7ONK

Crystal structure of PBP3 from P. aeruginosa in complex with AIC499

Summary for 7ONK

• Entry DOI: 10.2210/pdb7onk/pdb
• Related: 7ONX
• Descriptor: Peptidoglycan D,D-transpeptidase FtsI, (2S)-2-[(Z)-[1-(2-azanyl-1,3-thiazol-4-yl)-2-[[(2S)-3-methyl-1-oxidanylidene-3-(sulfooxyamino)butan-2-yl]amino]-2-oxidanylidene-ethylidene]amino]oxy-3-[4-[N-[(3R)-piperidin-3-yl]carbamimidoyl]phenoxy]propanoic acid, CHLORIDE ION, ... (5 entities in total)
• Functional Keywords: monobactam, pbp3, peptidoglycan synthesis, drug complex, protein binding
• Biological source: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
• Total number of polymer chains: 2
• Total formula weight: 117841.15

Authors

Freischem, S.,Grimm, I.,Weiergraeber, O.H. (deposition date: 2021-05-25, release date: 2021-08-04, Last modification date: 2024-01-31)

• Primary citation: Freischem, S.,Grimm, I.,Lopez-Perez, A.,Willbold, D.,Klenke, B.,Vuong, C.,Dingley, A.J.,Weiergraber, O.H.; Interaction Mode of the Novel Monobactam AIC499 Targeting Penicillin Binding Protein 3 of Gram-Negative Bacteria.; Biomolecules, 11:-, 2021; PubMed: 34356681; DOI: 10.3390/biom11071057

Experimental method

X-RAY DIFFRACTION (1.73 Å)