2HT1
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1H8I
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![BU of 1h8i by Molmil](/molmil-images/mine/1h8i) | X-ray crystal structure of human alpha-thrombin with a tripeptide phosphonate inhibitor. | Descriptor: | HIRUDIN I, N-[(benzyloxy)carbonyl]-beta-phenyl-D-phenylalanyl-N-[(1S)-4-methoxy-1-phosphonobutyl]-L-prolinamide, THROMBIN | Authors: | Skordalakes, E, Dodson, G.G, Green, D, Deadman, J. | Deposit date: | 2001-02-08 | Release date: | 2001-03-02 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Inhibition of Human Alpha-Thrombin by a Phosphonate Tripeptide Proceeds Via a Metastable Pentacoordinated Phosphorus Intermediate J.Mol.Biol., 311, 2001
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1H8D
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![BU of 1h8d by Molmil](/molmil-images/mine/1h8d) | X-ray structure of the human alpha-thrombin complex with a tripeptide phosphonate inhibitor. | Descriptor: | HIRUDIN I, N-[(benzyloxy)carbonyl]-beta-phenyl-D-phenylalanyl-N-{(1S,3E)-1-[dihydroxy(diphenoxy)-lambda~5~-phosphanyl]-4-methoxybut-3-en-1-yl}-L-prolinamide, THROMBIN | Authors: | Skordalakes, E, Dodson, G.G, Green, D, Deadman, J. | Deposit date: | 2001-02-01 | Release date: | 2001-02-26 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Inhibition of Human Alpha-Thrombin by a Phosphonate Tripeptide Proceeds Via a Metastable Pentacoordinated Phosphorus Intermediate J.Mol.Biol., 311, 2001
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1A3B
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![BU of 1a3b by Molmil](/molmil-images/mine/1a3b) | COMPLEX OF HUMAN ALPHA-THROMBIN WITH THE BIFUNCTIONAL BORONATE INHIBITOR BOROLOG1 | Descriptor: | ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), Hirudin, ... | Authors: | Skordalakes, E, Elgendy, S, Dodson, G, Goodwin, C.A, Green, D, Scully, M.F, Freyssinet, J.H, Kakkar, V.V, Deadman, J. | Deposit date: | 1998-01-20 | Release date: | 1998-06-03 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Bifunctional peptide boronate inhibitors of thrombin: crystallographic analysis of inhibition enhanced by linkage to an exosite 1 binding peptide. Biochemistry, 37, 1998
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1A3E
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![BU of 1a3e by Molmil](/molmil-images/mine/1a3e) | COMPLEX OF HUMAN ALPHA-THROMBIN WITH THE BIFUNCTIONAL BORONATE INHIBITOR BOROLOG2 | Descriptor: | ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), BOROLOG2, ... | Authors: | Skordalakes, E, Elgendy, S, Goodwin, C.A, Green, D, Scullly, M.F, Kakkar, V.V, Freyssinet, J.M, Dodson, G, Deadman, J. | Deposit date: | 1998-01-21 | Release date: | 1998-06-03 | Last modified: | 2023-08-02 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Bifunctional peptide boronate inhibitors of thrombin: crystallographic analysis of inhibition enhanced by linkage to an exosite 1 binding peptide. Biochemistry, 37, 1998
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7SBE
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1XPR
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![BU of 1xpr by Molmil](/molmil-images/mine/1xpr) | Structural mechanism of inhibition of the Rho transcription termination factor by the antibiotic 5a-formylbicyclomycin (FB) | Descriptor: | 5'-R(*CP*UP*CP*UP*CP*UP*CP*U)-3', 5A-FORMYLBICYCLOMYCIN, MAGNESIUM ION, ... | Authors: | Skordalakes, E, Brogan, A.P, Park, B.S, Kohn, H, Berger, J.M. | Deposit date: | 2004-10-09 | Release date: | 2004-11-02 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (3.15 Å) | Cite: | Structural mechanism of inhibition of the rho transcription termination factor by the antibiotic bicyclomycin Structure, 13, 2005
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1XPU
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![BU of 1xpu by Molmil](/molmil-images/mine/1xpu) | Structural mechanism of inhibition of the Rho transcription termination factor by the antibiotic 5a-(3-formylphenylsulfanyl)-dihydrobicyclomycin (FPDB) | Descriptor: | 5'-R(*CP*UP*CP*UP*CP*UP*CP*U)-3', 5A-(3-FORMYLPHENYLSULFANYL)-DIHYDROBICYCLOMYCIN, MAGNESIUM ION, ... | Authors: | Skordalakes, E, Brogan, A.P, Park, B.S, Kohn, H, Berger, J.M. | Deposit date: | 2004-10-09 | Release date: | 2004-11-02 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (3.05 Å) | Cite: | Structural mechanism of inhibition of the rho transcription termination factor by the antibiotic bicyclomycin Structure, 13, 2005
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1XPO
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![BU of 1xpo by Molmil](/molmil-images/mine/1xpo) | Structural mechanism of inhibition of the Rho transcription termination factor by the antibiotic bicyclomycin | Descriptor: | 5'-R(*CP*UP*CP*UP*CP*UP*CP*U)-3', BICYCLOMYCIN, MAGNESIUM ION, ... | Authors: | Skordalakes, E, Brogan, A.P, Park, B.S, Kohn, H, Berger, J.M. | Deposit date: | 2004-10-09 | Release date: | 2005-02-08 | Last modified: | 2018-01-31 | Method: | X-RAY DIFFRACTION (3.15 Å) | Cite: | Structural mechanism of inhibition of the rho transcription termination factor by the antibiotic bicyclomycin Structure, 13, 2005
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1PV4
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1PVO
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5UGW
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![BU of 5ugw by Molmil](/molmil-images/mine/5ugw) | STRUCTURE OF THE HUMAN TELOMERASE THUMB DOMAIN | Descriptor: | GLUTATHIONE, Telomerase reverse transcriptase | Authors: | Skordalakes, E, Hoffman, H. | Deposit date: | 2017-01-10 | Release date: | 2017-02-08 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | Structural Analysis Reveals the Deleterious Effects of Telomerase Mutations in Bone Marrow Failure Syndromes. J. Biol. Chem., 292, 2017
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3KYL
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3DU5
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3DU6
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5CQG
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![BU of 5cqg by Molmil](/molmil-images/mine/5cqg) | Structure of Tribolium telomerase in complex with the highly specific inhibitor BIBR1532 | Descriptor: | 2-{[(2E)-3-(naphthalen-2-yl)but-2-enoyl]amino}benzoic acid, Telomerase reverse transcriptase | Authors: | Bryan, C, Rice, C, Hoffman, H, Harkisheimer, M, Sweeney, M, Skordalakes, E. | Deposit date: | 2015-07-21 | Release date: | 2015-09-09 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural Basis of Telomerase Inhibition by the Highly Specific BIBR1532. Structure, 23, 2015
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5W2L
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![BU of 5w2l by Molmil](/molmil-images/mine/5w2l) | Structure of a central domain of human Ctc1 | Descriptor: | CST complex subunit CTC1, MERCURY (II) ION | Authors: | Rice, C, Skordalakes, E. | Deposit date: | 2017-06-06 | Release date: | 2017-11-29 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Structural and functional analysis of an OB-fold in human Ctc1 implicated in telomere maintenance and bone marrow syndromes. Nucleic Acids Res., 46, 2018
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6E53
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![BU of 6e53 by Molmil](/molmil-images/mine/6e53) | Structure of TERT in complex with a novel telomerase inhibitor | Descriptor: | MAGNESIUM ION, RNA/DNA hairpin, Telomerase reverse transcriptase, ... | Authors: | Hernandez-Sanchez, W, Huang, W, Plucinsky, B, Garcia-Vazquez, N, Berdis, A.J, Skordalakes, E, Taylor, D.J. | Deposit date: | 2018-07-19 | Release date: | 2019-03-27 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | A non-natural nucleotide uses a specific pocket to selectively inhibit telomerase activity. Plos Biol., 17, 2019
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3FK3
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![BU of 3fk3 by Molmil](/molmil-images/mine/3fk3) | Structure of the Yeats Domain, Yaf9 | Descriptor: | Protein AF-9 homolog | Authors: | Wang, A.Y, Schulze, J.M, Skordalakes, E, Berger, J.M, Rine, J, Kobor, M.S. | Deposit date: | 2008-12-15 | Release date: | 2009-10-27 | Last modified: | 2021-03-31 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Asf1-like structure of the conserved Yaf9 YEATS domain and role in H2A.Z deposition and acetylation Proc.Natl.Acad.Sci.USA, 106, 2009
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4HCE
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![BU of 4hce by Molmil](/molmil-images/mine/4hce) | Crystal structure of the telomeric Saccharomyces cerevisiae Cdc13 OB2 domain | Descriptor: | Cell division control protein 13 | Authors: | Mason, M, Wannat, J.J, Harper, S, Schultz, D.C, Speicher, D.W, Johnson, F.B, Skordalakes, E. | Deposit date: | 2012-09-29 | Release date: | 2012-11-28 | Last modified: | 2013-01-30 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Cdc13 OB2 Dimerization Required for Productive Stn1 Binding and Efficient Telomere Maintenance. Structure, 21, 2013
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5UN7
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![BU of 5un7 by Molmil](/molmil-images/mine/5un7) | Structure of the human POT1-TPP1 telomeric complex | Descriptor: | Adrenocortical dysplasia protein homolog, POTASSIUM ION, Protection of telomeres protein 1, ... | Authors: | Rice, C, Doukov, T, Skordalakes, E. | Deposit date: | 2017-01-30 | Release date: | 2017-04-12 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural and functional analysis of the human POT1-TPP1 telomeric complex. Nat Commun, 8, 2017
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4LMO
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3LAW
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![BU of 3law by Molmil](/molmil-images/mine/3law) | Structure of GTP-bound L129F mutant Rab7 | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Ras-related protein Rab-7a | Authors: | McCray, B.A, Skordalakes, E, Taylor, J.P. | Deposit date: | 2010-01-07 | Release date: | 2010-01-26 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Disease mutations in Rab7 result in unregulated nucleotide exchange and inappropriate activation. Hum.Mol.Genet., 19, 2010
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3NWT
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![BU of 3nwt by Molmil](/molmil-images/mine/3nwt) | Crystal structure of the N-terminal domain of the yeast telomere-binding and telomerase regulatory protein Cdc13 | Descriptor: | Cell division control protein 13 | Authors: | Mitchell, M.T, Smith, J.S, Mason, M, Harper, S, Speicher, D.W, Johnson, F.B, Skordalakes, E. | Deposit date: | 2010-07-10 | Release date: | 2010-09-22 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Cdc13 N-terminal dimerization, DNA binding, and telomere length regulation. Mol.Cell.Biol., 30, 2010
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3NWS
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![BU of 3nws by Molmil](/molmil-images/mine/3nws) | Crystal structure of the N-terminal domain of the yeast telomere-binding and telomerase regulatory protein Cdc13 | Descriptor: | Cell division control protein 13 | Authors: | Mitchell, M.T, Smith, J.S, Mason, M, Harper, S, Speicher, D.W, Johnson, F.B, Skordalakes, E. | Deposit date: | 2010-07-10 | Release date: | 2010-09-22 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Cdc13 N-terminal dimerization, DNA binding, and telomere length regulation. Mol.Cell.Biol., 30, 2010
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