3LAW

Structure of GTP-bound L129F mutant Rab7

Summary for 3LAW

Entry DOI	10.2210/pdb3law/pdb
Descriptor	Ras-related protein Rab-7a, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... (4 entities in total)
Functional Keywords	protein - nucleotide complex, protein mutant, charcot-marie-tooth disease, cytoplasmic vesicle, disease mutation, endosome, gtp-binding, lipoprotein, lysosome, methylation, neuropathy, nucleotide-binding, phosphoprotein, prenylation, protein transport, proton transport
Biological source	Homo sapiens (human)
Cellular location	Late endosome: P51149
Total number of polymer chains	5
Total formula weight	120486.17
Authors	McCray, B.A.,Skordalakes, E.,Taylor, J.P. (deposition date: 2010-01-07, release date: 2010-01-26, Last modification date: 2024-02-21)
Primary citation	McCray, B.A.,Skordalakes, E.,Taylor, J.P. Disease mutations in Rab7 result in unregulated nucleotide exchange and inappropriate activation. Hum.Mol.Genet., 19:1033-1047, 2010 Cited by PubMed: 20028791 DOI: 10.1093/hmg/ddp567 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation