteasome. Proc.Natl.Acad.Sci.USA, 113, 2016
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