1Y97
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3KIO
| mouse RNase H2 complex | Descriptor: | Ribonuclease H2 subunit A, Ribonuclease H2 subunit B, Ribonuclease H2 subunit C | Authors: | Shaban, N, Harvey, S, Perrino, F.W, Hollis, T. | Deposit date: | 2009-11-02 | Release date: | 2009-11-17 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | The structure of the mammalian RNase H2 complex provides insight into RNA:DNA hybrid processing to prevent immune dysfunction. J.Biol.Chem., 285, 2010
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4WKJ
| Crystallographic Structure of a Dodecameric RNA-DNA Hybrid | Descriptor: | DNA (5'-D(*GP*AP*AP*TP*CP*AP*GP*GP*TP*GP*TP*C)-3'), MAGNESIUM ION, RNA (5'-R(*GP*AP*CP*AP*CP*CP*UP*GP*AP*UP*UP*C)-3') | Authors: | Davis, R.R, Shaban, N.M, Perrino, F.W, Hollis, T. | Deposit date: | 2014-10-02 | Release date: | 2014-10-22 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal structure of RNA-DNA duplex provides insight into conformational changes induced by RNase H binding. Cell Cycle, 14, 2015
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7U8Y
| TREX1 Structural Studies Capture Small Molecule Inhibition and Implicate Novel DNA Dynamics | Descriptor: | ALIZARIN RED, MANGANESE (II) ION, Three-prime repair exonuclease 1 | Authors: | Hemphill, W.O, Harvey, S.E, Simpson, S.R, Smalley, T.L, Salsbury, F.R, Perrino, F.W, Hollis, T. | Deposit date: | 2022-03-09 | Release date: | 2023-03-15 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.22 Å) | Cite: | TREX1 Structural Studies Capture Small Molecule Inhibition and Implicate Novel DNA Dynamics to be published
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4YNQ
| TREX1-dsDNA complex | Descriptor: | DNA (24-MER), DNA (5'-D(P*GP*TP*GP*CP*TP*GP*AP*CP*GP*TP*CP*AP*GP*CP*AP*CP*GP*AP*CP*G)-3'), MAGNESIUM ION, ... | Authors: | Fye, J.M, Harvey, S, Perrino, F.W, Hollis, T. | Deposit date: | 2015-03-10 | Release date: | 2015-05-27 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease. Proc.Natl.Acad.Sci.USA, 112, 2015
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3U6F
| Mouse TREX1 D200N mutant | Descriptor: | 1,4-BUTANEDIOL, 5'-D(*GP*AP*CP*G)-3', MAGNESIUM ION, ... | Authors: | Bailey, S.L, Harvey, S, Perrino, F.W, Hollis, T. | Deposit date: | 2011-10-12 | Release date: | 2011-12-28 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Defects in DNA degradation revealed in crystal structures of TREX1 exonuclease mutations linked to autoimmune disease. Dna Repair, 11, 2012
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3U3Y
| Mouse TREX1 D200H mutant | Descriptor: | 1,4-BUTANEDIOL, 5'-D(*GP*AP*CP*G)-3', CALCIUM ION, ... | Authors: | Bailey, S.L, Harvey, S, Perrino, F.W, Hollis, T. | Deposit date: | 2011-10-06 | Release date: | 2011-12-28 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.28 Å) | Cite: | Defects in DNA degradation revealed in crystal structures of TREX1 exonuclease mutations linked to autoimmune disease. Dna Repair, 11, 2012
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2IDO
| Structure of the E. coli Pol III epsilon-Hot proofreading complex | Descriptor: | 1,2-ETHANEDIOL, DNA polymerase III epsilon subunit, Hot protein, ... | Authors: | Kirby, T.W, Harvey, S, DeRose, E.F, Chalov, S, Chikova, A.K, Perrino, F.W, Schaaper, R.M, London, R.E, Pedersen, L.C. | Deposit date: | 2006-09-15 | Release date: | 2006-11-14 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure of the Escherichia coli DNA polymerase III epsilon-HOT proofreading complex. J.Biol.Chem., 281, 2006
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3EPG
| Structure of Human DNA Polymerase Iota complexed with N2-ethylguanine | Descriptor: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, 5'-D(*DTP*DCP*DTP*(2EG)P*DGP*DGP*DGP*DTP*DCP*DCP*DTP*DAP*DGP*DGP*DAP*DCP*DCP*(DOC))-3', DNA polymerase iota, ... | Authors: | Pence, M.G. | Deposit date: | 2008-09-29 | Release date: | 2008-12-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Lesion bypass of N2-ethylguanine by human DNA polymerase iota. J.Biol.Chem., 284, 2009
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3EPI
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2OA8
| Crystal Structure of mTREX1 with ssDNA | Descriptor: | 5'-D(*GP*AP*CP*G)-3', CALCIUM ION, Three prime repair exonuclease 1 | Authors: | de Silva, U, Hollis, T. | Deposit date: | 2006-12-15 | Release date: | 2007-02-20 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The Crystal Structure of TREX1 Explains the 3' Nucleotide Specificity and Reveals a Polyproline II Helix for Protein Partnering. J.Biol.Chem., 282, 2007
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2IOC
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3MXM
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3MXJ
| Crystal Structure of the mTREX1 Apoprotein | Descriptor: | Three prime repair exonuclease 1 | Authors: | Bailey, S.L, Hollis, T. | Deposit date: | 2010-05-07 | Release date: | 2011-05-18 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | X-ray Crystal Structures of TREX1 3' Exonuclease Autoimmune Disease Mutants To be Published
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3MXI
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3P5J
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