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3LAW

Structure of GTP-bound L129F mutant Rab7

Functional Information from GO Data
ChainGOidnamespacecontents
A0000045biological_processautophagosome assembly
A0000421cellular_componentautophagosome membrane
A0003924molecular_functionGTPase activity
A0003925molecular_functionG protein activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005764cellular_componentlysosome
A0005765cellular_componentlysosomal membrane
A0005768cellular_componentendosome
A0005770cellular_componentlate endosome
A0005794cellular_componentGolgi apparatus
A0005811cellular_componentlipid droplet
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006622biological_processprotein targeting to lysosome
A0006897biological_processendocytosis
A0006914biological_processautophagy
A0007174biological_processepidermal growth factor catabolic process
A0008333biological_processendosome to lysosome transport
A0009617biological_processresponse to bacterium
A0010008cellular_componentendosome membrane
A0015031biological_processprotein transport
A0016020cellular_componentmembrane
A0016042biological_processlipid catabolic process
A0016787molecular_functionhydrolase activity
A0019003molecular_functionGDP binding
A0019076biological_processviral release from host cell
A0022615biological_processprotein to membrane docking
A0030667cellular_componentsecretory granule membrane
A0030670cellular_componentphagocytic vesicle membrane
A0030672cellular_componentsynaptic vesicle membrane
A0030904cellular_componentretromer complex
A0031267molecular_functionsmall GTPase binding
A0031902cellular_componentlate endosome membrane
A0031966cellular_componentmitochondrial membrane
A0033162cellular_componentmelanosome membrane
A0034045cellular_componentphagophore assembly site membrane
A0042147biological_processretrograde transport, endosome to Golgi
A0043231cellular_componentintracellular membrane-bounded organelle
A0045022biological_processearly endosome to late endosome transport
A0045335cellular_componentphagocytic vesicle
A0045453biological_processbone resorption
A0045732biological_processpositive regulation of protein catabolic process
A0046907biological_processintracellular transport
A0048524biological_processpositive regulation of viral process
A0051650biological_processestablishment of vesicle localization
A0061724biological_processlipophagy
A0070062cellular_componentextracellular exosome
A0090382biological_processphagosome maturation
A0090383biological_processphagosome acidification
A0090385biological_processphagosome-lysosome fusion
A0097208cellular_componentalveolar lamellar body
A0099638biological_processendosome to plasma membrane protein transport
A1903542biological_processnegative regulation of exosomal secretion
A1903543biological_processpositive regulation of exosomal secretion
A1905366biological_processnegative regulation of intralumenal vesicle formation
A1905394molecular_functionretromer complex binding
B0000045biological_processautophagosome assembly
B0000421cellular_componentautophagosome membrane
B0003924molecular_functionGTPase activity
B0003925molecular_functionG protein activity
B0005515molecular_functionprotein binding
B0005525molecular_functionGTP binding
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005764cellular_componentlysosome
B0005765cellular_componentlysosomal membrane
B0005768cellular_componentendosome
B0005770cellular_componentlate endosome
B0005794cellular_componentGolgi apparatus
B0005811cellular_componentlipid droplet
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006622biological_processprotein targeting to lysosome
B0006897biological_processendocytosis
B0006914biological_processautophagy
B0007174biological_processepidermal growth factor catabolic process
B0008333biological_processendosome to lysosome transport
B0009617biological_processresponse to bacterium
B0010008cellular_componentendosome membrane
B0015031biological_processprotein transport
B0016020cellular_componentmembrane
B0016042biological_processlipid catabolic process
B0016787molecular_functionhydrolase activity
B0019003molecular_functionGDP binding
B0019076biological_processviral release from host cell
B0022615biological_processprotein to membrane docking
B0030667cellular_componentsecretory granule membrane
B0030670cellular_componentphagocytic vesicle membrane
B0030672cellular_componentsynaptic vesicle membrane
B0030904cellular_componentretromer complex
B0031267molecular_functionsmall GTPase binding
B0031902cellular_componentlate endosome membrane
B0031966cellular_componentmitochondrial membrane
B0033162cellular_componentmelanosome membrane
B0034045cellular_componentphagophore assembly site membrane
B0042147biological_processretrograde transport, endosome to Golgi
B0043231cellular_componentintracellular membrane-bounded organelle
B0045022biological_processearly endosome to late endosome transport
B0045335cellular_componentphagocytic vesicle
B0045453biological_processbone resorption
B0045732biological_processpositive regulation of protein catabolic process
B0046907biological_processintracellular transport
B0048524biological_processpositive regulation of viral process
B0051650biological_processestablishment of vesicle localization
B0061724biological_processlipophagy
B0070062cellular_componentextracellular exosome
B0090382biological_processphagosome maturation
B0090383biological_processphagosome acidification
B0090385biological_processphagosome-lysosome fusion
B0097208cellular_componentalveolar lamellar body
B0099638biological_processendosome to plasma membrane protein transport
B1903542biological_processnegative regulation of exosomal secretion
B1903543biological_processpositive regulation of exosomal secretion
B1905366biological_processnegative regulation of intralumenal vesicle formation
B1905394molecular_functionretromer complex binding
C0000045biological_processautophagosome assembly
C0000421cellular_componentautophagosome membrane
C0003924molecular_functionGTPase activity
C0003925molecular_functionG protein activity
C0005515molecular_functionprotein binding
C0005525molecular_functionGTP binding
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005764cellular_componentlysosome
C0005765cellular_componentlysosomal membrane
C0005768cellular_componentendosome
C0005770cellular_componentlate endosome
C0005794cellular_componentGolgi apparatus
C0005811cellular_componentlipid droplet
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0006622biological_processprotein targeting to lysosome
C0006897biological_processendocytosis
C0006914biological_processautophagy
C0007174biological_processepidermal growth factor catabolic process
C0008333biological_processendosome to lysosome transport
C0009617biological_processresponse to bacterium
C0010008cellular_componentendosome membrane
C0015031biological_processprotein transport
C0016020cellular_componentmembrane
C0016042biological_processlipid catabolic process
C0016787molecular_functionhydrolase activity
C0019003molecular_functionGDP binding
C0019076biological_processviral release from host cell
C0022615biological_processprotein to membrane docking
C0030667cellular_componentsecretory granule membrane
C0030670cellular_componentphagocytic vesicle membrane
C0030672cellular_componentsynaptic vesicle membrane
C0030904cellular_componentretromer complex
C0031267molecular_functionsmall GTPase binding
C0031902cellular_componentlate endosome membrane
C0031966cellular_componentmitochondrial membrane
C0033162cellular_componentmelanosome membrane
C0034045cellular_componentphagophore assembly site membrane
C0042147biological_processretrograde transport, endosome to Golgi
C0043231cellular_componentintracellular membrane-bounded organelle
C0045022biological_processearly endosome to late endosome transport
C0045335cellular_componentphagocytic vesicle
C0045453biological_processbone resorption
C0045732biological_processpositive regulation of protein catabolic process
C0046907biological_processintracellular transport
C0048524biological_processpositive regulation of viral process
C0051650biological_processestablishment of vesicle localization
C0061724biological_processlipophagy
C0070062cellular_componentextracellular exosome
C0090382biological_processphagosome maturation
C0090383biological_processphagosome acidification
C0090385biological_processphagosome-lysosome fusion
C0097208cellular_componentalveolar lamellar body
C0099638biological_processendosome to plasma membrane protein transport
C1903542biological_processnegative regulation of exosomal secretion
C1903543biological_processpositive regulation of exosomal secretion
C1905366biological_processnegative regulation of intralumenal vesicle formation
C1905394molecular_functionretromer complex binding
D0000045biological_processautophagosome assembly
D0000421cellular_componentautophagosome membrane
D0003924molecular_functionGTPase activity
D0003925molecular_functionG protein activity
D0005515molecular_functionprotein binding
D0005525molecular_functionGTP binding
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005764cellular_componentlysosome
D0005765cellular_componentlysosomal membrane
D0005768cellular_componentendosome
D0005770cellular_componentlate endosome
D0005794cellular_componentGolgi apparatus
D0005811cellular_componentlipid droplet
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0006622biological_processprotein targeting to lysosome
D0006897biological_processendocytosis
D0006914biological_processautophagy
D0007174biological_processepidermal growth factor catabolic process
D0008333biological_processendosome to lysosome transport
D0009617biological_processresponse to bacterium
D0010008cellular_componentendosome membrane
D0015031biological_processprotein transport
D0016020cellular_componentmembrane
D0016042biological_processlipid catabolic process
D0016787molecular_functionhydrolase activity
D0019003molecular_functionGDP binding
D0019076biological_processviral release from host cell
D0022615biological_processprotein to membrane docking
D0030667cellular_componentsecretory granule membrane
D0030670cellular_componentphagocytic vesicle membrane
D0030672cellular_componentsynaptic vesicle membrane
D0030904cellular_componentretromer complex
D0031267molecular_functionsmall GTPase binding
D0031902cellular_componentlate endosome membrane
D0031966cellular_componentmitochondrial membrane
D0033162cellular_componentmelanosome membrane
D0034045cellular_componentphagophore assembly site membrane
D0042147biological_processretrograde transport, endosome to Golgi
D0043231cellular_componentintracellular membrane-bounded organelle
D0045022biological_processearly endosome to late endosome transport
D0045335cellular_componentphagocytic vesicle
D0045453biological_processbone resorption
D0045732biological_processpositive regulation of protein catabolic process
D0046907biological_processintracellular transport
D0048524biological_processpositive regulation of viral process
D0051650biological_processestablishment of vesicle localization
D0061724biological_processlipophagy
D0070062cellular_componentextracellular exosome
D0090382biological_processphagosome maturation
D0090383biological_processphagosome acidification
D0090385biological_processphagosome-lysosome fusion
D0097208cellular_componentalveolar lamellar body
D0099638biological_processendosome to plasma membrane protein transport
D1903542biological_processnegative regulation of exosomal secretion
D1903543biological_processpositive regulation of exosomal secretion
D1905366biological_processnegative regulation of intralumenal vesicle formation
D1905394molecular_functionretromer complex binding
E0000045biological_processautophagosome assembly
E0000421cellular_componentautophagosome membrane
E0003924molecular_functionGTPase activity
E0003925molecular_functionG protein activity
E0005515molecular_functionprotein binding
E0005525molecular_functionGTP binding
E0005737cellular_componentcytoplasm
E0005739cellular_componentmitochondrion
E0005764cellular_componentlysosome
E0005765cellular_componentlysosomal membrane
E0005768cellular_componentendosome
E0005770cellular_componentlate endosome
E0005794cellular_componentGolgi apparatus
E0005811cellular_componentlipid droplet
E0005829cellular_componentcytosol
E0005886cellular_componentplasma membrane
E0006622biological_processprotein targeting to lysosome
E0006897biological_processendocytosis
E0006914biological_processautophagy
E0007174biological_processepidermal growth factor catabolic process
E0008333biological_processendosome to lysosome transport
E0009617biological_processresponse to bacterium
E0010008cellular_componentendosome membrane
E0015031biological_processprotein transport
E0016020cellular_componentmembrane
E0016042biological_processlipid catabolic process
E0016787molecular_functionhydrolase activity
E0019003molecular_functionGDP binding
E0019076biological_processviral release from host cell
E0022615biological_processprotein to membrane docking
E0030667cellular_componentsecretory granule membrane
E0030670cellular_componentphagocytic vesicle membrane
E0030672cellular_componentsynaptic vesicle membrane
E0030904cellular_componentretromer complex
E0031267molecular_functionsmall GTPase binding
E0031902cellular_componentlate endosome membrane
E0031966cellular_componentmitochondrial membrane
E0033162cellular_componentmelanosome membrane
E0034045cellular_componentphagophore assembly site membrane
E0042147biological_processretrograde transport, endosome to Golgi
E0043231cellular_componentintracellular membrane-bounded organelle
E0045022biological_processearly endosome to late endosome transport
E0045335cellular_componentphagocytic vesicle
E0045453biological_processbone resorption
E0045732biological_processpositive regulation of protein catabolic process
E0046907biological_processintracellular transport
E0048524biological_processpositive regulation of viral process
E0051650biological_processestablishment of vesicle localization
E0061724biological_processlipophagy
E0070062cellular_componentextracellular exosome
E0090382biological_processphagosome maturation
E0090383biological_processphagosome acidification
E0090385biological_processphagosome-lysosome fusion
E0097208cellular_componentalveolar lamellar body
E0099638biological_processendosome to plasma membrane protein transport
E1903542biological_processnegative regulation of exosomal secretion
E1903543biological_processpositive regulation of exosomal secretion
E1905366biological_processnegative regulation of intralumenal vesicle formation
E1905394molecular_functionretromer complex binding
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG A 1401
ChainResidue
ATHR22
ATHR40
AASP63
ATHR64
AGNP1400

site_idAC2
Number of Residues24
DetailsBINDING SITE FOR RESIDUE GNP A 1400
ChainResidue
AGLY20
ALYS21
ATHR22
ASER23
APHE33
ASER34
AASN35
ATYR37
ATHR40
AGLY66
AASN125
ALYS126
AASP128
APHE129
ASER155
AALA156
ALYS157
AHOH216
AMG1401
BPHE45
AASP16
ASER17
AGLY18
AVAL19

site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG B 1401
ChainResidue
BTHR22
BTHR40
BASP63
BTHR64
BGNP1400

site_idAC4
Number of Residues22
DetailsBINDING SITE FOR RESIDUE GNP B 1400
ChainResidue
BSER17
BGLY18
BVAL19
BGLY20
BLYS21
BTHR22
BSER23
BPHE33
BSER34
BASN35
BTYR37
BTHR40
BGLY66
BASN125
BLYS126
BASP128
BPHE129
BSER155
BALA156
BLYS157
BMG1401
DTHR47

site_idAC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MG C 1401
ChainResidue
CTHR22
CTHR40
CASP63
CGNP1400

site_idAC6
Number of Residues22
DetailsBINDING SITE FOR RESIDUE GNP C 1400
ChainResidue
ATHR47
CSER17
CGLY18
CVAL19
CGLY20
CLYS21
CTHR22
CSER23
CPHE33
CSER34
CASN35
CTYR37
CTHR40
CGLY66
CASN125
CLYS126
CASP128
CPHE129
CSER155
CALA156
CLYS157
CMG1401

site_idAC7
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG D 1401
ChainResidue
DTHR22
DTHR40
DASP63
DTHR64
DGNP1400

site_idAC8
Number of Residues22
DetailsBINDING SITE FOR RESIDUE GNP D 1400
ChainResidue
DGLY66
DASN125
DLYS126
DASP128
DPHE129
DALA156
DLYS157
DMG1401
EPHE45
ETHR47
DSER17
DGLY18
DVAL19
DGLY20
DLYS21
DTHR22
DSER23
DSER34
DASN35
DTYR37
DALA39
DTHR40

site_idAC9
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG E 1401
ChainResidue
ETHR22
ETHR40
EASP63
ETHR64
EGNP1400

site_idBC1
Number of Residues24
DetailsBINDING SITE FOR RESIDUE GNP E 1400
ChainResidue
CPHE45
EASP16
ESER17
EGLY18
EVAL19
EGLY20
ELYS21
ETHR22
ESER23
EPHE33
ESER34
EASN35
ETYR37
ETHR40
EALA65
EGLY66
EASN125
ELYS126
EASP128
EPHE129
ESER155
EALA156
ELYS157
EMG1401

Functional Information from PROSITE/UniProt
site_idPS00675
Number of Residues14
DetailsSIGMA54_INTERACT_1 Sigma-54 interaction domain ATP-binding region A signature. VIIlGDSGVGKtsL
ChainResidueDetails
AVAL11-LEU24

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues25
DetailsBINDING: BINDING => ECO:0000269|PubMed:15933719, ECO:0000269|PubMed:20028791
ChainResidueDetails
AGLY15
BALA156
CGLY15
CSER34
CASP63
CASN125
CALA156
DGLY15
DSER34
DASP63
DASN125
ASER34
DALA156
EGLY15
ESER34
EASP63
EASN125
EALA156
AASP63
AASN125
AALA156
BGLY15
BSER34
BASP63
BASN125

site_idSWS_FT_FI2
Number of Residues5
DetailsMOD_RES: N-acetylthreonine => ECO:0007744|PubMed:25944712
ChainResidueDetails
ATHR2
BTHR2
CTHR2
DTHR2
ETHR2

site_idSWS_FT_FI3
Number of Residues5
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER72
BSER72
CSER72
DSER72
ESER72

site_idSWS_FT_FI4
Number of Residues5
DetailsMOD_RES: Cysteine methyl ester => ECO:0000250
ChainResidueDetails
ACYS207
BCYS207
CCYS207
DCYS207
ECYS207

site_idSWS_FT_FI5
Number of Residues10
DetailsLIPID: S-geranylgeranyl cysteine => ECO:0000250
ChainResidueDetails
ACYS205
ECYS207
ACYS207
BCYS205
BCYS207
CCYS205
CCYS207
DCYS205
DCYS207
ECYS205

site_idSWS_FT_FI6
Number of Residues15
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36476874
ChainResidueDetails
ALYS191
DLYS191
DLYS194
ELYS191
ELYS194
ALYS194
BLYS191
BLYS194
CLYS191
CLYS194

223166

PDB entries from 2024-07-31

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