1ZGI
thrombin in complex with an oxazolopyridine inhibitor 21
Summary for 1ZGI
Entry DOI | 10.2210/pdb1zgi/pdb |
Descriptor | Thrombin, Hirudin, (R)-2-(2-(1H-1,2,4-TRIAZOL-1-YL)BENZYL)-N-(2,2-DIFLUORO-2-(PIPERIDIN-2-YL)ETHYL)OXAZOLO[4,5-C]PYRIDIN-4-AMINE, ... (4 entities in total) |
Functional Keywords | thrombin, thrombin inhibitor complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted, extracellular space: P00734 Secreted: P28511 |
Total number of polymer chains | 2 |
Total formula weight | 34882.82 |
Authors | Deng, J.Z.,McMasters, D.R.,Rabbat, P.M.,Williams, P.D.,Coburn, C.A.,Yan, Y.,Kuo, L.C.,Lewis, S.D.,Lucas, B.J.,Krueger, J.A.,Strulovici, B.,Vacca, J.P.,Lyle, T.A.,Burgey, C.S. (deposition date: 2005-04-21, release date: 2005-09-27, Last modification date: 2013-03-13) |
Primary citation | Deng, J.Z.,McMasters, D.R.,Rabbat, P.M.,Williams, P.D.,Coburn, C.A.,Yan, Y.,Kuo, L.C.,Lewis, S.D.,Lucas, B.J.,Krueger, J.A.,Strulovici, B.,Vacca, J.P.,Lyle, T.A.,Burgey, C.S. Development of an oxazolopyridine series of dual thrombin/factor Xa inhibitors via structure-guided lead optimization. Bioorg.Med.Chem.Lett., 15:4411-4416, 2005 Cited by PubMed: 16137886DOI: 10.1016/j.bmcl.2005.07.022 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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