2X2A
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![BU of 2x2a by Molmil](/molmil-images/mine/2x2a) | Free acetyl-CypA trigonal form | Descriptor: | GLYCEROL, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A, SULFATE ION | Authors: | Lammers, M, Neumann, H, Chin, J.W, James, L.C. | Deposit date: | 2010-01-12 | Release date: | 2010-03-23 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Acetylation Regulates Cyclophilin a Catalysis, Immunosuppression and HIV Isomerization. Nat.Chem.Biol., 6, 2010
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2X2D
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![BU of 2x2d by Molmil](/molmil-images/mine/2x2d) | acetyl-CypA:HIV-1 N-term capsid domain complex | Descriptor: | CAPSID PROTEIN P24, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A | Authors: | Lammers, M, Neumann, H, Chin, J.W, James, L.C. | Deposit date: | 2010-01-12 | Release date: | 2010-03-23 | Last modified: | 2018-01-24 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Acetylation Regulates Cyclophilin a Catalysis, Immunosuppression and HIV Isomerisation Nat.Chem.Biol., 6, 2010
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2WOZ
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![BU of 2woz by Molmil](/molmil-images/mine/2woz) | The novel beta-propeller of the BTB-Kelch protein Krp1 provides the binding site for Lasp-1 that is necessary for pseudopodia extension | Descriptor: | KELCH REPEAT AND BTB DOMAIN-CONTAINING PROTEIN 10 | Authors: | Gray, C.H, McGarry, L.C, Spence, H.J, Riboldi-Tunnicliffe, A, Ozanne, B.W. | Deposit date: | 2009-07-31 | Release date: | 2009-09-01 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Novel beta-propeller of the BTB-Kelch protein Krp1 provides a binding site for Lasp-1 that is necessary for pseudopodial extension. J. Biol. Chem., 284, 2009
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2X2C
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![BU of 2x2c by Molmil](/molmil-images/mine/2x2c) | acetyl-CypA:cyclosporine complex | Descriptor: | CYCLOSPORIN A, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A | Authors: | Lammers, M, Neumann, H, Chin, J.W, James, L.C. | Deposit date: | 2010-01-12 | Release date: | 2010-03-23 | Last modified: | 2018-05-02 | Method: | X-RAY DIFFRACTION (2.41 Å) | Cite: | Acetylation Regulates Cyclophilin a Catalysis, Immunosuppression and HIV Isomerisation Nat.Chem.Biol., 6, 2010
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2X5U
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![BU of 2x5u by Molmil](/molmil-images/mine/2x5u) | 80 microsecond Laue diffraction snapshot from crystals of a photosynthetic reaction centre without illumination. | Descriptor: | BACTERIOCHLOROPHYLL B, BACTERIOPHEOPHYTIN B, FE (II) ION, ... | Authors: | Wohri, A.B, Katona, G, Johansson, L.C, Fritz, E, Malmerberg, E, Andersson, M, Vincent, J, Eklund, M, Cammarata, M, Wulff, M, Davidsson, J, Groenhof, G, Neutze, R. | Deposit date: | 2010-02-10 | Release date: | 2010-05-12 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Light-induced structural changes in a photosynthetic reaction center caught by Laue diffraction. Science, 328, 2010
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2WJN
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![BU of 2wjn by Molmil](/molmil-images/mine/2wjn) | Lipidic sponge phase crystal structure of photosynthetic reaction centre from Blastochloris viridis (high dose) | Descriptor: | 15-cis-1,2-dihydroneurosporene, BACTERIOCHLOROPHYLL B, BACTERIOPHEOPHYTIN B, ... | Authors: | Wohri, A.B, Wahlgren, W.Y, Malmerberg, E, Johansson, L.C, Neutze, R, Katona, G. | Deposit date: | 2009-05-27 | Release date: | 2009-09-22 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Lipidic sponge phase crystal structure of a photosynthetic reaction center reveals lipids on the protein surface. Biochemistry, 48, 2009
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2X82
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![BU of 2x82 by Molmil](/molmil-images/mine/2x82) | |
2X25
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![BU of 2x25 by Molmil](/molmil-images/mine/2x25) | Free acetyl-CypA orthorhombic form | Descriptor: | PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A | Authors: | Lammers, M, Neumann, H, Chin, J.W, James, L.C. | Deposit date: | 2010-01-11 | Release date: | 2010-03-23 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Acetylation Regulates Cyclophilin a Catalysis, Immunosuppression and HIV Isomerization. Nat.Chem.Biol., 6, 2010
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2WIO
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![BU of 2wio by Molmil](/molmil-images/mine/2wio) | Structure of the histidine tagged, open cytochrome P450 Eryk from S. erythraea | Descriptor: | ERYTHROMYCIN B/D C-12 HYDROXYLASE, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Savino, C, Montemiglio, L.C, Sciara, G, Miele, A.E, Kedrew, S.G, Gianni, S, Vallone, B. | Deposit date: | 2009-05-14 | Release date: | 2009-07-21 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Investigating the Structural Plasticity of a Cytochrome P450: Three-Dimensional Structures of P450 Eryk and Binding to its Physiological Substrate. J.Biol.Chem., 284, 2009
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2WLW
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![BU of 2wlw by Molmil](/molmil-images/mine/2wlw) | Structure of the N-terminal capsid domain of HIV-2 | Descriptor: | PEPTIDYL-PROLYL CIS-TRANS ISOMERASE | Authors: | Price, A.J, Marzetta, F, Lammers, M, Ylinen, L.M.J, Schaller, T, Wilson, S.J, Towers, G.J, James, L.C. | Deposit date: | 2009-06-26 | Release date: | 2009-09-22 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Active Site Remodelling Switches HIV Specificity of Antiretroviral Trimcyp Nat.Struct.Mol.Biol., 16, 2009
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2WJM
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![BU of 2wjm by Molmil](/molmil-images/mine/2wjm) | Lipidic sponge phase crystal structure of the photosynthetic reaction centre from Blastochloris viridis (low dose) | Descriptor: | 15-cis-1,2-dihydroneurosporene, BACTERIOCHLOROPHYLL B, BACTERIOPHEOPHYTIN B, ... | Authors: | Woehri, A.B, Wahlgren, W.Y, Malmerberg, E, Johansson, L.C, Neutze, R, Katona, G. | Deposit date: | 2009-05-27 | Release date: | 2009-09-22 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Lipidic sponge phase crystal structure of a photosynthetic reaction center reveals lipids on the protein surface. Biochemistry, 48, 2009
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2WLV
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![BU of 2wlv by Molmil](/molmil-images/mine/2wlv) | Structure of the N-terminal capsid domain of HIV-2 | Descriptor: | GAG POLYPROTEIN | Authors: | Price, A.J, Marzetta, F, Lammers, M, Ylinen, L.M.J, Schaller, T, Wilson, S.J, Towers, G.J, James, L.C. | Deposit date: | 2009-06-26 | Release date: | 2009-09-22 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | Active Site Remodelling Switches HIV Specificity of Antiretroviral Trimcyp Nat.Struct.Mol.Biol., 16, 2009
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2XFH
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![BU of 2xfh by Molmil](/molmil-images/mine/2xfh) | Structure of cytochrome P450 EryK cocrystallized with inhibitor clotrimazole. | Descriptor: | 1-[(2-CHLOROPHENYL)(DIPHENYL)METHYL]-1H-IMIDAZOLE, DIMETHYL SULFOXIDE, ERYTHROMYCIN B/D C-12 HYDROXYLASE, ... | Authors: | Savino, C, Montemiglio, L.C, Gianni, S, Vallone, B. | Deposit date: | 2010-05-24 | Release date: | 2010-09-29 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Azole Drugs Trap Cytochrome P450 Eryk in Alternative Conformational States. Biochemistry, 49, 2010
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1WWC
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![BU of 1wwc by Molmil](/molmil-images/mine/1wwc) | NT3 BINDING DOMAIN OF HUMAN TRKC RECEPTOR | Descriptor: | PROTEIN (NT-3 GROWTH FACTOR RECEPTOR TRKC) | Authors: | Ultsch, M.H, Wiesmann, C, Simmons, L.C, Henrich, J, Yang, M, Reilly, D, Bass, S.H, De Vos, A.M. | Deposit date: | 1999-04-30 | Release date: | 1999-07-07 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structures of the neurotrophin-binding domain of TrkA, TrkB and TrkC. J.Mol.Biol., 290, 1999
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1XD8
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![BU of 1xd8 by Molmil](/molmil-images/mine/1xd8) | Crystal Structure of the Nitrogenase Fe protein Asp39Asn | Descriptor: | IRON/SULFUR CLUSTER, Nitrogenase iron protein 1 | Authors: | Jang, S.B, Jeong, M.S, Seefeldt, L.C, Peters, J.W. | Deposit date: | 2004-09-05 | Release date: | 2005-03-01 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural and biochemical implications of single amino acid substitutions in the nucleotide-dependent switch regions of the nitrogenase Fe protein from Azotobacter vinelandii J.Biol.Inorg.Chem., 9, 2004
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1XDB
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![BU of 1xdb by Molmil](/molmil-images/mine/1xdb) | Crystal Structure of the Nitrogenase Fe protein Asp129Glu | Descriptor: | IRON/SULFUR CLUSTER, Nitrogenase iron protein 1 | Authors: | Jang, S.B, Jeong, M.S, Seefeldt, L.C, Peters, J.W. | Deposit date: | 2004-09-05 | Release date: | 2005-03-01 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural and biochemical implications of single amino acid substitutions in the nucleotide-dependent switch regions of the nitrogenase Fe protein from Azotobacter vinelandii J.Biol.Inorg.Chem., 9, 2004
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1ZGI
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![BU of 1zgi by Molmil](/molmil-images/mine/1zgi) | thrombin in complex with an oxazolopyridine inhibitor 21 | Descriptor: | (R)-2-(2-(1H-1,2,4-TRIAZOL-1-YL)BENZYL)-N-(2,2-DIFLUORO-2-(PIPERIDIN-2-YL)ETHYL)OXAZOLO[4,5-C]PYRIDIN-4-AMINE, Hirudin, Thrombin | Authors: | Deng, J.Z, McMasters, D.R, Rabbat, P.M, Williams, P.D, Coburn, C.A, Yan, Y, Kuo, L.C, Lewis, S.D, Lucas, B.J, Krueger, J.A, Strulovici, B, Vacca, J.P, Lyle, T.A, Burgey, C.S. | Deposit date: | 2005-04-21 | Release date: | 2005-09-27 | Last modified: | 2013-03-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Development of an oxazolopyridine series of dual thrombin/factor Xa inhibitors via structure-guided lead optimization. Bioorg.Med.Chem.Lett., 15, 2005
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1YEZ
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![BU of 1yez by Molmil](/molmil-images/mine/1yez) | Solution structure of the conserved protein from the gene locus MM1357 of Methanosarcina mazei. Northeast Structural Genomics target MaR30. | Descriptor: | MM1357 | Authors: | Rossi, P, Aramini, J.M, Swapna, G.V.T, Huang, Y.P, Xiao, R, Ho, C.K, Ma, L.C, Acton, T.B, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2004-12-29 | Release date: | 2005-02-22 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Solution structure of the conserved protein from the gene locus MM1357 of Methanosarcina mazei. Northeast Structural Genomics target MaR30. To be Published
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1YRK
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![BU of 1yrk by Molmil](/molmil-images/mine/1yrk) | The C2 Domain of PKC is a new Phospho-Tyrosine Binding Domain | Descriptor: | 13-residue peptide, ACETIC ACID, Protein kinase C, ... | Authors: | Benes, C.H, Wu, N, Elia, A.E, Dharia, T, Cantley, L.C, Soltoff, S.P. | Deposit date: | 2005-02-03 | Release date: | 2005-07-26 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | The C2 domain of PKCdelta is a phosphotyrosine binding domain. Cell(Cambridge,Mass.), 121, 2005
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1YW2
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![BU of 1yw2 by Molmil](/molmil-images/mine/1yw2) | Mutated Mus Musculus P38 Kinase (mP38) | Descriptor: | 2-(ETHOXYMETHYL)-4-(4-FLUOROPHENYL)-3-[2-(2-HYDROXYPHENOXY)PYRIMIDIN-4-YL]ISOXAZOL-5(2H)-ONE, Mitogen-activated protein kinase 14 | Authors: | Laughlin, S.K, Clark, M.P, Djung, J.F, Golebiowski, A, Brugel, T.A, Sabat, M, Bookland, R.G, Laufersweiler, M.J, Vanrens, J.C, Townes, J.A, De, B, Hsieh, L.C, Xu, S.C, Walter, R.L, Mekel, M.J, Janusz, M.J. | Deposit date: | 2005-02-16 | Release date: | 2005-05-10 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | The development of new isoxazolone based inhibitors of tumor necrosis factor-alpha (TNF-alpha) production. Bioorg.Med.Chem.Lett., 15, 2005
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1ZJN
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![BU of 1zjn by Molmil](/molmil-images/mine/1zjn) | Human DNA Polymerase beta complexed with DNA containing an A-A mismatched primer terminus with dGTP | Descriptor: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3', 5'-D(P*GP*TP*CP*GP*G)-3', ... | Authors: | Batra, V.K, Beard, W.A, Shock, D.D, Pedersen, L.C, Wilson, S.H. | Deposit date: | 2005-04-29 | Release date: | 2005-08-16 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.61 Å) | Cite: | Nucleotide-induced DNA polymerase active site motions accommodating a mutagenic DNA intermediate. STRUCTURE, 13, 2005
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1YRS
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![BU of 1yrs by Molmil](/molmil-images/mine/1yrs) | Crystal structure of KSP in complex with inhibitor 1 | Descriptor: | 3-[(5S)-1-ACETYL-3-(2-CHLOROPHENYL)-4,5-DIHYDRO-1H-PYRAZOL-5-YL]PHENOL, ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIF11, ... | Authors: | Cox, C.D, Breslin, M.J, Mariano, B.J, Coleman, P.J, Buser, C.A, Walsh, E.S, Hamilton, K, Kohl, N.E, Torrent, M, Yan, Y, Kuo, L.C, Hartman, G.D. | Deposit date: | 2005-02-04 | Release date: | 2005-04-12 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Kinesin spindle protein (KSP) inhibitors. Part 1: The discovery of 3,5-diaryl-4,5-dihydropyrazoles as potent and selective inhibitors of the mitotic kinesin KSP BIOORG.MED.CHEM.LETT., 15, 2005
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1ZGV
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![BU of 1zgv by Molmil](/molmil-images/mine/1zgv) | Thrombin in complex with an oxazolopyridine inhibitor 2 | Descriptor: | Hirudin, N7-BUTYL-N2-(5-CHLORO-2-METHYLPHENYL)-5-METHYL[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE-2,7-DIAMINE, Thrombin | Authors: | Deng, J.Z, McMasters, D.R, Rabbat, P.M, Williams, P.D, Coburn, C.A, Yan, Y, Kuo, L.C, Lewis, S.D, Lucas, B.J, Krueger, J.A, Strulovici, B, Vacca, J.P, Lyle, T.A, Burgey, C.S. | Deposit date: | 2005-04-22 | Release date: | 2005-09-27 | Last modified: | 2013-03-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Development of an oxazolopyridine series of dual thrombin/factor Xa inhibitors via structure-guided lead optimization. Bioorg.Med.Chem.Lett., 15, 2005
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1ZM1
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![BU of 1zm1 by Molmil](/molmil-images/mine/1zm1) | Crystal structures of complex F. succinogenes 1,3-1,4-beta-D-glucanase and beta-1,3-1,4-cellotriose | Descriptor: | Beta-glucanase, CALCIUM ION, beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-3)-beta-D-glucopyranose | Authors: | Tsai, L.C, Shyur, L.F, Cheng, Y.S, Lee, S.H. | Deposit date: | 2005-05-10 | Release date: | 2006-05-10 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of truncated Fibrobacter succinogenes 1,3-1,4-beta-D-glucanase in complex with beta-1,3-1,4-cellotriose J.Mol.Biol., 354, 2005
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1XW4
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![BU of 1xw4 by Molmil](/molmil-images/mine/1xw4) | Crystal Structure of Human Sulfiredoxin (Srx) in Complex with ADP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Sulfiredoxin | Authors: | Murray, M.S, Jonsson, T.J, Johnson, L.C, Poole, L.B, Lowther, W.T. | Deposit date: | 2004-10-29 | Release date: | 2005-05-24 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis for the retroreduction of inactivated peroxiredoxins by human sulfiredoxin. Biochemistry, 44, 2005
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