1R9V
 
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8BI2
 | | Syk kinase domain in complex with macrocyclic inhibitor 20a | | Descriptor: | 10,13,23-trimethyl-16-oxa-2,4,8,9,13,19,23,30-octazapentacyclo[19.5.2.1^{3,7}.1^{8,11}.0^{24,28}]triaconta-1(27),3,5,7(30),9,11(29),21,24(28),25-nonaen-20-one, Tyrosine-protein kinase SYK | | Authors: | Read, J.A, Patel, J. | | Deposit date: | 2022-11-01 | | Release date: | 2023-06-14 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (1.508 Å) | | Cite: | Optimization of a series of novel, potent and selective Macrocyclic SYK inhibitors.
Bioorg.Med.Chem.Lett., 91, 2023
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4ZJV
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7AYY
 | | Structure of the human 8-oxoguanine DNA Glycosylase hOGG1 in complex with activator TH10785 | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLYCEROL, N-glycosylase/DNA lyase, ... | | Authors: | Masuyer, G, Davies, J.R, Stenmark, P. | | Deposit date: | 2020-11-13 | | Release date: | 2022-06-01 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function.
Science, 376, 2022
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7AYZ
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7AZ0
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6QI5
 | | Near Atomic Structure of an Atadenovirus Shows a possible gene duplication event and Intergenera Variations in Cementing Proteins | | Descriptor: | Hexon protein, PIIIa, Penton protein, ... | | Authors: | Condezo, G.N, Marabini, R, Gomez-Blanco, J, SanMartin, C. | | Deposit date: | 2019-01-17 | | Release date: | 2020-08-05 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Near-atomic structure of an atadenovirus reveals a conserved capsid-binding motif and intergenera variations in cementing proteins.
Sci Adv, 7, 2021
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8ODZ
 | | Cryo-EM structure of a pre-dimerized murine IL-12 complete extracellular signaling complex (Class 1). | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-12 receptor subunit beta-1,Death-associated protein kinase 1, Interleukin-12 receptor subunit beta-2,Calmodulin-1, ... | | Authors: | Felix, J, Bloch, Y, Savvides, S.N. | | Deposit date: | 2023-03-10 | | Release date: | 2024-02-07 | | Last modified: | 2024-05-01 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23.
Nat.Struct.Mol.Biol., 31, 2024
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8OE4
 | | Cryo-EM structure of a pre-dimerized human IL-23 complete extracellular signaling complex. | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-12 receptor subunit beta-1,Death-associated protein kinase 1, ... | | Authors: | Bloch, Y, Felix, J, Savvides, S.N. | | Deposit date: | 2023-03-10 | | Release date: | 2024-02-07 | | Last modified: | 2024-05-01 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23.
Nat.Struct.Mol.Biol., 31, 2024
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8ODX
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8OE0
 | | Cryo-EM structure of a pre-dimerized murine IL-12 complete extracellular signaling complex (Class 2). | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-12 receptor subunit beta-1,Death-associated protein kinase 1, ... | | Authors: | Felix, J, Bloch, Y, Savvides, S.N. | | Deposit date: | 2023-03-10 | | Release date: | 2024-02-07 | | Last modified: | 2024-05-01 | | Method: | ELECTRON MICROSCOPY (4.6 Å) | | Cite: | Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23.
Nat.Struct.Mol.Biol., 31, 2024
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2H6Y
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2H71
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8P9Y
 | | SARS-CoV-2 S protein S:D614G mutant in 3-down with binding site of an entry inhibitor | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, SODIUM ION, ... | | Authors: | Adhav, A, Forcada-Nadal, A, Marco-Marin, C, Lopez-Redondo, M.L, Llacer, J.L. | | Deposit date: | 2023-06-06 | | Release date: | 2023-09-27 | | Method: | ELECTRON MICROSCOPY (4.3 Å) | | Cite: | C-2 Thiophenyl Tryptophan Trimers Inhibit Cellular Entry of SARS-CoV-2 through Interaction with the Viral Spike (S) Protein.
J.Med.Chem., 66, 2023
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8P99
 | | SARS-CoV-2 S-protein:D614G mutant in 1-up conformation | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1,Spike glycoprotein | | Authors: | Adhav, A, Forcada-Nadal, A, Marco-Marin, C, Lopez-Redondo, M.L, Llacer, J.L. | | Deposit date: | 2023-06-05 | | Release date: | 2023-09-27 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | C-2 Thiophenyl Tryptophan Trimers Inhibit Cellular Entry of SARS-CoV-2 through Interaction with the Viral Spike (S) Protein.
J.Med.Chem., 66, 2023
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8PAS
 | | Crystal structure of MAP4K1 with a SMOL inhibitor | | Descriptor: | 4-[2,6-bis(fluoranyl)-4-(3-morpholin-4-ylpropylcarbamoylamino)phenoxy]-~{N}-[(4-methyl-1,2,5-oxadiazol-3-yl)methyl]-1~{H}-pyrrolo[2,3-b]pyridine-3-carboxamide, Mitogen-activated protein kinase kinase kinase kinase 1 | | Authors: | Friberg, A. | | Deposit date: | 2023-06-08 | | Release date: | 2024-06-26 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Identification and optimization of Azaindole based MAP4K1 Inhibitors and the discovery of BAY-405
To Be Published
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8PAR
 | | Crystal structure of human MAP4K1 with an inhibitor, BAY-405 | | Descriptor: | GLYCEROL, Mitogen-activated protein kinase kinase kinase kinase 1, ~{N}-[3,5-bis(fluoranyl)-4-[[3-[1-(trifluoromethyl)cyclopropyl]-1~{H}-pyrrolo[2,3-b]pyridin-4-yl]oxy]phenyl]-2,9-dioxa-4-azaspiro[5.5]undec-3-en-3-amine | | Authors: | Schaefer, M. | | Deposit date: | 2023-06-08 | | Release date: | 2024-06-26 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Identification and optimization of Azaindole based MAP4K1 Inhibitors and the discovery of BAY-405
To Be Published
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6ZV3
 | | TFIIS N-terminal domain (TND) from human MED26 | | Descriptor: | Mediator of RNA polymerase II transcription subunit 26 | | Authors: | Veverka, V. | | Deposit date: | 2020-07-23 | | Release date: | 2021-12-01 | | Last modified: | 2024-06-19 | | Method: | SOLUTION NMR | | Cite: | A ubiquitous disordered protein interaction module orchestrates transcription elongation.
Science, 374, 2021
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6ZV1
 | | TFIIS N-terminal domain (TND) from human IWS1 | | Descriptor: | Protein IWS1 homolog | | Authors: | Veverka, V. | | Deposit date: | 2020-07-23 | | Release date: | 2021-12-01 | | Last modified: | 2024-06-19 | | Method: | SOLUTION NMR | | Cite: | A ubiquitous disordered protein interaction module orchestrates transcription elongation.
Science, 374, 2021
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6ZV2
 | | TFIIS N-terminal domain (TND) from human PPP1R10 | | Descriptor: | Serine/threonine-protein phosphatase 1 regulatory subunit 10 | | Authors: | Veverka, V. | | Deposit date: | 2020-07-23 | | Release date: | 2021-12-01 | | Last modified: | 2024-06-19 | | Method: | SOLUTION NMR | | Cite: | A ubiquitous disordered protein interaction module orchestrates transcription elongation.
Science, 374, 2021
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6ZUZ
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6ZV4
 | | Human TFIIS N-terminal domain in complex with IWS1 | | Descriptor: | Transcription elongation factor A protein 1,Protein IWS1 homolog | | Authors: | Veverka, V. | | Deposit date: | 2020-07-23 | | Release date: | 2021-12-01 | | Last modified: | 2024-06-19 | | Method: | SOLUTION NMR | | Cite: | A ubiquitous disordered protein interaction module orchestrates transcription elongation.
Science, 374, 2021
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6ZV0
 | | TFIIS N-terminal domain (TND) from human LEDGF/p75 | | Descriptor: | PC4 and SFRS1-interacting protein | | Authors: | Veverka, V. | | Deposit date: | 2020-07-23 | | Release date: | 2021-12-01 | | Last modified: | 2024-06-19 | | Method: | SOLUTION NMR | | Cite: | A ubiquitous disordered protein interaction module orchestrates transcription elongation.
Science, 374, 2021
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6ZUY
 | | Human TFIIS N-terminal domain (TND) | | Descriptor: | Transcription elongation factor A protein 1 | | Authors: | Veverka, V. | | Deposit date: | 2020-07-23 | | Release date: | 2021-12-01 | | Last modified: | 2024-06-19 | | Method: | SOLUTION NMR | | Cite: | A ubiquitous disordered protein interaction module orchestrates transcription elongation.
Science, 374, 2021
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6SPF
 | | Pseudomonas aeruginosa 70s ribosome from an aminoglycoside resistant clinical isolate | | Descriptor: | 16S rRNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | | Authors: | Halfon, Y, Jimenez-Fernande, A, La Ros, R, Espinos, R, Krogh Johansen, H, Matzov, D, Eyal, Z, Bashan, A, Zimmerman, E, Belousoff, M, Molin, S, Yonath, A. | | Deposit date: | 2019-09-01 | | Release date: | 2019-10-23 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (2.89 Å) | | Cite: | Structure ofPseudomonas aeruginosaribosomes from an aminoglycoside-resistant clinical isolate.
Proc.Natl.Acad.Sci.USA, 116, 2019
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